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Tyrosyl-DNA phosphodiesterase 2 Inhibitors (IC50, Ki)

Structure
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▼
Compound Name
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Standard Type
▲
▼
Standard Values (in nM)
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▼
CamptothecinIC500.0 [1], 111000.0 [2]
2,4-Dioxo-10-[3-(1h-Tetrazol-5-Yl)phenyl]-2,3,4,10-Tetrahydropyrimido[4,5-B]quinoline-8-CarbonitrileIC50590.0 [1], 1000.0 [2]
6-[3-(Dimethylamino)propyl]indeno[1,2-c][2,7]naphthyridine-5,11-dioneIC5037000.0 [1], 80000.0 [2]
6-Iodoisoquinoline-1,3(2h,4h)-dioneIC507600.0 [1], 9300.0 [2]
6-(Trifluoromethyl)isoquinoline-1,3(2H,4H)-dioneIC503500.0 [1], 7000.0 [2]
Ethyl 2-methyl-4,9-dioxofuro[2,3-g]quinoline-3-carboxylateIC5011000.0 [1], 22000.0 [2]
3-Acetyl-2-methylfuro[2,3-g]quinoline-4,9-dioneIC5035000.0 [1], 36000.0 [2]
4-Hydroxybutyl 2-methyl-4,9-dioxofuro[2,3-g]quinoline-3-carboxylateIC5012000.0 [1], 26000.0 [2]
(2-Cyanophenyl) 2-methyl-4,9-dioxofuro[2,3-g]quinoline-3-carboxylateIC50111000.0 [1]
2-(2-Methyl-4,9-dioxofuro[2,3-g]quinoline-3-carbonyl)oxyacetic acidIC5037000.0 [1], 51000.0 [2]
But-3-ynyl 2-methyl-4,9-dioxofuro[2,3-g]quinoline-3-carboxylateIC5015000.0 [1], 22000.0 [2]
3-[4-[2-(2-Methyl-4,9-dioxofuro[2,3-g]quinoline-3-carbonyl)oxyethyl]triazol-1-yl]propanoic acidIC5016000.0 [1], 20000.0 [2]
2-[1-(3-Hydroxypropyl)triazol-4-yl]ethyl 2-methyl-4,9-dioxofuro[2,3-g]quinoline-3-carboxylateIC5066000.0 [1], 72000.0 [2]
Pyridin-3-yl 2-methyl-4,9-dioxofuro[2,3-g]quinoline-3-carboxylateIC507700.0 [1], 8800.0 [2]
(3-Ethynylphenyl) 2-methyl-4,9-dioxofuro[2,3-g]quinoline-3-carboxylateIC5013000.0 [1], 43000.0 [2]
(4-Chlorophenyl) 2-methyl-4,9-dioxofuro[2,3-g]quinoline-3-carboxylateIC507500.0 [1], 11000.0 [2]
(4-Bromophenyl) 2-methyl-4,9-dioxofuro[2,3-g]quinoline-3-carboxylateIC5012000.0 [1], 35000.0 [2]
[(2R)-2,3-Dihydroxypropyl] 2-methyl-4,9-dioxofuro[2,3-g]quinoline-3-carboxylateIC5015000.0 [1], 50000.0 [2]
2,2,2-Trifluoroethyl 2-methyl-4,9-dioxofuro[2,3-g]quinoline-3-carboxylateIC5024000.0 [1], 28000.0 [2]
2-Cyanoethyl 2-methyl-4,9-dioxofuro[2,3-g]quinoline-3-carboxylateIC5013000.0 [1], 14000.0 [2]
3-[4-[3-(2-Methyl-4,9-dioxofuro[2,3-g]quinoline-3-carbonyl)oxyphenyl]triazol-1-yl]propanoic acidIC5013000.0 [1], 22000.0 [2]
