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Voltage-gated potassium channel subunit Kv1.5 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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▼
N-[3-(4-Ethyl-benzenesulfonylamino)-2-hydroxy-indan-5-yl]-3-methoxy-benzamideIC5033.0 [1], 50.0 [2], 100.0 [3], 160.0 [4]
N-[(7R,8R)-8-[(4-Butylphenyl)sulfonylamino]-7-hydroxy-5,6,7,8-tetrahydronaphthalen-2-yl]-3-methoxybenzamideIC5050.0 [1], 140.0 [2], 2900.0 [3]
2-(3,4-Dimethylphenyl)-3-(4-methoxyphenethyl)thiazolidin-4-oneIC50137.0 [1], 200.0 [2], 900.0 [3]
[[(1S,2S,5R)-5-Methyl-2-propan-2-ylcyclohexyl]-phenylphosphoryl]benzeneIC5030.0 [1], 500.0 [2]
5-(4-Phenoxybutoxy)psoralenIC5088.0 [1], 3450.0 [2]
4-Methoxy-3-[(2-methyl-2-phenylpropyl)amino]-1H-isoindol-1-oneIC5034.0 [1], 84.0 [2]
CID 135532473IC50170.0 [1]
CID 135532763IC5070.0 [1]
[7-(3,4-Dichlorophenyl)-5-methyl-4,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl]-pyrrolidin-1-ylmethanoneIC50660.0 [1]
[7-(3,4-Dichlorophenyl)-5-methyl-4,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl]-[(2S)-2-(methoxymethyl)pyrrolidin-1-yl]methanoneIC50200.0 [1]
4-Methoxy-N-(2-methyl-2-phenylpropyl)-1,2-benzoxazol-3-amineIC5043.0 [1]
4-Methoxy-N-(2-methyl-2-phenylpropyl)-1,2-benzothiazol-3-amineIC5024.0 [1], 25.0 [2]
N-[(3S,4R)-6-[(2S)-2-[(2,6-Dimethylanilino)methyl]pyrrolidine-1-carbonyl]-3-hydroxy-2,2-dimethyl-3,4-dihydrochromen-4-yl]-4-ethylbenzenesulfonamideIC5060.0 [1], 120.0 [2]
1-[(1R,2R)-1,2-Diphenyl-2-piperidin-1-ylethyl]piperidineIC50200.0 [1], 1700.0 [2]
2-(4-Methoxy-benzenesulfonylamino)-N-((S)-1-phenyl-propyl)-benzamideIC50600.0 [1]
1-(2-(3,4-Dimethylphenyl)thiazolidin-3-yl)-2-(4-methoxyphenyl)ethanoneIC50537.0 [1]
(3S,4R)-4-[(4-Ethylphenyl)sulfonylamino]-3-hydroxy-N,2,2-trimethyl-N-phenyl-3,4-dihydrochromene-6-carboxamideIC50280.0 [1], 281.0 [2]
(3S,4R)-N-Ethyl-4-[(4-ethylphenyl)sulfonylamino]-N-[(2-fluorophenyl)methyl]-3-hydroxy-2,2-dimethyl-3,4-dihydrochromene-6-carboxamideIC50170.0 [1], 172.0 [2]
N-[(7R,8R)-8-[(4-Ethylphenyl)sulfonylamino]-7-hydroxy-5,6,7,8-tetrahydronaphthalen-2-yl]-3-methoxybenzamideIC50440.0 [1]
[(1S)-1-Phenylethyl] N-[[2-[2-(2-pyridin-2-ylethylcarbamoyl)phenyl]phenyl]methyl]carbamateIC50160.0 [1], 200.0 [2]
N-[6-[(1S)-1-(4-Fluorophenyl)-2,2-dipyridin-3-ylethyl]pyridin-2-yl]methanesulfonamideIC509.0 [1], 11.0 [2]
