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Voltage-gated calcium channel alpha2/delta subunit 2 Inhibitors (IC50, Ki)

Structure
Compound Name
Standard Type
Standard Values (in nM)
2-(4-Ethoxyphenyl)-3,4-dimethyl-7-piperidin-1-ylpyrazolo[3,4-d]pyridazineIC501000.0 [1]
2-[4-Chloro-2-(trifluoromethoxy)phenyl]-7-(3-methoxyazetidin-1-yl)-3,4-dimethylpyrazolo[3,4-d]pyridazineIC503981.0 [1]
2-(4-Ethoxy-2-fluorophenyl)-7-(3-methoxyazetidin-1-yl)-3,4-dimethylpyrazolo[3,4-d]pyridazineIC50200.0 [1]
2-(4-Ethoxyphenyl)-7-[(3R)-3-methoxypyrrolidin-1-yl]-3,4-dimethylpyrazolo[3,4-d]pyridazineIC5079.0 [1]
2-(4-Ethoxyphenyl)-3,4-dimethyl-7-pyrrolidin-1-ylpyrazolo[3,4-d]pyridazineIC5022.0 [1]
2-(4-Ethoxyphenyl)-3,4-dimethyl-7-(4-methylpiperazin-1-yl)pyrazolo[3,4-d]pyridazineIC501071.0 [1]
7-[(3R)-3-Fluoropyrrolidin-1-yl]-3,4-dimethyl-2-[4-(2,2,2-trifluoroethoxy)phenyl]pyrazolo[3,4-d]pyridazineIC50631.0 [1]
2-(2,4-Dichlorophenyl)-7-(3-methoxyazetidin-1-yl)-3,4-dimethylpyrazolo[3,4-d]pyridazineIC506310.0 [1]
2-(4-Ethoxyphenyl)-7-[(3R)-3-fluoropyrrolidin-1-yl]-3,4-dimethylpyrazolo[3,4-d]pyridazineIC5085.0 [1]
2-(4-Ethoxyphenyl)-7-(3-methoxyazetidin-1-yl)-3,4-dimethylpyrazolo[3,4-d]pyridazineIC50126.0 [1]
2-(4-Ethoxyphenyl)-3,4-dimethyl-7-piperazin-1-ylpyrazolo[3,4-d]pyridazineIC501000.0 [1]
1-[2-(4-Ethoxyphenyl)-3,4-dimethylpyrazolo[3,4-d]pyridazin-7-yl]piperidin-4-olIC50398.0 [1]
(3R)-1-[2-(4-Ethoxyphenyl)-3,4-dimethylpyrazolo[3,4-d]pyridazin-7-yl]pyrrolidin-3-olIC501585.0 [1]
3,4-Dimethyl-7-pyrrolidin-1-yl-2-[4-(trifluoromethoxy)phenyl]pyrazolo[3,4-d]pyridazineIC501995.0 [1]
7-(1,4-Diazepan-1-yl)-2-(4-ethoxyphenyl)-3,4-dimethylpyrazolo[3,4-d]pyridazineIC501000.0 [1]
3,4-Dimethyl-2-(4-propan-2-yloxyphenyl)-7-pyrrolidin-1-ylpyrazolo[3,4-d]pyridazineIC50316.0 [1]
2-(2,4-Dichlorophenyl)-3,4-dimethyl-7-pyrrolidin-1-ylpyrazolo[3,4-d]pyridazineIC50631.0 [1]
2-[4-Chloro-2-(trifluoromethoxy)phenyl]-3,4-dimethyl-7-pyrrolidin-1-ylpyrazolo[3,4-d]pyridazineIC50794.0 [1]
7-(Azetidin-1-yl)-2-(4-ethoxyphenyl)-3,4-dimethylpyrazolo[3,4-d]pyridazineIC5059.0 [1]
2-(4-Ethoxyphenyl)-N,3,4-trimethylpyrazolo[3,4-d]pyridazin-7-amineIC50537.0 [1]
3,4-Dimethyl-7-pyrrolidin-1-yl-2-[4-(2,2,2-trifluoroethoxy)phenyl]pyrazolo[3,4-d]pyridazineIC50398.0 [1]
7-(3-Methoxyazetidin-1-yl)-3,4-dimethyl-2-[4-(2,2,2-trifluoroethoxy)phenyl]pyrazolo[3,4-d]pyridazineIC501995.0 [1]
7-(Azepan-1-yl)-2-(4-ethoxyphenyl)-3,4-dimethylpyrazolo[3,4-d]pyridazineIC502131.0 [1]
(3S)-1-[2-(4-Ethoxyphenyl)-3,4-dimethylpyrazolo[3,4-d]pyridazin-7-yl]pyrrolidin-3-amineIC5010.0 [1]
7-(3,3-Difluoropyrrolidin-1-yl)-2-(4-ethoxyphenyl)-3,4-dimethylpyrazolo[3,4-d]pyridazineIC50794.0 [1]
2-(4-Ethoxyphenyl)-N,N,3,4-tetramethylpyrazolo[3,4-d]pyridazin-7-amineIC50158.0 [1]



References

This online tool may be cited as follows

MLA

"Quest Database™ Voltage-gated calcium channel alpha2/delta subunit 2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc.21 Dec2024https://www.aatbio.com/data-sets/voltage-gated-calcium-channel-alpha2-delta-subunit-2-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024December 21). Quest Database™ Voltage-gated calcium channel alpha2/delta subunit 2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/voltage-gated-calcium-channel-alpha2-delta-subunit-2-inhibitors-ic50-ki.
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