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Crotonaldehyde HSA (Human Serum Albumin) Conjugate
Crotonaldehyde is a common environmental pollutant, formed upon combustion of fossil fuels and wood. Inhalation of tobbacco smoke is also a significant source of crotonaldehyde. Crotonaldehyde exhibits many toxicological properties, including an ability to cause multi-organ toxicity in laboratory animals; DNA damage and mutagenicity in vitro; and carcinogenicity in vivo. As a reactive bifunctional electrophile, crotonaldehyde readily generates adducts in a range of cell macromolecules. Crotonaldehyde human serum albumin(HAS) conjugate was fully characterized, and has been used for developing crotonaldehyde-quantifying assays.
References
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Resolution and Quantitation of Mercapturic Acids Derived from Crotonaldehyde, Methacrolein, and Methyl Vinyl Ketone in the Urine of Smokers and Nonsmokers.
Authors: Chen, Menglan and Carmella, Steven G and Li, Yupeng and Zhao, Yingchun and Hecht, Stephen S
Journal: Chemical research in toxicology (2020): 669-677
Authors: Chen, Menglan and Carmella, Steven G and Li, Yupeng and Zhao, Yingchun and Hecht, Stephen S
Journal: Chemical research in toxicology (2020): 669-677
Crotonaldehyde-induced alterations in testicular enzyme function and hormone levels, and apoptosis in the testes of male Wistar rats are associated with oxidative damage.
Authors: Zhang, Biao and Wei, Ping and Men, Jinlong and Zhang, Shuman and Shao, Hua and Zhang, Zhihu
Journal: Toxicology mechanisms and methods (2020): 19-32
Authors: Zhang, Biao and Wei, Ping and Men, Jinlong and Zhang, Shuman and Shao, Hua and Zhang, Zhihu
Journal: Toxicology mechanisms and methods (2020): 19-32
A computational foray into the mechanism and catalysis of the adduct formation reaction of guanine with crotonaldehyde.
Authors: Kroeger, Asja A and Karton, Amir
Journal: Journal of computational chemistry (2019): 630-637
Authors: Kroeger, Asja A and Karton, Amir
Journal: Journal of computational chemistry (2019): 630-637
[Study on lung injury induced by subchronic exposure to crotonaldehyde in male rats].
Authors: Li, S S and Zhang, B and Zhang, S M and Zhang, Z H and Wei, Y N
Journal: Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygie (2019): 728-731
Authors: Li, S S and Zhang, B and Zhang, S M and Zhang, Z H and Wei, Y N
Journal: Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygie (2019): 728-731
Autophagy in Crotonaldehyde-Induced Endothelial Toxicity.
Authors: Lee, Seung Eun and Park, Hye Rim and Park, Cheung-Seog and Ahn, Hyun-Jong and Cho, Jeong-Je and Lee, Jongsung and Park, Yong Seek
Journal: Molecules (Basel, Switzerland) (2019)
Authors: Lee, Seung Eun and Park, Hye Rim and Park, Cheung-Seog and Ahn, Hyun-Jong and Cho, Jeong-Je and Lee, Jongsung and Park, Yong Seek
Journal: Molecules (Basel, Switzerland) (2019)
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