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Bodi Fluor™ 488-Cephaeline Conjugate
Cephaeline is an alkaloid that is found in Cephaelis ipecacuanha and other plant species including Psychotria acuminate. Cephaeline induces vomiting by stimulating the stomach lining and is found in commercial products such as syrup of ipecac. Chemically, it is closely related to emetine. It has been reported that the expectorant action of ipecacuanha is due in whole or in major part to its content of emetine and cephaeline. The expectorant action of synthetic 2-dehydroemetine is essentially similar to that of emetine and cephaeline. This Bodipy-labeled has been used to study the mechanism of cephaeline.
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Common stock solution preparation
Table 1. Volume of DMSO needed to reconstitute specific mass of Bodi Fluor™ 488-Cephaeline Conjugate to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.
| 0.1 mg | 0.5 mg | 1 mg | 5 mg | 10 mg | |
| 1 mM | 135.007 µL | 675.037 µL | 1.35 mL | 6.75 mL | 13.501 mL |
| 5 mM | 27.001 µL | 135.007 µL | 270.015 µL | 1.35 mL | 2.7 mL |
| 10 mM | 13.501 µL | 67.504 µL | 135.007 µL | 675.037 µL | 1.35 mL |
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Spectrum
References
View all 17 references: Citation Explorer
distribution and excretion of 3H-labeled cephaeline- and emetine-spiked ipecac syrup in rats
Authors: Asano, T.; Ishihara, K.; Wakui, Y.; Yanagisawa, T.; Kimura, M.; Kamei, H.; Yoshida, T.; Kuroiwa, Y.; Fujii, Y.; Yamashita, M.; Kuramochi, T.; Tomisawa, H.; Tateishi, M., Absorption
Journal: Eur J Drug Metab Pharmacokinet (2002): 17-27
Authors: Asano, T.; Ishihara, K.; Wakui, Y.; Yanagisawa, T.; Kimura, M.; Kamei, H.; Yoshida, T.; Kuroiwa, Y.; Fujii, Y.; Yamashita, M.; Kuramochi, T.; Tomisawa, H.; Tateishi, M., Absorption
Journal: Eur J Drug Metab Pharmacokinet (2002): 17-27
Biotransformation of the ipecac alkaloids cephaeline and emetine from ipecac syrup in rats
Authors: Asano, T.; Watanabe, J.; Sadakane, C.; Ishihara, K.; Hirakura, K.; Wakui, Y.; Yanagisawa, T.; Kimura, M.; Kamei, H.; Yoshida, T.; Fujii, Y.; Yamashita, M.
Journal: Eur J Drug Metab Pharmacokinet (2002): 29-35
Authors: Asano, T.; Watanabe, J.; Sadakane, C.; Ishihara, K.; Hirakura, K.; Wakui, Y.; Yanagisawa, T.; Kimura, M.; Kamei, H.; Yoshida, T.; Fujii, Y.; Yamashita, M.
Journal: Eur J Drug Metab Pharmacokinet (2002): 29-35
High-performance liquid chromatographic assay with fluorescence detection for the determination of cephaeline and emetine in human plasma and urine
Authors: Asano, T.; Sadakane, C.; Ishihara, K.; Yanagisawa, T.; Kimura, M.; Kamei, H.
Journal: J Chromatogr B Biomed Sci Appl (2001): 197-206
Authors: Asano, T.; Sadakane, C.; Ishihara, K.; Yanagisawa, T.; Kimura, M.; Kamei, H.
Journal: J Chromatogr B Biomed Sci Appl (2001): 197-206
and their inhibitory effects on P450 enzyme activities
Authors: Asano, T.; Kushida, H.; Sadakane, C.; Ishihara, K.; Wakui, Y.; Yanagisawa, T.; Kimura, M.; Kamei, H.; Yoshida, T., Metabolism of ipecac alkaloids cephaeline and emetine by human hepatic microsomal cytochrome P450s, undefined
Journal: Biol Pharm Bull (2001): 678-82
Authors: Asano, T.; Kushida, H.; Sadakane, C.; Ishihara, K.; Wakui, Y.; Yanagisawa, T.; Kimura, M.; Kamei, H.; Yoshida, T., Metabolism of ipecac alkaloids cephaeline and emetine by human hepatic microsomal cytochrome P450s, undefined
Journal: Biol Pharm Bull (2001): 678-82
in pharmaceutical preparations by high-performance liquid chromatography using spectrofluorimetric detection
Authors: Elvidge, D. A.; Johnson, G. W.; Harrison, J. R., Selective, stability-indicating assay of the major ipecacuanha alkaloids, emetine and cephaeline, undefined
Journal: J Chromatogr (1989): 107-18
Authors: Elvidge, D. A.; Johnson, G. W.; Harrison, J. R., Selective, stability-indicating assay of the major ipecacuanha alkaloids, emetine and cephaeline, undefined
Journal: J Chromatogr (1989): 107-18
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