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Voltage-gated calcium channel alpha2/delta subunit 1 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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GabapentinIC5027.0 [1]
6-(4-Ethoxy-phenyl)-1,4,5,7-tetramethyl-6H-pyrrolo[3,4-d]pyridazineIC50180.0 [1]
[6-(4-Ethoxy-phenyl)-4,5,7-trimethyl-6H-pyrrolo[3,4-d]pyridazin-1-yl]-methyl-amineIC5040.0 [1]
4-N-Acridin-9-yl-1-N,1-N-diethylpentane-1,4-diamineIC50220.0 [1]
6-(4-Methoxyphenyl)-1,4,5,7-tetramethyl-6H-pyrrolo[3,4-d]pyridazineIC5010000.0 [1]
6-(4-Ethoxy-phenyl)-1-(2-methoxy-phenyl)-4,5,7-trimethyl-6H-pyrrolo[3,4-d]pyridazineIC50737.0 [1]
1-(4-Chloro-phenyl)-6-(4-ethoxy-phenyl)-4,5,7-trimethyl-6H-pyrrolo[3,4-d]pyridazineIC50701.0 [1]
6-(4-Ethoxy-phenyl)-1,5,7-trimethyl-4-(4-trifluoromethoxy-phenyl)-6H-pyrrolo[3,4-d]pyridazineIC501729.0 [1]
6-(4-Ethoxy-phenyl)-1,5,7-trimethyl-4-p-tolyl-6H-pyrrolo[3,4-d]pyridazineIC5086.0 [1]
1,6-Bis-(4-ethoxy-phenyl)-4,5,7-trimethyl-6H-pyrrolo[3,4-d]pyridazineIC50153.0 [1]
(1S)-N-(2-Phenylethyl)-1-[6-[[3-(trifluoromethyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]oxymethyl]pyridin-2-yl]ethanamineIC5030.0 [1]
6-(4-Ethoxy-phenyl)-1-isobutyl-4,5,7-trimethyl-6H-pyrrolo[3,4-d]pyridazineIC50171.0 [1]
6-(4-Ethoxy-phenyl)-1-(4-fluoro-phenyl)-4,5,7-trimethyl-6H-pyrrolo[3,4-d]pyridazineIC50528.0 [1]
1-(3-Chloro-phenyl)-6-(4-ethoxy-phenyl)-4,5,7-trimethyl-6H-pyrrolo[3,4-d]pyridazineIC501597.0 [1]
1-(2-Chloro-phenyl)-6-(4-ethoxy-phenyl)-4,5,7-trimethyl-6H-pyrrolo[3,4-d]pyridazineIC504367.0 [1]
6-(4-Ethoxyphenyl)-N-(4-methoxyphenyl)-1,5,7-trimethylpyrrolo[3,4-d]pyridazin-4-amineIC50440.0 [1]
1-Cyclopentyl-6-(4-ethoxy-phenyl)-4,5,7-trimethyl-6H-pyrrolo[3,4-d]pyridazineIC50185.0 [1]
6-(4-Ethoxyphenyl)-1,5,7-trimethyl-4-pentylpyrrolo[3,4-d]pyridazineIC50360.0 [1]
[6-(4-Ethoxy-phenyl)-4,5,7-trimethyl-6H-pyrrolo[3,4-d]pyridazin-1-yl]-p-tolyl-amineIC50240.0 [1]
6-(4-Ethoxy-phenyl)-1-ethyl-4,5,7-trimethyl-6H-pyrrolo[3,4-d]pyridazineIC50250.0 [1]
1,4,5,7-Tetramethyl-6-(4-propoxy-phenyl)-6H-pyrrolo[3,4-d]pyridazineIC505180.0 [1]
1-Cyclopentylmethyl-6-(4-ethoxy-phenyl)-4,5,7-trimethyl-6H-pyrrolo[3,4-d]pyridazineIC50211.0 [1]
6-(4-Ethoxy-phenyl)-1-(3-methoxy-phenyl)-4,5,7-trimethyl-6H-pyrrolo[3,4-d]pyridazineIC50335.0 [1]
6-(2-Ethoxyphenyl)-1,4,5,7-tetramethylpyrrolo[3,4-d]pyridazineIC501850.0 [1]
1-Cyclohexyl-6-(4-ethoxy-phenyl)-4,5,7-trimethyl-6H-pyrrolo[3,4-d]pyridazineIC50235.0 [1]
(4S)-4-N-Acridin-9-yl-1-N,1-N-diethylheptane-1,4-diamineIC509.0 [1]
[6-(4-Ethoxy-phenyl)-4,5,7-trimethyl-6H-pyrrolo[3,4-d]pyridazin-1-yl]-phenyl-amineIC5075.0 [1]
[6-(4-Ethoxy-phenyl)-4,5,7-trimethyl-6H-pyrrolo[3,4-d]pyridazin-1-yl]-dimethyl-amineIC50170.0 [1]
6-(4-Ethoxy-phenyl)-1,5,7-trimethyl-4-phenyl-6H-pyrrolo[3,4-d]pyridazineIC50382.0 [1]
