![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_f42fd43f31c773953ea40e13f2e300fa.svg) | 3,4-Dichloro-N-[(3S)-1-[[4-[3-(dimethylamino)propoxy]phenyl]methyl]pyrrolidin-3-yl]benzamide | IC50 | 158.49 [1], 170.0 [2] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_f42fd43f31c773953ea40e13f2e300fa.svg) | 3,4-Dichloro-N-[(3S)-1-[[4-[3-(dimethylamino)propoxy]phenyl]methyl]pyrrolidin-3-yl]benzamide | Ki | 199.53 [1], 200.0 [2], 250.0 [3] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_7553dcc631cc3324db9867d9c46a343c.svg) | CID 21023902 | IC50 | 6.0 [1], 8.0 [2], 14.0 [3] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_7553dcc631cc3324db9867d9c46a343c.svg) | CID 21023902 | Ki | 5.4 [1], 8.0 [2] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_0802892133aea0855e024440ac2eece3.svg) | Human Urotensin II | IC50 | 13.0 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_0802892133aea0855e024440ac2eece3.svg) | Human Urotensin II | Ki | 0.79 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_11475b14f1edd0c31d4790fa37a5cd9d.svg) | Palosuran | IC50 | 5.0 [1], 39.0 [2], 320.0 [3] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_11475b14f1edd0c31d4790fa37a5cd9d.svg) | Palosuran | Ki | 41.0 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_4f103d0d894ea5329b6e849675329a36.svg) | (2S)-2-[[(4R,7S,10S,13S,16S,19S)-10-(4-Aminobutyl)-19-[[(2S)-2-amino-3-carboxypropanoyl]amino]-16-benzyl-7-[(4-hydroxyphenyl)methyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]amino]-3-methylbutanoic acid | Ki | 0.25 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_c51ca214888894ac7c47eca6d783dc38.svg) | (2S)-2-[[(4R,7S,10S,13S,16S,19S)-10-(4-Aminobutyl)-19-[[(2S)-2-amino-3-carboxypropanoyl]amino]-16-benzyl-7-[(4-hydroxyphenyl)methyl]-13-(1H-indol-3-ylmethyl)-20,20-dimethyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]amino]-3-methylbutanoic acid | Ki | 0.2 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_08d0ce8f8d7e0fbeffdbbbd3a1e82763.svg) | Urantide | Ki | 5.01 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_6c5d28ea5a3d84cd2302738b24d7cb14.svg) | N-[(2S)-1-[[(3S)-1-[[4-[3-(Dimethylamino)propoxy]phenyl]methyl]pyrrolidin-3-yl]amino]-4-methyl-1-oxopentan-2-yl]-1-benzothiophene-2-carboxamide | IC50 | 630.96 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_6c5d28ea5a3d84cd2302738b24d7cb14.svg) | N-[(2S)-1-[[(3S)-1-[[4-[3-(Dimethylamino)propoxy]phenyl]methyl]pyrrolidin-3-yl]amino]-4-methyl-1-oxopentan-2-yl]-1-benzothiophene-2-carboxamide | Ki | 110.0 [1], 125.89 [2] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_fdaff23b305879842210e040b720e2ee.svg) | (4R,10Br)-4-(3,4-dimethoxyphenyl)-10-(4-ethylpiperazin-1-yl)-2,3,4,10b-tetrahydro-1H-pyrido[1,2-b]isoindol-6-one | Ki | 64.0 [1], 390.0 [2] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_71143f5cfeab9e2125c16b998024e084.svg) | 2-Bromo-N-[4-chloro-3-[[(3R)-1-methyl-3-pyrrolidinyl]oxy]phenyl]-4,5-dimethoxybenzenesulfonamide | IC50 | 23.0 [1], 43.0 [2] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_110cf02a1ad7590f28ea0102916b57ce.svg) | (2S)-2-[[(4R,7S,10S,13S,16S,19R)-10-(4-Aminobutyl)-19-[[(2S)-2-amino-3-carboxypropanoyl]amino]-16-benzyl-7-[(4-hydroxyphenyl)methyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]amino]-3-methylbutanoic