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Tyrosine-protein kinase TIE-2 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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7-[cis-4-(4-Methylpiperazin-1-Yl)cyclohexyl]-5-(4-Phenoxyphenyl)-7h-Pyrrolo[2,3-D]pyrimidin-4-AmineIC50250.0 [1], 5850.0 [2]
1-[4-(4-Aminothieno[2,3-d]pyrimidin-5-yl)phenyl]-3-(3-methylphenyl)ureaIC50720.0 [1], 724.44 [2], 730.0 [3]
StaurosporineIC5050.9 [1], 52.0 [2], 213.2 [3]
SorafenibIC500.83 [1], 6.77 [2], 7.85 [3]
CabozantinibIC5014.3 [1]
Nvp-tae 684IC5012.0 [1], 1167.0 [2], 12000.0 [3]
4-Amino-5-(4-Phenoxyphenyl)-7h-Pyrrolo[2,3-D]pyrimidin-7-Yl-CyclopentaneIC501980.0 [1], 9070.0 [2]
3-((4-Bromo-2,6-difluorobenzyl)oxy)-5-(3-(4-(pyrrolidin-1-yl)butyl)ureido)isothiazole-4-carboxamideIC5010.1 [1], 18.0 [2], 620.0 [3]
3-(1H-Indol-3-yl)-4-(3,4,5-trimethoxyphenyl)pyrrole-2,5-dioneIC50740.0 [1], 2633.0 [2], 2800.0 [3]
AMG-Tie2-1IC501.0 [1], 10.0 [2]
GW768505A (free base)IC502.0 [1], 6.3 [2]
Thienopyrimidine deriv. 11IC50109.65 [1], 110.0 [2]
3-(2-Aminoquinazolin-6-Yl)-4-Methyl-N-[3-(Trifluoromethyl)phenyl]benzamideIC501.0 [1], 2.0 [2]
4-Methyl-3-[3-[2-(methylamino)pyrimidin-4-yl]pyridin-2-yl]oxy-N-[2-morpholin-4-yl-5-(trifluoromethyl)phenyl]benzamideIC5010.0 [1], 317.0 [2]
N-[3-Methyl-4-[3-[2-(methylamino)pyrimidin-4-yl]pyridin-2-yl]oxynaphthalen-1-yl]-1H-benzimidazol-2-amineIC502.0 [1]
N-(4-(3-(2-(Methylamino)pyrimidin-4-yl)pyridin-2-yloxy)naphthalen-1-yl)-1H-benzo[d]imidazol-2-amineIC501.0 [1], 20.0 [2]
Methyl N-[6-[4-[[2-fluoro-5-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-1H-benzimidazol-2-yl]carbamateIC506.9 [1], 8.7 [2], 10.0 [3]
CrizotinibIC505.0 [1], 448.0 [2]
VandetanibIC50567.0 [1], 2500.0 [2]
DoramapimodIC5025.0 [1], 10000.0 [2]
4-[4-(6-Methoxy-2-naphthalenyl)-2-(4-methylsulfinylphenyl)-1H-imidazol-5-yl]pyridineIC50250.0 [1], 20000.0 [2]
3-(4-{4-Aminofuro[2,3-d]pyrimidin-5-yl}phenyl)-1-[2-fluoro-5-(trifluoromethyl)phenyl]ureaIC5013.49 [1], 18.3 [2]
3-(3-Hydroxypropyl)-7-(propan-2-yloxymethyl)-3,13-diazahexacyclo[14.7.0.02,10.04,9.011,15.017,22]tricosa-1(16),2(10),4(9),5,7,11(15),17,19,21-nonaen-14-oneIC5010000.0 [1]
1-[2-Fluoro-4-(5-methylpyrrolo[3,2-d]pyrimidin-4-yl)oxyphenyl]-3-[3-(trifluoromethyl)phenyl]ureaIC5020.0 [1], 100.0 [2]
Cep-11981IC5022.0 [1], 50.0 [2]
4-(5-(6-Methoxynaphthalen-2-yl)-1-methyl-2-(4-(methylsulfinyl)phenyl)-1H-imidazol-4-yl)pyridineIC5060.0 [1]
Methyl N-[6-[4-[(3-ethylphenyl)carbamoylamino]phenoxy]-1H-benzimidazol-2-yl]carbamateIC5018.0 [1], 170.0 [2]
Methyl N-[6-[4-[(3-bromophenyl)carbamoylamino]phenoxy]-1H-benzimidazol-2-yl]carbamateIC508.0 [1], 13.0 [2]
Methyl N-[6-[4-[[2-fluoro-5-(trifluoromethyl)phenyl]carbamoylamino]phenyl]sulfanyl-1H-benzimidazol-2-yl]carbamateIC5010.0 [1], 76.0 [2]
Methyl N-(5-(4-((3-chlorophenyl)aminocarbonylamino)phenoxy)-1H-benzimidazol-2-yl)carbamateIC5040.0 [1], 50.0 [2]
