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Tyrosine-protein kinase ZAP-70 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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▼
StaurosporineIC501.3 [1], 8.63 [2], 12.4 [3], 53.0 [4]
CID 44462758IC5060.0 [1], 68.0 [2], 1805.0 [3]
DoramapimodIC5020000.0 [1], 30000.0 [2]
2-(2-Aminoethylamino)-4-(m-tolylamino)pyrimidine-5-carboxamideIC505011.87 [1], 5200.0 [2]
5-[[(1S,2R)-2-Aminocyclohexyl]amino]-7-(3,5-dimethoxyanilino)-[1,2,4]triazolo[4,3-c]pyrimidine-8-carboxamideIC50120.0 [1]
5-[[(1S,2R)-2-Aminocyclohexyl]amino]-7-(3,5-dimethoxyanilino)-[1,2,4]triazolo[1,5-c]pyrimidine-8-carboxamideIC50330.0 [1]
{4-[6-((S)-3-Methyl-piperazin-1-yl)-pyridin-3-yl]-pyrimidin-2-yl}-(3,4,5-trimethoxy-phenyl)-amineIC5011.0 [1]
5-Amino-7-(3,5-dimethoxyanilino)imidazo[1,2-c]pyrimidine-8-carboxamideIC5010000.0 [1]
7-(3,5-Dimethoxyanilino)-5-(2-hydroxyethylamino)imidazo[1,2-c]pyrimidine-8-carboxamideIC501900.0 [1]
5-(2-Aminoethylamino)-7-(3,5-dimethoxyanilino)imidazo[1,2-c]pyrimidine-8-carboxamideIC503500.0 [1]
1,2,4-Oxadiazole Analogue 5dIC506000.0 [1], 7000.0 [2]
1,2,4-Oxadiazole Analogue 12bIC504000.0 [1]
1,2,4-Oxadiazole Analogue 12dIC504000.0 [1]
1,2,4-Oxadiazole Analogue 5fIC506000.0 [1], 7000.0 [2]
5-{[(1R,2S)-2-Aminocyclohexyl]amino}-3-[(4,6-dimethylpyridin-2-yl)amino]pyridine-2-carboxamideIC505.3 [1]
3-{[(1r,2s)-2-Aminocyclohexyl]amino}-5-(1h-Indol-7-Ylamino)-1,2,4-Triazine-6-CarboxamideIC50251.0 [1], 2526.0 [2]
(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[(2S)-2-[[(2S)-4-Amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-5-amino-2-[[(2S)-2,4-diamino-4-oxobutanoyl]amino]-5-oxopentanoyl]amino]-4-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-3-(4-phosphonooxyphenyl)propanoyl]amino]-4-oxobutanoyl]amino]-4-carboxybutanoyl]amino]-4-methylpentanoyl]amino]-4-oxobutanoyl]amino]-4-methylpentanoyl]amino]acetyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-4-carboxybutanoyl]amino]-4-carboxybutanoyl]amino]-3-(4-phosphonooxyphenyl)propanoyl]amino]-3-carboxypropanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentanoyl]amino]butanedioic acidIC5030.0 [1]
AlvocidibIC5050000.0 [1]
1-Tert-butyl-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC50100000000.0 [1]
SemaxanibIC5020700.0 [1]
6-DimethylaminopurineKi10000.0 [1]
CeritinibIC509700.0 [1]
Tyrphostin A23Ki10000.0 [1]
SotrastaurinIC5010000.0 [1]
Met Kinase InhibitorKi10000.0 [1]
OrantinibIC5028400.0 [1]
Nvp-aew541IC5010000.0 [1]
Sns-032IC5040000.0 [1]
Nvp-tae 684IC501598.0 [1]
DanusertibIC5010000.0 [1]
NeflamapimodIC505000.0 [1]
EntrectinibIC5010000.0 [1]
Azd-1152hqpaKi8200.0 [1]
2-(Pyridin-4-yl)-6,7-dihydro-1H-pyrrolo[3,2-c]pyridin-4(5H)-oneIC5010000.0 [1]
TamatinibIC5042.0 [1]
MilciclibIC5010000.0 [1]
O6-Cyclohexylmethoxy-2-(4'-sulphamoylanilino) purineKi10000.0 [1]
4-Amino-5-(4-Phenoxyphenyl)-7h-Pyrrolo[2,3-D]pyrimidin-7-Yl-CyclopentaneIC5050000.0 [1]
3-(1H-Indol-5-yl)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrrolo[2,3-b]pyridineIC505050.0 [1]