6-(4-Ethoxy-phenyl)-1-(4-methoxy-phenyl)-4,5,7-trimethyl-6H-pyrrolo[3,4-d]pyridazineIC50154.0 [1]
6-(4-Ethoxyphenyl)-1,5,7-trimethyl-4-(2,4,4-trimethylpentyl)pyrrolo[3,4-d]pyridazineIC50577.0 [1]
1-Biphenyl-4-yl-6-(4-ethoxy-phenyl)-4,5,7-trimethyl-6H-pyrrolo[3,4-d]pyridazineIC501263.0 [1]
N-Acridin-9-yl-1-cyclopropyl-N',N'-diethylbutane-1,4-diamineIC5052.0 [1]
2-(3-Methylphenyl)-N-[[6-[[3-(trifluoromethyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]oxymethyl]pyridin-2-yl]methyl]ethanamineIC5015.0 [1]
2-Phenyl-N-[[6-[[3-(trifluoromethyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]oxymethyl]pyridin-2-yl]methyl]propan-1-amineIC50198.0 [1]
[6-(3-Ethyl-[1,2,4]triazolo[3,4-a]phthalazin-6-yloxymethyl)-pyridin-2-ylmethyl]-phenethyl-amineIC50241.0 [1]
N-[[6-[[3-(Methoxymethyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]oxymethyl]pyridin-2-yl]methyl]-2-phenylethanamineIC50131.0 [1]
N-[2-(3-Methylphenyl)ethyl]-1-[6-[[3-(trifluoromethyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]oxymethyl]pyridin-2-yl]ethanamineIC5029.0 [1]
Phenethyl-[6-(3-phenyl-[1,2,4]triazolo[3,4-a]phthalazin-6-yloxymethyl)-pyridin-2-ylmethyl]-amineIC50195.0 [1]
N-(2-Phenylethyl)-1-[6-[[3-(trifluoromethyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]oxymethyl]pyridin-2-yl]propan-1-amineIC50183.0 [1]
Phenethyl-[6-([1,2,4]triazolo[3,4-a]phthalazin-6-yloxymethyl)-pyridin-2-ylmethyl]-amineIC50230.0 [1]
2-Methyl-N-(2-phenylethyl)-1-[6-[[3-(trifluoromethyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]oxymethyl]pyridin-2-yl]propan-1-amineIC50174.0 [1]
4-N-Acridin-9-yl-1-N,1-N-diethylheptane-1,4-diamineIC5018.0 [1]
(1R)-N-(2-Phenylethyl)-1-[6-[[3-(trifluoromethyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]oxymethyl]pyridin-2-yl]ethanamineIC5010000.0 [1]
2-(4-Methoxyphenyl)-N-[[6-[[3-(trifluoromethyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]oxymethyl]pyridin-2-yl]methyl]ethanamineIC50829.0 [1]
2-(2-Methylphenyl)-N-[[6-[[3-(trifluoromethyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]oxymethyl]pyridin-2-yl]methyl]ethanamineIC50448.0 [1]
2-(4-Methylphenyl)-N-[[6-[[3-(trifluoromethyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]oxymethyl]pyridin-2-yl]methyl]ethanamineIC50260.0 [1]
2-(3-Methoxyphenyl)-N-[[6-[[3-(trifluoromethyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]oxymethyl]pyridin-2-yl]methyl]ethanamineIC50116.0 [1]
N-[[6-[(3-Methylsulfanyl-[1,2,4]triazolo[3,4-a]phthalazin-6-yl)oxymethyl]pyridin-2-yl]methyl]-2-phenylethanamineIC50194.0 [1]
1-Phenyl-N-[[6-[[3-(trifluoromethyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]oxymethyl]pyridin-2-yl]methyl]propan-2-amineIC501369.0 [1]
[6-(3-Methyl-[1,2,4]triazolo[3,4-a]phthalazin-6-yloxymethyl)-pyridin-2-ylmethyl]-phenethyl-amineIC50145.0 [1]
