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Vasopressin V2 receptor Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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LixivaptanIC501.0 [1], 1.2 [2], 5.0 [3], 91.0 [4]
LixivaptanKi2.3 [1], 23.0 [2], 90.0 [3]
ArgipressinIC50242.0 [1]
ArgipressinKi1.2 [1], 1.36 [2], 1.48 [3], 32.0 [4]
Way-vna-932IC5080.0 [1], 80.3 [2]
Way-vna-932Ki39.9 [1], 50.0 [2]
2-Phenyl-4'-[(2,3,4,5-tetrahydro-1H-1-benzoazepine-1-yl)carbonyl]benzanilideIC500.57 [1]
2-Phenyl-4'-[(2,3,4,5-tetrahydro-1H-1-benzoazepine-1-yl)carbonyl]benzanilideKi0.57 [1], 7.5 [2]
CligosibanIC501530.0 [1], 2620.0 [2]
CligosibanKi10000.0 [1]
2-(4-Fluoro-2-methylphenyl)-5-[4-(6-methoxypyridin-3-yl)-5-methyl-1,2,4-triazol-3-yl]pyrazineKi10000.0 [1]
1-[4-[(5-Fluoro-2-methylbenzoyl)amino]benzoyl]-N-(2-piperidin-1-ylethyl)spiro[3,5-dihydro-2H-1-benzazepine-4,3'-cyclopentene]-1'-carboxamideIC508.0 [1], 9.0 [2], 39.0 [3], 48.0 [4]
OxytocinKi1544.0 [1], 3500.0 [2], 6000.0 [3]
QuercetinIC506309.57 [1], 15848.93 [2], 39810.72 [3]
SporanoxIC50794.33 [1], 6309.57 [2], 12589.25 [3]
MozavaptanIC50500.0 [1]
MozavaptanKi9.42 [1], 9.7 [2]
1-(1-(4-(3-Acetylaminopropoxy)benzoyl)-4-piperidyl)-3,4-dihydro-2(1H)-quinolinoneKi10000.0 [1], 81000.0 [2]
NelivaptanKi290.0 [1], 325.0 [2]
CID 6918320Ki37000.0 [1]
ClotrimazoleIC502511.89 [1], 15848.93 [2]
ConivaptanIC5011.0 [1]
ConivaptanKi0.36 [1]
Unii-ER33G946JTKi590.0 [1]
CID 3038506IC50330.0 [1]
CID 3038506Ki91.9 [1]
4-[(3,5-Dihydroxyphenyl)methyl]-N-[[2-methyl-4-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepine-5-carbonyl)phenyl]methyl]piperazine-1-carboxamideKi58.4 [1], 1000.0 [2]
Unii-4V7CN33O10IC5034.0 [1], 52.0 [2]
(2S)-2-(4-Methyl-1,4-diazepane-1-carbothioyl)-N-[[2-methyl-4-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepine-5-carbonyl)phenyl]methyl]pyrrolidine-1-carboxamideKi1000.0 [1]
CID 6918854Ki630.96 [1]
1-[1-[2-[2-(2-Fluoroethoxy)-4-(1-methylsulfonylpiperidin-4-yl)oxyphenyl]acetyl]piperidin-4-yl]-3,4-dihydroquinolin-2-oneKi1800.0 [1]
(2-Chloro-4-pyrrolidin-1-yl-phenyl)-(2,3,4,5-tetrahydro-benzo[b]azepin-1-yl)-methanoneIC509.0 [1]
(2R)-2-[(2R,5R)-5-(2,3-Dihydro-1H-inden-2-yl)-2-(2-methylpropyl)-3,6-dioxopiperazin-1-yl]-2-(4-fluorophenyl)-N-propan-2-ylacetamideKi1258.93 [1]
(2R)-2-[(2R,5R)-5-(2,3-Dihydro-1H-inden-2-yl)-2-(2-methylpropyl)-3,6-dioxopiperazin-1-yl]-2-[4-(dimethylamino)phenyl]-N-propan-2-ylacetamideKi79432.82 [1]
