Voltage-gated calcium channel alpha2/delta subunit 2 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	2-(4-Ethoxyphenyl)-3,4-dimethyl-7-piperidin-1-ylpyrazolo[3,4-d]pyridazine	IC50	1000.0 [1]
	2-[4-Chloro-2-(trifluoromethoxy)phenyl]-7-(3-methoxyazetidin-1-yl)-3,4-dimethylpyrazolo[3,4-d]pyridazine	IC50	3981.0 [1]
	2-(4-Ethoxy-2-fluorophenyl)-7-(3-methoxyazetidin-1-yl)-3,4-dimethylpyrazolo[3,4-d]pyridazine	IC50	200.0 [1]
	2-(4-Ethoxyphenyl)-7-[(3R)-3-methoxypyrrolidin-1-yl]-3,4-dimethylpyrazolo[3,4-d]pyridazine	IC50	79.0 [1]
	2-(4-Ethoxyphenyl)-3,4-dimethyl-7-pyrrolidin-1-ylpyrazolo[3,4-d]pyridazine	IC50	22.0 [1]
	2-(4-Ethoxyphenyl)-3,4-dimethyl-7-(4-methylpiperazin-1-yl)pyrazolo[3,4-d]pyridazine	IC50	1071.0 [1]
	7-[(3R)-3-Fluoropyrrolidin-1-yl]-3,4-dimethyl-2-[4-(2,2,2-trifluoroethoxy)phenyl]pyrazolo[3,4-d]pyridazine	IC50	631.0 [1]
	2-(2,4-Dichlorophenyl)-7-(3-methoxyazetidin-1-yl)-3,4-dimethylpyrazolo[3,4-d]pyridazine	IC50	6310.0 [1]
	2-(4-Ethoxyphenyl)-7-[(3R)-3-fluoropyrrolidin-1-yl]-3,4-dimethylpyrazolo[3,4-d]pyridazine	IC50	85.0 [1]
	2-(4-Ethoxyphenyl)-7-(3-methoxyazetidin-1-yl)-3,4-dimethylpyrazolo[3,4-d]pyridazine	IC50	126.0 [1]
	2-(4-Ethoxyphenyl)-3,4-dimethyl-7-piperazin-1-ylpyrazolo[3,4-d]pyridazine	IC50	1000.0 [1]
	1-[2-(4-Ethoxyphenyl)-3,4-dimethylpyrazolo[3,4-d]pyridazin-7-yl]piperidin-4-ol	IC50	398.0 [1]
	(3R)-1-[2-(4-Ethoxyphenyl)-3,4-dimethylpyrazolo[3,4-d]pyridazin-7-yl]pyrrolidin-3-ol	IC50	1585.0 [1]
	3,4-Dimethyl-7-pyrrolidin-1-yl-2-[4-(trifluoromethoxy)phenyl]pyrazolo[3,4-d]pyridazine	IC50	1995.0 [1]
	7-(1,4-Diazepan-1-yl)-2-(4-ethoxyphenyl)-3,4-dimethylpyrazolo[3,4-d]pyridazine	IC50	1000.0 [1]
	3,4-Dimethyl-2-(4-propan-2-yloxyphenyl)-7-pyrrolidin-1-ylpyrazolo[3,4-d]pyridazine	IC50	316.0 [1]
	2-(2,4-Dichlorophenyl)-3,4-dimethyl-7-pyrrolidin-1-ylpyrazolo[3,4-d]pyridazine	IC50	631.0 [1]
	2-[4-Chloro-2-(trifluoromethoxy)phenyl]-3,4-dimethyl-7-pyrrolidin-1-ylpyrazolo[3,4-d]pyridazine	IC50	794.0 [1]
	7-(Azetidin-1-yl)-2-(4-ethoxyphenyl)-3,4-dimethylpyrazolo[3,4-d]pyridazine	IC50	59.0 [1]
	2-(4-Ethoxyphenyl)-N,3,4-trimethylpyrazolo[3,4-d]pyridazin-7-amine	IC50	537.0 [1]
	3,4-Dimethyl-7-pyrrolidin-1-yl-2-[4-(2,2,2-trifluoroethoxy)phenyl]pyrazolo[3,4-d]pyridazine	IC50	398.0 [1]
	7-(3-Methoxyazetidin-1-yl)-3,4-dimethyl-2-[4-(2,2,2-trifluoroethoxy)phenyl]pyrazolo[3,4-d]pyridazine	IC50	1995.0 [1]
	7-(Azepan-1-yl)-2-(4-ethoxyphenyl)-3,4-dimethylpyrazolo[3,4-d]pyridazine	IC50	2131.0 [1]
	(3S)-1-[2-(4-Ethoxyphenyl)-3,4-dimethylpyrazolo[3,4-d]pyridazin-7-yl]pyrrolidin-3-amine	IC50	10.0 [1]
	7-(3,3-Difluoropyrrolidin-1-yl)-2-(4-ethoxyphenyl)-3,4-dimethylpyrazolo[3,4-d]pyridazine	IC50	794.0 [1]
	2-(4-Ethoxyphenyl)-N,N,3,4-tetramethylpyrazolo[3,4-d]pyridazin-7-amine	IC50	158.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 26 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Voltage-gated calcium channel alpha2/delta subunit 2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/voltage-gated-calcium-channel-alpha2-delta-subunit-2-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 20). Quest Database™ Voltage-gated calcium channel alpha2/delta subunit 2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/voltage-gated-calcium-channel-alpha2-delta-subunit-2-inhibitors-ic50-ki.
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