acid | Ki | 0.25 [1], 1.23 [2] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_4524246d80d13ca40101aae9ce4b2e73.svg) | (2S)-2-[[(4R,7S,10S,13S,16S,19R)-10-(4-Aminobutyl)-19-[[(2S)-2-aminopropanoyl]amino]-16-benzyl-7-[(4-hydroxyphenyl)methyl]-13-(1H-indol-3-ylmethyl)-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]amino]-3-methylbutanoic acid | IC50 | 12.0 [1], 19.5 [2] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_9a87eeb71c5664a4e017230aa03de8ee.svg) | Benzamide,N-[(3S)-1-[[3-bromo-4-(4-piperidinyloxy)phenyl]methyl]-3-pyrrolidinyl]-3,4-dichloro- | IC50 | 4.0 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_9a87eeb71c5664a4e017230aa03de8ee.svg) | Benzamide,N-[(3S)-1-[[3-bromo-4-(4-piperidinyloxy)phenyl]methyl]-3-pyrrolidinyl]-3,4-dichloro- | Ki | 4.0 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_1b48a956e74746f5e565a1e731523162.svg) | 2-(3,4-Dichloro-N-methylanilino)-1-[(2R,3R)-3-phenyl-2-(pyrrolidin-1-ylmethyl)piperidin-1-yl]ethanone | Ki | 6.0 [1], 6.31 [2] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_5467034919471af55e2d80dda1a2fcce.svg) | CID 25126427 | IC50 | 8.0 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_5467034919471af55e2d80dda1a2fcce.svg) | CID 25126427 | Ki | 4.0 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_d4687c932b17c97370777a75c83e05af.svg) | 4-Bromo-N-{(S)-1-[4-(3-dimethylamino-propoxy)-benzyl]-pyrrolidin-3-yl}-benzamide | Ki | 316.23 [1], 320.0 [2] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_1df909b11ae475a51e994c23bd8468e7.svg) | 2-(3,4-Dichloro-N-methylanilino)-1-[(2S,3S)-3-phenyl-2-(pyrrolidin-1-ylmethyl)piperidin-1-yl]ethanone | Ki | 1584.89 [1], 1600.0 [2] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_3ec993534fd56f81affa2ed24b9ad860.svg) | 2-(3,4-Dichloro-N-methylanilino)-1-[2-(pyrrolidin-1-ylmethyl)piperidin-1-yl]ethanone | IC50 | 630.96 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_3ec993534fd56f81affa2ed24b9ad860.svg) | 2-(3,4-Dichloro-N-methylanilino)-1-[2-(pyrrolidin-1-ylmethyl)piperidin-1-yl]ethanone | Ki | 398.11 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_c091a75167d796c12e7499693513685f.svg) | 2-(3,4-Dichloro-N-methylanilino)-1-[3-phenyl-2-(pyrrolidin-1-ylmethyl)piperidin-1-yl]ethanone | Ki | 16.0 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_87231084709b7175e43cf8ced924eedd.svg) | (2S)-2-[[(4S,7S,10S,13S,16S,19S)-10-(4-Aminobutyl)-19-[[(2S)-2-amino-3-carboxypropanoyl]amino]-16-benzyl-7-[(4-hydroxyphenyl)methyl]-13-(1H-indol-3-ylmethyl)-3,3,20,20-tetramethyl-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,11,14,17-pentazacycloicosane-4-carbonyl]amino]-3-methylbutanoic acid | Ki | 1.26 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_ee2844892914d3a907ba7b13a2e51d03.svg) | 2-Bromo-N-[3-[2-(dimethylamino)ethoxy]-4-(trifluoromethyl)phenyl]-4,5-dimethoxybenzenesulfonamide | IC50 | 100.0 [1], 134.0 [2] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_84830344f2981c2fe60c0aa4e2cc47db.svg) | N-[(4R)-4-(3,4-Dimethoxyphenyl)-4-[1,3-dioxo-4-(4-propan-2-ylpiperazin-1-yl)isoindol-2-yl]butyl]thiophene-2-sulfonamide | IC50 | 150.0 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_84830344f2981c2fe60c0aa4e2cc47db.svg) | N-[(4R)-4-(3,4-Dimethoxyphenyl)-4-[1,3-dioxo-4-(4-propan-2-ylpiperazin-1-yl)isoindol-2-yl]butyl]thiophene-2-sulfonamide | Ki | 45.0 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_96a212294e0303d6578a70d34948e798.svg) | N-[4-(3,4-Dimethoxyphenyl)-4-[1,3-dioxo-4-[4-[(1R)-1-phenylethyl]piperazin-1-yl]isoindol-2-yl]butyl]thiophene-2-sulfonamide | IC50 | 250.0 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_96a212294e0303d6578a70d34948e798.svg) | N-[4-(3,4-Dimethoxyphenyl)-4-[1,3-dioxo-4-[4-[(1R)-1-phenylethyl]piperazin-1-yl]isoindol-2-yl]butyl]thiophene-2-sulfonamide | Ki | 76.0 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_cf5aadf3e8adb0f090c8e70189bc25b7.svg) | 2-[(3,4-Dimethoxyphenyl)methyl]-4-[4-[(1R)-1-phenylethyl]piperazin-1-yl]isoindole-1,3-dione | IC50 | 1900.0 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_cf5aadf3e8adb0f090c8e70189bc25b7.svg) | 2-[(3,4-Dimethoxyphenyl)methyl]-4-[4-[(1R)-1-phenylethyl]piperazin-1-yl]isoindole-1,3-dione | Ki | 570.0 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_286bf3edbc3919d719324dde867b408b.svg) | N-[(4R)-4-(3,4-Dimethoxyphenyl)-4-[1,3-dioxo-4-[4-[(1R)-1-phenylethyl]piperazin-1-yl]isoindol-2-yl]butyl]-3,5-dimethyl-1H-pyrazole-4-sulfonamide | IC50 | 47.0 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_286bf3edbc3919d719324dde867b408b.svg) | N-[(4R)-4-(3,4-Dimethoxyphenyl)-4-[1,3-dioxo-4-[4-[(1R)-1-phenylethyl]piperazin-1-yl]isoindol-2-yl]butyl]-3,5-dimethyl-1H-pyrazole-4-sulfonamide | Ki | 13.0 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_c5b86cf5f182ba08102b0f840dccb619.svg) | N-[(4R)-4-(3,4-Dimethoxyphenyl)-4-[1,3-dioxo-4-[4-[(1R)-1-phenylethyl]piperazin-1-yl]isoindol-2-yl]butyl]thiophene-2-sulfonamide | IC50 | 240.0 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_c5b86cf5f182ba08102b0f840dccb619.svg) | N-[(4R)-4-(3,4-Dimethoxyphenyl)-4-[1,3-dioxo-4-[4-[(1R)-1-phenylethyl]piperazin-1-yl]isoindol-2-yl]butyl]thiophene-2-sulfonamide | Ki | 49.0 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_b9e0f568b81551f12ae84410506725de.svg) | N-Butyl-5H-pyrido[4,3-b]indol-1-amine | IC50 | 501.19 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_b9e0f568b81551f12ae84410506725de.svg) | N-Butyl-5H-pyrido[4,3-b]indol-1-amine | Ki | 3.98 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_9ae8c4e966c099786a2c39b371218712.svg) | N-[(4R)-4-(3,4-Dimethoxyphenyl)-4-[7-(4-ethylpiperazin-1-yl)-3-oxo-1H-isoindol-2-yl]butyl]-3,5-dimethyl-1H-pyrazole-4-carboxamide | IC50 | 130.0 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_9ae8c4e966c099786a2c39b371218712.svg) | N-[(4R)-4-(3,4-Dimethoxyphenyl)-4-[7-(4-ethylpiperazin-1-yl)-3-oxo-1H-isoindol-2-yl]butyl]-3,5-dimethyl-1H-pyrazole-4-carboxamide | Ki | 11.0 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_4328dadf951cca3e664f4b9dfb19444e.svg) | N-[(4R)-4-(3,4-Dimethoxyphenyl)-4-[7-(4-ethylpiperazin-1-yl)-3-oxo-1H-isoindol-2-yl]butyl]-N-methylthiophene-2-sulfonamide | IC50 | 88.0 