Calculator
BOC-Asp(OMe)-FMK [Boc-D(OMe)-FMK]
The FMK peptides are potent, cell permeable, irreversible capase inhibitors. It is useful for detecting and monitoring apoptosis in vitro and in vivo applications. BOC-ASP(OMe)-FMK is the key intermediate for developing and preparing FMK-based capase inhibitors and probes. The Asp(OMe)-FMK-based caspase inhibitors are cell permeable and irreversibly binds to activated caspases to block apoptosis. Caspases, which act as molecular chainsaw are the central components of apoptosis response. Caspases are cysteine proteases that cleave after aspartate residue in their substrates. At least 7 of 14 known mammalian caspases have important role in apoptosis.
Calculators
Common stock solution preparation
Table 1. Volume of DMF needed to reconstitute specific mass of BOC-Asp(OMe)-FMK [Boc-D(OMe)-FMK] to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.
| 0.1 mg | 0.5 mg | 1 mg | 5 mg | 10 mg | |
| 1 mM | 379.838 µL | 1.899 mL | 3.798 mL | 18.992 mL | 37.984 mL |
| 5 mM | 75.968 µL | 379.838 µL | 759.676 µL | 3.798 mL | 7.597 mL |
| 10 mM | 37.984 µL | 189.919 µL | 379.838 µL | 1.899 mL | 3.798 mL |
Molarity calculator
Enter any two values (mass, volume, concentration) to calculate the third.
| Mass (Calculate) | Molecular weight | Volume (Calculate) | Concentration (Calculate) | Moles | ||||
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References
View all 31 references: Citation Explorer
Leucine-rich amelogenin peptide induces osteogenesis by activation of the Wnt pathway
Authors: Warotayanont R, Frenkel B, Snead ML, Zhou Y.
Journal: Biochem Biophys Res Commun (2009): 558
Authors: Warotayanont R, Frenkel B, Snead ML, Zhou Y.
Journal: Biochem Biophys Res Commun (2009): 558
Design of nontoxic analogues of cathelicidin-derived bovine antimicrobial peptide BMAP-27: the role of leucine as well as phenylalanine zipper sequences in determining its toxicity
Authors: Ahmad A, Azmi S, Srivastava RM, Srivastava S, P and ey BK, Saxena R, Bajpai VK, Ghosh JK.
Journal: Biochemistry (2009): 10905
Authors: Ahmad A, Azmi S, Srivastava RM, Srivastava S, P and ey BK, Saxena R, Bajpai VK, Ghosh JK.
Journal: Biochemistry (2009): 10905
A glycine-leucine-rich peptide structurally related to the plasticins from skin secretions of the frog Leptodactylus laticeps (Leptodactylidae)
Authors: Conlon JM, Abdel-Wahab YH, Flatt PR, Leprince J, Vaudry H, Jouenne T, Condamine E.
Journal: Peptides (2009): 888
Authors: Conlon JM, Abdel-Wahab YH, Flatt PR, Leprince J, Vaudry H, Jouenne T, Condamine E.
Journal: Peptides (2009): 888
Leucine-rich amelogenin peptide induces osteogenesis in mouse embryonic stem cells
Authors: Warotayanont R, Zhu D, Snead ML, Zhou Y.
Journal: Biochem Biophys Res Commun (2008): 1
Authors: Warotayanont R, Zhu D, Snead ML, Zhou Y.
Journal: Biochem Biophys Res Commun (2008): 1
Leucine-rich glioma inactivated 3 is involved in amyloid beta peptide uptake by astrocytes and endocytosis itself
Authors: Okabayashi S, Kimura N.
Journal: Neuroreport (2008): 1175
Authors: Okabayashi S, Kimura N.
Journal: Neuroreport (2008): 1175
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