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Tyrosine-protein kinase YES Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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DasatinibIC500.5 [1], 1.0 [2]
SaracatinibIC500.7 [1], 4.0 [2], 6.2 [3]
7-(2,6-Dichlorophenyl)-5-methyl-N-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1,2,4-benzotriazin-3-amineIC5010.0 [1], 10.3 [2]
7-(2,6-Dichlorophenyl)-5-methyl-N-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1,2,4-benzotriazin-3-amineKi12.9 [1]
4-Chloro-3-(5-methyl-3-(4-(2-(pyrrolidin-1-yl)ethoxy)phenylamino)benzo[e][1,2,4]triazin-7-yl)phenolIC500.3 [1], 0.5 [2]
7-(2,6-Dimethylphenyl)-5-methyl-N-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1,2,4-benzotriazin-3-amineIC501.0 [1], 1.2 [2]
7-(2-Chlorophenyl)-5-methyl-N-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1,2,4-benzotriazin-3-amineIC5021.7 [1], 22.0 [2]
4-[[7-(2-Chloro-5-hydroxyphenyl)-5-methyl-1,2,4-benzotriazin-3-yl]amino]-N-(2-pyrrolidin-1-ylethyl)benzenesulfonamideIC501.28 [1], 1.3 [2]
5-Methyl-7-phenyl-N-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)benzo[e][1,2,4]triazin-3-amineIC50110.0 [1], 111.0 [2]
StaurosporineIC502.35 [1], 4.4 [2]
IbrutinibIC506.5 [1]
DorsomorphinIC5029.8 [1], 195.9 [2]
DovitinibIC501.4 [1], 31.0 [2]
(R)-6-(4-((4-Ethylpiperazin-1-yl)methyl)phenyl)-N-(1-phenylethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amineIC5013.1 [1], 17.5 [2]
N-[(1-Methylpiperidin-4-yl)methyl]-3-[3-(trifluoromethoxy)phenyl]imidazo[1,2-b]pyridazin-6-amineIC50240.0 [1], 2670.0 [2]
RebastinibIC501.5 [1], 2.5 [2]
AZ-628IC5051.2 [1], 348.3 [2]
AZ-23IC503.0 [1], 39.1 [2]
AMG-Tie2-1IC508.7 [1], 22.0 [2]
7-(2,6-Dimethylphenyl)-N-phenylbenzo[e][1,2,4]triazin-3-amineIC50822.0 [1]
7-(2,6-Dimethylphenyl)-5-methyl-N-[3-(2-pyrrolidin-1-ylethoxy)phenyl]-1,2,4-benzotriazin-3-amineIC503.7 [1]
7-(2,6-Dimethylphenyl)-5-methyl-N-[4-[2-(4-methylpiperazin-1-yl)ethoxy]phenyl]-1,2,4-benzotriazin-3-amineIC507.7 [1]
1-(2,2-Diethoxyethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)pyrazolo[3,4-d]pyrimidin-4-amineIC50566.0 [1]
4-[[7-(2,6-Dimethylphenyl)-5-methyl-1,2,4-benzotriazin-3-yl]amino]-N-(2-pyrrolidin-1-ylethyl)benzenesulfonamideIC503.1 [1]
3-[[7-(2-Chloro-5-hydroxyphenyl)-5-methyl-1,2,4-benzotriazin-3-yl]amino]-N-[2-(dimethylamino)ethyl]benzamideIC501.24 [1]
4-Chloro-3-{6-methyl-3-[4-(2-pyrrolidin-1-yl-ethoxy)-phenylamino]-benzo[1,2,4]triazin-7-yl}-phenolIC500.7 [1]
2-PropenaMide, N-[cis-4-[4-aMino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyriMidin-1-yl]cyclohexyl]-IC500.8 [1]
5-[[7-(2,6-Dimethylphenyl)-5-methyl-1,2,4-benzotriazin-3-yl]amino]-N-(2-pyrrolidin-1-ylethyl)furan-2-carboxamideIC5018.3 [1]