2,4-Dichloro-N-[4-(6,11-dihydropyrrolo[2,1-c][1,4]benzodiazepine-5-carbonyl)phenyl]benzamideIC503.2 [1]
(4-Amino-2-methyl-phenyl)-(7-chloro-2,3,4,5-tetrahydro-benzo[b]azepin-1-yl)-methanoneIC504.1 [1], 18.0 [2]
1H-1-Benzazepine, 1-(4-aminobenzoyl)-2,3,4,5-tetrahydro-IC50180.0 [1]
1H-1-Benzazepine, 1-(4-aminobenzoyl)-2,3,4,5-tetrahydro-Ki1000.0 [1]
2-(N-(4-Ethoxyphenyl)sulfonyl-4-methylanilino)-N-[(2-hydroxy-1H-indol-3-yl)imino]acetamideKi2500.0 [1]
(2R)-2-(2,4-Difluorophenyl)-2-[(2R,5R)-5-(2,3-dihydro-1H-inden-2-yl)-2-(2-methylpropyl)-3,6-dioxopiperazin-1-yl]-N,N-dimethylacetamideKi39.81 [1], 316.23 [2]
1-[4-(2-Methylbenzoylamino)benzoyl]-2,3,4,5-tetrahydro-1H-benzazepineKi2.68 [1], 7.2 [2]
[2-Chloro-4-(3-methylpyrazol-1-yl)phenyl]-(1-methyl-4,10-dihydropyrazolo[4,3-c][1,5]benzodiazepin-5-yl)methanoneKi29.0 [1]
(2Z)-2-[1-[2-Chloro-4-(3-methylpyrazol-1-yl)benzoyl]-4,4-difluoro-2,3-dihydro-1-benzazepin-5-ylidene]-N-(2-hydroxyethyl)acetamideKi9.7 [1]
5-[3-(Ethoxymethyl)-5-(4-ethoxy-3-methylphenyl)-1,2,4-triazol-4-yl]-2-methoxypyridineKi10000.0 [1]
N-[4-[(12S)-6-Chloro-2,10-diazatetracyclo[11.2.1.02,12.04,9]hexadeca-4(9),5,7-triene-10-carbonyl]phenyl]-2-(trifluoromethyl)benzamideIC507.0 [1]
N-[4-[(12S)-6-Chloro-2,10-diazatetracyclo[11.2.1.02,12.04,9]hexadeca-4(9),5,7-triene-10-carbonyl]phenyl]-2-(trifluoromethyl)benzamideKi9.0 [1]
N-[4-[(4As)-1,2,4,4a,5,11-hexahydro-[1,4]thiazino[3,4-c][1,4]benzodiazepine-6-carbonyl]phenyl]-2-phenylbenzamideKi3.2 [1], 15.0 [2]
N-[2-(Dimethylamino)ethyl]-1-[4-[(2-phenylbenzoyl)amino]benzoyl]spiro[3,5-dihydro-2H-1-benzazepine-4,3'-cyclopentene]-1'-carboxamideIC5011.0 [1], 100.0 [2]
(4R)-1-[4-[(2-Chloro-5-fluorobenzoyl)amino]-3-ethoxybenzoyl]spiro[3,5-dihydro-2H-1-benzazepine-4,3'-cyclopentene]-1'-carboxylic acidIC5071.0 [1], 150.0 [2]
1-[4-[(2-Chloro-5-fluorobenzoyl)amino]-3-methoxybenzoyl]spiro[3,5-dihydro-2H-1-benzazepine-4,3'-cyclopentene]-1'-carboxylic acidIC5092.0 [1], 120.0 [2]
(4R)-1-[4-[(2-Chloro-5-fluorobenzoyl)amino]benzoyl]spiro[3,5-dihydro-2H-1-benzazepine-4,3'-cyclopentene]-1'-carboxylic acidIC5053.0 [1], 100.0 [2]
N-[3-Chloro-4-[(12R)-2,10-diazatetracyclo[11.2.1.02,12.04,9]hexadeca-4,6,8-triene-10-carbonyl]phenyl]-2-phenylbenzamideIC5015.0 [1]
N-[3-Chloro-4-[(12R)-2,10-diazatetracyclo[11.2.1.02,12.04,9]hexadeca-4,6,8-triene-10-carbonyl]phenyl]-2-phenylbenzamideKi30.0 [1]