7-[cis-4-(4-Methylpiperazin-1-Yl)cyclohexyl]-5-(4-Phenoxyphenyl)-7h-Pyrrolo[2,3-D]pyrimidin-4-AmineIC5020000.0 [1]
A-770041IC5025000.0 [1]
(4S,6Z,9S,10S)-9,10,18-Trihydroxy-16-methoxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),6,15,17-tetraene-2,8-dioneIC5010000.0 [1]
Cdk2 Inhibitor IIKi10000.0 [1]
Syk Inhibitor IIIC5011200.0 [1]
Bms-509744IC5050000.0 [1]
4-Methyl-3-(2-((2-morpholinoethyl)amino)quinazolin-6-yl)-N-(3-(trifluoromethyl)phenyl)benzamideIC5025000.0 [1]
Nms-P937 (nms1286937)IC5010000.0 [1]
CID 11634725Ki4000.0 [1]
Pyrimidone, 22IC505400.0 [1]
7-Butyl-6-(4-methoxyphenyl)-5H-pyrrolo[2,3-b]pyrazineKi2630.27 [1]
2-(4-Fluoroanilino)-5-[3-fluoro-4-[6-methoxy-7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxyphenyl]-3-methylpyrimidin-4-oneIC508300.0 [1]
MivavotinibIC5075.0 [1]
CID 59604787IC5010000.0 [1]
5-[2,4-Dihydroxy-6-(4-Nitrophenoxy)phenyl]-N-(1-Methylpiperidin-4-Yl)-1,2-Oxazole-3-CarboxamideIC5010.0 [1]
(4S)-4-[[(2S)-2-[[(2S)-2-Acetamido-3-(4-phosphonooxyphenyl)propanoyl]amino]-4-carboxybutanoyl]amino]-5-[[(2S,3S)-1-amino-3-methyl-1-oxopentan-2-yl]amino]-5-oxopentanoic acidIC50530000.0 [1]
2-{[(3r,4r)-3-Aminotetrahydro-2h-Pyran-4-Yl]amino}-4-[(4-Methylphenyl)amino]pyrimidine-5-CarboxamideIC5019952.62 [1]
N'-(Pyrrolidino[2,1-B]isoindolin-4-ON-8-YL)-N-(pyridin-2-YL)ureaIC5010000.0 [1]
CID 44814409IC5010000.0 [1]
N-(3-Cyclopropyl-1H-pyrazol-5-YL)-2-(2-naphthyl)acetamideIC5010000.0 [1]
5-(2-Aminopyrimidin-4-yl)-2-phenyl-1H-pyrrole-3-carboxamideIC5010000.0 [1]
2-[1-(4,4-Difluorocyclohexyl)-piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamideIC5010000.0 [1]
(2R)-2-[(2S)-4-[3-Chloro-5-fluoro-6-(2H-pyrazolo[3,4-b]pyridin-3-yl)pyridin-2-yl]piperazin-2-yl]-3-methylbutan-2-olKi1000.0 [1]
Unii-8FX9DP2Y1WIC501000.0 [1]
9H-Imidazo(4,5-H)isoquinolin-9-one, 2-((2,6-dichlorophenyl)amino)-1,8-dihydro-6,7-dimethyl-IC5080000.0 [1]
Lck InhibitorIC501500.0 [1]
2-(2-Aminoethylamino)-4-(p-tolylamino)pyrimidine-5-carboxamideIC506500.0 [1]
N'-(5-Chloro-1,3-benzodioxol-4-yl)-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamineIC5030000.0 [1]
Unii-09RR39UU4VIC5050000.0 [1]
(E)-3-[4-[[[8-Carbamoyl-7-(3,5-dimethoxyanilino)imidazo[1,2-c]pyrimidin-5-yl]amino]methyl]phenyl]prop-2-enoic acidIC5047.0 [1]
5-(2-Aminoethylamino)-7-(3,5-dimethoxyphenylamino)-1,2,4-triazolo[4,3-c]pyrimidine-8-carboxamideIC508300.0 [1]
5-[[(1R,2S)-2-Aminocyclohexyl]amino]-7-(3,5-dimethoxyanilino)-2-phenylimidazo[1,2-c]pyrimidine-8-carboxamideIC50600.0 [1]
3-[[4-[2,2-Dimethylpropyl(methyl)amino]-6-(4-methyl-1,4-diazepan-1-yl)-1,3,5-triazin-2-yl]amino]-N-methoxy-4-methylbenzamideIC5050000.0 [1]
CID 11675054IC5010000.0 [1]
(2,6-Dimethylphenyl) N-[2-[3,5-dimethoxy-4-[3-(4-methylpiperazin-1-yl)propoxy]anilino]pyrimidin-4-yl]-N-(2,4-dimethoxyphenyl)carbamateIC50370.0 [1]
3-[(4-Morpholin-4-ylbenzoyl)amino]-N-[(1S)-1-phenyl-2-pyrrolidin-1-ylethyl]-1H-thieno[3,2-c]pyrazole-5-carboxamideIC5010000.0 [1]