2-[[7-(2,6-Dimethylphenyl)-5-methyl-1,2,4-benzotriazin-3-yl]amino]-N-(2-pyrrolidin-1-ylethyl)-1,3-thiazole-4-carboxamideIC507.3 [1]
BosutinibIC500.4 [1]
Su6656IC5020.0 [1]
DoramapimodIC508900.0 [1]
Lfm-a13IC50500000.0 [1]
CID 53469448IC503195.0 [1]
1-Cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)ureaIC501.0 [1]
1-(Tert-Butyl)-3-(p-tolyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC5036.0 [1]
CID 44462758IC50123.0 [1]
1-[4-Amino-7-(3-hydroxypropyl)-5-(4-methylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-fluoroethanoneIC50510.0 [1]
CID 11973736IC502500.0 [1]
CID 59604787IC5010000.0 [1]
3-[[2-[3-(Morpholin-4-ylmethyl)phenyl]thieno[3,2-b]pyridin-7-yl]amino]phenolIC502.1 [1]
N-(2-Chloro-6-methylphenyl)-2-[(2,6-dimethylpyrimidin-4-yl)amino]-1,3-thiazole-5-carboxamideIC502.0 [1]
CID 44814409IC5010000.0 [1]
N-(Pyridin-4-yl)-3-[1-(4-chlorobenzyl)indol-3-yl]-propanamideIC5030000.0 [1]
Unii-8FX9DP2Y1WIC504.7 [1]
7-(2,6-Dichlorophenyl)-5-methyl-N-[4-[2-(1-oxidopyrrolidin-1-ium-1-yl)ethoxy]phenyl]-1,2,4-benzotriazin-3-amineKi5.97 [1]
(3Z)-N-Methyl-3-[[3-[3-(4-methylpiperazin-1-yl)propyl]-4,5,6,7-tetrahydro-1H-indol-2-yl]methylidene]-2-oxo-1H-indole-5-sulfonamideIC5010.0 [1]
4-Chloro-3-(5-methyl-3-(4-(piperidin-4-ylsulfonyl)phenylamino)benzo[e][1,2,4]triazin-7-yl)phenolIC504.1 [1]
N-(3-(2-(Diethylamino)ethoxy)phenyl)-7-(2,6-dimethylphenyl)-5-methylbenzo[e][1,2,4]triazin-3-amineIC502.6 [1]
Tert-butyl N-[4-[4-amino-1-[2-[4-(dimethylamino)piperidin-1-yl]ethyl]pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl]carbamateIC500.5 [1]
2-[[N-[2-[3-Ethylsulfonyl-4-(4-methylpiperazin-1-yl)anilino]-5-fluoropyrimidin-4-yl]-5-(hydroxymethyl)-2-methylanilino]methyl]benzonitrileIC504.0 [1]
Ripk1-IN-7IC50384.0 [1]
4-Chloro-3-(5-methyl-3-(4-(3-(pyrrolidin-1-yl)propyl)phenylamino)benzo[e][1,2,4]triazin-7-yl)phenolIC504.8 [1]
[6-Chloro-4-methyl-3-[[3-(methylsulfamoylamino)phenyl]methyl]-2-oxochromen-7-yl] N,N-dimethylcarbamateIC5050000.0 [1]
4-Chloro-3-(5-methyl-3-{[4-(piperazin-1-ylcarbonyl)phenyl]amino}-1,2,4-benzotriazin-7-yl)phenolIC505.2 [1]
5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-tert-butylpyridine-3-sulfonamideIC5010000.0 [1]
3-[1-[(4-Chlorophenyl)methyl]indol-3-yl]-N-(4-nitrophenyl)propanamideIC5038100.0 [1]
1-[5-Tert-butyl-3-[4-[2-(dimethylamino)ethyl]-5-oxo-1,4-diazepane-1-carbonyl]thiophen-2-yl]-3-(2,3-dichlorophenyl)ureaIC5030000.0 [1]
7,8-Dichloro-9-methyl-1-oxospiro[2,4-dihydropyrido[3,4-b]indole-3,4'-piperidine]-4-carbonitrileIC5010000.0 [1]
N-(7-Methoxyquinolin-6-yl)thieno[3,2-d]pyrimidine-7-carboxamideIC5050000.0 [1]
6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-oneIC5010000.0 [1]
8-Butyl-1-Methyl-7-(2-Methylphenyl)-1h-Imidazo[2,1-F]purine-2,4(3h,8h)-DioneIC50284.0 [1]
