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Vesicular acetylcholine transporter Inhibitors (IC50, Ki)

Structure
Compound Name
Standard Type
Standard Values (in nM)
(-)-VesamicolIC5020.0 [1]
P-FluorobenzyltrozamicolKi0.22 [1], 0.44 [2]
BenzovesamicolKi0.06 [1]
M-IodobenzyltrozamicolKi0.13 [1]
(+)-trans-(4-Fluorophenyl)(1-(3-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)piperidin-4-yl)methanoneKi2.7 [1], 108.0 [2]
(4-Aminophenyl)-[1-[(2R,3R)-3-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl]piperidin-4-yl]methanoneKi1.68 [1]
Hemicholinium-3IC5012.0 [1]
Vesamicol hydrochlorideIC503000.0 [1]
VesamicolIC50500.0 [1]
4-PhenylpiperidineIC5090000.0 [1]
HtsipKi0.36 [1]
1'-Benzyl-1-(2-fluoroethyl)spiro[1H-2-benzofuran-3,4'-piperidine]Ki1.4 [1]
(1R,2R)-2-Spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylcyclohexan-1-olKi7.6 [1]
1-(4-Bromophenyl)-3-(4-phenylpiperidin-1-yl)propan-2-olKi170.0 [1]
1-(4-Fluorophenyl)-4-(3-phenyl-8-aza-bicyclo[3.2.1]octan-8-yl)butan-1-oneKi594.0 [1]
1'-Benzyl-1-(3-fluoropropyl)spiro[1H-2-benzofuran-3,4'-piperidine]Ki1.0 [1]
(3R,4R)-1-[(4-Fluorophenyl)methyl]-3-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpiperidin-4-olKi0.36 [1]
(3R,4R)-1-[(3-Iodophenyl)methyl]-3-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpiperidin-4-olKi0.67 [1]
1-(4-Fluorophenyl)-4-(1-methylspiro[2H-indole-3,4'-piperidine]-1'-yl)butan-1-oneKi570.0 [1]
trans-trans-1-(4-Fluorobenzyl)-7-(4-phenylpiperidin-1-yl)-decahydroquinolin-6-olKi0.99 [1]
trans-trans-1-(4-Fluorobenzyl)-6-(4-phenylpiperidin-1-yl)-decahydroquinolin-7-olKi10.0 [1]
trans-trans-1-(3-Iodobenzyl)-6-(4-phenylpiperidin-1-yl)-decahydroquinolin-7-olKi5.2 [1]
trans-trans-1-(3-Iodobenzyl)-7-(4-phenylpiperidin-1-yl)-decahydroquinolin-6-olKi7.7 [1]
(1R,2R)-2-(1-Methylspiro[2H-indole-3,4'-piperidine]-1'-yl)cyclohexan-1-olKi74.0 [1]
(2R,3R)-3-(1-Methylspiro[2H-indole-3,4'-piperidine]-1'-yl)-1,2,3,4-tetrahydronaphthalen-2-olKi77.0 [1]
1-(4-Fluorophenyl)-4-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylbutan-1-oneKi85.0 [1]
trans-trans-1-(3-Iodoallyl)-7-(4-phenylpiperidin-1-yl)-decahydroquinolin-6-olKi0.4 [1]
6-MethoxyvesamicolIC502000.0 [1]
4-Tert-Butyl-2-(4-phenyl-piperidin-1-yl)-cyclohexanolIC5020.0 [1]
3-(4-Phenylpiperidino)-5-aminotetralin-2-olIC50100.0 [1]
1-(4-Fluoro-phenyl)-2-(3-phenyl-8-aza-bicyclo[3.2.1]oct-8-yl)-ethanoneKi3400.0 [1]
(1R)-1-(3-Bromophenyl)-2-(1-methylspiro[2H-indole-3,4'-piperidine]-1'-yl)ethanolKi182.0 [1]
(2R)-1-(4-Bromophenyl)-3-(1-methylspiro[2H-indole-3,4'-piperidine]-1'-yl)propan-2-olKi420.0 [1]
(1R)-1-(3-Bromophenyl)-2-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylethanolKi600.0 [1]
(2R)-1-(4-Bromophenyl)-3-spiro[1,2-dihydroindene-3,4'-piperidine]-1'-ylpropan-2-olKi86.0 [1]
Phenyl[(3R,4R)-3-(4-phenylpiperidino)-4-hydroxypiperidino] ketoneIC5034.0 [1]
(1R,2R,4S)-4-[(4-Fluorophenyl)methoxy]-2-(4-phenylpiperidin-1-yl)cyclohexan-1-olKi10.7 [1]
CID 10385293Ki0.77 [1]
