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Indocyanine Green *CAS 3599-32-4*
Indocyanine green (ICG) is a cyanine dye used in medical diagnostics. ICG is used for determining cardiac output, hepatic function, liver blood flow, and for ophthalmic angiography. ICG has a peak spectral absorption close to 800 nm. These infrared frequencies penetrate retinal layers, allowing ICG angiography to image deeper patterns of circulation than fluorescein angiography. ICG binds tightly to plasma proteins and becomes confined to the vascular system. ICG has a half-life of 150 to 180 seconds and is removed from circulation exclusively by the liver to bile juice. A recent study indicated ICG targets atheromas within 20 min of injection and provides sufficient signal enhancement for in vivo detection of lipid-rich, inflamed, coronary-sized plaques in atherosclerotic rabbits. Ex vivo fluorescence reflectance imaging showed high plaque target-to-background ratios in atheroma-bearing rabbits injected with ICG compared to atheroma-bearing rabbits injected with saline.
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Common stock solution preparation
Table 1. Volume of DMSO needed to reconstitute specific mass of Indocyanine Green *CAS 3599-32-4* to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.
| 0.1 mg | 0.5 mg | 1 mg | 5 mg | 10 mg | |
| 1 mM | 129.039 µL | 645.195 µL | 1.29 mL | 6.452 mL | 12.904 mL |
| 5 mM | 25.808 µL | 129.039 µL | 258.078 µL | 1.29 mL | 2.581 mL |
| 10 mM | 12.904 µL | 64.519 µL | 129.039 µL | 645.195 µL | 1.29 mL |
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Spectrum
Product family
| Name | Excitation (nm) | Emission (nm) |
| Helixyte™ Green *20X Aqueous PCR Solution* | 498 | 522 |
| Helixyte™ Green *10,000X Aqueous PCR Solution* | 498 | 522 |
| Thiolite™ Green | 505 | 524 |
| CytoTell™ Green | 510 | 525 |
| LysoBrite™ Green | 501 | 510 |
| Q4ever™ Green *1250X DMSO Solution* | 503 | 527 |
| Droplite™ Green | 421 | 521 |
| FerroBrite™ Green | 453 | 552 |
Citations
View all 3 citations: Citation Explorer
Tuning nanoparticle core composition drives orthogonal fluorescence amplification for enhanced tumour imaging
Authors: Pan, Meijie and Zhao, Ruiyang and Fu, Chuanxun and Tang, Mingmei and Zhou, Jiayi and Ma, Bin and Liu, Jianxiong and Yang, Ye and Chen, Binlong and Zhang, Qiang and others,
Journal: Nature Communications (2024): 7824
Authors: Pan, Meijie and Zhao, Ruiyang and Fu, Chuanxun and Tang, Mingmei and Zhou, Jiayi and Ma, Bin and Liu, Jianxiong and Yang, Ye and Chen, Binlong and Zhang, Qiang and others,
Journal: Nature Communications (2024): 7824
Novel strategies for enhanced fluorescence visualization of glioblastoma tumors based on HPMA copolymers conjugated with tumor targeting and/or cell-penetrating peptides
Authors: Grosmanov{\'a}, Eli{\v{s}}ka and Pola, Robert and Filipov{\'a}, Marcela and Henry, Maxime and Coll, Jean-Luc and Etrych, Tom{\'a}{\v{s}}
Journal: View (2024): 20230116
Authors: Grosmanov{\'a}, Eli{\v{s}}ka and Pola, Robert and Filipov{\'a}, Marcela and Henry, Maxime and Coll, Jean-Luc and Etrych, Tom{\'a}{\v{s}}
Journal: View (2024): 20230116
Nanodiamonds for bioapplications, recent developments
Authors: Bondon, Nicolas and Raehm, Laurence and Charnay, Clarence and Boukherroub, Rabah and Durand, Jean-Olivier
Journal: Journal of Materials Chemistry B (2020): 10878--10896
Authors: Bondon, Nicolas and Raehm, Laurence and Charnay, Clarence and Boukherroub, Rabah and Durand, Jean-Olivier
Journal: Journal of Materials Chemistry B (2020): 10878--10896
References
View all 37 references: Citation Explorer
Simultaneous confocal laser endomicroscopy and chromoendoscopy with topical cresyl violet
Authors: Goetz M, Toermer T, Vieth M, Dunbar K, Hoffman A, Galle PR, Neurath MF, Delaney P, Kiesslich R.
Journal: Gastrointest Endosc (2009): 959
Authors: Goetz M, Toermer T, Vieth M, Dunbar K, Hoffman A, Galle PR, Neurath MF, Delaney P, Kiesslich R.
Journal: Gastrointest Endosc (2009): 959
Single-molecule fluorescence spectroelectrochemistry of cresyl violet
Authors: Lei C, Hu D, Ackerman EJ.
Journal: Chem Commun (Camb) (2008): 5490
Authors: Lei C, Hu D, Ackerman EJ.
Journal: Chem Commun (Camb) (2008): 5490
Electronic absorption spectra of cresyl violet acetate in anisotropic and isotropic solvents
Authors: Jafari A, Ghanadzadeh A, Tajalli H, Yeganeh M, Moghadam M.
Journal: Spectrochim Acta A Mol Biomol Spectrosc (2007): 717
Authors: Jafari A, Ghanadzadeh A, Tajalli H, Yeganeh M, Moghadam M.
Journal: Spectrochim Acta A Mol Biomol Spectrosc (2007): 717
Chromoendoscopy in Barrett's oesophagus: is cresyl violet the magic bullet
Authors: Kiesslich R, Neurath MF.
Journal: Dig Liver Dis (2006): 301
Authors: Kiesslich R, Neurath MF.
Journal: Dig Liver Dis (2006): 301
Infarct volume quantification in mouse focal cerebral ischemia: a comparison of triphenyltetrazolium chloride and cresyl violet staining techniques
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Journal: J Neurosci Methods (2004): 203
Authors: Tureyen K, Vemuganti R, Sailor KA, Dempsey RJ.
Journal: J Neurosci Methods (2004): 203
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