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Voltage-gated potassium channel, IKs; KCNQ1(Kv7.1)/KCNE1(MinK) Inhibitors (IC50, Ki)

Structure
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▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
SildenafilIC50158489.32 [1], 398107.17 [2]
MoxifloxacinIC50158489.32 [1], 398107.17 [2]
TadalafilIC50158489.32 [1], 251188.64 [2]
DarunavirIC5050118.72 [1], 316227.77 [2]
NebivololIC5015848.93 [1], 39810.72 [2]
DofetilideIC50158489.32 [1], 251188.64 [2]
AmbrisentanIC5063095.73 [1], 501187.23 [2]
Chromanol 293BIC500.0 [1], 5000.0 [2]
N-[(3S,4R)-6-Cyano-3-hydroxy-2,2-dimethyl-3,4-dihydrochromen-4-yl]-N-methylethanesulfonamideIC505000.0 [1], 44500.0 [2]
Unii-4IF4R31066IC50120.0 [1]
(2-Fluorophenyl)-(4-fluorophenyl)phenylacetamideIC509.0 [1], 2000.0 [2]
LamotrigineIC50158489.32 [1]
EverolimusIC50100000.0 [1]
SunitinibIC5063095.73 [1]
DasatinibIC50251188.64 [1]
DuloxetineIC5010000.0 [1]
LapatinibIC50251188.64 [1]
NelfinavirIC5079432.82 [1]
SitagliptinIC50316227.77 [1]
NilotinibIC50398107.17 [1]
RaltegravirIC5025118.86 [1]
VardenafilIC50630957.34 [1]
TolterodineIC5079432.82 [1]
MaravirocIC5063095.73 [1]
PaliperidoneIC50251188.64 [1]
EtravirineIC501258925.41 [1]
TelbivudineIC50251188.64 [1]
AlfuzosinIC50125892.54 [1]
SolifenacinIC5031622.78 [1]
DoripenemIC50316227.77 [1]
PalonosetronIC5050118.72 [1]
DarifenacinIC5019952.62 [1]
SilodosinIC50251188.64 [1]
AlvimopanIC5050118.72 [1]
LacosamideIC50251188.64 [1]
N-(6-Cyano-3-hydroxy-2,2-dimethyl-3,4-dihydrochromen-4-yl)-N-methylethanesulfonamideIC506900.0 [1]
N-(6-Chloropyridin-3-yl)-3,4-difluorobenzamideIC5041000.0 [1]
N-(6-Chloropyridin-3-yl)-4-fluorobenzamideIC5066000.0 [1]
ZuranoloneIC5030000.0 [1]
N-(2-Chloro-5-pyrimidinyl)-3,4-difluorobenzamideIC50100000.0 [1]
(2S)-2-Phenyl-N-(2-pyrrolidin-1-ylphenyl)butanamideIC508120.0 [1]
4-Chloro-N-(6-chloropyridin-3-yl)benzamideIC5015000.0 [1]
N-[3-Hydroxy-2,2-dimethyl-6-(4,4,4-trifluoro-butoxy)-chroman-4-yl]-N-methyl-methanesulfonamideIC50240.0 [1]
CID 10171527IC5093000.0 [1]
N-(6-Chloropyridin-3-yl)-3-fluorobenzamideIC5077000.0 [1]
N-(2-Chloropyrimidin-5-yl)-3-fluorobenzamideIC50100000.0 [1]
3-Chloro-N-(2-chloropyrimidin-5-yl)benzamideIC5078000.0 [1]
N-(2-Chloropyrimidin-5-yl)-3-(trifluoromethyl)benzamideIC5035000.0 [1]
N-[(3R,4S)-6-Fluoro-3-hydroxy-2,2-dimethyl-3,4-dihydrochromen-4-yl]-N-methylethanesulfonamideIC50700.0 [1]
N-[(3S,4R)-3-Hydroxy-2,2-dimethyl-6-phenylmethoxy-3,4-dihydrochromen-4-yl]-N-methylethanesulfonamideIC50400.0 [1]
N-[(3R,4S)-3-Hydroxy-2,2-dimethyl-6-phenylmethoxy-3,4-dihydrochromen-4-yl]-N-methylethanesulfonamideIC5050.0 [1]
N-[6-[(1S)-1-(4-Fluorophenyl)-2,2-dipyridin-3-ylethyl]pyridin-2-yl]methanesulfonamideIC50790.0 [1]
N-(6-Benzyloxy-3-hydroxy-2,2-dimethyl-chroman-4-yl)-N-methyl-methanesulfonamideIC50200.0 [1]
N-[(3S,4R)-6-Fluoro-3-hydroxy-2,2-dimethyl-3,4-dihydrochromen-4-yl]-N-methylethanesulfonamideIC502200.0 [1]
N-(6-Chloropyridin-3-yl)-3-fluoro-4-(2-methylpropylsulfonyl)benzamideIC5054000.0 [1]
N-(6-Chloropyridin-3-yl)-3-fluoro-4-(2-methylpropylsulfanyl)benzamideIC50100000.0 [1]
N-(6-Chloropyridin-3-yl)-3-fluoro-4-[(4-fluorophenyl)methylsulfonyl]benzamideIC50100000.0 [1]
