Mouse Anti-PEG mAb [Anti-Polyethylene glycol monoclonal antibody]
PEG Antibody, mAb, Mouse has high affinity for the PEG backbone. The antibody binds to the variety of PEG such as PEG40K, PEG20K, PEG5K, PEG12, PEGylated drugs and PEG conjugates.Some reagents such as Tween-20, Triton X-100 and NP-40 interfere with the PEG antibody interaction due to structural similarity to PEG. Antibody solution should not contain such reagents in the assay of PEGylated molecules.
References
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Beyond hydrophilic polymers in amphiphilic polymer-based self-assembled NanoCarriers: Small hydrophilic carboxylate-capped disulfide drug delivery system and its multifunctionality and multispatial targetability.
Authors: Choi, Yeon Su and Cho, Hana and Choi, Won-Gu and Lee, Sung Su and Huh, Kang Moo and Shim, Min Suk and Park, In Suh and Cho, Yong-Yeon and Lee, Joo Young and Lee, Hye Suk and Kang, Han Chang
Journal: Biomaterials (2022): 121307
Authors: Choi, Yeon Su and Cho, Hana and Choi, Won-Gu and Lee, Sung Su and Huh, Kang Moo and Shim, Min Suk and Park, In Suh and Cho, Yong-Yeon and Lee, Joo Young and Lee, Hye Suk and Kang, Han Chang
Journal: Biomaterials (2022): 121307
A PBPK model recapitulates early kinetics of anti-PEG antibody-mediated clearance of PEG-liposomes.
Authors: Talkington, Anne M and McSweeney, Morgan D and Wessler, Timothy and Rath, Marielle K and Li, Zibo and Zhang, Tao and Yuan, Hong and Frank, Jonathan E and Forest, M Gregory and Cao, Yanguang and Lai, Samuel K
Journal: Journal of controlled release : official journal of the Controlled Release Society (2022): 518-527
Authors: Talkington, Anne M and McSweeney, Morgan D and Wessler, Timothy and Rath, Marielle K and Li, Zibo and Zhang, Tao and Yuan, Hong and Frank, Jonathan E and Forest, M Gregory and Cao, Yanguang and Lai, Samuel K
Journal: Journal of controlled release : official journal of the Controlled Release Society (2022): 518-527
Subvisible Particles Derived by Dropping Stress Enhance Anti-PEG Antibody Production and Clearance of PEGylated Proteins in Mice.
Authors: Nakajima, Takaki and Nagano, Kazuya and Fukuda, Yuka and Ishima, Yu and Shibata, Hiroko and Isaka, Ryo and Zhang, Tian-Qi and Haga, Yuya and Higashisaka, Kazuma and Tsujino, Hirofumi and Ishida, Tatsuhiro and Ishii-Watabe, Akiko and Tsutsumi, Yasuo
Journal: Journal of pharmaceutical sciences (2022): 1363-1369
Authors: Nakajima, Takaki and Nagano, Kazuya and Fukuda, Yuka and Ishima, Yu and Shibata, Hiroko and Isaka, Ryo and Zhang, Tian-Qi and Haga, Yuya and Higashisaka, Kazuma and Tsujino, Hirofumi and Ishida, Tatsuhiro and Ishii-Watabe, Akiko and Tsutsumi, Yasuo
Journal: Journal of pharmaceutical sciences (2022): 1363-1369
Toxicity of high-molecular-weight polyethylene glycols in Sprague Dawley rats.
Authors: Fang, Jia-Long and Vanlandingham, Michelle M and Beland, Frederick A and Felton, Robert P and Maisha, Mackean P and Olson, Greg R and Patton, Ralph E and Rosenberg, Amy S and Gamboa da Costa, Gonçalo
Journal: Toxicology letters (2022): 22-30
Authors: Fang, Jia-Long and Vanlandingham, Michelle M and Beland, Frederick A and Felton, Robert P and Maisha, Mackean P and Olson, Greg R and Patton, Ralph E and Rosenberg, Amy S and Gamboa da Costa, Gonçalo
Journal: Toxicology letters (2022): 22-30
Using Bio-Layer Interferometry to Evaluate Anti-PEG Antibody-Mediated Complement Activation.
Authors: Mostafa, Mahmoud and Elsadek, Nehal E and Emam, Sherif E and Ando, Hidenori and Shimizu, Taro and Abdelkader, Hamdy and Ishima, Yu and Aly, Usama Farghaly and Sarhan, Hatem A and Ishida, Tatsuhiro
Journal: Biological & pharmaceutical bulletin (2022): 129-135
Authors: Mostafa, Mahmoud and Elsadek, Nehal E and Emam, Sherif E and Ando, Hidenori and Shimizu, Taro and Abdelkader, Hamdy and Ishima, Yu and Aly, Usama Farghaly and Sarhan, Hatem A and Ishida, Tatsuhiro
Journal: Biological & pharmaceutical bulletin (2022): 129-135
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