N-(1-Hydroxy-2-methylpropan-2-yl)-3-oxo-2-(1-phenylethyl)-1H-isoindole-1-carboxamideIC5010000.0 [1], 32000.0 [2]
4-[[(4-Methoxy-1,1-dioxo-1,2-benzothiazol-3-ylidene)amino]methyl]-4-phenylcyclohexan-1-olIC5034.0 [1], 300.0 [2]
(1R)-1-[2-(3,5-Dichlorophenyl)pyridin-3-yl]-2,2-dipyridin-3-ylethanolIC5011.0 [1], 29.0 [2]
N-Tert-butyl-5-hydroxy-4-methyl-3-oxo-2-[(2-phenylphenyl)methyl]-1H-isoindole-1-carboxamideIC503200.0 [1], 3400.0 [2]
N-Benzyl-3-oxo-2-(1-phenylethyl)-1H-isoindole-1-carboxamideIC501500.0 [1], 6000.0 [2]
N-Tert-butyl-3-oxo-2-[(2-phenylphenyl)methyl]-1H-isoindole-1-carboxamideIC503000.0 [1], 3300.0 [2]
N-Tert-butyl-5-(methanesulfonamido)-3-oxo-2-[(2-phenylphenyl)methyl]-1H-isoindole-1-carboxamideIC507600.0 [1], 17000.0 [2]
N-Tert-butyl-5-(methanesulfonamido)-4-methyl-3-oxo-2-[(2-phenylphenyl)methyl]-1H-isoindole-1-carboxamideIC504500.0 [1], 31000.0 [2]
N-Tert-butyl-6-cyano-3-oxo-2-[(2-phenylphenyl)methyl]-1H-isoindole-1-carboxamideIC502400.0 [1], 3300.0 [2]
N-Tert-butyl-5-(fluoromethoxy)-4-methyl-3-oxo-2-[(2-phenylphenyl)methyl]-1H-isoindole-1-carboxamideIC501300.0 [1], 1700.0 [2]
N-Tert-butyl-7-hydroxy-3-oxo-2-[(2-phenylphenyl)methyl]-1H-isoindole-1-carboxamideIC502100.0 [1], 3000.0 [2]
N-Tert-butyl-5-methoxy-4-methyl-3-oxo-2-[(2-phenylphenyl)methyl]-1H-isoindole-1-carboxamideIC50800.0 [1], 2200.0 [2]
N-Butyl-2-[2-(4-chlorophenyl)propyl]-3-oxo-1H-isoindole-1-carboxamideIC50700.0 [1], 1100.0 [2]
N-Tert-butyl-5-hydroxy-3-oxo-2-[(2-phenylphenyl)methyl]-1H-isoindole-1-carboxamideIC506900.0 [1], 8400.0 [2]
LidocaineIC502188000.0 [1]
NifedipineIC506100.0 [1]
QuinidineIC507300.0 [1]
FlecainideIC5051000.0 [1]
SertindoleIC502000.0 [1]
AcacetinIC503400.0 [1]
VernakalantIC503200.0 [1]
SenicapocIC501000.0 [1]
OroidinIC5016000.0 [1]
4'-MethoxyflavoneIC509000.0 [1]
ClathrodinIC5030000.0 [1]
2'-(Benzyloxycarbonylaminomethyl)biphenyl-2-carboxylic acid 2-(2-pyridyl)ethylamideIC50700.0 [1]
N-[(2,4-Difluorophenyl)methyl]-2-[2-[[[2-(4-methoxyphenyl)acetyl]amino]methyl]phenyl]benzamideIC501200.0 [1]
HymenidinIC507600.0 [1]
AuglurantIC50100000.0 [1]
N-[2-Methyl-3-[[4-[4-[[4-(trifluoromethoxy)phenyl]methoxy]piperidin-1-yl]-1,3,5-triazin-2-yl]amino]phenyl]acetamideIC5033300.0 [1]
4-Methoxy-N-(2,4,6-trimethylphenyl)benzenesulfonamideIC5050118.72 [1]
ZuranoloneIC5030000.0 [1]
[(7R)-7-(3,4-Dichlorophenyl)-5-methyl-4,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl]-[4-(4-fluorophenyl)piperazin-1-yl]methanoneIC5070.0 [1]