(4Ar,6R,7R,8aR)-7-(4-Phenyl-piperidin-1-yl)-decahydro-quinolin-6-olKi96.0 [1]
(3R,4R)-1-[(4-Fluorophenyl)methyl]-3-(1-methylspiro[2H-indole-3,4'-piperidine]-1'-yl)piperidin-4-olKi33.0 [1]
1-(2-Bromobenzyl)-4-(4-phenylpiperazin-1-yl)piperidin-3-olIC5011.0 [1]
(3R,4R)-1-[(3-Iodophenyl)methyl]-3-(1-methylspiro[2H-indole-3,4'-piperidine]-1'-yl)piperidin-4-olKi17.0 [1]
[4-(2-Fluoroethoxy)phenyl]-[1-[(2R,3R)-3-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl]piperidin-4-yl]methanoneKi1.74 [1]
[4-[2-(2-Fluoroethoxy)ethoxy]phenyl]-[1-[(2R,3R)-3-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl]piperidin-4-yl]methanoneKi0.87 [1]
[4-[2-[2-(2-Fluoroethoxy)ethoxy]ethoxy]phenyl]-[1-[(2R,3R)-3-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl]piperidin-4-yl]methanoneKi1.23 [1]
[1-[(2R,3R)-3,8-Dihydroxy-1,2,3,4-tetrahydronaphthalen-2-yl]piperidin-4-yl]-(4-fluorophenyl)methanoneKi4.64 [1]
[1-[(2R,3R)-3,5-Dihydroxy-1,2,3,4-tetrahydronaphthalen-2-yl]piperidin-4-yl]-(4-fluorophenyl)methanoneKi56.2 [1]
[1-[(2R,3R)-8-(2-Fluoroethoxy)-3-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl]piperidin-4-yl]-(4-fluorophenyl)methanoneKi1.55 [1]
[1-[8-(2-Fluoroethoxy)-3-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl]piperidin-4-yl]-(4-fluorophenyl)methanoneKi0.59 [1]
[1-[(2R,3R)-5-(2-Fluoroethoxy)-3-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl]piperidin-4-yl]-(4-fluorophenyl)methanoneKi92.8 [1]
(4-Fluorophenyl)-[(6R,7R)-6-hydroxy-7-(4-phenylpiperidin-1-yl)-5,6,7,8-tetrahydronaphthalen-1-yl]methanoneKi2.7 [1]
2-Piperidin-1-yl-cyclohexanolIC5040000.0 [1]
2-(Methylbenzylamino)cyclohexanolIC5010000.0 [1]
2-(4-Phenyl-3,6-dihydropyridin-1(2H)-yl)cyclohexanolIC50200.0 [1]
1-(2-Hydroxy-cyclohexyl)-4-phenyl-piperidin-3-olIC50200.0 [1]
2-(4-Phenyl-piperidin-1-yl)-cyclohexanoneIC5040000.0 [1]
2-(4-Cyclohexyl-piperidin-1-yl)-cyclohexanolIC5040.0 [1]
2-[4-(4-Chloro-phenyl)-piperidin-1-yl]-cyclohexanolIC50100.0 [1]
2-(4-Benzyl-piperidin-1-yl)-cyclohexanolIC50300.0 [1]
2-[4-(3-Phenyl-propyl)-piperidin-1-yl]-cyclohexanolIC5070.0 [1]
3-[1-(2-Hydroxycyclohexyl)piperidin-4-yl]-1H-benzimidazol-2-oneIC501000.0 [1]
1-[1-(2-Hydroxy-cyclohexyl)-4-phenyl-piperidin-4-yl]-propan-1-oneIC5050.0 [1]
2-(3,4-Dihydro-1H-isoquinolin-2-yl)-cyclohexanolIC505000.0 [1]
2-(Indan-1-ylamino)-cyclohexanolIC503000.0 [1]
2-(3-Methyl-3-phenyl-piperidin-1-yl)-cyclohexanolIC504000.0 [1]
2-(3-Aza-bicyclo[3.2.2]non-3-yl)-cyclohexanolIC5020000.0 [1]
4-(4-Chloro-phenyl)-1-(2-hydroxy-cyclohexyl)-piperidin-4-olIC50500.0 [1]
2-(4-Phenyl-piperazin-1-yl)-cyclohexanolIC50300.0 [1]
2-(4-Benzo[1,3]dioxol-5-ylmethyl-piperazin-1-yl)-cyclohexanolIC50300.0 [1]
2-[4-[2-[1-(2-Hydroxycyclohexyl)piperidin-4-yl]ethyl]piperidin-1-yl]cyclohexan-1-olIC501000.0 [1]
2-[4-[3-[1-(2-Hydroxycyclohexyl)piperidin-4-yl]propyl]piperidin-1-yl]cyclohexan-1-olIC50200.0 [1]
8-(2-Hydroxy-cyclohexyl)-1-phenyl-1,3,8-triaza-spiro[4.5]decan-4-oneIC501000.0 [1]
2-(4-Phenyl-piperidin-1-yl)-cyclopentanolIC502000.0 [1]
