Vascular endothelial growth factor receptor 1 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Vatalanib	IC50	140.0 [1]
	2-(Pyridin-4-Ylmethylamino)-~{n}-[3-(Trifluoromethyl)phenyl]benzamide	IC50	170.0 [1]
	N-(4-Chloro-2-fluorophenyl)-6,7-dimethoxyquinazolin-4-amine	IC50	14100.0 [1]
	Vandetanib	IC50	100.0 [1]
	Staurosporine	IC50	5.4 [1], 8.19 [2], 15.97 [3], 19.0 [4], 35.0 [5]
	2-{[(Pyridin-4-yl)methyl]amino}-N-(quinolin-3-yl)benzamide	IC50	15.0 [1], 160.0 [2]
	Semaxanib	IC50	8.0 [1], 43.0 [2], 3000.0 [3]
	Linifanib	IC50	3.0 [1], 37.0 [2], 70.0 [3]
	(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-Acetamido-4-methylsulfanylbutanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-methylpentanoyl]amino]-6-aminohexanoyl]pyrrolidine-2-carbonyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-5-amino-5-oxopentanoyl]amino]acetyl]amino]-N-[(2S)-1-[[(2S,3S)-1-amino-3-methyl-1-oxopentan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]pentanediamide	IC50	102700.0 [1], 160000.0 [2]
	Sorafenib	IC50	18.0 [1], 31.0 [2], 165.0 [3]
	Nintedanib	IC50	23.4 [1], 34.0 [2], 104.0 [3]
	Foretinib	IC50	0.8 [1], 6.8 [2]
	N4-(3-Bromophenyl)-6-(naphthalen-1-ylmethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine	IC50	16000.0 [1], 19200.0 [2]
	4-N-(3-Bromophenyl)-6-[(2-methylphenyl)methyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine	IC50	50000.0 [1]
	4-N-(3-Bromophenyl)-6-[(2,5-dimethoxyphenyl)methyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine	IC50	31100.0 [1], 45900.0 [2]
	c[YYDEGLEE]-NH2	IC50	23000.0 [1], 32000.0 [2], 39900.0 [3]
	Sunitinib	IC50	1.0 [1]
	Sunitinib	Ki	2.0 [1]
	Pazopanib	IC50	10.0 [1], 98.0 [2]
	Dovitinib	IC50	3.0 [1], 10.0 [2]
	Motesanib	IC50	2.0 [1]
	Tivozanib	IC50	0.21 [1], 6.26 [2]
	VEGF receptor tyrosine kinase inhibitor III	IC50	1.0 [1], 170.0 [2]
	Lucitanib	IC50	7.0 [1]
	N-(4-Bromo-2-fluorophenyl)-6-methoxy-7-[2-(triazol-1-yl)ethoxy]quinazolin-4-amine	IC50	700.0 [1]
	Ilorasertib	IC50	1.25 [1], 32.0 [2]
	Tak-593	IC50	3.2 [1]
	3-(4-{4-Aminofuro[2,3-d]pyrimidin-5-yl}phenyl)-1-[2-fluoro-5-(trifluoromethyl)phenyl]urea	IC50	7.76 [1], 8.51 [2]
	1-[4-(4-Aminothieno[2,3-d]pyrimidin-5-yl)phenyl]-3-(3-methylphenyl)urea	IC50	2.0 [1]
	2-Benzyl-N4-(3-bromophenyl)-1H-indole-4,6-diamine	IC50	50000.0 [1]
	6-(2-Phenylethyl)-4-N-[3-(trifluoromethyl)phenyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine	IC50	200000.0 [1]
	2-(2-Chlorobenzyl)-N4-(3-bromophenyl)-1H-indole-4,6-diamine	IC50	26800.0 [1]
	N-(4-Chloro-2-fluorophenyl)-6-methoxy-7-(2-methoxyethoxy)quinazolin-4-amine	IC50	400.0 [1]
	4-N-(3-Bromo-4-fluorophenyl)-6-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine	IC50	200000.0 [1]
	1-Methyl-1-[[5-[7-[(4-methylpiperazin-1-yl)methyl]-2,4-dihydroindeno[1,2-c]pyrazol-3-yl]thiophen-2-yl]methyl]-3-[3-(trifluoromethyl)phenyl]urea	IC50	14.0 [1]