N-(6-Chloropyridin-3-yl)-3-fluoro-4-(2-phenylethylamino)benzamideIC50100000.0 [1]
N-(6-Butoxy-3-hydroxy-2,2-dimethyl-chroman-4-yl)-N-methyl-methanesulfonamideIC50250.0 [1]
N-(3-Hydroxy-2,2-dimethyl-6-propoxy-chroman-4-yl)-N-methyl-methanesulfonamideIC50900.0 [1]
N-(6-Chloropyridin-3-yl)-4-(trifluoromethyl)benzamideIC502900.0 [1]
N-(6-Fluoro-3-hydroxy-2,2-dimethyl-3,4-dihydrochromen-4-yl)-N-methylethanesulfonamideIC501200.0 [1]
N-(6-Cyano-3-hydroxy-2,2-dimethyl-3,4-dihydrochromen-4-yl)-N-methylbutane-1-sulfonamideIC5058000.0 [1]
N-(3-Hydroxy-2,2-dimethyl-3,4-dihydrochromen-4-yl)-N-methylethanesulfonamideIC503100.0 [1]
N-(6-Chloro-3-hydroxy-2,2-dimethyl-chroman-4-yl)-N-methyl-methanesulfonamideIC501100.0 [1]
N-(6-Chloropyridin-3-yl)-3-fluoro-4-propan-2-yloxybenzamideIC50100000.0 [1]
N-(6-Chloropyridin-3-yl)-3,4-dimethylbenzamideIC50100000.0 [1]
N-(6-Chloropyridin-3-yl)-3-fluoro-4-methoxybenzamideIC50100000.0 [1]
N-(6-Chloropyridin-3-yl)-3-fluoro-4-phenoxybenzamideIC501300.0 [1]
N-(6-Chloropyridin-3-yl)-3-fluoro-4-propan-2-ylsulfanylbenzamideIC505800.0 [1]
N-(6-Chloropyridin-3-yl)-3-fluoro-4-methylbenzamideIC5033000.0 [1]
N-(6-Chloropyridin-3-yl)-4-cyano-3-fluorobenzamideIC5051000.0 [1]
N-(6-Chloropyridin-3-yl)-3-fluoro-4-(4-fluorophenyl)sulfonylbenzamideIC50100000.0 [1]
N-(6-Chloropyridin-3-yl)-3-fluoro-4-(4-fluorophenyl)sulfanylbenzamideIC50100000.0 [1]
N-(6-Chloropyridin-3-yl)-4-ethoxy-3-fluorobenzamideIC50100000.0 [1]
N-(6-Chloropyridin-3-yl)-3-fluoro-4-[(4-fluorophenyl)methylsulfanyl]benzamideIC50100000.0 [1]
N-[[1-[2-(Tert-butylcarbamoylamino)ethyl]-4-(hydroxymethyl)piperidin-4-yl]methyl]-3,5-dichlorobenzamideIC5033000.0 [1]
N-(6-Chloropyridin-3-yl)-4-phenoxybenzamideIC501900.0 [1]
2-Chloro-5-benzoylaminopyridineIC50100000.0 [1]
N-(6-Chloropyridin-3-yl)-3-(trifluoromethyl)benzamideIC505800.0 [1]
N-(6-Chloropyridin-3-yl)-3-fluoro-4-(trifluoromethyl)benzamideIC503400.0 [1]
N-(6-Chloropyridin-3-yl)-4-fluoro-3-(trifluoromethyl)benzamideIC503400.0 [1]
N-[(3S,4R)-3-Hydroxy-2,2-dimethyl-6-(4,4,4-trifluorobutoxy)-3,4-dihydrochromen-4-yl]-N-methylmethanesulfonamideIC50440.0 [1]
4-Chloro-N-(6-chloropyridin-3-yl)-3-fluorobenzamideIC5015000.0 [1]
3,4-Dichloro-N-(6-chloropyridin-3-yl)benzamideIC5017000.0 [1]
3-Chloro-N-(6-chloropyridin-3-yl)benzamideIC5041000.0 [1]
3-Chloro-N-(6-chloropyridin-3-yl)-4-fluorobenzamideIC5022000.0 [1]
N-(6-Chloropyridin-3-yl)-4-phenylbenzamideIC5030000.0 [1]
CID 9947787IC5049000.0 [1]
Items per page: 1 - 10 of 89
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References

This online tool may be cited as follows

MLA

"Quest Database™ Voltage-gated potassium channel, IKs; KCNQ1(Kv7.1)/KCNE1(MinK) Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 22 Dec. 2024, https://www.aatbio.com/data-sets/voltage-gated-potassium-channel-iks-kcnq1-kv7-1-kcne1-mink-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, December 22). Quest Database™ Voltage-gated potassium channel, IKs; KCNQ1(Kv7.1)/KCNE1(MinK) Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/voltage-gated-potassium-channel-iks-kcnq1-kv7-1-kcne1-mink-inhibitors-ic50-ki.
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