(10R,13S,16S,19S)-N-[(2S)-1-[[(2R)-1-Amino-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-19-(2-amino-2-oxoethyl)-13-benzyl-10-[(4-ethoxyphenyl)methyl]-8,11,14,17,20-pentaoxo-16-propan-2-yl-9,12,15,18,21-pentazaspiro[5.19]pentacosane-22-carboxamideKi400000.0 [1], 3900000.0 [2]
N-[3-Chloro-4-(2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl)phenyl]-3-methylpyrazole-1-carboxamideIC5013.0 [1]
N-[3-Chloro-4-(2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl)phenyl]-3-methylpyrazole-1-carboxamideKi38.0 [1]
1-[4-[(2-Phenylbenzoyl)amino]benzoyl]spiro[3,5-dihydro-2H-1-benzazepine-4,3'-cyclopentene]-1'-carboxylic acidIC5014.0 [1], 360.0 [2]
1-[4-[(5-Fluoro-2-methylbenzoyl)amino]-2-methoxybenzoyl]spiro[3,5-dihydro-2H-1-benzazepine-4,3'-cyclopentene]-1'-carboxylic acidIC50110.0 [1], 140.0 [2]
1-[4-[(5-Fluoro-2-methylbenzoyl)amino]benzoyl]-N-(2-pyrrolidin-1-ylethyl)spiro[3,5-dihydro-2H-1-benzazepine-4,3'-cyclopentene]-1'-carboxamideIC5039.0 [1], 48.0 [2]
N-[4-[1'-(Hydroxymethyl)spiro[3,5-dihydro-2H-1-benzazepine-4,3'-cyclopentene]-1-carbonyl]phenyl]-2-phenylbenzamideIC5018.0 [1], 190.0 [2]
N-[4-[1'-(Methylaminomethyl)spiro[3,5-dihydro-2H-1-benzazepine-4,3'-cyclopentene]-1-carbonyl]phenyl]-2-phenylbenzamideIC5044.0 [1], 1800.0 [2]
N-[4-[(4As)-1,2,4,4a,5,11-hexahydro-[1,4]oxazino[3,4-c][1,4]benzodiazepine-6-carbonyl]phenyl]-2-phenylbenzamideKi3.7 [1], 16.0 [2]
N-[4-[(4As)-1,2,4,4a,5,11-hexahydro-[1,4]oxazino[3,4-c][1,4]benzodiazepine-6-carbonyl]-3-chlorophenyl]-5-fluoro-2-methylbenzamideKi2.8 [1], 12.0 [2]
N-[4-[(4As)-1,2,4,4a,5,11-hexahydro-[1,4]oxazino[3,4-c][1,4]benzodiazepine-6-carbonyl]-3-chlorophenyl]-4-fluoro-2-phenylbenzamideKi1.9 [1], 2.0 [2]
N-[4-[(4As)-1,2,4,4a,5,11-hexahydro-[1,4]oxazino[3,4-c][1,4]benzodiazepine-6-carbonyl]-3-chlorophenyl]-4-methoxy-2-phenylbenzamideKi4.2 [1], 5.0 [2]
N-[4-[(4As)-1,2,4,4a,5,11-hexahydro-[1,4]oxazino[3,4-c][1,4]benzodiazepine-6-carbonyl]-3-chlorophenyl]-5-fluoro-2-phenylbenzamideKi11.0 [1], 12.0 [2]
N-[4-[(4As)-1,2,4,4a,5,11-hexahydro-[1,4]oxazino[3,4-c][1,4]benzodiazepine-6-carbonyl]-3-chlorophenyl]-2-(4-hydroxyphenyl)benzamideKi4.2 [1], 11.0 [2]
N-[4-[(4As)-1,2,4,4a,5,11-hexahydro-[1,4]oxazino[3,4-c][1,4]benzodiazepine-6-carbonyl]-3-chlorophenyl]-2-(3-hydroxyphenyl)benzamideKi5.0 [1], 20.0 [2]
N-[4-[(4As)-1,2,4,4a,5,11-hexahydro-[1,4]oxazino[3,4-c][1,4]benzodiazepine-6-carbonyl]-3-chlorophenyl]-2-(4-methoxyphenyl)benzamideKi2.8 [1], 3.0 [2]
