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Ubiquitin carboxyl-terminal hydrolase 1/WD repeat-containing protein 48 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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N-(4-(1H-1,2,3-Triazol-1-yl)benzyl)-2-(2-isopropylphenyl)-5-methylpyrimidin-4-amineIC5076.0 [1], 174.0 [2], 820.0 [3]
TrifluoperazineIC508000.0 [1]
PimozideIC502000.0 [1]
FlupentixolIC507000.0 [1]
RottlerinIC508000.0 [1]
GW7647IC505000.0 [1]
N-(Thiophen-2-ylmethyl)-2-[2-(trifluoromethyl)phenyl]quinazolin-4-amineIC507900.0 [1]
N-[Dideuterio-[4-(triazol-1-yl)phenyl]methyl]-2-[2-(1,1,1,2,3,3,3-heptadeuteriopropan-2-yl)phenyl]-5-methylpyrimidin-4-amineIC50190.0 [1]
2-[2-(Trifluoromethyl)phenyl]-N-[[4-[2-(trifluoromethyl)pyridin-4-yl]phenyl]methyl]quinazolin-4-amineIC504900.0 [1]
N-[(4-Imidazol-1-ylphenyl)methyl]-5-methyl-2-(2-propan-2-ylphenyl)pyrimidin-4-amineIC50300.0 [1]
2-(2-Cyclobutylphenyl)-5-methyl-N-[[4-(triazol-1-yl)phenyl]methyl]pyrimidin-4-amineIC50180.0 [1]
5-Methyl-2-(2-propan-2-ylphenyl)-N-[2-[4-(triazol-1-yl)phenyl]propan-2-yl]pyrimidin-4-amineIC50590.0 [1]
2-[2-(1,1,1,3,3,3-Hexadeuteriopropan-2-yl)phenyl]-5-methyl-N-[[4-(triazol-1-yl)phenyl]methyl]pyrimidin-4-amineIC50140.0 [1]
2-[2-(1,1,1,2,3,3,3-Heptadeuteriopropan-2-yl)phenyl]-5-methyl-N-[[4-(triazol-1-yl)phenyl]methyl]pyrimidin-4-amineIC50100.0 [1]
2-[2-(1,1,1,2,3,3,3-Heptadeuteriopropan-2-yl)phenyl]-5-methyl-N-[2-[4-(triazol-1-yl)phenyl]propan-2-yl]pyrimidin-4-amineIC50760.0 [1]
N-[Dideuterio-[4-(triazol-1-yl)phenyl]methyl]-5-methyl-2-(2-propan-2-ylphenyl)pyrimidin-4-amineIC50120.0 [1]
2-Phenyl-3a,9a-dihydrobenzo[f][1,3]benzoxazole-4,9-dioneIC50540.0 [1]
2-(4-Fluorophenyl)-3a,9a-dihydrobenzo[f][1,3]benzoxazole-4,9-dioneIC50880.0 [1]
N-[(4-Phenylphenyl)methyl]-2-[2-(trifluoromethyl)phenyl]quinazolin-4-amineIC503700.0 [1]
N-[(3,4-Dichlorophenyl)methyl]-2-[2-(trifluoromethyl)phenyl]quinazolin-4-amineIC5010400.0 [1]
2-[2-(Trifluoromethyl)phenyl]-N-[[4-(trifluoromethyl)phenyl]methyl]quinazolin-4-amineIC508900.0 [1]
4-[[[2-[2-(Trifluoromethyl)phenyl]quinazolin-4-yl]amino]methyl]benzonitrileIC505700.0 [1]
N-[(4-Methoxyphenyl)methyl]-2-[2-(trifluoromethyl)phenyl]quinazolin-4-amineIC506200.0 [1]
N-[(5-Methylthiophen-2-yl)methyl]-2-[2-(trifluoromethyl)phenyl]quinazolin-4-amineIC505100.0 [1]
N-(1,3-Benzodioxol-5-ylmethyl)-2-[2-(trifluoromethyl)phenyl]quinazolin-4-amineIC508400.0 [1]
N-Benzyl-2-[2-(trifluoromethyl)phenyl]quinazolin-4-amineIC503100.0 [1]
N-[(4-Fluorophenyl)methyl]-2-[2-(trifluoromethyl)phenyl]quinazolin-4-amineIC503400.0 [1]
N-[(4-Chlorophenyl)methyl]-2-[2-(trifluoromethyl)phenyl]quinazolin-4-amineIC504800.0 [1]
N-[[4-(3,4-Dichlorophenyl)phenyl]methyl]-2-[2-(trifluoromethyl)phenyl]quinazolin-4-amineIC502200.0 [1]
N-[[4-(3-Chlorophenyl)phenyl]methyl]-2-[2-(trifluoromethyl)phenyl]quinazolin-4-amineIC502700.0 [1]