2-(4-Methoxyphenyl)-6-methyl-4H-chromen-4-oneIC5013700.0 [1]
3-((Dimethylamino)methyl)-6-methoxy-2-methyl-4-phenylisoquinolin-1(2H)-oneIC50190.0 [1]
2-Phenyl-1,1-di(pyridin-3-yl)-2-(pyrrolidin-1-yl)ethanolIC50284.0 [1]
[(7R)-7-(3,4-Dichlorophenyl)-5-methyl-4,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl]-[(2S)-2-(4-fluorophenyl)pyrrolidin-1-yl]methanoneIC5050.0 [1]
[7-(3,4-Dichlorophenyl)-5-methyl-4,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl]-[(2R)-2-(methoxymethyl)pyrrolidin-1-yl]methanoneIC501000.0 [1]
6-[[[1-[2-(7-Methoxy-2-oxoquinoxalin-1-yl)ethyl]piperidin-4-yl]amino]methyl]-4H-pyrido[3,2-b][1,4]oxazin-3-oneIC50100000.0 [1]
4-(3-(2-Fluorobenzyl)ureido)-N,N-diisopropyl-3-phenyl-2-(pyridin-3-yl)butanamideIC50150.0 [1]
Dronedarone hydrochlorideIC502370.0 [1]
N-[(4R)-4-(4-Methoxyphenyl)-3-[2-(4-methoxyphenyl)ethyl]-2-oxoimidazolidin-1-yl]methanesulfonamideIC50480.0 [1]
6-Chloro-2-(4-methoxyphenyl)-4H-chromen-4-oneIC5023500.0 [1]
N-[(E)-3-(2-Amino-1H-imidazol-5-yl)prop-2-enyl]-1H-indole-2-carboxamideIC5030000.0 [1]
N-[(E)-3-(2-Amino-1H-imidazol-5-yl)prop-2-enyl]-5-fluoro-1H-indole-2-carboxamideIC5030000.0 [1]
1-[(1S,2S)-2-(2-Naphthalen-1-ylethoxy)cyclohexyl]pyrrolidin-3-oneIC507700.0 [1]
1-[(1R,2R)-2-(2-Naphthalen-1-ylethoxy)cyclohexyl]pyrrolidin-3-oneIC504300.0 [1]
{2-[2-(3-Methyl-butylcarbamoyl)-pyridin-3-yl]-benzyl}-carbamic acid benzyl esterIC502600.0 [1]
N-Benzyl-N-(1-methyl-1H-imidazol-2-ylmethyl)-2-(toluene-4-sulfonylamino)-benzamideIC50700.0 [1]
N-Benzyl-N-(3-imidazol-1-yl-propyl)-2-(toluene-4-sulfonylamino)-benzamideIC508500.0 [1]
DichloroclathrodinIC506100.0 [1]
N-Benzyl-N-ethyl-2-(toluene-4-sulfonylamino)-benzamideIC505000.0 [1]
{2-[2-(Cyclopropylmethyl-carbamoyl)-pyridin-3-yl]-benzyl}-carbamic acid 1-phenyl-ethyl esterIC50400.0 [1]
(1R,2R)-1-(3,4-Dichlorophenethoxy)-2-(4-morpholinyl)cyclohexaneIC503600.0 [1]
N-[(2S)-1-Amino-1-oxo-3-phenylpropan-2-yl]-2-[2-[(naphthalen-1-ylsulfonylamino)methyl]phenyl]benzamideIC509100.0 [1]
2-Morpholin-4-yl-2-phenylethanolIC5060000.0 [1]
Benzyl N-[[4-[2-(3-methylbutylcarbamoyl)phenyl]pyridin-3-yl]methyl]carbamateIC507000.0 [1]
[(1R)-1-Phenylethyl] N-[[2-[2-(2-pyridin-2-ylethylcarbamoyl)phenyl]phenyl]methyl]carbamateIC502400.0 [1]
N-[(2S)-1-Amino-3-methyl-1-oxobutan-2-yl]-2-[2-[(naphthalen-1-ylsulfonylamino)methyl]phenyl]benzamideIC5011200.0 [1]