N-[4-[(4As)-1,2,4,4a,5,11-hexahydro-[1,4]oxazino[3,4-c][1,4]benzodiazepine-6-carbonyl]-3-chlorophenyl]-2-(3-methoxyphenyl)benzamideKi2.0 [1], 3.7 [2]
N-[4-[(4As)-1,2,4,4a,5,11-hexahydro-[1,4]oxazino[3,4-c][1,4]benzodiazepine-6-carbonyl]-3-chlorophenyl]-4-hydroxy-2-phenylbenzamideKi1.4 [1], 6.0 [2]
N-[4-[(4As)-1,2,4,4a,5,11-hexahydro-[1,4]oxazino[3,4-c][1,4]benzodiazepine-6-carbonyl]-3-chlorophenyl]-5-hydroxy-2-phenylbenzamideKi13.0 [1], 70.0 [2]
N-[4-(8-Methyl-1,2,4,4a,5,11-hexahydro-[1,4]thiazino[3,4-c][1,4]benzodiazepine-6-carbonyl)phenyl]-2-phenylbenzamideKi8.0 [1], 23.0 [2]
N-[4-[(4Ar)-1,2,4,4a,5,11-hexahydro-[1,4]thiazino[3,4-c][1,4]benzodiazepine-6-carbonyl]phenyl]-2-phenylbenzamideKi25.0 [1], 40.0 [2]
N-[4-(3,3-Dioxo-1,2,4,4a,5,11-hexahydro-[1,4]thiazino[3,4-c][1,4]benzodiazepine-6-carbonyl)phenyl]-2-phenylbenzamideKi40.0 [1], 65.0 [2]
N-[4-(1,2,4,4a,5,11-Hexahydro-[1,4]thiazino[3,4-c][1,4]benzodiazepine-6-carbonyl)-3-chlorophenyl]-5-fluoro-2-phenylbenzamideKi37.0 [1], 70.0 [2]
N-[4-(1,2,4,4a,5,11-Hexahydro-[1,4]thiazino[3,4-c][1,4]benzodiazepine-6-carbonyl)-3-chlorophenyl]-5-fluoro-2-methylbenzamideKi60.0 [1], 300.0 [2]
N-[4-[(12S)-6-Chloro-2,10-diazatetracyclo[11.2.1.02,12.04,9]hexadeca-4(9),5,7-triene-10-carbonyl]phenyl]-2-(4-methylphenyl)benzamideIC505.0 [1]
N-[4-[(12S)-6-Chloro-2,10-diazatetracyclo[11.2.1.02,12.04,9]hexadeca-4(9),5,7-triene-10-carbonyl]phenyl]-2-(4-methylphenyl)benzamideKi13.0 [1]
2-Chloro-N-[4-[(12S)-6-chloro-2,10-diazatetracyclo[11.2.2.02,12.04,9]heptadeca-4(9),5,7-triene-10-carbonyl]phenyl]benzamideIC5013.0 [1]
2-Chloro-N-[4-[(12S)-6-chloro-2,10-diazatetracyclo[11.2.2.02,12.04,9]heptadeca-4(9),5,7-triene-10-carbonyl]phenyl]benzamideKi520.0 [1]
2-Chloro-N-[4-[(12S)-6-chloro-2,10-diazatetracyclo[11.2.1.02,12.04,9]hexadeca-4(9),5,7-triene-10-carbonyl]phenyl]benzamideIC5010.0 [1]
2-Chloro-N-[4-[(12S)-6-chloro-2,10-diazatetracyclo[11.2.1.02,12.04,9]hexadeca-4(9),5,7-triene-10-carbonyl]phenyl]benzamideKi32.0 [1]
2-Methyl-N-[4-(1,2,3,4-tetrahydro-1,5-benzodiazepine-5-carbonyl)phenyl]benzamideIC5028.0 [1]
2-Methyl-N-[4-(1,2,3,4-tetrahydro-1,5-benzodiazepine-5-carbonyl)phenyl]benzamideKi160.0 [1]
N-[4-[(12S)-6-Chloro-2,10-diazatetracyclo[11.2.1.02,12.04,9]hexadeca-4(9),5,7-triene-10-carbonyl]phenyl]-2-fluorobenzamideIC5026.0 [1]
