Vesicular acetylcholine transporter Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	(-)-Vesamicol	IC50	20.0 [1]
	P-Fluorobenzyltrozamicol	Ki	0.22 [1], 0.44 [2]
	Benzovesamicol	Ki	0.06 [1]
	M-Iodobenzyltrozamicol	Ki	0.13 [1]
	(+)-trans-(4-Fluorophenyl)(1-(3-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)piperidin-4-yl)methanone	Ki	2.7 [1], 108.0 [2]
	(4-Aminophenyl)-[1-[(2R,3R)-3-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl]piperidin-4-yl]methanone	Ki	1.68 [1]
	Hemicholinium-3	IC50	12.0 [1]
	Vesamicol hydrochloride	IC50	3000.0 [1]
	Vesamicol	IC50	500.0 [1]
	4-Phenylpiperidine	IC50	90000.0 [1]
	Htsip	Ki	0.36 [1]
	1'-Benzyl-1-(2-fluoroethyl)spiro[1H-2-benzofuran-3,4'-piperidine]	Ki	1.4 [1]
	(1R,2R)-2-Spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylcyclohexan-1-ol	Ki	7.6 [1]
	1-(4-Bromophenyl)-3-(4-phenylpiperidin-1-yl)propan-2-ol	Ki	170.0 [1]
	1-(4-Fluorophenyl)-4-(3-phenyl-8-aza-bicyclo[3.2.1]octan-8-yl)butan-1-one	Ki	594.0 [1]
	1'-Benzyl-1-(3-fluoropropyl)spiro[1H-2-benzofuran-3,4'-piperidine]	Ki	1.0 [1]
	(3R,4R)-1-[(4-Fluorophenyl)methyl]-3-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpiperidin-4-ol	Ki	0.36 [1]
	(3R,4R)-1-[(3-Iodophenyl)methyl]-3-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpiperidin-4-ol	Ki	0.67 [1]
	1-(4-Fluorophenyl)-4-(1-methylspiro[2H-indole-3,4'-piperidine]-1'-yl)butan-1-one	Ki	570.0 [1]
	trans-trans-1-(4-Fluorobenzyl)-7-(4-phenylpiperidin-1-yl)-decahydroquinolin-6-ol	Ki	0.99 [1]
	trans-trans-1-(4-Fluorobenzyl)-6-(4-phenylpiperidin-1-yl)-decahydroquinolin-7-ol	Ki	10.0 [1]
	trans-trans-1-(3-Iodobenzyl)-6-(4-phenylpiperidin-1-yl)-decahydroquinolin-7-ol	Ki	5.2 [1]
	trans-trans-1-(3-Iodobenzyl)-7-(4-phenylpiperidin-1-yl)-decahydroquinolin-6-ol	Ki	7.7 [1]
	(1R,2R)-2-(1-Methylspiro[2H-indole-3,4'-piperidine]-1'-yl)cyclohexan-1-ol	Ki	74.0 [1]
	(2R,3R)-3-(1-Methylspiro[2H-indole-3,4'-piperidine]-1'-yl)-1,2,3,4-tetrahydronaphthalen-2-ol	Ki	77.0 [1]
	1-(4-Fluorophenyl)-4-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylbutan-1-one	Ki	85.0 [1]
	trans-trans-1-(3-Iodoallyl)-7-(4-phenylpiperidin-1-yl)-decahydroquinolin-6-ol	Ki	0.4 [1]
	6-Methoxyvesamicol	IC50	2000.0 [1]
	4-Tert-Butyl-2-(4-phenyl-piperidin-1-yl)-cyclohexanol	IC50	20.0 [1]
	3-(4-Phenylpiperidino)-5-aminotetralin-2-ol	IC50	100.0 [1]
	1-(4-Fluoro-phenyl)-2-(3-phenyl-8-aza-bicyclo[3.2.1]oct-8-yl)-ethanone	Ki	3400.0 [1]
	(1R)-1-(3-Bromophenyl)-2-(1-methylspiro[2H-indole-3,4'-piperidine]-1'-yl)ethanol	Ki	182.0 [1]
	(2R)-1-(4-Bromophenyl)-3-(1-methylspiro[2H-indole-3,4'-piperidine]-1'-yl)propan-2-ol	Ki	420.0 [1]
	(1R)-1-(3-Bromophenyl)-2-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylethanol	Ki	600.0 [1]
	(2R)-1-(4-Bromophenyl)-3-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropan-2-ol	Ki	86.0 [1]
	Phenyl[(3R,4R)-3-(4-phenylpiperidino)-4-hydroxypiperidino] ketone	IC50	34.0 [1]
	(1R,2R,4S)-4-[(4-Fluorophenyl)methoxy]-2-(4-phenylpiperidin-1-yl)cyclohexan-1-ol	Ki	10.7 [1]
	CID 10385293	Ki	0.77 [1]