5-Tert-Butyl-2-(4-phenyl-piperidin-1-yl)-cyclohexanolIC5090.0 [1]
2-Phenyl-6-(4-phenyl-piperidin-1-yl)-cyclohexanolIC50600.0 [1]
2-[4-[1-(2-Hydroxycyclohexyl)piperidin-4-yl]piperidin-1-yl]cyclohexan-1-olIC50200.0 [1]
2-[4-(4-Chloro-phenyl)-3,6-dihydro-2H-pyridin-1-yl]-cyclohexanolIC50200.0 [1]
2-(4-o-Tolyl-piperazin-1-yl)-cyclohexanolIC50100.0 [1]
2-[4-(4-Methoxy-phenyl)-piperazin-1-yl]-cyclohexanolIC50300.0 [1]
2-[4-(4-Nitro-phenyl)-piperidin-1-yl]-cyclohexanolIC50100.0 [1]
2-[4-(4-Amino-phenyl)-piperidin-1-yl]-cyclohexanolIC50500.0 [1]
N-[4-[1-(2-Hydroxycyclohexyl)piperidin-4-yl]phenyl]acetamideIC5020000.0 [1]
2-[4-(4-Dimethylamino-phenyl)-piperidin-1-yl]-cyclohexanolIC50300.0 [1]
2-[4-(4-Methylamino-phenyl)-piperidin-1-yl]-cyclohexanolIC50400.0 [1]
2-[4-(2,4-Dinitro-phenyl)-piperidin-1-yl]-cyclohexanolIC50300.0 [1]
2-[Methyl-(3-phenyl-propyl)-amino]-cyclohexanolIC502000.0 [1]
Acetic acid 2-(4-phenyl-piperidin-1-yl)-cyclohexyl esterIC502000.0 [1]
1-(2-Hydroxy-cyclohexyl)-1-methyl-4-phenyl-piperidiniumIC501000.0 [1]
1-(2-Hydroxy-butyl)-1-methyl-4-phenyl-piperidiniumIC502000.0 [1]
2-(1-Methyl-4-phenylpiperidin-1-ium-1-yl)ethanolIC508000.0 [1]
1-(2-Acetoxy-cyclohexyl)-1-methyl-4-phenyl-piperidiniumIC505000.0 [1]
8-Amino-3-(4-phenylpiperidin-1-yl)-1,2,3,4-tetrahydronaphthalen-2-olIC50300.0 [1]
N-[7-Hydroxy-6-(4-phenylpiperidin-1-yl)-5,6,7,8-tetrahydronaphthalen-1-yl]acetamideIC502000.0 [1]
N-[6-Hydroxy-7-(4-phenylpiperidin-1-yl)-5,6,7,8-tetrahydronaphthalen-1-yl]acetamideIC5050.0 [1]
N-[6-Hydroxy-4-iodo-7-(4-phenylpiperidin-1-yl)-5,6,7,8-tetrahydronaphthalen-1-yl]acetamideIC50300.0 [1]
4-[[6-Hydroxy-7-(4-phenylpiperidin-1-yl)-5,6,7,8-tetrahydronaphthalen-1-yl]amino]-4-oxobutanoic acidIC5050.0 [1]
4-[[7-Hydroxy-6-(4-phenylpiperidin-1-yl)-5,6,7,8-tetrahydronaphthalen-1-yl]amino]-4-oxobutanoic acidIC50500.0 [1]
N-[6-Hydroxy-7-(4-phenylpiperidin-1-yl)-5,6,7,8-tetrahydronaphthalen-1-yl]-5-(2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl)pentanamideIC50100.0 [1]
N-[6-Hydroxy-7-(4-phenylpiperidin-1-yl)-5,6,7,8-tetrahydronaphthalen-1-yl]-4-[2-[4-[[6-hydroxy-7-(4-phenylpiperidin-1-yl)-5,6,7,8-tetrahydronaphthalen-1-yl]amino]-4-oxobutanoyl]hydrazinyl]-4-oxobutanamideIC501000.0 [1]
N-[2-[[2-[[6-Hydroxy-7-(4-phenylpiperidin-1-yl)-5,6,7,8-tetrahydronaphthalen-1-yl]amino]-2-oxoethyl]amino]-2-oxoethyl]-5-(2-oxo-1,3,3a,4,6,6a-hexahydrothieno[3,4-d]imidazol-4-yl)pentanamideIC50200.0 [1]



References

This online tool may be cited as follows

MLA

"Quest Database™ Vesicular acetylcholine transporter Inhibitors (IC50, Ki)." AAT Bioquest, Inc.22 Dec2024https://www.aatbio.com/data-sets/vesicular-acetylcholine-transporter-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024December 22). Quest Database™ Vesicular acetylcholine transporter Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/vesicular-acetylcholine-transporter-inhibitors-ic50-ki.
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