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OG488 Diacetate Taxol Conjugate *Cell-Permeable*
OG488 Diacetate Taxol Conjugate is the same compound as Oregon Green™ 488 Taxol, bis-acetate. Taxol, also known as Paclitaxel, is an anticancer agent. Taxol is known to promote tubulin assembly into stable aggregated structures. The OG488 Diacetate Taxol Conjugate is an effective fluorescent probe for studying microtubules in live cells. The diacetate blocking groups are readily cleaved in live cells by intracellular esterases to release the bright green OG488 fluorophore. The fluorescent label OG488 Diacetate is attached to paclitaxel by derivatization of the 7-β-hydroxy group of native paclitaxel, minimizing the interference of OG488 fluorophore on the binding of the probe to microtubules. OG488 Diacetate Taxol Conjugate has been successfully used for live-cell tubulin labeling. It is much more cell-permeable than OG488 Taxol Conjugate (#23175).
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References
View all 9 references: Citation Explorer
Sensitivity to antitubulin chemotherapeutics is potentiated by a photoactivable nanoliposome.
Authors: Wang, Xiaobing and Liu, Xiufang and Li, Yixiang and Wang, Pan and Feng, Xiaolan and Liu, Quanhong and Yan, Fei and Zheng, Hairong
Journal: Biomaterials (2017): 50-62
Authors: Wang, Xiaobing and Liu, Xiufang and Li, Yixiang and Wang, Pan and Feng, Xiaolan and Liu, Quanhong and Yan, Fei and Zheng, Hairong
Journal: Biomaterials (2017): 50-62
[Nimotuzumab significantly enhances chemosensitivity of
PC9 human lung adenocarcinoma cells to paclitaxel in vitro].
Authors: Xiao, Yu and Cao, Baoshan and Liang, Li
Journal: Zhongguo fei ai za zhi = Chinese journal of lung cancer (2015): 98-103
Authors: Xiao, Yu and Cao, Baoshan and Liang, Li
Journal: Zhongguo fei ai za zhi = Chinese journal of lung cancer (2015): 98-103
[Down-regulated βIII-tubulin expression can reverse paclitaxel resistance in A549/taxol cells lines].
Authors: Zhuo, Yinling and Guo, Qisen
Journal: Zhongguo fei ai za zhi = Chinese journal of lung cancer (2014): 581-7
Authors: Zhuo, Yinling and Guo, Qisen
Journal: Zhongguo fei ai za zhi = Chinese journal of lung cancer (2014): 581-7
Ion specific effects in bundling and depolymerization of taxol-stabilized microtubules.
Authors: Needleman, Daniel J and Ojeda-Lopez, Miguel A and Raviv, Uri and Miller, Herbert P and Li, Youli and Song, Chaeyeon and Feinstein, Stuart C and Wilson, Leslie and Choi, Myung Chul and Safinya, Cyrus R
Journal: Faraday discussions (2013): 31-45
Authors: Needleman, Daniel J and Ojeda-Lopez, Miguel A and Raviv, Uri and Miller, Herbert P and Li, Youli and Song, Chaeyeon and Feinstein, Stuart C and Wilson, Leslie and Choi, Myung Chul and Safinya, Cyrus R
Journal: Faraday discussions (2013): 31-45
Vibrational circular dichroism analysis reveals a conformational change of the baccatin III ring of paclitaxel: visualization of conformations using a new code for structure-activity relationships.
Authors: Izumi, Hiroshi and Ogata, Atsushi and Nafie, Laurence A and Dukor, Rina K
Journal: The Journal of organic chemistry (2008): 2367-72
Authors: Izumi, Hiroshi and Ogata, Atsushi and Nafie, Laurence A and Dukor, Rina K
Journal: The Journal of organic chemistry (2008): 2367-72
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