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U5 small nuclear ribonucleoprotein 200 kDa helicase Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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(3S,3'R,5'S)-5-Fluoro-3'-methyl-1'-(1-methylimidazole-4-carbonyl)-5'-(2-methylpropyl)spiro[1H-indole-3,2'-pyrrolidine]-2-oneIC5021.0 [1], 480.0 [2]
(3S,3'R,5'S)-1'-(1-Benzylimidazole-4-carbonyl)-5-fluoro-3'-methyl-5'-(2-methylpropyl)spiro[1H-indole-3,2'-pyrrolidine]-2-oneIC5011.0 [1], 350.0 [2]
HippuristanolIC5030000.0 [1]
Eif4A3-IN-2IC50100000.0 [1]
3-[2-(3-Fluoropyridin-2-yl)-6-methyl-3,4-dihydro-2H-chromen-7-yl]-6-(2,2,2-trifluoroethyl)-1,4-dihydropyrido[4,3-d]pyrimidine-2,7-dioneIC5036000.0 [1]
4-Chloro-7-fluoro-6-propan-2-yl-1H-indole-2-carboxylic acidIC50100000.0 [1]
6-Benzyl-3-[3-(1,3-thiazol-5-ylmethoxy)phenyl]-1,4-dihydropyrido[4,3-d]pyrimidine-2,7-dioneIC5079.0 [1]
6-Benzyl-3-(3-phenylmethoxyphenyl)-1,4-dihydropyrido[4,3-d]pyrimidine-2,7-dioneIC50790.0 [1]
Methyl (3S,3'R,5'S)-6-fluoro-5'-(2-methylpropyl)-2-oxo-1'-(pyridine-2-carbonyl)spiro[1H-indole-3,2'-pyrrolidine]-3'-carboxylateIC5088000.0 [1]
Methyl (3S,3'R,5'S)-5'-(2-methylpropyl)-2-oxo-1'-(2-pyridin-2-ylacetyl)spiro[1H-indole-3,2'-pyrrolidine]-3'-carboxylateIC50100000.0 [1]
6-Benzyl-3-[2-(3-fluoropyridin-2-yl)-3,4-dihydro-2H-chromen-7-yl]-1,4-dihydropyrido[4,3-d]pyrimidine-2,7-dioneIC501700.0 [1]
Methyl (3S,3'S,5'S)-5'-(2-methylpropyl)-2-oxo-1'-(pyridine-2-carbonyl)spiro[1H-indole-3,2'-pyrrolidine]-3'-carboxylateIC50100000.0 [1]
6-Benzyl-3-(2-phenylmethoxyphenyl)-1,4-dihydropyrido[4,3-d]pyrimidine-2,7-dioneIC5058000.0 [1]
Methyl (3S,3'R,5'S)-5-fluoro-5'-(2-methylpropyl)-1'-(1-methylpyrazole-3-carbonyl)-2-oxospiro[1H-indole-3,2'-pyrrolidine]-3'-carboxylateIC504600.0 [1]
Methyl (3S,3'R,5'S)-1-methyl-5'-(2-methylpropyl)-2-oxo-1'-(pyridine-2-carbonyl)spiro[indole-3,2'-pyrrolidine]-3'-carboxylateIC50100000.0 [1]
6-Benzyl-3-[3-(pyridin-2-ylmethoxy)phenyl]-1,4-dihydropyrido[4,3-d]pyrimidine-2,7-dioneIC501400.0 [1]
(3S,3'R,5'S)-3'-(Chloromethyl)-5'-(2-methylpropyl)-1'-(pyridine-2-carbonyl)spiro[1H-indole-3,2'-pyrrolidine]-2-oneIC502800.0 [1]
Eif4A3-IN-1IC50100000.0 [1]
(3R,3'S,5'R)-1'-(1-Benzylimidazole-4-carbonyl)-5-fluoro-3'-methyl-5'-(2-methylpropyl)spiro[1H-indole-3,2'-pyrrolidine]-2-oneIC50100000.0 [1]
Methyl (3S,3'R,5'S)-5-fluoro-1'-(1-methylimidazole-2-carbonyl)-5'-(2-methylpropyl)-2-oxospiro[1H-indole-3,2'-pyrrolidine]-3'-carboxylateIC501700.0 [1]
Methyl (3S,3'R,5'S)-5'-methyl-2-oxo-1'-(pyridine-2-carbonyl)spiro[1H-indole-3,2'-pyrrolidine]-3'-carboxylateIC50100000.0 [1]
(3S,3'R,5'S)-3'-(Fluoromethyl)-5'-(2-methylpropyl)-1'-(pyridine-2-carbonyl)spiro[1H-indole-3,2'-pyrrolidine]-2-oneIC501300.0 [1]
(3S,3'R,5'S)-3'-Methyl-5'-(2-methylpropyl)-1'-(pyridine-2-carbonyl)spiro[1H-indole-3,2'-pyrrolidine]-2-oneIC50360.0 [1]
6-Benzyl-3-[2-(3-fluoropyridin-2-yl)-6-methyl-3,4-dihydro-2H-chromen-7-yl]-1,4-dihydropyrido[4,3-d]pyrimidine-2,7-dioneIC505300.0 [1]
Methyl (3S,3'R,5'S)-5-fluoro-5'-(2-methylpropyl)-2-oxo-1'-(pyridine-4-carbonyl)spiro[1H-indole-3,2'-pyrrolidine]-3'-carboxylateIC50100000.0 [1]
Methyl (3S,3'R,5'S)-5-fluoro-5'-(2-methylpropyl)-2-oxo-1'-(pyridine-3-carbonyl)spiro[1H-indole-3,2'-pyrrolidine]-3'-carboxylateIC50100000.0 [1]
(3S,3'R,5'S)-5'-(2-Methylpropyl)-2-oxo-1'-(pyridine-2-carbonyl)spiro[1H-indole-3,2'-pyrrolidine]-3'-carboxylic acid;hydrochlorideIC50100000.0 [1]
