Tyrosine-protein kinase TIE-2 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	7-[cis-4-(4-Methylpiperazin-1-Yl)cyclohexyl]-5-(4-Phenoxyphenyl)-7h-Pyrrolo[2,3-D]pyrimidin-4-Amine	IC50	250.0 [1], 5850.0 [2]
	1-[4-(4-Aminothieno[2,3-d]pyrimidin-5-yl)phenyl]-3-(3-methylphenyl)urea	IC50	720.0 [1], 724.44 [2], 730.0 [3]
	Staurosporine	IC50	50.9 [1], 52.0 [2], 213.2 [3]
	Sorafenib	IC50	0.83 [1], 6.77 [2], 7.85 [3]
	Cabozantinib	IC50	14.3 [1]
	Nvp-tae 684	IC50	12.0 [1], 1167.0 [2], 12000.0 [3]
	4-Amino-5-(4-Phenoxyphenyl)-7h-Pyrrolo[2,3-D]pyrimidin-7-Yl-Cyclopentane	IC50	1980.0 [1], 9070.0 [2]
	3-((4-Bromo-2,6-difluorobenzyl)oxy)-5-(3-(4-(pyrrolidin-1-yl)butyl)ureido)isothiazole-4-carboxamide	IC50	10.1 [1], 18.0 [2], 620.0 [3]
	3-(1H-Indol-3-yl)-4-(3,4,5-trimethoxyphenyl)pyrrole-2,5-dione	IC50	740.0 [1], 2633.0 [2], 2800.0 [3]
	AMG-Tie2-1	IC50	1.0 [1], 10.0 [2]
	GW768505A (free base)	IC50	2.0 [1], 6.3 [2]
	Thienopyrimidine deriv. 11	IC50	109.65 [1], 110.0 [2]
	3-(2-Aminoquinazolin-6-Yl)-4-Methyl-N-[3-(Trifluoromethyl)phenyl]benzamide	IC50	1.0 [1], 2.0 [2]
	4-Methyl-3-[3-[2-(methylamino)pyrimidin-4-yl]pyridin-2-yl]oxy-N-[2-morpholin-4-yl-5-(trifluoromethyl)phenyl]benzamide	IC50	10.0 [1], 317.0 [2]
	N-[3-Methyl-4-[3-[2-(methylamino)pyrimidin-4-yl]pyridin-2-yl]oxynaphthalen-1-yl]-1H-benzimidazol-2-amine	IC50	2.0 [1]
	N-(4-(3-(2-(Methylamino)pyrimidin-4-yl)pyridin-2-yloxy)naphthalen-1-yl)-1H-benzo[d]imidazol-2-amine	IC50	1.0 [1], 20.0 [2]
	Methyl N-[6-[4-[[2-fluoro-5-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-1H-benzimidazol-2-yl]carbamate	IC50	6.9 [1], 8.7 [2], 10.0 [3]
	Crizotinib	IC50	5.0 [1], 448.0 [2]
	Vandetanib	IC50	567.0 [1], 2500.0 [2]
	Doramapimod	IC50	25.0 [1], 10000.0 [2]
	4-[4-(6-Methoxy-2-naphthalenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridine	IC50	250.0 [1], 20000.0 [2]
	3-(4-{4-Aminofuro[2,3-d]pyrimidin-5-yl}phenyl)-1-[2-fluoro-5-(trifluoromethyl)phenyl]urea	IC50	13.49 [1], 18.3 [2]
	3-(3-Hydroxypropyl)-7-(propan-2-yloxymethyl)-3,13-diazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1(16),2(10),4(9),5,7,11(15),17,19,21-nonaen-14-one	IC50	10000.0 [1]
	1-[2-Fluoro-4-(5-methylpyrrolo[3,2-d]pyrimidin-4-yl)oxyphenyl]-3-[3-(trifluoromethyl)phenyl]urea	IC50	20.0 [1], 100.0 [2]
	Cep-11981	IC50	22.0 [1], 50.0 [2]
	4-(5-(6-Methoxynaphthalen-2-yl)-1-methyl-2-(4-(methylsulfinyl)phenyl)-1H-imidazol-4-yl)pyridine	IC50	60.0 [1]
	Methyl N-[6-[4-[(3-ethylphenyl)carbamoylamino]phenoxy]-1H-benzimidazol-2-yl]carbamate	IC50	18.0 [1], 170.0 [2]
	Methyl N-[6-[4-[(3-bromophenyl)carbamoylamino]phenoxy]-1H-benzimidazol-2-yl]carbamate	IC50	8.0 [1], 13.0 [2]
	Methyl N-[6-[4-[[2-fluoro-5-(trifluoromethyl)phenyl]carbamoylamino]phenyl]sulfanyl-1H-benzimidazol-2-yl]carbamate	IC50	10.0 [1], 76.0 [2]
	Methyl N-(5-(4-((3-chlorophenyl)aminocarbonylamino)phenoxy)-1H-benzimidazol-2-yl)carbamate	IC50	40.0 [1], 50.0 [2]
	N-[6-[4-[[2-Fluoro-5-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-1H-benzimidazol-2-yl]furan-2-carboxamide	IC50	5.2 [1], 6.2 [2]