N-[4-[(12S)-6-Chloro-2,10-diazatetracyclo[11.2.1.02,12.04,9]hexadeca-4(9),5,7-triene-10-carbonyl]phenyl]-2-fluorobenzamideKi180.0 [1]
N-[3-(Dimethylamino)propyl]-1-[4-[(5-fluoro-2-methylbenzoyl)amino]benzoyl]spiro[3,5-dihydro-2H-1-benzazepine-4,3'-cyclopentene]-1'-carboxamideIC5023.0 [1], 31.0 [2]
1-[4-[(2-Fluorobenzoyl)amino]benzoyl]-N-(2-piperidin-1-ylethyl)spiro[3,5-dihydro-2H-1-benzazepine-4,3'-cyclopentene]-1'-carboxamideIC501000.0 [1]
1-[4-[(2-Fluorobenzoyl)amino]benzoyl]-N-(2-pyrrolidin-1-ylethyl)spiro[3,5-dihydro-2H-1-benzazepine-4,3'-cyclopentene]-1'-carboxamideIC501000.0 [1]
N-[2-(Dimethylamino)ethyl]-1-[4-[(5-fluoro-2-methylbenzoyl)amino]benzoyl]spiro[3,5-dihydro-2H-1-benzazepine-4,3'-cyclopentene]-1'-carboxamideIC5020.0 [1], 105.0 [2]
Methyl 2-[[1-[4-[(5-fluoro-2-methylbenzoyl)amino]benzoyl]spiro[3,5-dihydro-2H-1-benzazepine-4,3'-cyclopentene]-1'-carbonyl]amino]acetateIC5010.0 [1], 440.0 [2]
N-(2-Hydroxyethyl)-1-[4-[(2-phenylbenzoyl)amino]benzoyl]spiro[3,5-dihydro-2H-1-benzazepine-4,3'-cyclopentene]-1'-carboxamideIC5011.0 [1], 170.0 [2]
2-[[1-[4-[(2-Phenylbenzoyl)amino]benzoyl]spiro[3,5-dihydro-2H-1-benzazepine-4,3'-cyclopentene]-1'-carbonyl]amino]acetic acidIC5018.0 [1], 350.0 [2]
N-[3-(Dimethylamino)propyl]-1-[4-[(2-phenylbenzoyl)amino]benzoyl]spiro[3,5-dihydro-2H-1-benzazepine-4,3'-cyclopentene]-1'-carboxamideIC5016.0 [1], 20.0 [2]
1-[4-[(2-Fluorobenzoyl)amino]benzoyl]-N-(2-hydroxyethyl)spiro[3,5-dihydro-2H-1-benzazepine-4,3'-cyclopentene]-1'-carboxamideIC501000.0 [1]
2-[(2R)-5-[4-[(2-Phenylbenzoyl)amino]benzoyl]-3,4-dihydro-2H-1,5-benzothiazepin-2-yl]acetic acidIC507.0 [1], 36.0 [2]
3-[(2R)-5-[4-[(2-Phenylbenzoyl)amino]benzoyl]-3,4-dihydro-2H-1,5-benzothiazepin-2-yl]propanoic acidIC5016.0 [1], 40.0 [2]
N-[4-[2-(2-Hydroxyethyl)-3,4-dihydro-2H-1,5-benzothiazepine-5-carbonyl]phenyl]-2-phenylbenzamideIC508.0 [1], 100.0 [2]
3-[(2S)-5-[4-[(2-Phenylbenzoyl)amino]benzoyl]-3,4-dihydro-2H-1,5-benzothiazepin-2-yl]propanoic acidIC5015.0 [1], 30.0 [2]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Vasopressin V2 receptor Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 22 Dec. 2024, https://www.aatbio.com/data-sets/vasopressin-v2-receptor-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, December 22). Quest Database™ Vasopressin V2 receptor Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/vasopressin-v2-receptor-inhibitors-ic50-ki.
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