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cAMP AM
cAMP-AM is the cell-permeant cAMP. After permeation and metabolic activation by esterases the polar cAMP is released which is trapped inside the cell and subsequently metabolized quickly, resulting in a pulse-type signal. cAMP is a second messenger, used for intracellular signal transduction, such as transferring into cells the effects of hormones like glucagon and adrenaline, which cannot pass through the plasma membrane. It is involved in the activation of protein kinases and regulates the effects of adrenaline and glucagon. cAMP also binds to and regulates the function of ion channels such as the HCN channels and a few other cyclic nucleotide-binding proteins such as Epac1 and RAPGEF2.
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Common stock solution preparation
Table 1. Volume of DMSO needed to reconstitute specific mass of cAMP AM to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.
| 0.1 mg | 0.5 mg | 1 mg | 5 mg | 10 mg | |
| 1 mM | 249.209 µL | 1.246 mL | 2.492 mL | 12.46 mL | 24.921 mL |
| 5 mM | 49.842 µL | 249.209 µL | 498.418 µL | 2.492 mL | 4.984 mL |
| 10 mM | 24.921 µL | 124.604 µL | 249.209 µL | 1.246 mL | 2.492 mL |
Molarity calculator
Enter any two values (mass, volume, concentration) to calculate the third.
| Mass (Calculate) | Molecular weight | Volume (Calculate) | Concentration (Calculate) | Moles | ||||
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References
View all 115 references: Citation Explorer
Mechanisms of hydrogen sulfide (H2S) action on synaptic transmission at the mouse neuromuscular junction
Authors: Gerasimova E, Lebedeva J, Yakovlev A, Zefirov A, Giniatullin R, Sitdikova G.
Journal: Neuroscience (2015): 577
Authors: Gerasimova E, Lebedeva J, Yakovlev A, Zefirov A, Giniatullin R, Sitdikova G.
Journal: Neuroscience (2015): 577
Induction of miR-132 and miR-212 Expression by Glucagon-Like Peptide 1 (GLP-1) in Rodent and Human Pancreatic beta-Cells
Authors: Shang J, Li J, Keller MP, Hohmeier HE, Wang Y, Feng Y, Zhou HH, Shen X, Rabaglia M, Soni M, Attie AD, Newgard CB, Thornberry NA, Howard AD, Zhou YP.
Journal: Mol Endocrinol (2015): 1243
Authors: Shang J, Li J, Keller MP, Hohmeier HE, Wang Y, Feng Y, Zhou HH, Shen X, Rabaglia M, Soni M, Attie AD, Newgard CB, Thornberry NA, Howard AD, Zhou YP.
Journal: Mol Endocrinol (2015): 1243
Store-operated cAMP signaling contributes to Ca2+-activated Cl- secretion in T84 colonic cells
Authors: Nichols JM, Maiellaro I, Abi-Jaoude J, Curci S, Hofer AM.
Journal: Am J Physiol Gastrointest Liver Physiol (2015): G670
Authors: Nichols JM, Maiellaro I, Abi-Jaoude J, Curci S, Hofer AM.
Journal: Am J Physiol Gastrointest Liver Physiol (2015): G670
Exchange protein directly activated by cAMP mediates slow delayed-rectifier current remodeling by sustained beta-adrenergic activation in guinea pig hearts
Authors: Aflaki M, Qi XY, Xiao L, Ordog B, Tadevosyan A, Luo X, Maguy A, Shi Y, Tardif JC, Nattel S.
Journal: Circ Res (2014): 993
Authors: Aflaki M, Qi XY, Xiao L, Ordog B, Tadevosyan A, Luo X, Maguy A, Shi Y, Tardif JC, Nattel S.
Journal: Circ Res (2014): 993
The nephrotoxic Ifosfamide-metabolite chloroacetaldehyde interferes with renal extracellular matrix homeostasis
Authors: Benesic A, Schwerdt G, Hennemeier I, Sauvant C, Mildenberger S, Gekle M.
Journal: Cell Physiol Biochem (2014): 1106
Authors: Benesic A, Schwerdt G, Hennemeier I, Sauvant C, Mildenberger S, Gekle M.
Journal: Cell Physiol Biochem (2014): 1106
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