	Methyl N-[6-[4-[[2-fluoro-5-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-1,3-benzothiazol-2-yl]carbamate	IC50	6.5 [1], 7.2 [2]
	Methyl N-[6-[4-[[2-fluoro-5-(trifluoromethyl)phenyl]carbamoylamino]phenyl]sulfonyl-1H-benzimidazol-2-yl]carbamate	IC50	120.0 [1], 160.0 [2]
	Methyl N-[6-[3-[[2-fluoro-5-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-1H-benzimidazol-2-yl]carbamate	IC50	28.0 [1], 81.0 [2]
	N-[6-[4-[[2-Fluoro-5-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-1H-benzimidazol-2-yl]benzamide	IC50	13.0 [1], 120.0 [2]
	Thienopyrimidine deriv. 20	IC50	208.93 [1], 210.0 [2]
	Thienopyrimidine deriv. 24	IC50	100.0 [1]
	Thienopyrimidine deriv. 26	IC50	169.82 [1], 170.0 [2]
	N-[3-[3-(Dimethylamino)propyl]-5-(trifluoromethyl)phenyl]-4-methyl-3-[(3-pyrimidin-4-ylpyridin-2-yl)amino]benzamide	IC50	1.0 [1]
	5-(4-Phenoxyphenyl)-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine-4-amine	IC50	430.0 [1]
	Pyrazolo[3,4-d]pyrimidine 5	IC50	4680.0 [1]
	Thienopyrimidine deriv. 74	IC50	338.84 [1], 340.0 [2]
	Thienopyrimidine deriv. 10	IC50	1288.25 [1], 1300.0 [2]
	Thienopyrimidine deriv. 12	IC50	890.0 [1], 891.25 [2]
	Thienopyrimidine deriv. 13	IC50	912.01 [1], 920.0 [2]
	Thienopyrimidine deriv. 14	IC50	360.0 [1], 363.08 [2]
	Thienopyrimidine deriv. 15	IC50	1584.89 [1], 1600.0 [2]
	Thienopyrimidine deriv. 17	IC50	398.11 [1], 400.0 [2]
	Thienopyrimidine deriv. 18	IC50	850.0 [1], 851.14 [2]
	Thienopyrimidine deriv. 19	IC50	891.25 [1], 900.0 [2]
	Thienopyrimidine deriv. 21	IC50	1200.0 [1], 1202.26 [2]
	Thienopyrimidine deriv. 23	IC50	1096.48 [1], 1100.0 [2]
	Thienopyrimidine deriv. 27	IC50	360.0 [1], 363.08 [2]
	Thienopyrimidine deriv. 28	IC50	16.98 [1], 17.0 [2]
	Thienopyrimidine deriv. 51	IC50	120.0 [1], 120.23 [2]
	Thienopyrimidine deriv. 52	IC50	467.74 [1], 470.0 [2]
	Thienopyrimidine deriv. 53	IC50	140.0 [1], 141.25 [2]
	Thienopyrimidine deriv. 59	IC50	426.58 [1], 430.0 [2]
	Thienopyrimidine deriv. 60	IC50	630.0 [1], 630.96 [2]
	Thienopyrimidine deriv. 79	IC50	288.4 [1], 290.0 [2]
	Thienopyrimidine deriv. 83	IC50	269.15 [1], 270.0 [2]
	Thienopyrimidine deriv. 84	IC50	257.04 [1], 260.0 [2]
	Thienopyrimidine deriv. 85	IC50	218.78 [1], 220.0 [2]
	Thienopyrimidine deriv. 86	IC50	109.65 [1], 110.0 [2]
	Thienopyrimidine deriv. 87	IC50	190.0 [1], 190.55 [2]
	5,6-Bis(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-amine	IC50	1000.0 [1]
	4-Methyl-3-(3-(pyrimidin-4-yl)pyridin-2-ylamino)-N-(3-(trifluoromethyl)phenyl)benzamide	IC50	3.6 [1], 4.0 [2]
	1-Methyl-1-[[5-[7-[(4-methylpiperazin-1-yl)methyl]-2,4-dihydroindeno[1,2-c]pyrazol-3-yl]thiophen-2-yl]methyl]-3-[3-(trifluoromethyl)phenyl]urea	IC50	259.0 [1]
	N-[2-[3-(Dimethylamino)propyl-methylamino]-5-(trifluoromethyl)phenyl]-2-fluoro-5-[3-[4-(methylamino)-1,3,5-triazin-2-yl]pyridin-2-yl]oxybenzamide	IC50	30.0 [1], 62.0 [2]
