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(-)-Blebbistatin *CAS#: 856925-71-8*

(-)-Blebbistatin is a cell-permeable inhibitor for non muscle myosin II ATPase with IC50 of 2 µM. It does not inhibit myosin light chain kinase, inhibits contraction of the cleavage furrow without disrupting mitosis or contractile ring assembly.

References

View all 41 references: Citation Explorer
The mechanical uncoupler blebbistatin is associated with significant electrophysiological effects in the isolated rabbit heart
Authors: Brack KE, Narang R, Winter J, Ng GA.
Journal: Exp Physiol (2013): 1009
Homology model of nonmuscle myosin heavy chain IIA and binding mode analysis with its inhibitor blebbistatin
Authors: Lv Y, Lu S, Lu T, Kou J, Yu B.
Journal: J Mol Model (2013): 1801
Enrichment of cell populations in metaphase, anaphase, and telophase by synchronization using nocodazole and blebbistatin: a novel method suitable for examining dynamic changes in proteins during mitotic progression
Authors: Matsui Y, Nakayama Y, Okamoto M, Fukumoto Y, Yamaguchi N.
Journal: Eur J Cell Biol (2012): 413
Modifications of mechanoelectric feedback induced by 2,3-butanedione monoxime and Blebbistatin in Langendorff-perfused rabbit hearts
Authors: Brines L, Such-Miquel L, Gallego D, Trapero I, Del Canto I, Zarzoso M, Soler C, Pelechano F, Canoves J, Alberola A, Such L, Chorro FJ.
Journal: Acta Physiol (Oxf) (2012): 29
Blebbistatin, a myosin inhibitor, is phototoxic to human cancer cells under exposure to blue light
Authors: Mikulich A, Kavaliauskiene S, Juzenas P.
Journal: Biochim Biophys Acta (2012): 870
Page updated on November 21, 2024

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Physical properties

Molecular weight

292.33

Solvent

DMSO

Storage, safety and handling

H-phraseH303, H313, H333
Hazard symbolXN
Intended useResearch Use Only (RUO)
R-phraseR20, R21, R22

Storage

Freeze (< -15 °C); Minimize light exposure
UNSPSC12352200

CAS

856925-71-8
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