2-[2-[[[(3S)-3-Phenylbutanoyl]amino]methyl]phenyl]-N-(2-pyridin-2-ylethyl)benzamideIC501000.0 [1]
{2-[3-(3-Methyl-butylcarbamoyl)-pyridin-2-yl]-benzyl}-carbamic acid benzyl esterIC507800.0 [1]
2-[2-[[[(3R)-3-Phenylbutanoyl]amino]methyl]phenyl]-N-(2-pyridin-2-ylethyl)benzamideIC50300.0 [1]
Benzyl N-[[2-[2-[[(2S)-1-amino-4-methyl-1-oxopentan-2-yl]carbamoyl]phenyl]phenyl]methyl]carbamateIC50300.0 [1]
N-(3-Methylbutyl)-2-[2-[(2-phenylethylamino)methyl]phenyl]benzamideIC504000.0 [1]
2-[2-[[(4-Acetylphenyl)sulfonylamino]methyl]phenyl]-N-[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]benzamideIC507700.0 [1]
Benzyl N-[[2-[2-[[3-(dimethylamino)-2,2-dimethylpropyl]carbamoyl]phenyl]phenyl]methyl]carbamateIC502200.0 [1]
N-[(2S)-1-Amino-1-oxo-3-phenylpropan-2-yl]-2-[2-[[[3-(trifluoromethyl)phenyl]sulfonylamino]methyl]phenyl]benzamideIC504800.0 [1]
4-(3-Fluorophenyl)-6-methoxy-2-[2-[2-methoxyethyl(methyl)amino]ethyl]-1-oxoisoquinoline-3-carbonitrileIC50790.0 [1]
2-(2,3-Dihydroxypropyl)-4-(3-fluorophenyl)-6-methoxy-1-oxo-1,2-dihydroisoquinoline-3-carbonitrileIC50870.0 [1]
1-{[(2S)-2,3-Dihydroxypropyl]amino}-6-methoxy-4-phenylisoquinoline-3-carbonitrileIC50680.0 [1]
1-{[(2R)-2,3-Dihydroxypropyl]oxy}-6-methoxy-4-phenylisoquinoline-3-carbonitrileIC50160.0 [1]
4-(3-Fluorophenyl)-2-(2-hydroxyethyl)-6-methoxy-1-oxo-1,2-dihydroisoquinoline-3-carbonitrileIC50690.0 [1]
2-Morpholino-1,1-di(pyridin-3-yl)hexan-1-olIC502869.0 [1]
2-Phenyl-2-(piperidin-1-yl)-1,1-di(pyridin-3-yl)ethanolIC50206.0 [1]
2-(1,4-Oxazepan-4-yl)-2-phenyl-1,1-di(pyridin-3-yl)ethanolIC50517.0 [1]
2-(Dimethylamino)-2-phenyl-1,1-di(pyridin-3-yl)ethanolIC50850.0 [1]
2-Morpholino-1,1-di(pyridin-3-yl)octan-1-olIC503357.0 [1]
2-Morpholino-3-phenyl-1,1-di(pyridin-3-yl)propan-1-olIC504946.0 [1]
2-((2-Methoxyethyl)(methyl)amino)-2-phenyl-1,1-di(pyridin-3-yl)ethanolIC50583.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Voltage-gated potassium channel subunit Kv1.5 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Dec. 2024, https://www.aatbio.com/data-sets/voltage-gated-potassium-channel-subunit-kv1-5-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, December 21). Quest Database™ Voltage-gated potassium channel subunit Kv1.5 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/voltage-gated-potassium-channel-subunit-kv1-5-inhibitors-ic50-ki.
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