(3-Chlorophenyl) 2-methyl-4,9-dioxofuro[2,3-g]quinoline-3-carboxylateIC5011000.0 [1], 14000.0 [2]
2-Dimethoxyphosphorylethyl 2-methyl-4,9-dioxofuro[2,3-g]quinoline-3-carboxylateIC509000.0 [1], 17000.0 [2]
2-(2-Hydroxyethoxy)ethyl 2-methyl-4,9-dioxofuro[2,3-g]quinoline-3-carboxylateIC5013000.0 [1], 22000.0 [2]
(2-Chlorophenyl) 2-methyl-4,9-dioxofuro[2,3-g]quinoline-3-carboxylateIC5010000.0 [1], 14000.0 [2]
(3-Cyanophenyl) 2-methyl-4,9-dioxofuro[2,3-g]quinoline-3-carboxylateIC5010000.0 [1], 12000.0 [2]
[3-[1-(3-Hydroxypropyl)triazol-4-yl]phenyl] 2-methyl-4,9-dioxofuro[2,3-g]quinoline-3-carboxylateIC508100.0 [1], 8300.0 [2]
5-Hydroxypentyl 2-methyl-4,9-dioxofuro[2,3-g]quinoline-3-carboxylateIC5019000.0 [1], 45000.0 [2]
[4-[(2S)-2-Acetamido-3-methoxy-3-oxopropyl]phenyl] 2-methyl-4,9-dioxofuro[2,3-g]quinoline-3-carboxylateIC5017000.0 [1], 23000.0 [2]
[4-(4-Acetylpiperazin-1-yl)phenyl] 2-methyl-4,9-dioxofuro[2,3-g]quinoline-3-carboxylateIC5034000.0 [1], 37000.0 [2]
(4-Methylsulfonylphenyl) 2-methyl-4,9-dioxofuro[2,3-g]quinoline-3-carboxylateIC5014000.0 [1], 16000.0 [2]
(2-Methoxycarbonylthiophen-3-yl) 2-methyl-4,9-dioxofuro[2,3-g]quinoline-3-carboxylateIC5022000.0 [1], 24000.0 [2]
(4-Cyanophenyl) 2-methyl-4,9-dioxofuro[2,3-g]quinoline-3-carboxylateIC5013000.0 [1], 15000.0 [2]
2,3-Dihydroxypropyl 2-methyl-4,9-dioxofuro[2,3-g]quinoline-3-carboxylateIC5011000.0 [1], 20000.0 [2]
2-Phenylethyl 2-methyl-4,9-dioxofuro[2,3-g]quinoline-3-carboxylateIC5024000.0 [1], 53000.0 [2]
Methyl 2-methyl-4,9-dioxofuro[2,3-g]quinoline-3-carboxylateIC5012000.0 [1], 26000.0 [2]
1,3-Benzodioxol-5-yl 2-methyl-4,9-dioxofuro[2,3-g]quinoline-3-carboxylateIC50111000.0 [1]
6-(3-Acetylphenyl)-4H-isoquinoline-1,3-dioneIC505500.0 [1], 15000.0 [2]
6-(3-Bromophenyl)-4H-isoquinoline-1,3-dioneIC506500.0 [1], 8000.0 [2]
6-(3-Hydroxyphenyl)-4H-isoquinoline-1,3-dioneIC5013000.0 [1], 35000.0 [2]
N-[3-(1,3-Dioxo-4H-isoquinolin-6-yl)phenyl]methanesulfonamideIC5018000.0 [1], 25000.0 [2]
8-Iodo-4H-isoquinoline-1,3-dioneIC502600.0 [1], 7500.0 [2]
7-(3-Chlorophenyl)-4H-isoquinoline-1,3-dioneIC501700.0 [1], 3200.0 [2]
6-(Furan-2-yl)-4H-isoquinoline-1,3-dioneIC5010000.0 [1], 25000.0 [2]
6-Quinolin-3-yl-4H-isoquinoline-1,3-dioneIC509300.0 [1], 111000.0 [2]
1,3-Dioxo-4H-isoquinoline-7-carboxylic acidIC503000.0 [1], 5200.0 [2]
6-(3-Chlorophenyl)-4H-isoquinoline-1,3-dioneIC503300.0 [1], 5600.0 [2]