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_4328dadf951cca3e664f4b9dfb19444e.svg) | N-[(4R)-4-(3,4-Dimethoxyphenyl)-4-[7-(4-ethylpiperazin-1-yl)-3-oxo-1H-isoindol-2-yl]butyl]-N-methylthiophene-2-sulfonamide | Ki | 5.0 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_8deb985339bd9960952f7e9a9b981db1.svg) | N-[(4R)-4-(3,4-Dimethoxyphenyl)-4-[3-oxo-7-(4-propan-2-ylpiperazin-1-yl)-1H-isoindol-2-yl]butyl]thiophene-2-sulfonamide | IC50 | 53.0 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_8deb985339bd9960952f7e9a9b981db1.svg) | N-[(4R)-4-(3,4-Dimethoxyphenyl)-4-[3-oxo-7-(4-propan-2-ylpiperazin-1-yl)-1H-isoindol-2-yl]butyl]thiophene-2-sulfonamide | Ki | 4.0 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_49762915748fef383c1d5b3c711e7f4e.svg) | 2-[(1R)-1-(3,4-Dimethoxyphenyl)-4-(thiophen-2-ylmethylamino)butyl]-4-(4-ethylpiperazin-1-yl)-3H-isoindol-1-one | IC50 | 59.0 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_49762915748fef383c1d5b3c711e7f4e.svg) | 2-[(1R)-1-(3,4-Dimethoxyphenyl)-4-(thiophen-2-ylmethylamino)butyl]-4-(4-ethylpiperazin-1-yl)-3H-isoindol-1-one | Ki | 18.0 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_dc73a6d4497180d193a94d2bb5b840bc.svg) | N-[(4R)-4-(3,4-Dimethoxyphenyl)-4-[7-(4-ethylpiperazin-1-yl)-3-oxo-1H-isoindol-2-yl]butyl]thiophene-2-carboxamide | IC50 | 140.0 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_dc73a6d4497180d193a94d2bb5b840bc.svg) | N-[(4R)-4-(3,4-Dimethoxyphenyl)-4-[7-(4-ethylpiperazin-1-yl)-3-oxo-1H-isoindol-2-yl]butyl]thiophene-2-carboxamide | Ki | 18.0 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_d7e98b043c506ee1dcfeeffa874b94ca.svg) | N-[(4R)-4-[7-(4-Cyclopropylpiperazin-1-yl)-3-oxo-1H-isoindol-2-yl]-4-(3,4-dimethoxyphenyl)butyl]-N-methylthiophene-2-sulfonamide | IC50 | 1200.0 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_d7e98b043c506ee1dcfeeffa874b94ca.svg) | N-[(4R)-4-[7-(4-Cyclopropylpiperazin-1-yl)-3-oxo-1H-isoindol-2-yl]-4-(3,4-dimethoxyphenyl)butyl]-N-methylthiophene-2-sulfonamide | Ki | 59.0 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_f4dbebea03555746acfd391aff3cd91c.svg) | N-[(4R)-4-(3,4-Dimethoxyphenyl)-4-[3-oxo-7-(4-propan-2-ylpiperazin-1-yl)-1H-isoindol-2-yl]butyl]-N-methylthiophene-2-sulfonamide | IC50 | 500.0 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_f4dbebea03555746acfd391aff3cd91c.svg) | N-[(4R)-4-(3,4-Dimethoxyphenyl)-4-[3-oxo-7-(4-propan-2-ylpiperazin-1-yl)-1H-isoindol-2-yl]butyl]-N-methylthiophene-2-sulfonamide | Ki | 11.0 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_e7e2804f0e1976153342036d10dc7659.svg) | N-[(4R)-4-[7-(4-Cyclobutylpiperazin-1-yl)-3-oxo-1H-isoindol-2-yl]-4-(3,4-dimethoxyphenyl)butyl]-N-methylthiophene-2-sulfonamide | IC50 | 510.0 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_e7e2804f0e1976153342036d10dc7659.svg) | N-[(4R)-4-[7-(4-Cyclobutylpiperazin-1-yl)-3-oxo-1H-isoindol-2-yl]-4-(3,4-dimethoxyphenyl)butyl]-N-methylthiophene-2-sulfonamide | Ki | 44.0 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_38e1718808f7f36948c082bf6a8717f8.svg) | N-[(4R)-4-(3,4-Dimethoxyphenyl)-4-[7-(4-methylpiperazin-1-yl)-3-oxo-1H-isoindol-2-yl]butyl]-N-methylthiophene-2-sulfonamide | IC50 | 340.0 