	(4S)-5-[[(2S,3S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S,3R)-1-[[(2S)-1-[[2-[[(2S)-1-[[(2S)-1-Amino-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-4-methylsulfanyl-1-oxobutan-2-yl]amino]-2-oxoethyl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-4-carboxy-1-oxobutan-2-yl]amino]-3-methyl-1-oxopentan-2-yl]amino]-4-[[(2S)-2-[[2-[[(2S)-2,4-diamino-4-oxobutanoyl]amino]acetyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-5-oxopentanoic acid	IC50	28000.0 [1]
	4-N-[4-Fluoro-3-(trifluoromethyl)phenyl]-6-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine	IC50	200000.0 [1]
	4-N-(3-Bromophenyl)-6-[(2,4-dichlorophenyl)methyl]-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine	IC50	50000.0 [1]
	N4-(3-Bromophenyl)-2-(naphthalen-2-ylmethyl)-1H-indole-4,6-diamine	IC50	15200.0 [1]
	N4-(3-Bromophenyl)-6-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine	IC50	45100.0 [1]
	4-N-(3-Ethynylphenyl)-6-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine	IC50	200000.0 [1]
	4-N-(4-Chloro-2-fluorophenyl)-6-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine	IC50	200000.0 [1]
	N4-1H-Indol-5-yl-6-(2-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidine-2,4-diamine	IC50	200000.0 [1]
	Anilinoquinazoline deriv. 21	IC50	1100.0 [1]
	Anilinoquinazoline deriv. 22	IC50	200.0 [1]
	Anilinoquinazoline deriv. 28	IC50	100.0 [1]
	Anilinoquinazoline deriv. 32	IC50	1500.0 [1], 15000.0 [2]
	N-[4-[(4-Methylpiperazin-1-yl)methyl]phenyl]-4-(thieno[2,3-d]pyrimidin-4-ylamino)-1H-pyrazole-5-carboxamide	IC50	19.8 [1]
	c[YYAEGLEE]-NH2	IC50	25000.0 [1], 35000.0 [2]
	3-[(3S,6S,9S,12S,15S,18S,21S,26S)-26-Carbamoyl-12-(2-carboxyethyl)-15-(carboxymethyl)-18,21-bis[(4-hydroxyphenyl)methyl]-9-methyl-6-(2-methylpropyl)-2,5,8,11,14,17,20,23-octaoxo-1,4,7,10,13,16,19,22-octazacyclohexacos-3-yl]propanoic acid	IC50	101000.0 [1], 105000.0 [2]
	(3R,6S,9S,14S,17S,23S,26S)-9-[[(2S)-2-Acetamido-4-methylsulfanylbutanoyl]amino]-3-(4-aminobutyl)-N-[(2S,3S)-1-amino-3-methyl-1-oxopentan-2-yl]-17-(3-amino-3-oxopropyl)-6-[(2S)-butan-2-yl]-23-(1H-imidazol-5-ylmethyl)-2,5,8,16,19,22,25-heptaoxo-1,4,7,15,18,21,24-heptazabicyclo[24.3.0]nonacosane-14-carboxamide	IC50	91600.0 [1], 105500.0 [2]
	(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-Acetamido-4-methylsulfanylbutanoyl]amino]pent-4-enoyl]amino]-3-methylpentanoyl]amino]-6-aminohexanoyl]pyrrolidine-2-carbonyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-5-amino-5-oxopentanoyl]amino]-N-[(2S)-1-[[(2S,3S)-1-amino-3-methyl-1-oxopentan-2-yl]amino]-1-oxopent-4-en-2-yl]pentanediamide	IC50	36500.0 [1], 42300.0 [2]
	(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-Acetamido-4-methylsulfanylbutanoyl]amino]pent-4-enoyl]amino]-3-methylpentanoyl]amino]-6-aminohexanoyl]pyrrolidine-2-carbonyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-5-amino-5-oxopentanoyl]amino]acetyl]amino]-N-[(2S)-1-[[(2S,3S)-1-amino-3-methyl-1-oxopentan-2-yl]amino]-1-oxopent-4-en-2-yl]pentanediamide	IC50	61200.0 [1], 61800.0 [2]