8-(4-Ethylphenyl)-5-Methyl-2,5-Dihydropyrazolo[4,3-C][2,1]benzothiazine 4,4-DioxideIC501800.0 [1]
1-Ethyl-8-(4-Ethylphenyl)-5-Methyl-1,5-Dihydropyrazolo[4,3-C][2,1]benzothiazine 4,4-DioxideIC5010000.0 [1]
2-[4-[2-Acetamido-3-[[(1S)-1-[3-carbamoyl-4-(cyclohexylmethoxy)phenyl]ethyl]amino]-3-oxopropyl]-2-[ethoxy(hydroxy)phosphoryl]phenoxy]acetic acidIC50156000.0 [1]
(3Z)-3-[[3-[3-(Dimethylamino)propyl]-4,5,6,7-tetrahydro-1H-indol-2-yl]methylidene]-N-methyl-2-oxo-1H-indole-5-sulfonamideIC5010.0 [1]
N-(5-Chloro-1,3-benzodioxol-4-yl)-5-(oxan-4-yloxy)-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-amineIC503.0 [1]
3-[2-[(Z)-[5-(Methylsulfamoyl)-2-oxo-1H-indol-3-ylidene]methyl]-4,5,6,7-tetrahydro-1H-indol-3-yl]propanamideIC5010.0 [1]
(3Z)-5-Ethylsulfonyl-3-[[3-[3-(4-methylpiperazin-1-yl)propyl]-4,5,6,7-tetrahydro-1H-indol-2-yl]methylidene]-1H-indol-2-oneIC5030.0 [1]
2-[4-[2-Acetamido-3-[[(1S)-1-[3-carbamoyl-4-(cyclohexylmethoxy)phenyl]ethyl]amino]-3-oxopropyl]-2-phosphonophenoxy]acetic acidIC50110000.0 [1]
2-[4-[3-[2-[(Z)-[5-(Methylsulfamoyl)-2-oxo-1H-indol-3-ylidene]methyl]-4,5,6,7-tetrahydro-1H-indol-3-yl]propyl]piperazin-1-yl]acetic acidIC5010.0 [1]
2-[3-(3-Piperidin-4-ylpropoxy)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamideKi2000.0 [1]
2-[3-(Methanesulfonamido)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamideKi2000.0 [1]
3-[2-(4-Amino-1-ethylpyrazolo[3,4-d]pyrimidin-3-yl)ethynyl]-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamideIC500.8 [1]
N-[3-[[4-[(5-Cyclopropyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]amino]phenyl]butanamideKi470.0 [1]
N-[3-[[4-[(5-Cyclopropyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]amino]phenyl]-7-[(2R)-2-(furan-2-yl)pyrrolidin-1-yl]-7-oxoheptanamideKi610.0 [1]
N-[3-[[4-[(5-Cyclopropyl-1H-pyrazol-3-yl)amino]pyrimidin-2-yl]amino]phenyl]-N'-[(1R)-1-(furan-2-yl)ethyl]heptanediamideKi800.0 [1]
1-[2-[4-[(Dimethylamino)methyl]piperidin-1-yl]ethyl]-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)pyrazolo[3,4-d]pyrimidin-4-amineIC5012.0 [1]
1-[2-[4-[2-(Dimethylamino)ethyl]piperidin-1-yl]ethyl]-3-(4-methylphenyl)pyrazolo[3,4-d]pyrimidin-4-amineIC50696.0 [1]
1-[2-[4-[(Dimethylamino)methyl]piperidin-1-yl]ethyl]-3-(4-methylphenyl)pyrazolo[3,4-d]pyrimidin-4-amineIC50344.0 [1]
1-[2-[4-(Dimethylamino)piperidin-1-yl]ethyl]-3-(4-methylphenyl)pyrazolo[3,4-d]pyrimidin-4-amineIC5071.0 [1]
1-Tert-butyl-3-[7-(4-hydroxy-3-methoxyphenyl)-1,5-naphthyridin-2-yl]ureaIC5042900.0 [1]
4-[8-Amino-3-[(3R)-1-(2-methylpropanoyl)piperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-3-fluoro-N-[4-(trifluoromethyl)pyridin-2-yl]benzamideIC50189.0 [1]
4-[8-Amino-3-[(2R)-4-(oxan-4-yl)morpholin-2-yl]imidazo[1,5-a]pyrazin-1-yl]-3-fluoro-N-[4-(trifluoromethyl)pyridin-2-yl]benzamideIC5060.0 [1]
