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DBCO Sulfo-NHS Ester
DBCO-Sulfo-NHS Ester is a water-soluble version of the popular DBCO NHS Ester (#4529). It is an excellent building block for labeling antibodies, proteins, and other primary amine-bearing macromolecules (e.g., peptides and amino-modified DNA/RNA oligos) in aqueous buffers. Dibenzocyclooctyne (DBCO) compounds might be the most common class of Cu-free click reaction reagents that possesses reasonably fast kinetics and good stability in aqueous buffers. The Cu-free click reaction, i.e., the strain-promoted alkyne-azide cycloaddition (SPAAC) is a bioorthogonal reaction utilizing a pair of reagents, cyclooctynes and azides that exclusively and efficiently react with each other while remain inert to naturally occurring functional groups such as hydroxy, amino and thiol groups. SPAAC enables labeling a wide variety of biomolecules without any auxiliary reagents in an aqueous and otherwise complex chemical environment through the formation of a stable triazole.
References
View all 35 references: Citation Explorer
A versatile method for conjugating lipid nanoparticles on T cells through combination of click chemistry and metabolic glycoengineering.
Authors: Li, Xin and Weller, Sven and Clergeaud, Gael and Andresen, Thomas L
Journal: Biotechnology journal (2024): e2300339
Authors: Li, Xin and Weller, Sven and Clergeaud, Gael and Andresen, Thomas L
Journal: Biotechnology journal (2024): e2300339
A Short Review of Research Progress on the Synthesis Approaches of Aza-Dibenzocyclooctyne Derivatives.
Authors: He, Yinming and Liu, Li and Cheng, Liang
Journal: Molecules (Basel, Switzerland) (2023)
Authors: He, Yinming and Liu, Li and Cheng, Liang
Journal: Molecules (Basel, Switzerland) (2023)
Peptide-Decorated Degradable Polycarbonate Nanogels for Eliciting Antigen-Specific Immune Responses.
Authors: Stickdorn, Judith and Czysch, Christian and Medina-Montano, Carolina and Stein, Lara and Xu, Lujuan and Scherger, Maximilian and Schild, Hansjörg and Grabbe, Stephan and Nuhn, Lutz
Journal: International journal of molecular sciences (2023)
Authors: Stickdorn, Judith and Czysch, Christian and Medina-Montano, Carolina and Stein, Lara and Xu, Lujuan and Scherger, Maximilian and Schild, Hansjörg and Grabbe, Stephan and Nuhn, Lutz
Journal: International journal of molecular sciences (2023)
Highly selective preparation of N-terminus Horseradish peroxidase-DNA conjugate with fully retained enzymatic activity: HRP-DNA structure - activity relation.
Authors: Ban, Željka and Barišić, Antun and Crnolatac, Ivo and Kazazić, Saša and Škulj, Sanja and Savini, Filippo and Bertoša, Branimir and Barišić, Ivan and Piantanida, Ivo
Journal: Enzyme and microbial technology (2023): 110257
Authors: Ban, Željka and Barišić, Antun and Crnolatac, Ivo and Kazazić, Saša and Škulj, Sanja and Savini, Filippo and Bertoša, Branimir and Barišić, Ivan and Piantanida, Ivo
Journal: Enzyme and microbial technology (2023): 110257
From Bench to Cell: A Roadmap for Assessing the Bioorthogonal "Click" Reactivity of Magnetic Nanoparticles for Cell Surface Engineering.
Authors: Idiago-López, Javier and Moreno-Antolín, Eduardo and Eceiza, Maite and Aizpurua, Jesús M and Grazú, Valeria and de la Fuente, Jesús M and Fratila, Raluca M
Journal: Bioconjugate chemistry (2022): 1620-1633
Authors: Idiago-López, Javier and Moreno-Antolín, Eduardo and Eceiza, Maite and Aizpurua, Jesús M and Grazú, Valeria and de la Fuente, Jesús M and Fratila, Raluca M
Journal: Bioconjugate chemistry (2022): 1620-1633
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