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1,2-Diaminoanthraquinone *CAS 1758-68-5*
The role of nitric oxide (NO) as a putative mediator of neuronal death can be understood best if NO is detected directly. 1,2-Diaminoanthraquinone (DAQ) is a red fluorescent probe that is used to detect nitric oxide (NO) productions in live cell and animals. DAQ has minimal neurotoxic effects and it neither influences normal evoked field potential amplitudes nor does it affect induction of long-term potentiation (LTP) in comparison to controls. DAQ is used to directly capture released NO during neurodegeneration in vivo and at the cellular site of its generation. The non-fluorescent 1,2-diaminoanthraquinone (DAQ) is injected into the eyes of rats whose optic nerve is injured to induce retrograde degeneration of the ganglion cells. The reaction product of DAQ with NO is a triazole with red fluorescence. The DAQ-based methodology of NO assessment is convenient and applicable to numerous living systems both in vivo and in vitro.
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Common stock solution preparation
Table 1. Volume of DMSO needed to reconstitute specific mass of 1,2-Diaminoanthraquinone *CAS 1758-68-5* to given concentration. Note that volume is only for preparing stock solution. Refer to sample experimental protocol for appropriate experimental/physiological buffers.
| 0.1 mg | 0.5 mg | 1 mg | 5 mg | 10 mg | |
| 1 mM | 419.745 µL | 2.099 mL | 4.197 mL | 20.987 mL | 41.974 mL |
| 5 mM | 83.949 µL | 419.745 µL | 839.49 µL | 4.197 mL | 8.395 mL |
| 10 mM | 41.974 µL | 209.872 µL | 419.745 µL | 2.099 mL | 4.197 mL |
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Citations
View all 1 citations: Citation Explorer
S100A9 as a Key Myocardial Injury Factor Interacting with ATP5 Exacerbates Mitochondrial Dysfunction and Oxidative Stress in Sepsis-Induced Cardiomyopathy
Authors: Pei, Hui and Qu, Jie and Chen, Jianming and Zhao, Guangju and Lu, ZhongQiu
Journal: Journal of Inflammation Research (2024): 4483--4503
Authors: Pei, Hui and Qu, Jie and Chen, Jianming and Zhao, Guangju and Lu, ZhongQiu
Journal: Journal of Inflammation Research (2024): 4483--4503
References
View all 6 references: Citation Explorer
Floral transition and nitric oxide emission during flower development in Arabidopsis thaliana is affected in nitrate reductase-deficient plants
Authors: Seligman K, Saviani EE, Oliveira HC, Pinto-Maglio CA, Salgado I.
Journal: Plant Cell Physiol (2008): 1112
Authors: Seligman K, Saviani EE, Oliveira HC, Pinto-Maglio CA, Salgado I.
Journal: Plant Cell Physiol (2008): 1112
Spectroscopic studies of 1,2-diaminoanthraquinone (DAQ) as a fluorescent probe for the imaging of nitric oxide in living cells
Authors: Galindo F, Kabir N, Gavrilovic J, Russell DA.
Journal: Photochem Photobiol Sci (2008): 126
Authors: Galindo F, Kabir N, Gavrilovic J, Russell DA.
Journal: Photochem Photobiol Sci (2008): 126
Microbial transformation of amino- and hydroxyanthraquinones by Beauveria bassiana ATCC 7159
Authors: Zhan J, Gunatilaka AA.
Journal: J Nat Prod (2006): 1525
Authors: Zhan J, Gunatilaka AA.
Journal: J Nat Prod (2006): 1525
Neuromuscular contacts induce nitric oxide signals in skeletal myotubes in vitro
Authors: Puttmann B, Gerlach EM, Kruger M, Blottner D.
Journal: Neurosignals (2005): 85
Authors: Puttmann B, Gerlach EM, Kruger M, Blottner D.
Journal: Neurosignals (2005): 85
Spatial nitric oxide imaging using 1,2-diaminoanthraquinone to investigate the involvement of nitric oxide in long-term potentiation in rat brain slices
Authors: von Bohlen und Halbach O, Albrecht D, Heinemann U, Schuchmann S.
Journal: Neuroimage (2002): 633
Authors: von Bohlen und Halbach O, Albrecht D, Heinemann U, Schuchmann S.
Journal: Neuroimage (2002): 633
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