N-[[4-(4-Chlorophenyl)phenyl]methyl]-2-[2-(trifluoromethyl)phenyl]quinazolin-4-amineIC503600.0 [1]
N-[(4-Pyridin-4-ylphenyl)methyl]-2-[2-(trifluoromethyl)phenyl]quinazolin-4-amineIC501900.0 [1]
2-(2-Methoxyphenyl)-N-[(4-pyridin-3-ylphenyl)methyl]quinazolin-4-amineIC50940.0 [1]
1-[2-[5-Methyl-4-[(4-pyridin-3-ylphenyl)methylamino]pyrimidin-2-yl]phenyl]ethanoneIC508700.0 [1]
2-(2-Propan-2-ylphenyl)-N-[(4-pyridin-3-ylphenyl)methyl]thieno[3,2-d]pyrimidin-4-amineIC50110.0 [1]
2-(2-Propan-2-ylphenyl)-N-[(4-pyridin-3-ylphenyl)methyl]thieno[2,3-d]pyrimidin-4-amineIC50280.0 [1]
5-Methyl-N-[[1-(oxetan-3-yl)piperidin-4-yl]methyl]-2-(2-propan-2-ylphenyl)pyrimidin-4-amineIC5013600.0 [1]
N-[[4-(6-Fluoropyridin-3-yl)phenyl]methyl]-5-methyl-2-(2-propan-2-ylphenyl)pyrimidin-4-amineIC5080.0 [1]
N-[(4-Pyrimidin-5-ylphenyl)methyl]-2-[2-(trifluoromethyl)phenyl]quinazolin-4-amineIC503000.0 [1]
2-(2-Fluorophenyl)-N-[(4-pyridin-3-ylphenyl)methyl]quinazolin-4-amineIC506500.0 [1]
5-Fluoro-2-(2-propan-2-ylphenyl)-N-[(4-pyridin-3-ylphenyl)methyl]pyrimidin-4-amineIC50110.0 [1]
5-Methyl-N-[(3-methylphenyl)methyl]-2-(2-propan-2-ylphenyl)pyrimidin-4-amineIC50130.0 [1]
N-[(4-Pyridin-3-ylphenyl)methyl]-2-[2-(trifluoromethyl)phenyl]quinazolin-4-amineIC501100.0 [1]
5-Methyl-2-(2-propan-2-ylphenyl)-N-[(1-pyridin-3-ylazetidin-3-yl)methyl]pyrimidin-4-amineIC5021700.0 [1]
[2-[5-Methyl-4-[(4-pyridin-3-ylphenyl)methylamino]pyrimidin-2-yl]phenyl]methanolIC5010500.0 [1]
1-[2-[5-Methyl-4-[(4-pyridin-3-ylphenyl)methylamino]pyrimidin-2-yl]phenyl]ethanolIC502000.0 [1]
5-Methyl-2-(2-propan-2-ylphenyl)-N-[(1-pyrazin-2-ylpiperidin-4-yl)methyl]pyrimidin-4-amineIC50140.0 [1]
5-Methoxy-2-(2-propan-2-ylphenyl)-N-[(4-pyridin-3-ylphenyl)methyl]pyrimidin-4-amineIC5070.0 [1]
2-(2-Ethylphenyl)-N-[(4-pyridin-3-ylphenyl)methyl]quinazolin-4-amineIC50780.0 [1]
5-Methyl-2-(2-propan-2-ylphenyl)-N-[(1-pyridin-3-ylpyrrolidin-3-yl)methyl]pyrimidin-4-amineIC50800.0 [1]
5-N,5-N-Dimethyl-2-(2-propan-2-ylphenyl)-4-N-[(4-pyridin-3-ylphenyl)methyl]pyrimidine-4,5-diamineIC50190.0 [1]
2-(2-Propan-2-ylphenyl)-N-[(4-pyridin-3-ylphenyl)methyl]pyrrolo[2,1-f][1,2,4]triazin-4-amineIC50260.0 [1]
N-(3-Pyridin-3-ylprop-2-ynyl)-2-[2-(trifluoromethyl)phenyl]quinazolin-4-amineIC508900.0 [1]
2-(2-Propan-2-ylphenyl)-N-[(4-pyridin-3-ylphenyl)methyl]-6,7-dihydro-5H-cyclopenta[d]pyrimidin-4-amineIC50160.0 [1]
2-[2-(Difluoromethyl)phenyl]-5-methyl-N-[[4-(triazol-1-yl)phenyl]methyl]pyrimidin-4-amineIC50820.0 [1]
6-Methyl-2-(2-propan-2-ylphenyl)-N-[(4-pyridin-3-ylphenyl)methyl]pyrimidin-4-amineIC50210.0 [1]
2-(2-Nitrophenyl)-N-[(4-pyridin-3-ylphenyl)methyl]quinazolin-4-amineIC507800.0 [1]
5-Methyl-N-[[1-(6-methylpyridin-3-yl)piperidin-4-yl]methyl]-2-(2-propan-2-ylphenyl)pyrimidin-4-amineIC5090.0 [1]
2-(2-Methylphenyl)-N-[(4-pyridin-3-ylphenyl)methyl]quinazolin-4-amineIC501100.0 [1]