	(2S)-2-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-Acetamidopent-4-enoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-methylpentanoyl]amino]-6-aminohexanoyl]pyrrolidine-2-carbonyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-5-amino-5-oxopentanoyl]amino]acetyl]amino]-N-[(2S)-1-[[(2S)-1-amino-1-oxopent-4-en-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]pentanediamide	IC50	76800.0 [1], 98800.0 [2]
	(2S)-2-[[2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-Acetamido-4-methylsulfanylbutanoyl]amino]pent-4-enoyl]amino]-3-methylpentanoyl]amino]-6-aminohexanoyl]pyrrolidine-2-carbonyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]acetyl]amino]-N-[(2S)-1-[[(2S,3S)-1-amino-3-methyl-1-oxopentan-2-yl]amino]-1-oxopent-4-en-2-yl]pentanediamide	IC50	90300.0 [1], 109500.0 [2]
	(3S,6S,9S,14S,17S,23S,26S,29S)-9-[[(2S)-2-Acetamido-4-methylsulfanylbutanoyl]amino]-3-(4-aminobutyl)-N-[(2S,3S)-1-amino-3-methyl-1-oxopentan-2-yl]-17,23-bis(3-amino-3-oxopropyl)-6-[(2S)-butan-2-yl]-26-(1H-imidazol-5-ylmethyl)-2,5,8,12,16,19,22,25,28-nonaoxo-1,4,7,11,15,18,21,24,27-nonazabicyclo[27.3.0]dotriacontane-14-carboxamide	IC50	87600.0 [1], 93200.0 [2]
	Methyl (2S,4R)-1-[3-[[7-[4-[(2-fluoro-5-methylphenyl)carbamoylamino]phenoxy]thieno[3,2-b]pyridine-2-carbonyl]amino]propyl]-4-hydroxypyrrolidine-2-carboxylate	IC50	10.0 [1], 15.0 [2]
	N-[2-(Diethylamino)ethyl]-7-[4-[(2-fluoro-5-methylphenyl)carbamoylamino]phenoxy]thieno[3,2-b]pyridine-2-carboxamide	IC50	5.0 [1], 13.0 [2]
	N-[3-(Diethylamino)propyl]-7-[4-[(2-fluoro-5-methylphenyl)carbamoylamino]phenoxy]thieno[3,2-b]pyridine-2-carboxamide	IC50	3.0 [1], 12.0 [2]
	7-[4-[(2-Fluoro-5-methylphenyl)carbamoylamino]phenoxy]-N-[3-(2H-tetrazol-5-yl)propyl]thieno[3,2-b]pyridine-2-carboxamide	IC50	4.0 [1], 20.0 [2]
	7-[4-[(2-Fluoro-5-methylphenyl)carbamoylamino]phenoxy]-N-[2-(2H-tetrazol-5-yl)ethyl]thieno[3,2-b]pyridine-2-carboxamide	IC50	10.0 [1], 19.0 [2]
	Ethyl 2-[4-[3-[[7-[4-[(2-fluoro-5-methylphenyl)carbamoylamino]phenoxy]thieno[3,2-b]pyridine-2-carbonyl]amino]propyl]piperazin-1-yl]acetate	IC50	5.0 [1], 13.0 [2]
	7-[4-[(2-Fluoro-5-methylphenyl)carbamoylamino]phenoxy]-N-[3-[3-(hydroxymethyl)piperidin-1-yl]propyl]thieno[3,2-b]pyridine-2-carboxamide	IC50	3.0 [1], 10.0 [2]
	7-[4-[(2-Fluoro-5-methylphenyl)carbamoylamino]phenoxy]-N-[3-[2-(hydroxymethyl)morpholin-4-yl]propyl]thieno[3,2-b]pyridine-2-carboxamide	IC50	10.0 [1], 15.0 [2]
	Methyl 2-[3-[[7-[4-[(2-fluoro-5-methylphenyl)carbamoylamino]phenoxy]thieno[3,2-b]pyridine-2-carbonyl]amino]propylamino]acetate	IC50	6.0 [1], 11.0 [2]
	Methyl 2-[3-[[7-[4-[(2-fluoro-5-methylphenyl)carbamoylamino]phenoxy]thieno[3,2-b]pyridine-2-carbonyl]amino]propyl-(2-methoxy-2-oxoethyl)amino]acetate	IC50	9.0 [1], 14.0 [2]
	Ethyl 4-[2-[[7-[3-fluoro-4-[(2-fluoro-5-methylphenyl)carbamoylamino]phenoxy]thieno[3,2-b]pyridine-2-carbonyl]amino]ethyl]piperazine-1-carboxylate	IC50	13.0 [1], 14.0 [2]
	Ethyl 4-[3-[[7-[3-fluoro-4-[(2-fluoro-5-methylphenyl)carbamoylamino]phenoxy]thieno[3,2-b]pyridine-2-carbonyl]amino]propyl]piperazine-1-carboxylate	IC50	9.0 [1], 14.0 [2]