	19-Methyl-3,13,19,20-tetrazahexacyclo[14.7.0.02,10.04,9.011,15.017,21]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-14-one	IC50	1300.0 [1], 1357.0 [2]
	N-[4-[3-[2-(Methylamino)pyrimidin-4-yl]pyridin-2-yl]oxynaphthalen-1-yl]-6-(trifluoromethyl)-1H-benzimidazol-2-amine	IC50	27.0 [1]
	N-(4-(3-(2-(Methylamino)pyrimidin-4-yl)pyridin-2-yloxy)naphthalen-1-yl)benzo[d]oxazol-2-amine	IC50	16.0 [1]
	N-(4-(3-(2-(Methylamino)pyrimidin-4-yl)pyridin-2-yloxy)naphthalen-1-yl)benzo[d]thiazol-2-amine	IC50	44.0 [1]
	N-(4-(Benzo[d]thiazol-2-yl)-2-methylphenyl)-6,7-dimethoxyquinazolin-4-amine	IC50	840.0 [1]
	1-(4-(3-(2-(Methylamino)pyrimidin-4-yl)pyridin-2-yloxy)naphthalen-1-yl)-3-phenylurea	IC50	5.0 [1]
	6-(3,4-Dichlorophenyl)-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-amine	IC50	1778.28 [1], 1780.0 [2]
	3-[4-Amino-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-6-yl]benzamide	IC50	537.03 [1], 540.0 [2]
	3-[4-Amino-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-6-yl]-N,N-dimethylbenzamide	IC50	1479.11 [1], 1480.0 [2]
	Furo[2,3-d]pyrimidine deriv. 7d	IC50	300.0 [1], 302.0 [2]
	Furo[2,3-d]pyrimidine deriv. 7e	IC50	600.0 [1], 602.56 [2]
	Furo[2,3-d]pyrimidine deriv. 7f	IC50	190.0 [1], 190.55 [2]
	Furo[2,3-d]pyrimidine deriv. 7h	IC50	501.0 [1], 501.19 [2]
	Furo[2,3-d]pyrimidine deriv. 7i	IC50	851.0 [1], 851.14 [2]
	Furo[2,3-d]pyrimidine deriv. 7j	IC50	28.0 [1], 28.18 [2]
	Furo[2,3-d]pyrimidine deriv. 7l	IC50	21.88 [1], 22.0 [2]
	Furo[2,3-d]pyrimidine deriv. 7m	IC50	58.88 [1], 59.0 [2]
	Furo[2,3-d]pyrimidine deriv. 7n	IC50	275.0 [1], 275.42 [2]
	Pyrazolo[3,4-d]pyrimidine 6	IC50	521.0 [1]
	Pyrazolo[3,4-d]pyrimidine 11	IC50	2450.0 [1]
	Pyrazolo[3,4-d]pyrimidine 15	IC50	1020.0 [1], 1130.0 [2]
	Thienopyrimidine deriv. 9	IC50	1200.0 [1], 1202.26 [2]
	Thienopyrimidine deriv. 16	IC50	1000.0 [1]
	Thienopyrimidine deriv. 22	IC50	128.82 [1], 130.0 [2]
	Thienopyrimidine deriv. 80	IC50	575.44 [1], 580.0 [2]
	Thienopyrimidine deriv. 81	IC50	870.96 [1], 880.0 [2]
	Thienopyrimidine deriv. 82	IC50	250.0 [1], 251.19 [2]
	5-(4-Phenoxyphenyl)-7-tert-butyl-7H-pyrrolo[2,3-d]pyrimidine-4-amine	IC50	2680.0 [1]
	Methyl N-[6-[4-[[2-fluoro-5-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]imidazo[1,2-a]pyridin-2-yl]carbamate	IC50	1.5 [1], 3.4 [2]
	N-[6-[4-[[2-Fluoro-5-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-1H-benzimidazol-2-yl]pyridine-3-carboxamide	IC50	16.0 [1], 20.0 [2]
	N-[6-[4-[[2-Fluoro-5-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-1H-benzimidazol-2-yl]acetamide	IC50	2.6 [1], 3.3 [2]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Tyrosine-protein kinase TIE-2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Feb. 2025, https://www.aatbio.com/data-sets/tyrosine-protein-kinase-tie-2-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 20). Quest Database™ Tyrosine-protein kinase TIE-2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/tyrosine-protein-kinase-tie-2-inhibitors-ic50-ki.
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