Cholyl-iFluor® 647 conjugate

Name: Cholyl-iFluor® 647 conjugate
Brand: AAT Bioquest
SKU: 36703
Price: 325 USD
Availability: InStock

Cholyl-iFluor® 647 conjugate is a red fluorescent analog of our green fluorescent Cholyl-Lys-Fluorescein (#36701). It is an iFluor® 647-labeled bile acid derivative that closely parallels the cellular binding and uptake properties of cholic acid derivatives. It is a divalent 'unipolar' anionic fluorescent monohydroxy bile salt analog with physical, biological and cholestatic properties that are similar to those of lithocholate, glycolithocholate and their derivatives and thus offers a potentially useful probe for studying mechanisms of monohydroxy bile salt-induced cholestasis at the hepatocellular level. Cholyl-iFluor® 647 conjugate can be used as a tool for the visualization of bile acid transport for the samples that have either strong blue or green fluorescence since its strong red fluorescence is well separated from blue or green fluorescence.

Spectrum

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Product family

Name	Excitation (nm)	Emission (nm)	Extinction coefficient (cm ^-1 M ^-1)	Quantum yield	Correction Factor (260 nm)	Correction Factor (280 nm)	Correction Factor (656 nm)
iFluor® 647-streptavidin conjugate	656	670	250000¹	0.25¹	0.03	0.03	0.0793
Phalloidin-iFluor® 647 Conjugate	656	670	250000¹	0.25¹	0.03	0.03	0.0793

References

View all 19 references: Citation Explorer

Novel hypolipidemic conjugates of fatty acid and bile acid with lysine for linkage.
Authors: Jin, Xue-Yuan and Zhu, Chuan-Bao and Fan, Shi-Yong and Sun, Jia-Lin and Shi, Yu-Cong and Wang, Chu-Han and Wang, Hui-Fen and Zhong, Bo-Hua and Yao, Yi-Shan and Shi, Wei-Guo
Journal: Drug development and industrial pharmacy (2019): 995-998

The fatty acid-bile acid conjugate Aramchol reduces liver fat content in patients with nonalcoholic fatty liver disease.
Authors: Safadi, Rifaat and Konikoff, Fred M and Mahamid, Mahmud and Zelber-Sagi, Shira and Halpern, Maya and Gilat, Tuvia and Oren, Ran and ,
Journal: Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Associatio (2014): 2085-91.e1

L-arginine conjugates of bile acids-a possible treatment for non-alcoholic fatty liver disease.
Authors: Voloshin, Irina and Hahn-Obercyger, Michal and Anavi, Sarit and Tirosh, Oren
Journal: Lipids in health and disease (2014): 69

Amino acid-bile acid based molecules: extremely narrow surfactant nanotubes formed by a phenylalanine-substituted cholic acid.
Authors: Travaglini, Leana and D'Annibale, Andrea and Schillén, Karin and Olsson, Ulf and Sennato, Simona and Pavel, Nicolae V and Galantini, Luciano
Journal: Chemical communications (Cambridge, England) (2012): 12011-3

Fatty acid bile acid conjugate inhibits hepatic stearoyl coenzyme A desaturase and is non-atherogenic.
Authors: Leikin-Frenkel, Alicia and Gonen, Ayelet and Shaish, Aviv and Goldiner, Ilana and Leikin-Gobbi, Diana and Konikoff, Fred M and Harats, Dror and Gilat, Tuvia
Journal: Archives of medical research (2010): 397-404

Page updated on November 20, 2024

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Catalog Number	36703
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Physical properties

Molecular weight	1289.57
Solvent	DMSO

Spectral properties

Correction Factor (260 nm)	0.03
Correction Factor (280 nm)	0.03
Correction Factor (656 nm)	0.0793
Extinction coefficient (cm ^-1 M ^-1)	250000¹
Excitation (nm)	656
Emission (nm)	670
Quantum yield	0.25¹

Storage, safety and handling

H-phrase	H303, H313, H333
Hazard symbol	XN
Intended use	Research Use Only (RUO)
R-phrase	R20, R21, R22
Storage	Freeze (< -15 °C); Minimize light exposure
UNSPSC	12171501