	(4Ar,6R,7R,8aR)-7-(4-Phenyl-piperidin-1-yl)-decahydro-quinolin-6-ol	Ki	96.0 [1]
	(3R,4R)-1-[(4-Fluorophenyl)methyl]-3-(1-methylspiro[2H-indole-3,4'-piperidine]-1'-yl)piperidin-4-ol	Ki	33.0 [1]
	1-(2-Bromobenzyl)-4-(4-phenylpiperazin-1-yl)piperidin-3-ol	IC50	11.0 [1]
	(3R,4R)-1-[(3-Iodophenyl)methyl]-3-(1-methylspiro[2H-indole-3,4'-piperidine]-1'-yl)piperidin-4-ol	Ki	17.0 [1]
	[4-(2-Fluoroethoxy)phenyl]-[1-[(2R,3R)-3-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl]piperidin-4-yl]methanone	Ki	1.74 [1]
	[4-[2-(2-Fluoroethoxy)ethoxy]phenyl]-[1-[(2R,3R)-3-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl]piperidin-4-yl]methanone	Ki	0.87 [1]
	[4-[2-[2-(2-Fluoroethoxy)ethoxy]ethoxy]phenyl]-[1-[(2R,3R)-3-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl]piperidin-4-yl]methanone	Ki	1.23 [1]
	[1-[(2R,3R)-3,8-Dihydroxy-1,2,3,4-tetrahydronaphthalen-2-yl]piperidin-4-yl]-(4-fluorophenyl)methanone	Ki	4.64 [1]
	[1-[(2R,3R)-3,5-Dihydroxy-1,2,3,4-tetrahydronaphthalen-2-yl]piperidin-4-yl]-(4-fluorophenyl)methanone	Ki	56.2 [1]
	[1-[(2R,3R)-8-(2-Fluoroethoxy)-3-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl]piperidin-4-yl]-(4-fluorophenyl)methanone	Ki	1.55 [1]
	[1-[8-(2-Fluoroethoxy)-3-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl]piperidin-4-yl]-(4-fluorophenyl)methanone	Ki	0.59 [1]
	[1-[(2R,3R)-5-(2-Fluoroethoxy)-3-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl]piperidin-4-yl]-(4-fluorophenyl)methanone	Ki	92.8 [1]
	(4-Fluorophenyl)-[(6R,7R)-6-hydroxy-7-(4-phenylpiperidin-1-yl)-5,6,7,8-tetrahydronaphthalen-1-yl]methanone	Ki	2.7 [1]
	2-Piperidin-1-yl-cyclohexanol	IC50	40000.0 [1]
	2-(Methylbenzylamino)cyclohexanol	IC50	10000.0 [1]
	2-(4-Phenyl-3,6-dihydropyridin-1(2H)-yl)cyclohexanol	IC50	200.0 [1]
	1-(2-Hydroxy-cyclohexyl)-4-phenyl-piperidin-3-ol	IC50	200.0 [1]
	2-(4-Phenyl-piperidin-1-yl)-cyclohexanone	IC50	40000.0 [1]
	2-(4-Cyclohexyl-piperidin-1-yl)-cyclohexanol	IC50	40.0 [1]
	2-[4-(4-Chloro-phenyl)-piperidin-1-yl]-cyclohexanol	IC50	100.0 [1]
	2-(4-Benzyl-piperidin-1-yl)-cyclohexanol	IC50	300.0 [1]
	2-[4-(3-Phenyl-propyl)-piperidin-1-yl]-cyclohexanol	IC50	70.0 [1]
	3-[1-(2-Hydroxycyclohexyl)piperidin-4-yl]-1H-benzimidazol-2-one	IC50	1000.0 [1]
	1-[1-(2-Hydroxy-cyclohexyl)-4-phenyl-piperidin-4-yl]-propan-1-one	IC50	50.0 [1]
	2-(3,4-Dihydro-1H-isoquinolin-2-yl)-cyclohexanol	IC50	5000.0 [1]
	2-(Indan-1-ylamino)-cyclohexanol	IC50	3000.0 [1]
	2-(3-Methyl-3-phenyl-piperidin-1-yl)-cyclohexanol	IC50	4000.0 [1]
	2-(3-Aza-bicyclo[3.2.2]non-3-yl)-cyclohexanol	IC50	20000.0 [1]
	4-(4-Chloro-phenyl)-1-(2-hydroxy-cyclohexyl)-piperidin-4-ol	IC50	500.0 [1]
	2-(4-Phenyl-piperazin-1-yl)-cyclohexanol	IC50	300.0 [1]
	2-(4-Benzo[1,3]dioxol-5-ylmethyl-piperazin-1-yl)-cyclohexanol	IC50	300.0 [1]
	2-[4-[2-[1-(2-Hydroxycyclohexyl)piperidin-4-yl]ethyl]piperidin-1-yl]cyclohexan-1-ol	IC50	1000.0 [1]
	2-[4-[3-[1-(2-Hydroxycyclohexyl)piperidin-4-yl]propyl]piperidin-1-yl]cyclohexan-1-ol	IC50	200.0 [1]
	8-(2-Hydroxy-cyclohexyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-one	IC50	1000.0 [1]
