AMC [7-Amino-4-methylcoumarin] *CAS 26093-31-2*
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Additional ordering information
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Physical properties
Molecular weight | 175.19 |
Solvent | DMSO |
Spectral properties
Excitation (nm) | 341 |
Emission (nm) | 441 |
Storage, safety and handling
H-phrase | H303, H313, H333 |
Hazard symbol | XN |
Intended use | Research Use Only (RUO) |
R-phrase | R20, R21, R22 |
Storage | Freeze (< -15 °C); Minimize light exposure |
UNSPSC | 12171501 |
Overview | ![]() ![]() |
See also: Coumarins
CAS 26093-31-2 | Molecular weight 175.19 | Excitation (nm) 341 | Emission (nm) 441 |
This compound is the precursor for a variety of AMC enzyme substrates. It is also used as a calibration standard for AMC-based enzyme substrates. Fluorogenic AMC substrates are widely used for measuring a variety of protease activities.
Calculators
Common stock solution preparation
Table 1. Volume of DMSO needed to reconstitute specific mass of AMC [7-Amino-4-methylcoumarin] *CAS 26093-31-2* to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.
0.1 mg | 0.5 mg | 1 mg | 5 mg | 10 mg | |
1 mM | 570.809 µL | 2.854 mL | 5.708 mL | 28.54 mL | 57.081 mL |
5 mM | 114.162 µL | 570.809 µL | 1.142 mL | 5.708 mL | 11.416 mL |
10 mM | 57.081 µL | 285.404 µL | 570.809 µL | 2.854 mL | 5.708 mL |
Molarity calculator
Enter any two values (mass, volume, concentration) to calculate the third.
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Citations
View all 3 citations: Citation Explorer
MXene-sensitized electrochemiluminescence sensor for thrombin activity detection and inhibitor screening
Authors: Deng, Zijie and Tan, Xueping and Guo, Dongnan and Zhang, Jing and Xu, Dan and Hou, Xiaofang and Wang, Sicen and Zhang, Junbo and Wei, Fen and Zhang, Dongdong
Journal: Microchimica Acta (2023): 328
Authors: Deng, Zijie and Tan, Xueping and Guo, Dongnan and Zhang, Jing and Xu, Dan and Hou, Xiaofang and Wang, Sicen and Zhang, Junbo and Wei, Fen and Zhang, Dongdong
Journal: Microchimica Acta (2023): 328
Reduced hepatic bradykinin degradation accounts for cold-induced BAT thermogenesis and WAT browning in male mice
Authors: Xiao, Fei and Jiang, Haizhou and Li, Zi and Jiang, Xiaoxue and Chen, Shanghai and Niu, Yuguo and Yin, Hanrui and Shu, Yousheng and Peng, Bo and Lu, Wei and others,
Journal: Nature Communications (2023): 2523
Authors: Xiao, Fei and Jiang, Haizhou and Li, Zi and Jiang, Xiaoxue and Chen, Shanghai and Niu, Yuguo and Yin, Hanrui and Shu, Yousheng and Peng, Bo and Lu, Wei and others,
Journal: Nature Communications (2023): 2523
Modulation of CD4&plus; T-cell activation by CD95 co-stimulation
Authors: Paulsen, Maren and Valentin, Signe and Mathew, Biny and Adam-Klages, Sabine and Bertsch, Uwe and Lavrik, Inna and Krammer, Peter H and Kabelitz, Dieter and Janssen, Ottmar
Journal: Cell Death & Differentiation (2011): 619--631
Authors: Paulsen, Maren and Valentin, Signe and Mathew, Biny and Adam-Klages, Sabine and Bertsch, Uwe and Lavrik, Inna and Krammer, Peter H and Kabelitz, Dieter and Janssen, Ottmar
Journal: Cell Death & Differentiation (2011): 619--631
References
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In vitro assays for the determination of histone deacetylase activity
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Hepatocyte growth factor is a preferred in vitro substrate for human hepsin, a membrane-anchored serine protease implicated in prostate and ovarian cancers
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Application notes
Abbreviation of Common Chemical Compounds Related to Peptides
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iFluor® Dye Selection Guide
A Comparison of Fluorescent Red Calcium Indicators for Detecting Intracellular Calcium Mobilization in CHO Cells
A Meta-Analysis of Common Calcium Indicators
A New Red Fluorescent & Robust Screen Quest™ Rhod-4™ Ca2+Indicator for Screening GPCR & Ca2+ Channel Targets