3-[1H-Benzimidazol-2-yl(phenyl)methylene]-1,3-dihydro-2H-indol-2-oneIC5026000.0 [1]
7-{[(1r,2s)-2-Aminocyclohexyl]amino}-5-(1h-Indol-7-Ylamino)pyrido[4,3-D]pyrimidin-4(3h)-OneIC50133.0 [1]
8-[2-(Dimethylamino)ethoxy]-2-(4-phenoxyphenyl)-6,11-dihydro-5H-pyrazolo[5,1-b][1,3]benzodiazepine-1-carboxamideIC501000.0 [1]
(3E)-3-[(4-Hydroxyphenyl)methylidene]-1-[(3E)-3-[(4-hydroxyphenyl)methylidene]-2-oxo-3a,4-dihydrocyclopenta[b]indol-1-yl]cyclopenta[b]indol-2-oneKi1548.82 [1]
7-[[(1R,2S)-2-Aminocyclohexyl]amino]-5-[3-(triazol-2-yl)anilino]-3H-pyrido[4,3-d]pyrimidin-4-oneIC5074.0 [1]
(13R,15S)-13-Methyl-16-oxa-8,9,12,22,24-pentazahexacyclo[15.6.2.16,9.112,15.02,7.021,25]heptacosa-1(24),2,4,6,17,19,21(25)-heptaene-23,27-dioneIC501000.0 [1]
4-Methyl-3-[2-(methylamino)quinazolin-6-yl]-N-[2-(1-methylpiperidin-4-yl)oxy-5-(trifluoromethyl)phenyl]benzamideIC5025000.0 [1]
N-[2-[3-(Dimethylamino)propyl-methylamino]-5-(trifluoromethyl)phenyl]-2-fluoro-5-[3-[4-(methylamino)-1,3,5-triazin-2-yl]pyridin-2-yl]oxybenzamideIC5025000.0 [1]
2-(2-Aminoethylamino)-4-(phenylamino)pyrimidine-5-carboxamideIC5013200.0 [1]
2-[2-(3,5-Dimethylanilino)pyrimidin-4-yl]-N-[(2S)-1-hydroxypropan-2-yl]-4-methyl-1,3-thiazole-5-carboxamideKi240.0 [1]
3-[3-[[4-(1,3-Thiazol-2-yl)pyrimidin-2-yl]amino]-5-(trifluoromethyl)phenoxy]propan-1-olKi677.0 [1]
2-(2-Aminoethylamino)-4-(3-cyanophenylamino)pyrimidine-5-carboxamideIC508400.0 [1]
7-(3,5-Dimethoxyanilino)-5-[(2-methylcyclohexyl)amino]imidazo[1,2-c]pyrimidine-8-carboxamideIC503300.0 [1]
2-(4-Methyl-2-(2-(3-methyl-5-(trifluoromethyl)phenylamino)pyrimidin-4-yl)thiazol-5-yl)ethanolKi3500.0 [1]
2-(2-(2-(3,5-Dimethylphenylamino)pyrimidin-4-yl)-4-methylthiazol-5-yl)ethanolKi560.0 [1]
N-(3,5-Dimethylphenyl)-4-(4-methyl-1,3-thiazol-2-yl)pyrimidin-2-amineKi1030.0 [1]
N-[3-Methyl-5-(trifluoromethyl)phenyl]-4-(1,3-thiazol-2-yl)pyrimidin-2-amineKi891.0 [1]
2-[2-(3,5-Dimethylanilino)pyrimidin-4-yl]-N-[(2R)-1-hydroxypropan-2-yl]-4-methyl-1,3-thiazole-5-carboxamideKi1500.0 [1]
4-(4-Fluorophenyl)-N-[4-[3-[2-(methylamino)pyrimidin-4-yl]pyridin-2-yl]oxyphenyl]phthalazin-1-amineIC5025000.0 [1]
3-Substituted indolin-2-one 11aIC5025000.0 [1]
1,2,4-Oxadiazole Analogue 4iIC5055000.0 [1]
1,2,4-Oxadiazole Analogue 4kIC50500000.0 [1]
1,2,4-Oxadiazole Analogue 4aIC50500000.0 [1]
1-[5-Tert-butyl-3-[4-[2-(dimethylamino)ethyl]-5-oxo-1,4-diazepane-1-carbonyl]thiophen-2-yl]-3-(2,3-dichlorophenyl)ureaIC5030000.0 [1]
7,8-Dichloro-9-methyl-1-oxospiro[2,4-dihydropyrido[3,4-b]indole-3,4'-piperidine]-4-carbonitrileIC5010000.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Tyrosine-protein kinase ZAP-70 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Dec. 2024, https://www.aatbio.com/data-sets/tyrosine-protein-kinase-zap-70-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, December 21). Quest Database™ Tyrosine-protein kinase ZAP-70 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/tyrosine-protein-kinase-zap-70-inhibitors-ic50-ki.
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