	2-(4-Phenyl-piperidin-1-yl)-cyclopentanol	IC50	2000.0 [1]
	5-Tert-Butyl-2-(4-phenyl-piperidin-1-yl)-cyclohexanol	IC50	90.0 [1]
	2-Phenyl-6-(4-phenyl-piperidin-1-yl)-cyclohexanol	IC50	600.0 [1]
	2-[4-[1-(2-Hydroxycyclohexyl)piperidin-4-yl]piperidin-1-yl]cyclohexan-1-ol	IC50	200.0 [1]
	2-[4-(4-Chloro-phenyl)-3,6-dihydro-2H-pyridin-1-yl]-cyclohexanol	IC50	200.0 [1]
	2-(4-o-Tolyl-piperazin-1-yl)-cyclohexanol	IC50	100.0 [1]
	2-[4-(4-Methoxy-phenyl)-piperazin-1-yl]-cyclohexanol	IC50	300.0 [1]
	2-[4-(4-Nitro-phenyl)-piperidin-1-yl]-cyclohexanol	IC50	100.0 [1]
	2-[4-(4-Amino-phenyl)-piperidin-1-yl]-cyclohexanol	IC50	500.0 [1]
	N-[4-[1-(2-Hydroxycyclohexyl)piperidin-4-yl]phenyl]acetamide	IC50	20000.0 [1]
	2-[4-(4-Dimethylamino-phenyl)-piperidin-1-yl]-cyclohexanol	IC50	300.0 [1]
	2-[4-(4-Methylamino-phenyl)-piperidin-1-yl]-cyclohexanol	IC50	400.0 [1]
	2-[4-(2,4-Dinitro-phenyl)-piperidin-1-yl]-cyclohexanol	IC50	300.0 [1]
	2-[Methyl-(3-phenyl-propyl)-amino]-cyclohexanol	IC50	2000.0 [1]
	Acetic acid 2-(4-phenyl-piperidin-1-yl)-cyclohexyl ester	IC50	2000.0 [1]
	1-(2-Hydroxy-cyclohexyl)-1-methyl-4-phenyl-piperidinium	IC50	1000.0 [1]
	1-(2-Hydroxy-butyl)-1-methyl-4-phenyl-piperidinium	IC50	2000.0 [1]
	2-(1-Methyl-4-phenylpiperidin-1-ium-1-yl)ethanol	IC50	8000.0 [1]
	1-(2-Acetoxy-cyclohexyl)-1-methyl-4-phenyl-piperidinium	IC50	5000.0 [1]
	8-Amino-3-(4-phenylpiperidin-1-yl)-1,2,3,4-tetrahydronaphthalen-2-ol	IC50	300.0 [1]
	N-[7-Hydroxy-6-(4-phenylpiperidin-1-yl)-5,6,7,8-tetrahydronaphthalen-1-yl]acetamide	IC50	2000.0 [1]
	N-[6-Hydroxy-7-(4-phenylpiperidin-1-yl)-5,6,7,8-tetrahydronaphthalen-1-yl]acetamide	IC50	50.0 [1]
	N-[6-Hydroxy-4-iodo-7-(4-phenylpiperidin-1-yl)-5,6,7,8-tetrahydronaphthalen-1-yl]acetamide	IC50	300.0 [1]
	4-[[6-Hydroxy-7-(4-phenylpiperidin-1-yl)-5,6,7,8-tetrahydronaphthalen-1-yl]amino]-4-oxobutanoic acid	IC50	50.0 [1]
	4-[[7-Hydroxy-6-(4-phenylpiperidin-1-yl)-5,6,7,8-tetrahydronaphthalen-1-yl]amino]-4-oxobutanoic acid	IC50	500.0 [1]
	N-[6-Hydroxy-7-(4-phenylpiperidin-1-yl)-5,6,7,8-tetrahydronaphthalen-1-yl]-5-(2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl)pentanamide	IC50	100.0 [1]
	N-[6-Hydroxy-7-(4-phenylpiperidin-1-yl)-5,6,7,8-tetrahydronaphthalen-1-yl]-4-[2-[4-[[6-hydroxy-7-(4-phenylpiperidin-1-yl)-5,6,7,8-tetrahydronaphthalen-1-yl]amino]-4-oxobutanoyl]hydrazinyl]-4-oxobutanamide	IC50	1000.0 [1]
	N-[2-[[2-[[6-Hydroxy-7-(4-phenylpiperidin-1-yl)-5,6,7,8-tetrahydronaphthalen-1-yl]amino]-2-oxoethyl]amino]-2-oxoethyl]-5-(2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl)pentanamide	IC50	200.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Vesicular acetylcholine transporter Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/vesicular-acetylcholine-transporter-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 21). Quest Database™ Vesicular acetylcholine transporter Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/vesicular-acetylcholine-transporter-inhibitors-ic50-ki.
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