4-[8-Amino-3-[(3R)-1-(oxan-4-yl)piperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-3-fluoro-N-[4-(trifluoromethyl)pyridin-2-yl]benzamideIC5032.0 [1]
4-[8-Amino-3-[(2R)-4-(2-methylpropanoyl)morpholin-2-yl]imidazo[1,5-a]pyrazin-1-yl]-3-fluoro-N-[4-(trifluoromethyl)pyridin-2-yl]benzamideIC50266.0 [1]
5-(1,3-Benzodioxol-5-yl)-7-[[(2R)-1-ethenylsulfonylpyrrolidin-2-yl]methyl]pyrrolo[2,3-d]pyrimidin-4-amineIC5057.3 [1]
Ethyl 2-[4-[3-[2-[(Z)-[5-(methylsulfamoyl)-2-oxo-1H-indol-3-ylidene]methyl]-4,5,6,7-tetrahydro-1H-indol-3-yl]propyl]piperazin-1-yl]acetateIC5020.0 [1]
7-[2,6-Difluoro-4-[(1S,4S)-5-methyl-2,5-diazabicyclo[2.2.1]heptan-2-yl]phenyl]-3-(1H-indazol-4-yl)-2-pyridin-4-ylpyrazolo[1,5-a]pyrimidineIC50246.0 [1]
(3Z)-N-Methyl-3-[[3-(morpholin-4-ylmethyl)-4,5,6,7-tetrahydro-1H-indol-2-yl]methylidene]-2-oxo-1H-indole-5-sulfonamideIC5040.0 [1]
(3Z)-5-Ethylsulfonyl-3-[[3-(morpholin-4-ylmethyl)-4,5,6,7-tetrahydro-1H-indol-2-yl]methylidene]-1H-indol-2-oneIC50160.0 [1]
2-[4-[3-[2-[(Z)-(5-Ethylsulfonyl-2-oxo-1H-indol-3-ylidene)methyl]-4,5,6,7-tetrahydro-1H-indol-3-yl]propyl]piperazin-1-yl]acetic acidIC5010.0 [1]
(3Z)-5-Ethylsulfonyl-3-[[3-[3-(4-hydroxypiperidin-1-yl)propyl]-4,5,6,7-tetrahydro-1H-indol-2-yl]methylidene]-1H-indol-2-oneIC5020.0 [1]
(3Z)-3-[[3-[3-(4-Hydroxypiperidin-1-yl)propyl]-4,5,6,7-tetrahydro-1H-indol-2-yl]methylidene]-N-methyl-2-oxo-1H-indole-5-sulfonamideIC5010.0 [1]
(3Z)-5-Ethylsulfonyl-3-[[3-[3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl]-4,5,6,7-tetrahydro-1H-indol-2-yl]methylidene]-1H-indol-2-oneIC5040.0 [1]
3-[2-[(Z)-(5-Ethylsulfonyl-2-oxo-1H-indol-3-ylidene)methyl]-4,5,6,7-tetrahydro-1H-indol-3-yl]propanamideIC5030.0 [1]
(3Z)-3-[[3-[3-[4-(2-Hydroxyethyl)piperazin-1-yl]propyl]-4,5,6,7-tetrahydro-1H-indol-2-yl]methylidene]-N-methyl-2-oxo-1H-indole-5-sulfonamideIC5010.0 [1]
(3Z)-N-Methyl-3-[[3-(3-morpholin-4-ylpropyl)-4,5,6,7-tetrahydro-1H-indol-2-yl]methylidene]-2-oxo-1H-indole-5-sulfonamideIC5030.0 [1]
[5-[3-[2-[3-Carbamoyl-4-(cyclohexylmethoxy)phenyl]propan-2-ylamino]-3-oxopropyl]-2-(trifluoromethylsulfonyloxy)phenyl]phosphonic acidIC50500000.0 [1]
2-[4-[2-Acetamido-3-[[3-carbamoyl-4-(cyclohexylmethoxy)phenyl]methylamino]-3-oxopropyl]-2-phosphonophenoxy]acetic acidIC50500000.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Tyrosine-protein kinase YES Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Dec. 2024, https://www.aatbio.com/data-sets/tyrosine-protein-kinase-yes-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, December 21). Quest Database™ Tyrosine-protein kinase YES Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/tyrosine-protein-kinase-yes-inhibitors-ic50-ki.
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