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GTIF488 [iFluor® 488 gentamicin conjugate]
Gentamicin is widely used for treating tuberculosis and Gram-negative infections and is particularly useful in neonatal intensive care units. Fluorophore-tagged drugs, such as gentamicin- iFluor® 488 (GTIF488) conjugates, might be used to identify drug trafficking routes across the BLB and into hair cells, and specifically in the cochlea - the sensory organ responsible for hearing. Identifying the mechanisms involved in the intracochlear trafficking of ototoxic drugs to hair cells is of fundamental as well as clinical importance. GTIF488 is well excited with the common Argon laser at 488 nm. It provides researchers a valuable tool to study the cellular uptake, kinetics and distribution of gentamicin through fluorescence techniques, such as fluorescence microscopy, fluorescence correlation spectroscopy, single molecule spectroscopy. The iFluor® 488 is well compatible with the common FITC filter set.
Spectrum
References
View all 50 references: Citation Explorer
In vivo real-time imaging reveals megalin as the aminoglycoside gentamicin transporter into cochlea whose inhibition is otoprotective.
Authors: Kim, Jinkyung and Ricci, Anthony J
Journal: Proceedings of the National Academy of Sciences of the United States of America (2022)
Authors: Kim, Jinkyung and Ricci, Anthony J
Journal: Proceedings of the National Academy of Sciences of the United States of America (2022)
Identification of a series of hair-cell MET channel blockers that protect against aminoglycoside-induced ototoxicity.
Authors: Kenyon, Emma J and Kirkwood, Nerissa K and Kitcher, Siân R and Goodyear, Richard J and Derudas, Marco and Cantillon, Daire M and Baxendale, Sarah and de la Vega de León, Antonio and Mahieu, Virginia N and Osgood, Richard T and Wilson, Charlotte Donald and Bull, James C and Waddell, Simon J and Whitfield, Tanya T and Ward, Simon E and Kros, Corné J and Richardson, Guy P
Journal: JCI insight (2021)
Authors: Kenyon, Emma J and Kirkwood, Nerissa K and Kitcher, Siân R and Goodyear, Richard J and Derudas, Marco and Cantillon, Daire M and Baxendale, Sarah and de la Vega de León, Antonio and Mahieu, Virginia N and Osgood, Richard T and Wilson, Charlotte Donald and Bull, James C and Waddell, Simon J and Whitfield, Tanya T and Ward, Simon E and Kros, Corné J and Richardson, Guy P
Journal: JCI insight (2021)
Hair cell uptake of gentamicin in the developing mouse utricle.
Authors: Qian, Xiaoqing and He, Ziyu and Wang, Yanmei and Chen, Binjun and Hetrick, Alisa and Dai, Chunfu and Chi, Fanglu and Li, Hongzhe and Ren, Dongdong
Journal: Journal of cellular physiology (2020)
Authors: Qian, Xiaoqing and He, Ziyu and Wang, Yanmei and Chen, Binjun and Hetrick, Alisa and Dai, Chunfu and Chi, Fanglu and Li, Hongzhe and Ren, Dongdong
Journal: Journal of cellular physiology (2020)
Systemic Fluorescent Gentamicin Enters Neonatal Mouse Hair Cells Predominantly Through Sensory Mechanoelectrical Transduction Channels.
Authors: Makabe, Ayane and Kawashima, Yoshiyuki and Sakamaki, Yuriko and Maruyama, Ayako and Fujikawa, Taro and Ito, Taku and Kurima, Kiyoto and Griffith, Andrew J and Tsutsumi, Takeshi
Journal: Journal of the Association for Research in Otolaryngology : JARO (2020): 137-149
Authors: Makabe, Ayane and Kawashima, Yoshiyuki and Sakamaki, Yuriko and Maruyama, Ayako and Fujikawa, Taro and Ito, Taku and Kurima, Kiyoto and Griffith, Andrew J and Tsutsumi, Takeshi
Journal: Journal of the Association for Research in Otolaryngology : JARO (2020): 137-149
A new aminoglycoside etimicin shows low nephrotoxicity and ototoxicity in zebrafish embryos.
Authors: Shao, Weihao and Zhong, Dan and Jiang, Haowei and Han, Yujie and Yin, Yu and Li, Ruining and Qian, Xiuping and Chen, Daijie and Jing, Lili
Journal: Journal of applied toxicology : JAT (2020)
Authors: Shao, Weihao and Zhong, Dan and Jiang, Haowei and Han, Yujie and Yin, Yu and Li, Ruining and Qian, Xiuping and Chen, Daijie and Jing, Lili
Journal: Journal of applied toxicology : JAT (2020)
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