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_38e1718808f7f36948c082bf6a8717f8.svg) | N-[(4R)-4-(3,4-Dimethoxyphenyl)-4-[7-(4-methylpiperazin-1-yl)-3-oxo-1H-isoindol-2-yl]butyl]-N-methylthiophene-2-sulfonamide | Ki | 6.0 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_b155f7dbc5fac1ab413acfee8e4a07d5.svg) | N-[(4R)-4-(3,4-Dimethoxyphenyl)-4-(1,3-dioxo-4-piperazin-1-ylisoindol-2-yl)butyl]thiophene-2-sulfonamide | IC50 | 500.0 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_b155f7dbc5fac1ab413acfee8e4a07d5.svg) | N-[(4R)-4-(3,4-Dimethoxyphenyl)-4-(1,3-dioxo-4-piperazin-1-ylisoindol-2-yl)butyl]thiophene-2-sulfonamide | Ki | 150.0 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_dba3a7a3202027b0fda028e4a8a43f03.svg) | N-[(4R)-4-(3,4-Dimethoxyphenyl)-4-[4-(4-methylpiperazin-1-yl)-1,3-dioxoisoindol-2-yl]butyl]thiophene-2-sulfonamide | IC50 | 220.0 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_dba3a7a3202027b0fda028e4a8a43f03.svg) | N-[(4R)-4-(3,4-Dimethoxyphenyl)-4-[4-(4-methylpiperazin-1-yl)-1,3-dioxoisoindol-2-yl]butyl]thiophene-2-sulfonamide | Ki | 59.0 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_0205cbc58b25d6580d3124f4597fbaad.svg) | N-[(4R)-4-(3,4-Dimethoxyphenyl)-4-[4-(4-ethylpiperazin-1-yl)-1,3-dioxoisoindol-2-yl]butyl]thiophene-2-sulfonamide | IC50 | 150.0 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_0205cbc58b25d6580d3124f4597fbaad.svg) | N-[(4R)-4-(3,4-Dimethoxyphenyl)-4-[4-(4-ethylpiperazin-1-yl)-1,3-dioxoisoindol-2-yl]butyl]thiophene-2-sulfonamide | Ki | 35.0 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_6337cb47047ead4727afe4acb717c985.svg) | N-[(4R)-4-(3,4-Dimethoxyphenyl)-4-[1,3-dioxo-4-[4-[(1R)-1-phenylethyl]piperazin-1-yl]isoindol-2-yl]butyl]-5-methyl-1,2-oxazole-4-sulfonamide | IC50 | 130.0 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_6337cb47047ead4727afe4acb717c985.svg) | N-[(4R)-4-(3,4-Dimethoxyphenyl)-4-[1,3-dioxo-4-[4-[(1R)-1-phenylethyl]piperazin-1-yl]isoindol-2-yl]butyl]-5-methyl-1,2-oxazole-4-sulfonamide | Ki | 32.0 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_28c20d7e313d66adb13910a7540a684c.svg) | N-[(4R)-4-(3,4-Dimethoxyphenyl)-4-[1,3-dioxo-4-[4-[(1R)-1-phenylethyl]piperazin-1-yl]isoindol-2-yl]butyl]-5-methyl-1,2-oxazole-4-carboxamide | IC50 | 760.0 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_28c20d7e313d66adb13910a7540a684c.svg) | N-[(4R)-4-(3,4-Dimethoxyphenyl)-4-[1,3-dioxo-4-[4-[(1R)-1-phenylethyl]piperazin-1-yl]isoindol-2-yl]butyl]-5-methyl-1,2-oxazole-4-carboxamide | Ki | 130.0 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_1968649552adc02627db04a5c0bf79c5.svg) | N-[(4R)-4-(3,4-Dimethoxyphenyl)-4-[1,3-dioxo-4-[4-[(1R)-1-phenylethyl]piperazin-1-yl]isoindol-2-yl]butyl]-3,5-dimethyl-1H-pyrazole-4-carboxamide | IC50 | 37.0 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_1968649552adc02627db04a5c0bf79c5.svg) | N-[(4R)-4-(3,4-Dimethoxyphenyl)-4-[1,3-dioxo-4-[4-[(1R)-1-phenylethyl]piperazin-1-yl]isoindol-2-yl]butyl]-3,5-dimethyl-1H-pyrazole-4-carboxamide | Ki | 87.0 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_1bbf495fe5f045369f754ee952235899.svg) | N-[(4R)-4-(3,4-Dimethoxyphenyl)-4-[1,3-dioxo-4-[4-[(1R)-1-phenylethyl]piperazin-1-yl]isoindol-2-yl]butyl]-1,2-dimethylimidazole-4-sulfonamide | IC50 | 220.0 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_1bbf495fe5f045369f754ee952235899.svg) | N-[(4R)-4-(3,4-Dimethoxyphenyl)-4-[1,3-dioxo-4-[4-[(1R)-1-phenylethyl]piperazin-1-yl]isoindol-2-yl]butyl]-1,2-dimethylimidazole-4-sulfonamide | Ki | 16.0 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_4b081bbb499609980328dab0e1053223.svg) | N-[(4R)-4-(3,4-Dimethoxyphenyl)-4-[4-(4-ethylpiperazin-1-yl)-1,3-dioxoisoindol-2-yl]butyl]-1,2-dimethylimidazole-4-sulfonamide | IC50 | 810.0 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_4b081bbb499609980328dab0e1053223.svg) | N-[(4R)-4-(3,4-Dimethoxyphenyl)-4-[4-(4-ethylpiperazin-1-yl)-1,3-dioxoisoindol-2-yl]butyl]-1,2-dimethylimidazole-4-sulfonamide | Ki | 97.0 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_ea09d65d11b0bf11338457dc3f225888.svg) | N-[(4R)-4-(3,4-Dimethoxyphenyl)-4-(3-oxo-7-piperazin-1-yl-1H-isoindol-2-yl)butyl]-N-methylthiophene-2-sulfonamide | IC50 | 410.0 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_ea09d65d11b0bf11338457dc3f225888.svg) | N-[(4R)-4-(3,4-Dimethoxyphenyl)-4-(3-oxo-7-piperazin-1-yl-1H-isoindol-2-yl)butyl]-N-methylthiophene-2-sulfonamide | Ki | 49.0 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_3876d1a72ed9c30e540e7cbb403b7987.svg) | N-[(4R)-4-(3,4-Dimethoxyphenyl)-4-[3-oxo-7-[4-[(1R)-1-phenylethyl]piperazin-1-yl]-1H-isoindol-2-yl]butyl]-5-methyl-1,2-oxazole-4-carboxamide | IC50 | 320.0 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_3876d1a72ed9c30e540e7cbb403b7987.svg) | N-[(4R)-4-(3,4-Dimethoxyphenyl)-4-[3-oxo-7-[4-[(1R)-1-phenylethyl]piperazin-1-yl]-1H-isoindol-2-yl]butyl]-5-methyl-1,2-oxazole-4-carboxamide | Ki | 15.0 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_a19e78ce4b839e0ccb621fd42160874a.svg) | N-[(4S)-4-(3,4-Dimethoxyphenyl)-4-[1,3-dioxo-4-[4-[(1R)-1-phenylethyl]piperazin-1-yl]isoindol-2-yl]butyl]thiophene-2-sulfonamide | IC50 | 260.0 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_a19e78ce4b839e0ccb621fd42160874a.svg) | N-[(4S)-4-(3,4-Dimethoxyphenyl)-4-[1,3-dioxo-4-[4-[(1R)-1-phenylethyl]piperazin-1-yl]isoindol-2-yl]butyl]thiophene-2-sulfonamide | Ki | 120.0 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_67a7f513e6dd8d9ff125a7235291fbec.svg) | N-[(4R)-4-(3,4-Dimethoxyphenyl)-4-[7-(4-ethylpiperazin-1-yl)-3-oxo-1H-isoindol-2-yl]butyl]-1H-imidazole-5-sulfonamide | IC50 | 51.0 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_67a7f513e6dd8d9ff125a7235291fbec.svg) | N-[(4R)-4-(3,4-Dimethoxyphenyl)-4-[7-(4-ethylpiperazin-1-yl)-3-oxo-1H-isoindol-2-yl]butyl]-1H-imidazole-5-sulfonamide | Ki | 25.0 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_eaabfb3e854ade23de2efbbefb6de8a6.svg) | 2-[(1R)-4-[(6-Chloropyrazin-2-yl)amino]-1-(3,4-dimethoxyphenyl)butyl]-4-(4-ethylpiperazin-1-yl)-3H-isoindol-1-one | IC50 | 500.0 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_eaabfb3e854ade23de2efbbefb6de8a6.svg) | 2-[(1R)-4-[(6-Chloropyrazin-2-yl)amino]-1-(3,4-dimethoxyphenyl)butyl]-4-(4-ethylpiperazin-1-yl)-3H-isoindol-1-one | Ki | 62.0 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_af9d1cae6d90c722493a9bae115b9818.svg) | 