	Methyl 2-[3-[[7-[3-fluoro-4-[(2-fluoro-5-methylphenyl)carbamoylamino]phenoxy]thieno[3,2-b]pyridine-2-carbonyl]amino]propylamino]acetate	IC50	8.0 [1], 11.0 [2]
	Methyl 2-[3-[[7-[3-fluoro-4-[(2-fluoro-5-methylphenyl)carbamoylamino]phenoxy]thieno[3,2-b]pyridine-2-carbonyl]amino]propyl-(2-methoxy-2-oxoethyl)amino]acetate	IC50	10.0 [1], 12.0 [2]
	Methyl 2-[2-[[7-[3-fluoro-4-[(2-fluoro-5-methylphenyl)carbamoylamino]phenoxy]thieno[3,2-b]pyridine-2-carbonyl]amino]ethyl-(2-methoxy-2-oxoethyl)amino]acetate	IC50	11.0 [1], 17.0 [2]
	Methyl 1-[7-[3-fluoro-4-[(2-fluoro-5-methylphenyl)carbamoylamino]phenoxy]thieno[3,2-b]pyridine-2-carbonyl]pyrrolidine-3-carboxylate	IC50	8.0 [1], 17.0 [2]
	Ethyl 2-[4-[2-[4-[7-[3-fluoro-4-[(2-fluoro-5-methylphenyl)carbamoylamino]phenoxy]thieno[3,2-b]pyridine-2-carbonyl]piperazin-1-yl]acetyl]piperazin-1-yl]acetate	IC50	10.0 [1], 13.0 [2]
	Ethyl 2-[4-[7-[3-fluoro-4-[(2-fluoro-5-methylphenyl)carbamoylamino]phenoxy]thieno[3,2-b]pyridine-2-carbonyl]piperazin-1-yl]acetate	IC50	17.0 [1], 112.0 [2]
	Methyl 2-[2-[[7-[3-fluoro-4-[(2-fluoro-5-methylphenyl)carbamoylamino]phenoxy]thieno[3,2-b]pyridine-2-carbonyl]amino]ethylamino]acetate	IC50	9.0 [1], 13.0 [2]
	N-(2-Aminoethyl)-7-[3-fluoro-4-[(2-fluoro-5-methylphenyl)carbamoylamino]phenoxy]thieno[3,2-b]pyridine-2-carboxamide	IC50	11.0 [1], 15.0 [2]
	Tert-butyl N-[2-[[7-[3-fluoro-4-[(2-fluoro-5-methylphenyl)carbamoylamino]phenoxy]thieno[3,2-b]pyridine-2-carbonyl]amino]ethyl]carbamate	IC50	60.0 [1], 69.0 [2]
	7-[3-Fluoro-4-[(2-fluoro-5-methylphenyl)carbamoylamino]phenoxy]-N-[3-(4-methylpiperazin-1-yl)propyl]thieno[3,2-b]pyridine-2-carboxamide	IC50	6.0 [1], 11.0 [2]
	2,3,7,8-Tetrachlorodibenzo-P-dioxin	Ki	0.7 [1]
	Erlotinib	IC50	1000.0 [1]
	Hematoxyline	IC50	2900.0 [1]
	Digitin	Ki	1001.0 [1]
	Crizotinib	IC50	1000.0 [1]
	Dorsomorphin	IC50	11.0 [1]
	Axitinib	IC50	0.1 [1]
	Nintedanib esylate	IC50	34.0 [1]
	Cediranib	IC50	5.0 [1]
	Cabozantinib	IC50	12.0 [1]
	Ponatinib	IC50	20.9 [1]
	Chir-99021	IC50	5000.0 [1]
	Saracatinib	IC50	100000.0 [1]
	Doramapimod	IC50	250.0 [1]
	Quizartinib	IC50	10000.0 [1]
	Orantinib	IC50	28.0 [1]
	Brivanib	Ki	60.0 [1]
	3,9-Bis((ethylthio)methyl)-K-252a	IC50	209.0 [1]
	Nvp-tae 684	IC50	872.0 [1]
	(R)-6-(4-((4-Ethylpiperazin-1-yl)methyl)phenyl)-N-(1-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine	IC50	59.0 [1]
	Pyridone 6	IC50	1520.0 [1]
	1-Cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)urea	IC50	10.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Vascular endothelial growth factor receptor 1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 22 Feb. 2025, https://www.aatbio.com/data-sets/vascular-endothelial-growth-factor-receptor-1-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 22). Quest Database™ Vascular endothelial growth factor receptor 1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/vascular-endothelial-growth-factor-receptor-1-inhibitors-ic50-ki.
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