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Tyrosyl-tRNA synthetase Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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2-[[(2S)-2-Amino-3-(4-hydroxyphenyl)propanoyl]amino]-2-[(1S,3S,4S,5R,8R)-2,4,5,8-tetrahydroxy-7-oxa-2-azabicyclo[3.2.1]octan-3-yl]acetic acidIC501.4 [1], 22000.0 [2]
(2S)-2-[[(2S)-2-Amino-3-(4-hydroxyphenyl)propanoyl]amino]-2-[(2S,3S,4S,5S)-1,3,4,5-tetrahydroxypiperidin-2-yl]acetic acidIC501.2 [1]
(2S)-2-[[(2S)-2-Amino-3-(4-hydroxyphenyl)propanoyl]amino]-2-[(2S,3R,4S,5S)-3,4,5-trihydroxyoxan-2-yl]acetic acidIC50100.0 [1]
CapsaicinKi42000.0 [1]
Tyr-tyrIC503800.0 [1]
(2S)-2-[[(2S)-2-Amino-3-(4-hydroxyphenyl)propanoyl]amino]-2-[(1S,3S,4S,5R,8R)-2,4,5,8-tetrahydroxy-7-oxa-2-azabicyclo[3.2.1]octan-3-yl]acetic acidIC500.6 [1]
(2S)-2-[[(2S)-2-Amino-3-(4-hydroxyphenyl)propanoyl]amino]-2-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-methyloxan-2-yl]acetic acidIC504.0 [1]
Ethyl (2S)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-2-[(1S,4S,5S,6S)-4,5,6-trihydroxycyclohex-2-en-1-yl]acetateIC503.4 [1]
Ethyl (2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-2-[(1S,4S,5S,6S)-4,5,6-trihydroxycyclohex-2-en-1-yl]acetateIC50124.0 [1]
(2R)-2-[[(2S)-2-Amino-3-(4-hydroxyphenyl)propanoyl]amino]-2-[(2S,3S,4S,5S)-1,3,4,5-tetrahydroxypiperidin-2-yl]acetic acidIC5021.3 [1]
(S)-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-phenyl-acetic acidIC50900.0 [1]
2-[[(2S)-2-Amino-3-(4-hydroxyphenyl)propanoyl]amino]-2-(2-hydroxyphenyl)acetic acidIC50800.0 [1]
Methyl 2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-2-(2-hydroxyphenyl)acetateIC501200.0 [1]
2-[[(2S)-2-Amino-3-(4-hydroxyphenyl)propanoyl]amino]-2-(3-hydroxyphenyl)acetic acidIC503400.0 [1]
(2S)-2-[[(2S)-2-Amino-3-(4-hydroxyphenyl)propanoyl]amino]-2-(3,4-dihydroxyphenyl)acetic acidIC5011000.0 [1]
2-[[(2S)-2-Amino-3-(4-hydroxyphenyl)propanoyl]amino]-2-(2,3,4-trihydroxyphenyl)acetic acidIC50510.0 [1]
2-[[(2S)-2-Amino-3-(4-hydroxyphenyl)propanoyl]amino]-2-(2-fluorophenyl)acetic acidIC507800.0 [1]
Ethyl (2S)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-2-[(1S,2S,3S,4S)-2,3,4-trihydroxycyclohexyl]acetateIC50245.0 [1]
Ethyl (2R)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-2-[(1S,2S,3S,4S)-2,3,4-trihydroxycyclohexyl]acetateIC503000.0 [1]
(S)-[(S)-2-Amino-3-(4-hydroxy-phenyl)-propionylamino]-cyclohexyl-acetic acid methyl esterIC503000.0 [1]
(2S)-2-[[(2S)-2-Amino-3-(4-hydroxyphenyl)propanoyl]amino]-2-[(1R,5R,8S)-2,4,5,8-tetrahydroxy-7-oxa-2-azabicyclo[3.2.1]octan-3-yl]acetic acidIC502.0 [1]
(2R)-2-[[(2S)-2-Amino-3-(4-hydroxyphenyl)propanoyl]amino]-2-[(2S,3R,4S,5S)-3,4,5-trihydroxyoxan-2-yl]acetic acidIC50260.0 [1]
Butyl 2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-2-[(2R,4R,5R,6R)-4,5-dihydroxy-6-methyloxan-2-yl]acetateIC503.6 [1]
2-[[(2S)-2-Amino-3-(4-hydroxyphenyl)propanoyl]amino]-2-[(2S,3R,4R,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]acetic acidIC50190.0 [1]
Butyl (2S)-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-2-[(2S,3R,4S,5R,6R)-3,4,5-trihydroxy-6-methyloxan-2-yl]acetateIC500.8 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Tyrosyl-tRNA synthetase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/tyrosyl-trna-synthetase-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ Tyrosyl-tRNA synthetase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/tyrosyl-trna-synthetase-inhibitors-ic50-ki.
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