2-(2-Propan-2-ylphenyl)-N-[(4-pyridin-3-ylphenyl)methyl]-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-amineIC50860.0 [1]
2-(2-Chlorophenyl)-N-[(4-pyridin-3-ylphenyl)methyl]quinazolin-4-amineIC502100.0 [1]
2-(2-Propan-2-ylphenyl)-N-[(4-pyridin-3-ylphenyl)methyl]pyrimidin-4-amineIC50150.0 [1]
5-Methyl-2-(2-propan-2-ylphenyl)-N-(pyridin-3-ylmethyl)pyrimidin-4-amineIC501300.0 [1]
5-Methyl-N-[[4-(6-methylpyridin-3-yl)phenyl]methyl]-2-(2-propan-2-ylphenyl)pyrimidin-4-amineIC5050.0 [1]
2-(2-Cyclopropylphenyl)-5-methyl-N-[(4-pyridin-3-ylphenyl)methyl]pyrimidin-4-amineIC50180.0 [1]
2-(3-Methylphenyl)-2-[[5-methyl-2-(2-propan-2-ylphenyl)pyrimidin-4-yl]amino]ethanolIC5021000.0 [1]
5-Methyl-2-(2-propan-2-ylphenyl)-N-[[4-(2H-tetrazol-5-yl)phenyl]methyl]pyrimidin-4-amineIC505900.0 [1]
5-Methyl-2-(2-propan-2-ylphenyl)-N-[(1-pyridin-3-ylpiperidin-4-yl)methyl]pyrimidin-4-amineIC5080.0 [1]
2-(2-Propan-2-ylphenyl)-N-[(4-pyridin-3-ylphenyl)methyl]furo[3,2-d]pyrimidin-4-amineIC5080.0 [1]
2-(2-Propan-2-ylphenyl)-N-[(4-pyridin-3-ylphenyl)methyl]-7H-purin-6-amineIC50120.0 [1]
5-Methyl-2-(2-propan-2-ylphenyl)-N-(thiophen-2-ylmethyl)pyrimidin-4-amineIC50270.0 [1]
2-(2-Propan-2-ylphenyl)-4-N-[(4-pyridin-3-ylphenyl)methyl]pyrimidine-4,5-diamineIC50310.0 [1]
5-Methyl-2-(2-propan-2-ylphenyl)-N-[[4-[2-(trifluoromethyl)pyridin-4-yl]phenyl]methyl]pyrimidin-4-amineIC50320.0 [1]
2-(2-Bromophenyl)-N-[(4-pyridin-3-ylphenyl)methyl]quinazolin-4-amineIC501600.0 [1]
N-[(4-Cyclohexylphenyl)methyl]-2-[2-(trifluoromethyl)phenyl]quinazolin-4-amineIC509800.0 [1]
5-Methylsulfanyl-2-(2-propan-2-ylphenyl)-N-[(4-pyridin-3-ylphenyl)methyl]pyrimidin-4-amineIC50110.0 [1]
2-(2-Propan-2-ylphenyl)-N-[(4-pyridin-3-ylphenyl)methyl]quinazolin-4-amineIC50180.0 [1]
5-Methyl-2-(2-propan-2-ylphenyl)-N-[(4-pyridin-3-ylphenyl)methyl]pyrimidin-4-amineIC5070.0 [1]
5,6-Dimethyl-2-(2-propan-2-ylphenyl)-N-[(4-pyridin-3-ylphenyl)methyl]pyrimidin-4-amineIC50120.0 [1]
2-[2-(Difluoromethyl)phenyl]-N-[(4-pyridin-3-ylphenyl)methyl]quinazolin-4-amineIC501400.0 [1]
N-[(4-Morpholin-4-ylphenyl)methyl]-2-[2-(trifluoromethyl)phenyl]quinazolin-4-amineIC5010400.0 [1]
2-(2-Propan-2-ylphenyl)-N-[(4-pyridin-3-ylphenyl)methyl]-6,7-dihydro-5H-pyrrolo[3,4-d]pyrimidin-4-amineIC502900.0 [1]
Items per page: 1 - 10 of 82
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References

This online tool may be cited as follows

MLA

"Quest Database™ Ubiquitin carboxyl-terminal hydrolase 1/WD repeat-containing protein 48 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/ubiquitin-carboxyl-terminal-hydrolase-1-wd-repeat-containing-protein-48-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ Ubiquitin carboxyl-terminal hydrolase 1/WD repeat-containing protein 48 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/ubiquitin-carboxyl-terminal-hydrolase-1-wd-repeat-containing-protein-48-inhibitors-ic50-ki.
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