2-(3-Fluorophenyl)-N-[[6-[[3-(trifluoromethyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]oxymethyl]pyridin-2-yl]methyl]ethanamineIC50161.0 [1]
N-Acridin-9-yl-N',N'-diethyl-1-phenylbutane-1,4-diamineIC501100.0 [1]
(2S)-1-Phenyl-N-[[6-[[3-(trifluoromethyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]oxymethyl]pyridin-2-yl]methyl]propan-2-amineIC50700.0 [1]
2-(2-Methoxyphenyl)-N-[[6-[[3-(trifluoromethyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]oxymethyl]pyridin-2-yl]methyl]ethanamineIC503163.0 [1]
2-(2-Fluorophenyl)-N-[[6-[[3-(trifluoromethyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]oxymethyl]pyridin-2-yl]methyl]ethanamineIC50291.0 [1]
(4S)-4-N-Acridin-9-yl-1-N,1-N-diethylpentane-1,4-diamineIC50110.0 [1]
4-N-Acridin-9-yl-1-N,1-N-diethylhexane-1,4-diamineIC5038.0 [1]
[6-(3-Cyclohexyl-[1,2,4]triazolo[3,4-a]phthalazin-6-yloxymethyl)-pyridin-2-ylmethyl]-phenethyl-amineIC50145.0 [1]
4-N-Acridin-9-yl-1-N,1-N-diethyl-4-methylpentane-1,4-diamineIC50270.0 [1]
[6-(3-Isopropyl-[1,2,4]triazolo[3,4-a]phthalazin-6-yloxymethyl)-pyridin-2-ylmethyl]-phenethyl-amineIC50342.0 [1]
(1S)-N-[2-(3-Bromophenyl)ethyl]-1-[6-[[3-(trifluoromethyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]oxymethyl]pyridin-2-yl]ethanamineIC5028.0 [1]
6-(4-Ethoxyphenyl)-N-(1H-indol-5-yl)-1,5,7-trimethylpyrrolo[3,4-d]pyridazin-4-amineIC5030.0 [1]
6-(4-Ethoxyphenyl)-N-(1H-indazol-5-yl)-1,5,7-trimethylpyrrolo[3,4-d]pyridazin-4-amineIC5036.0 [1]
(4S)-1-N,1-N-Diethyl-4-N-(1,2,3,4,5,6,7,8-octahydroacridin-9-yl)pentane-1,4-diamineIC5043.0 [1]
N-[[6-[(3-Cyclopropyl-[1,2,4]triazolo[3,4-a]phthalazin-6-yl)oxymethyl]pyridin-2-yl]methyl]-2-phenylethanamineIC50272.0 [1]
2-(4-Fluorophenyl)-N-[[6-[[3-(trifluoromethyl)-[1,2,4]triazolo[3,4-a]phthalazin-6-yl]oxymethyl]pyridin-2-yl]methyl]ethanamineIC50630.0 [1]
2-(4-Ethoxyphenyl)-3,4-dimethyl-7-piperidin-1-ylpyrazolo[3,4-d]pyridazineIC5042.0 [1]
3-N-Acridin-9-yl-1-N,1-N-diethylbutane-1,3-diamineIC5010000.0 [1]
1-N,1-N-Diethyl-4-N-(1,2,3,4-tetrahydroacridin-9-yl)pentane-1,4-diamineIC50420.0 [1]
(4R)-4-N-Acridin-9-yl-1-N,1-N-diethylpentane-1,4-diamineIC5011000.0 [1]
6-(4-Ethoxyphenyl)-1-methoxy-4,5,7-trimethyl-6H-pyrrolo[3,4-d]pyridazineIC502181.0 [1]
5-N-Acridin-9-yl-1-N,1-N-diethylhexane-1,5-diamineIC506000.0 [1]
Acridin-9-yl-(1-methyl-4-morpholin-4-yl-butyl)-amineIC5010000.0 [1]
1-N,1-N-Diethyl-4-N-(1,2,3,4,5,6,7,8-octahydroacridin-9-yl)pentane-1,4-diamineIC50160.0 [1]
1-N,1-N-Diethyl-4-N-[2-(trifluoromethyl)-5,6,7,8-tetrahydroquinolin-4-yl]pentane-1,4-diamineIC5010000.0 [1]
N-[5-[(2S,6R)-2,6-Dimethylpiperidin-1-yl]pentan-2-yl]acridin-9-amineIC505900.0 [1]
N~4~-(Acridin-9-yl)-N~1~,N~1~-diethylbutane-1,4-diamineIC5013000.0 [1]