2-[(1R)-1-(3,4-Dimethoxyphenyl)-4-[(6-methoxypyrazin-2-yl)amino]butyl]-4-(4-ethylpiperazin-1-yl)-3H-isoindol-1-one | IC50 | 62.0 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_af9d1cae6d90c722493a9bae115b9818.svg) | 2-[(1R)-1-(3,4-Dimethoxyphenyl)-4-[(6-methoxypyrazin-2-yl)amino]butyl]-4-(4-ethylpiperazin-1-yl)-3H-isoindol-1-one | Ki | 8.0 [1] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_3dfa5cc1c8e0c37d2c93aa78f8a9a1c2.svg) | (3R)-3-[5-[(2-Bromo-4,5-dimethoxyphenyl)sulfonylmethyl]-2-chlorophenoxy]-1-methylpyrrolidine | IC50 | 34.0 [1], 60.0 [2] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_9234d2d083bebb2388c75e6bfce05e08.svg) | (3S)-3-[5-[(2-Bromo-4,5-dimethoxyphenyl)sulfonylmethyl]-2-chlorophenoxy]-1-methylpyrrolidine | IC50 | 742.0 [1], 1280.0 [2] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_adfda8668993b6d086360e3cd2f91076.svg) | N-[(2-Bromo-4,5-dimethoxyphenyl)methyl]-4-chloro-3-[(3R)-1-methylpyrrolidin-3-yl]oxyaniline | IC50 | 237.0 [1], 1328.0 [2] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_bc65579b70a452f40a46b2064e6a65ca.svg) | N-[(2-Bromo-4,5-dimethoxyphenyl)methyl]-4-chloro-3-[(3S)-1-methylpyrrolidin-3-yl]oxyaniline | IC50 | 1350.0 [1], 1450.0 [2] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_2a4adba893a2c4cdfc69cd702a5dae3f.svg) | N-[(2-Bromo-4,5-dimethoxyphenyl)methyl]-4-chloro-3-[2-(dimethylamino)ethoxy]aniline | IC50 | 1200.0 [1], 1300.0 [2] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_b3b1bd631fb9b371127d643e15f3975e.svg) | N-[(2-Bromophenyl)methyl]-4-chloro-3-[2-(dimethylamino)ethoxy]aniline | IC50 | 3500.0 [1], 6000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_2c134a1a724d0ffc109de50dd6b550fd.svg) | 4-Chloro-3-[2-(dimethylamino)ethoxy]-N-[[2-(trifluoromethyl)phenyl]methyl]aniline | IC50 | 520.0 [1], 765.0 [2] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_baa039a3630e7b3ac6ca5308df72b156.svg) | 2-Bromo-4,5-dimethoxy-N-[3-[(3S)-1-methylpiperidin-3-yl]oxy-4-(trifluoromethyl)phenyl]benzenesulfonamide | IC50 | 5000.0 [1], 5500.0 [2] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_dbf4d6a6b8da639c07411a50f4a4359f.svg) | 2-Bromo-4,5-dimethoxy-N-[3-[(3R)-1-methylpiperidin-3-yl]oxy-4-(trifluoromethyl)phenyl]benzenesulfonamide | IC50 | 120.0 [1], 160.0 [2] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_4f9fd6a63b0609d2e948c7543938ae41.svg) | 2-Bromo-4,5-dimethoxy-N-[3-[[(2R)-1-methylpyrrolidin-2-yl]methoxy]-4-(trifluoromethyl)phenyl]benzenesulfonamide | IC50 | 350.0 [1], 800.0 [2] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_9552503be5b239ebda2d42ad96c5257e.svg) | N-[(5-Bromo-1,3-benzodioxol-4-yl)methyl]-3-[(3S)-1-methylpyrrolidin-3-yl]oxy-4-(trifluoromethyl)aniline | IC50 | 620.0 [1], 1400.0 [2] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_acd9e45a5597a7d07dc7cd0069ac752e.svg) | N-[(2-Bromophenyl)methyl]-3-[(3S)-1-methylpyrrolidin-3-yl]oxy-4-(trifluoromethyl)aniline | IC50 | 821.0 [1], 1870.0 [2] |
![](https://images.aatbio.com/dataset/ic50/urotensin-ii-receptor_0b4e3558ed479dc635a12f0fb76acbee.svg) | N-[(3-Methoxyphenyl)methyl]-3-[(3S)-1-methylpyrrolidin-3-yl]oxy-4-(trifluoromethyl)aniline | IC50 | 691.0 [1], 1130.0 [2] |