6-(3-Chloro-4-fluorophenyl)-4H-isoquinoline-1,3-dioneIC504100.0 [1], 5300.0 [2]
6-(2,4-Difluorophenyl)-4H-isoquinoline-1,3-dioneIC504500.0 [1], 5500.0 [2]
6-Pyridin-3-yl-4H-isoquinoline-1,3-dioneIC5016000.0 [1], 23000.0 [2]
6-(4-Aminophenyl)-4H-isoquinoline-1,3-dioneIC5036000.0 [1], 40000.0 [2]
6-(3-Aminophenyl)-4H-isoquinoline-1,3-dioneIC5042000.0 [1], 55000.0 [2]
6-(3-Fluoro-4-methoxyphenyl)-4H-isoquinoline-1,3-dioneIC503000.0 [1], 4300.0 [2]
6-(4-Chlorophenyl)-4H-isoquinoline-1,3-dioneIC504500.0 [1], 6400.0 [2]
N-[4-(1,3-Dioxo-4H-isoquinolin-6-yl)phenyl]methanesulfonamideIC501900.0 [1], 2200.0 [2]
3-(1,3-Dioxo-4H-isoquinolin-6-yl)benzoic acidIC5021000.0 [1], 42000.0 [2]
6-(3-Nitrophenyl)-4H-isoquinoline-1,3-dioneIC5010000.0 [1], 25000.0 [2]
6-Phenyl-4H-isoquinoline-1,3-dioneIC5023000.0 [1], 111000.0 [2]
6-[4-(Trifluoromethyl)phenyl]-4H-isoquinoline-1,3-dioneIC502700.0 [1], 3200.0 [2]
7-(Furan-2-yl)-4H-isoquinoline-1,3-dioneIC5013000.0 [1], 50000.0 [2]
6-(1,3-Benzothiazol-2-yl)-4H-isoquinoline-1,3-dioneIC505100.0 [1], 11000.0 [2]
3-Pyridin-1-ium-1-ylpropyl 2-methyl-4,9-dioxofuro[2,3-g]quinoline-3-carboxylate;bromideIC5024000.0 [1], 32000.0 [2]
(3-Aminophenyl) 2-methyl-4,9-dioxofuro[2,3-g]quinoline-3-carboxylateIC5012000.0 [1], 16000.0 [2]
3-[4-(Dimethylamino)pyridin-1-ium-1-yl]propyl 2-methyl-4,9-dioxofuro[2,3-g]quinoline-3-carboxylate;bromideIC5038000.0 [1], 43000.0 [2]
(2-Hydroxyphenyl) 2-methyl-4,9-dioxofuro[3,2-g]quinoline-3-carboxylateIC5029000.0 [1], 39000.0 [2]
Sodium;3-[4-[3-(2-methyl-4,9-dioxofuro[2,3-g]quinoline-3-carbonyl)oxyphenyl]triazol-1-yl]propanoateIC5028000.0 [1], 50000.0 [2]
Ethyl 2-methyl-4,9-dioxofuro[3,2-g]quinoline-3-carboxylateIC5043000.0 [1], 54000.0 [2]
beta-LapachoneIC50970.0 [1]
2,3-Bis(2-hydroxyethylthio)-1,4-naphthalenedioneIC5071000.0 [1]
20-[3-(2-Hydroxyethylamino)propyl]-15,16-dimethoxy-5,7-dioxa-20-azapentacyclo[10.8.0.02,10.04,8.013,18]icosa-1(12),2,4(8),9,13,15,17-heptaene-11,19-dioneIC501000.0 [1]
7,10-Dimethyl-2,4-dioxo-2,3,4,10-tetrahydrobenzo[g]pteridine-8-carbaldehydeIC503500.0 [1]
Isoquinoline-1,3(2H,4H)-dioneIC5025000.0 [1]
n,n'-DibenzoylcystineIC504100.0 [1]
n,n'-Bis(phenylacetyl)cystineIC509000.0 [1]
1,6-Dimethyl-3-propylpyrimido[5,4-e][1,2,4]triazine-5,7-dioneIC501510.0 [1]
10-Methylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dioneIC5030000.0 [1]