Acridin-9-yl-(1-methyl-4-piperidin-1-yl-butyl)-amineIC5010000.0 [1]
Acridin-9-yl-(1-methyl-4-pyrrolidin-1-yl-butyl)-amineIC509900.0 [1]
4-N-Acridin-9-yl-1-N,1-N-di(propan-2-yl)pentane-1,4-diamineIC5010000.0 [1]
4-N-Acridin-9-yl-1-N-propan-2-ylpentane-1,4-diamineIC505100.0 [1]
(4R)-1-N,1-N-Diethyl-4-N-(1,2,3,4,5,6,7,8-octahydroacridin-9-yl)pentane-1,4-diamineIC50760.0 [1]
N-(2,3-Dihydro-1H-inden-1-yl)-6-(4-ethoxyphenyl)-1,5,7-trimethylpyrrolo[3,4-d]pyridazin-4-amineIC5054.0 [1]
6-(4-Ethoxyphenyl)-1,5,7-trimethyl-N-(1,2,3,4-tetrahydronaphthalen-1-yl)pyrrolo[3,4-d]pyridazin-4-amineIC50161.0 [1]
(3Ar,9bR)-2-[6-(4-ethoxyphenyl)-1,5,7-trimethylpyrrolo[3,4-d]pyridazin-4-yl]-1,3,3a,4,5,9b-hexahydrobenzo[e]isoindoleIC5084.0 [1]
1,3,4-Trimethyl-7-(4-methylcyclohexyl)-2-(4-propylphenyl)-2H-indeneIC502926.0 [1]
N-(4-Fluorobenzyl)-6-(4-ethoxyphenyl)-4,5,7-trimethyl-6H-pyrrolo[3,4-d]pyridazin-1-amineIC5094.0 [1]
N-(3-Chlorobenzyl)-6-(4-ethoxyphenyl)-4,5,7-trimethyl-6H-pyrrolo[3,4-d]pyridazin-1-amineIC5037.0 [1]
N-(4-Chlorobenzyl)-6-(4-ethoxyphenyl)-4,5,7-trimethyl-6H-pyrrolo[3,4-d]pyridazin-1-amineIC5065.0 [1]
2-[6-(4-Ethoxyphenyl)-1,5,7-trimethylpyrrolo[3,4-d]pyridazin-4-yl]-1,3,4,4b,8a,9-hexahydropyrido[3,4-b]indoleIC50135.0 [1]
N-[1-[6-(4-Ethoxyphenyl)-1,5,7-trimethylpyrrolo[3,4-d]pyridazin-4-yl]pyrrolidin-3-yl]acetamideIC50144.0 [1]
6-(4-Ethoxyphenyl)-4,5,7-trimethyl-N-(2-methylbutyl)-6H-pyrrolo[3,4-d]pyridazin-1-amineIC5084.0 [1]
6-(4-Ethoxyphenyl)-4,5,7-trimethyl-N-(pyridin-2-ylmethyl)-6H-pyrrolo[3,4-d]pyridazin-1-amineIC503000.0 [1]
6-(4-Ethoxyphenyl)-1,5,7-trimethyl-N-(4-methylpentan-2-yl)pyrrolo[3,4-d]pyridazin-4-amineIC50296.0 [1]
6-(4-Ethoxyphenyl)-1,5,7-trimethyl-N-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-ylmethyl)pyrrolo[3,4-d]pyridazin-4-amineIC5032.0 [1]
6-(4-Ethoxyphenyl)-1,5,7-trimethyl-N-[(6-methylpyridin-2-yl)methyl]pyrrolo[3,4-d]pyridazin-4-amineIC5084.0 [1]
N-(3-Fluorobenzyl)-6-(4-ethoxyphenyl)-4,5,7-trimethyl-6H-pyrrolo[3,4-d]pyridazin-1-amineIC5018.0 [1]
N-(4-Methoxybenzyl)-6-(4-ethoxyphenyl)-4,5,7-trimethyl-6H-pyrrolo[3,4-d]pyridazin-1-amineIC50702.0 [1]
N-(2-Methoxybenzyl)-6-(4-ethoxyphenyl)-4,5,7-trimethyl-6H-pyrrolo[3,4-d]pyridazin-1-amineIC5076.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Voltage-gated calcium channel alpha2/delta subunit 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 22 Dec. 2024, https://www.aatbio.com/data-sets/voltage-gated-calcium-channel-alpha2-delta-subunit-1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, December 22). Quest Database™ Voltage-gated calcium channel alpha2/delta subunit 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/voltage-gated-calcium-channel-alpha2-delta-subunit-1-inhibitors-ic50-ki.
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