Methyl (3S,3'R,5'S)-5-fluoro-5'-(2-methylpropyl)-2-oxo-1'-(pyridine-2-carbonyl)spiro[1H-indole-3,2'-pyrrolidine]-3'-carboxylateIC50910.0 [1]
6-Benzyl-3-[2-(3-fluoropyridin-2-yl)-6-methyl-3,4-dihydro-2H-chromen-7-yl]-1-methyl-4H-pyrido[4,3-d]pyrimidine-2,7-dioneIC50100000.0 [1]
Methyl (3S,3'R,5'S)-5-fluoro-1'-(1H-imidazole-5-carbonyl)-5'-(2-methylpropyl)-2-oxospiro[1H-indole-3,2'-pyrrolidine]-3'-carboxylateIC50390.0 [1]
(3S,3'R,5'S)-5'-(2-Methylpropyl)-2-oxo-1'-(pyridine-2-carbonyl)spiro[1H-indole-3,2'-pyrrolidine]-3'-carboxamideIC50100000.0 [1]
Methyl (3S,3'R,5'S)-5'-(2-methylpropyl)-2-oxo-1'-(pyridine-2-carbonyl)spiro[1H-indole-3,2'-pyrrolidine]-3'-carboxylateIC501600.0 [1]
Methyl (3S,3'R,5'S)-4-fluoro-5'-(2-methylpropyl)-2-oxo-1'-(pyridine-2-carbonyl)spiro[1H-indole-3,2'-pyrrolidine]-3'-carboxylateIC503400.0 [1]
Methyl (3S,3'R,5'S)-7-fluoro-5'-(2-methylpropyl)-2-oxo-1'-(pyridine-2-carbonyl)spiro[1H-indole-3,2'-pyrrolidine]-3'-carboxylateIC504300.0 [1]
Methyl (3S,3'R,5'S)-1'-(1-benzylimidazole-4-carbonyl)-5-fluoro-5'-(2-methylpropyl)-2-oxospiro[1H-indole-3,2'-pyrrolidine]-3'-carboxylateIC5044.0 [1]
3-[2-(3-Fluoropyridin-2-yl)-6-methyl-3,4-dihydro-2H-chromen-7-yl]-6-methyl-1,4-dihydropyrido[4,3-d]pyrimidine-2,7-dioneIC50100000.0 [1]
Methyl (3S,3'R,5'S)-1'-benzoyl-5-fluoro-5'-(2-methylpropyl)-2-oxospiro[1H-indole-3,2'-pyrrolidine]-3'-carboxylateIC50100000.0 [1]
Methyl (3S,3'R,5'S)-5-fluoro-1'-(1-methylimidazole-4-carbonyl)-5'-(2-methylpropyl)-2-oxospiro[1H-indole-3,2'-pyrrolidine]-3'-carboxylateIC50110.0 [1]
Methyl (3S,3'R,5'S)-5-chloro-5'-(2-methylpropyl)-2-oxo-1'-(pyridine-2-carbonyl)spiro[1H-indole-3,2'-pyrrolidine]-3'-carboxylateIC508000.0 [1]
Methyl (3S,3'R,5'R)-5'-benzyl-2-oxo-1'-(pyridine-2-carbonyl)spiro[1H-indole-3,2'-pyrrolidine]-3'-carboxylateIC50100000.0 [1]
Methyl (3R,3'S,5'R)-5'-(2-methylpropyl)-2-oxo-1'-(pyridine-2-carbonyl)spiro[1H-indole-3,2'-pyrrolidine]-3'-carboxylateIC50100000.0 [1]
(3R,3'S,5'R)-5-Fluoro-3'-methyl-1'-(1-methylimidazole-4-carbonyl)-5'-(2-methylpropyl)spiro[1H-indole-3,2'-pyrrolidine]-2-oneIC5084000.0 [1]
6-Benzyl-3-[3-(pyridin-3-ylmethoxy)phenyl]-1,4-dihydropyrido[4,3-d]pyrimidine-2,7-dioneIC50180.0 [1]
(3S,3'R,5'S)-3'-(Hydroxymethyl)-5'-(2-methylpropyl)-1'-(pyridine-2-carbonyl)spiro[1H-indole-3,2'-pyrrolidine]-2-oneIC5012000.0 [1]
5-[(3S)-4-(5-Bromopyridine-2-carbonyl)-3-(4-chlorophenyl)piperazine-1-carbonyl]-1-phenyl-3-[3-(trifluoromethyl)phenyl]pyridin-2-oneIC50100000.0 [1]
3-[5-[(3S)-4-(5-Bromopyridine-2-carbonyl)-3-(4-chlorophenyl)piperazine-1-carbonyl]-1-methyl-2-oxopyridin-3-yl]benzonitrileIC50100000.0 [1]
3-[5-[(Z)-(2-Cyclohexyl-5-imino-7-oxo-[1,3,4]thiadiazolo[3,2-a]pyrimidin-6-ylidene)methyl]furan-2-yl]benzoic acidIC505300.0 [1]
3-[5-[(Z)-(5-Imino-7-oxo-2-propyl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-6-ylidene)methyl]furan-2-yl]benzoic acidIC504200.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ U5 small nuclear ribonucleoprotein 200 kDa helicase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/u5-small-nuclear-ribonucleoprotein-200-kda-helicase-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ U5 small nuclear ribonucleoprotein 200 kDa helicase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/u5-small-nuclear-ribonucleoprotein-200-kda-helicase-inhibitors-ic50-ki.
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