ICG-TFP ester
Ordering information
Price | |
Catalog Number | |
Unit Size | |
Quantity |
Additional ordering information
Telephone | 1-800-990-8053 |
Fax | 1-800-609-2943 |
sales@aatbio.com | |
International | See distributors |
Bulk request | Inquire |
Custom size | Inquire |
Shipping | Standard overnight for United States, inquire for international |
Physical properties
Molecular weight | 981.06 |
Solvent | DMSO |
Storage, safety and handling
H-phrase | H303, H313, H333 |
Hazard symbol | XN |
Intended use | Research Use Only (RUO) |
R-phrase | R20, R21, R22 |
Storage | Freeze (< -15 °C); Minimize light exposure |
UNSPSC | 12171501 |
Overview | ![]() ![]() |
See also: Indocyanine Green
Molecular weight 981.06 |
Indocyanine green (ICG) is a cyanine dye used in medical diagnostics. It is used for determining cardiac output, hepatic function, and liver blood flow, and for ophthalmic angiography. It has a peak spectral absorption close to 800 nm. These infrared frequencies penetrate retinal layers, allowing ICG angiography to image deeper patterns of circulation than fluorescein angiography. The amino-reactive ICG-Sulfo-OSu (#180) is predominantly used to make various ICG bioconjugates with antibodies and other biological molecules since it has improved water solubility compared to other ICG amine-reactive derivatives. However, the well-known ICG-Sulfo-OSu is extremely unstable. ICG-TFP ester has significantly improved stability and good water solubility. Under the same conditions, it gives higher conjugation yield than ICG-Sulfo-OSu.
Calculators
Common stock solution preparation
Table 1. Volume of DMSO needed to reconstitute specific mass of ICG-TFP ester to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.
0.1 mg | 0.5 mg | 1 mg | 5 mg | 10 mg | |
1 mM | 101.931 µL | 509.653 µL | 1.019 mL | 5.097 mL | 10.193 mL |
5 mM | 20.386 µL | 101.931 µL | 203.861 µL | 1.019 mL | 2.039 mL |
10 mM | 10.193 µL | 50.965 µL | 101.931 µL | 509.653 µL | 1.019 mL |
Molarity calculator
Enter any two values (mass, volume, concentration) to calculate the third.
Mass (Calculate) | Molecular weight | Volume (Calculate) | Concentration (Calculate) | Moles | ||||
/ | = | x | = |
Citations
View all 5 citations: Citation Explorer
In vivo photoacoustic imaging of cancer using indocyanine green-labeled monoclonal antibody targeting the epidermal growth factor receptor
Authors: Sano, K., Ohashi, M., Kanazaki, K., Ding, N., Deguchi, J., Kanada, Y., Ono, M., Saji, H.
Journal: Biochem Biophys Res Commun (2015): 820-5
Authors: Sano, K., Ohashi, M., Kanazaki, K., Ding, N., Deguchi, J., Kanada, Y., Ono, M., Saji, H.
Journal: Biochem Biophys Res Commun (2015): 820-5
In vitro and in vivo analysis of indocyanine green-labeled panitumumab for optical imaging-a cautionary tale
Authors: Zhou, Y., Kim, Y. S., Milenic, D. E., Baidoo, K. E., Brechbiel, M. W.
Journal: Bioconjug Chem (2014): 1801-10
Authors: Zhou, Y., Kim, Y. S., Milenic, D. E., Baidoo, K. E., Brechbiel, M. W.
Journal: Bioconjug Chem (2014): 1801-10
Activatable fluorescent cys-diabody conjugated with indocyanine green derivative: consideration of fluorescent catabolite kinetics on molecular imaging
Authors: Sano, K., Nakajima, T., Ali, T., Bartlett, D. W., Wu, A. M., Kim, I., Paik, C. H., Choyke, P. L., Kobayashi, H.
Journal: J Biomed Opt (2013): 101304
Authors: Sano, K., Nakajima, T., Ali, T., Bartlett, D. W., Wu, A. M., Kim, I., Paik, C. H., Choyke, P. L., Kobayashi, H.
Journal: J Biomed Opt (2013): 101304
Dual-modality imaging with 99mTc and fluorescent indocyanine green using surface-modified silica nanoparticles for biopsy of the sentinel lymph node: an animal study
Authors: Tsuchimochi, M., Hayama, K., Toyama, M., Sasagawa, I., Tsubokawa, N.
Journal: EJNMMI Res (2013): 33
Authors: Tsuchimochi, M., Hayama, K., Toyama, M., Sasagawa, I., Tsubokawa, N.
Journal: EJNMMI Res (2013): 33
Short PEG-linkers improve the performance of targeted, activatable monoclonal antibody-indocyanine green optical imaging probes
Authors: Sano, K., Nakajima, T., Miyazaki, K., Ohuchi, Y., Ikegami, T., Choyke, P. L., Kobayashi, H.
Journal: Bioconjug Chem (2013): 811-6
Authors: Sano, K., Nakajima, T., Miyazaki, K., Ohuchi, Y., Ikegami, T., Choyke, P. L., Kobayashi, H.
Journal: Bioconjug Chem (2013): 811-6
Application notes
A Meta-Analysis of Common Calcium Indicators
A New Protein Crosslinking Method for Labeling and Modifying Antibodies
A Novel Fluorescent Probe for Imaging and Detecting Hydroxyl Radical in Living Cells
A Novel NO Wash Probeniceid-Free Calcium Assay for Functional Analysis of GPCR and Calcium Channel Targets
Abbreviation of Common Chemical Compounds Related to Peptides
A New Protein Crosslinking Method for Labeling and Modifying Antibodies
A Novel Fluorescent Probe for Imaging and Detecting Hydroxyl Radical in Living Cells
A Novel NO Wash Probeniceid-Free Calcium Assay for Functional Analysis of GPCR and Calcium Channel Targets
Abbreviation of Common Chemical Compounds Related to Peptides
FAQ
Are Cell Navigator® Cell Plasma Membrane Staining Kits suitable for cell culture medium samples?
Are there any alternatives to BrdU (Bromodeoxyuridine)?
Are there any alternatives to Cy5?
Are there any alternatives to indocyanine green (ICG)?
Are there any calcium indicators that don't require probenecid (PBC)?
Are there any alternatives to BrdU (Bromodeoxyuridine)?
Are there any alternatives to Cy5?
Are there any alternatives to indocyanine green (ICG)?
Are there any calcium indicators that don't require probenecid (PBC)?