6-(Furan-2-yl)-2-hydroxy-4H-isoquinoline-1,3-dioneIC50111000.0 [1]
7-(2-Furyl)-2-hydroxy-4H-isoquinoline-1,3-dioneIC50111000.0 [1]
6-Bromo-1H-benzo[de]isoquinoline-1,3(2H)-dioneIC50111000.0 [1]
6-(3-Morpholin-4-ylpropyl)indeno[1,2-c][2,7]naphthyridine-5,11-dioneIC50111000.0 [1]
6-(3-Imidazol-1-ylpropyl)indeno[1,2-c][2,7]naphthyridine-5,11-dioneIC50111000.0 [1]
10-Phenylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dioneIC5030000.0 [1]
7-Phenyl-1H-quinazoline-2,4-dioneIC50111000.0 [1]
6-Bromoisoquinoline-1,3(2h,4h)-dioneIC5011000.0 [1]
3-Hydroxypropyl 2-methyl-4,9-dioxofuro[2,3-g]quinoline-3-carboxylateIC5011000.0 [1]
N-(4-Methoxyphenyl)-2-methyl-4,9-dioxofuro[2,3-g]quinoline-3-carboxamideIC50111000.0 [1]
N-Ethyl-2-methyl-4,9-dioxofuro[2,3-g]quinoline-3-carboxamideIC50111000.0 [1]
N-(3-Chlorophenyl)-2-methyl-4,9-dioxofuro[2,3-g]quinoline-3-carboxamideIC50111000.0 [1]
Ethyl 4,9-dioxo-[1,2]oxazolo[5,4-g]quinoline-3-carboxylateIC503100.0 [1]
N-(2-Hydroxyphenyl)-2-methyl-4,9-dioxofuro[2,3-g]quinoline-3-carboxamideIC50111000.0 [1]
Naphthalen-2-yl 2-methyl-4,9-dioxofuro[2,3-g]quinoline-3-carboxylateIC50111000.0 [1]
[(2S)-2,3-Dihydroxypropyl] 2-methyl-4,9-dioxofuro[2,3-g]quinoline-3-carboxylateIC5014000.0 [1]
Ethyl 4,9-dioxo-2H-pyrazolo[3,4-g]quinoline-3-carboxylateIC50111000.0 [1]
Ethyl 4,9-dioxo-[1,2]oxazolo[4,5-g]quinoline-3-carboxylateIC502100.0 [1]
[3-(Prop-2-enoylamino)phenyl] 2-methyl-4,9-dioxofuro[2,3-g]quinoline-3-carboxylateIC5071000.0 [1]
(4-Aminophenyl) 2-methyl-4,9-dioxofuro[2,3-g]quinoline-3-carboxylateIC5019000.0 [1]
[4-(Prop-2-enoylamino)phenyl] 2-methyl-4,9-dioxofuro[2,3-g]quinoline-3-carboxylateIC5068000.0 [1]
2-Hydroxyethyl 2-methyl-4,9-dioxofuro[2,3-g]quinoline-3-carboxylateIC509800.0 [1]
(3-Hydroxyphenyl) 2-methyl-4,9-dioxofuro[2,3-g]quinoline-3-carboxylateIC508800.0 [1]
Phenyl 2-methyl-4,9-dioxofuro[2,3-g]quinoline-3-carboxylateIC5010000.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Tyrosyl-DNA phosphodiesterase 2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/tyrosyl-dna-phosphodiesterase-2-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ Tyrosyl-DNA phosphodiesterase 2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/tyrosyl-dna-phosphodiesterase-2-inhibitors-ic50-ki.
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