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Digoxigenin C9 acid
Digoxigenin (DIG) is a hapten, a small molecule with high antigenicity, which is used in many biological detections similarly to other popular haptens such as 2,4-Dinitrophenol (DNP) and biotin. Typically, digoxigenin is conjugated to a macrobiomolecule (e.g., proteins, nucleic acids, etc) to be detected. Anti-digoxigenin antibodies are labeled with fluorescent dyes or enzymes, directly or secondarily, for visualization and detection. Digoxigenin C9 acid is an affordable building block which can be used for attaching the digoxigenin moiety to peptides, proteins, amino-substituted oligonucleotides or other biological molecules. Digoxigenin-labeled biomolecules are used for biological detections in combination with anti-digoxigenin antibodies of high affinity and specificity.
References
View all 50 references: Citation Explorer
Digoxigenin.
Authors: Green, Michael R and Sambrook, Joseph
Journal: Cold Spring Harbor protocols (2022): pdb.top100784
Authors: Green, Michael R and Sambrook, Joseph
Journal: Cold Spring Harbor protocols (2022): pdb.top100784
Production of Digoxigenin-Labeled Riboprobes for In Situ Hybridization Experiments.
Authors: Barratt, Kristen S and Arkell, Ruth M
Journal: Current protocols in mouse biology (2020): e74
Authors: Barratt, Kristen S and Arkell, Ruth M
Journal: Current protocols in mouse biology (2020): e74
A smartphone readout system for gold nanoparticle-based lateral flow assays: application to monitoring of digoxigenin.
Authors: Ruppert, Christoph and Phogat, Navneet and Laufer, Stefan and Kohl, Matthias and Deigner, Hans-Peter
Journal: Mikrochimica acta (2019): 119
Authors: Ruppert, Christoph and Phogat, Navneet and Laufer, Stefan and Kohl, Matthias and Deigner, Hans-Peter
Journal: Mikrochimica acta (2019): 119
The cardenolides strophanthidin, digoxigenin and dihydroouabain act as activators of the human RORγ/RORγT receptors.
Authors: Karaś, Kaja and Sałkowska, Anna and Walczak-Drzewiecka, Aurelia and Ryba, Katarzyna and Dastych, Jarosław and Bachorz, Rafał A and Ratajewski, Marcin
Journal: Toxicology letters (2018): 314-324
Authors: Karaś, Kaja and Sałkowska, Anna and Walczak-Drzewiecka, Aurelia and Ryba, Katarzyna and Dastych, Jarosław and Bachorz, Rafał A and Ratajewski, Marcin
Journal: Toxicology letters (2018): 314-324
Synthesis of C3-Neoglycosides of digoxigenin and their anticancer activities.
Authors: Li, Xiao-San and Ren, Yi-Chang and Bao, Yu-Zhou and Liu, Jie and Zhang, Xiao-Kun and Zhang, You-Wei and Sun, Xue-Long and Yao, Xin-Sheng and Tang, Jin-Shan
Journal: European journal of medicinal chemistry (2018): 252-262
Authors: Li, Xiao-San and Ren, Yi-Chang and Bao, Yu-Zhou and Liu, Jie and Zhang, Xiao-Kun and Zhang, You-Wei and Sun, Xue-Long and Yao, Xin-Sheng and Tang, Jin-Shan
Journal: European journal of medicinal chemistry (2018): 252-262
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