N-[6-[4-[[2-Fluoro-5-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-1H-benzimidazol-2-yl]furan-2-carboxamideIC505.2 [1], 6.2 [2]
Methyl N-[6-[4-[[2-fluoro-5-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-1,3-benzothiazol-2-yl]carbamateIC506.5 [1], 7.2 [2]
Methyl N-[6-[4-[[2-fluoro-5-(trifluoromethyl)phenyl]carbamoylamino]phenyl]sulfonyl-1H-benzimidazol-2-yl]carbamateIC50120.0 [1], 160.0 [2]
Methyl N-[6-[3-[[2-fluoro-5-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-1H-benzimidazol-2-yl]carbamateIC5028.0 [1], 81.0 [2]
N-[6-[4-[[2-Fluoro-5-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-1H-benzimidazol-2-yl]benzamideIC5013.0 [1], 120.0 [2]
Thienopyrimidine deriv. 20IC50208.93 [1], 210.0 [2]
Thienopyrimidine deriv. 24IC50100.0 [1]
Thienopyrimidine deriv. 26IC50169.82 [1], 170.0 [2]
N-[3-[3-(Dimethylamino)propyl]-5-(trifluoromethyl)phenyl]-4-methyl-3-[(3-pyrimidin-4-ylpyridin-2-yl)amino]benzamideIC501.0 [1]
5-(4-Phenoxyphenyl)-7-isopropyl-7H-pyrrolo[2,3-d]pyrimidine-4-amineIC50430.0 [1]
Pyrazolo[3,4-d]pyrimidine 5IC504680.0 [1]
Thienopyrimidine deriv. 74IC50338.84 [1], 340.0 [2]
Thienopyrimidine deriv. 10IC501288.25 [1], 1300.0 [2]
Thienopyrimidine deriv. 12IC50890.0 [1], 891.25 [2]
Thienopyrimidine deriv. 13IC50912.01 [1], 920.0 [2]
Thienopyrimidine deriv. 14IC50360.0 [1], 363.08 [2]
Thienopyrimidine deriv. 15IC501584.89 [1], 1600.0 [2]
Thienopyrimidine deriv. 17IC50398.11 [1], 400.0 [2]
Thienopyrimidine deriv. 18IC50850.0 [1], 851.14 [2]
Thienopyrimidine deriv. 19IC50891.25 [1], 900.0 [2]
Thienopyrimidine deriv. 21IC501200.0 [1], 1202.26 [2]
Thienopyrimidine deriv. 23IC501096.48 [1], 1100.0 [2]
Thienopyrimidine deriv. 27IC50360.0 [1], 363.08 [2]
Thienopyrimidine deriv. 28IC5016.98 [1], 17.0 [2]
Thienopyrimidine deriv. 51IC50120.0 [1], 120.23 [2]
Thienopyrimidine deriv. 52IC50467.74 [1], 470.0 [2]
Thienopyrimidine deriv. 53IC50140.0 [1], 141.25 [2]
Thienopyrimidine deriv. 59IC50426.58 [1], 430.0 [2]
Thienopyrimidine deriv. 60IC50630.0 [1], 630.96 [2]
Thienopyrimidine deriv. 79IC50288.4 [1], 290.0 [2]
Thienopyrimidine deriv. 83IC50269.15 [1], 270.0 [2]
Thienopyrimidine deriv. 84IC50257.04 [1], 260.0 [2]
Thienopyrimidine deriv. 85IC50218.78 [1], 220.0 [2]
Thienopyrimidine deriv. 86IC50109.65 [1], 110.0 [2]
Thienopyrimidine deriv. 87IC50190.0 [1], 190.55 [2]
5,6-Bis(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-amineIC501000.0 [1]
4-Methyl-3-(3-(pyrimidin-4-yl)pyridin-2-ylamino)-N-(3-(trifluoromethyl)phenyl)benzamideIC503.6 [1], 4.0 [2]
1-Methyl-1-[[5-[7-[(4-methylpiperazin-1-yl)methyl]-2,4-dihydroindeno[1,2-c]pyrazol-3-yl]thiophen-2-yl]methyl]-3-[3-(trifluoromethyl)phenyl]ureaIC50259.0 [1]
N-[2-[3-(Dimethylamino)propyl-methylamino]-5-(trifluoromethyl)phenyl]-2-fluoro-5-[3-[4-(methylamino)-1,3,5-triazin-2-yl]pyridin-2-yl]oxybenzamideIC5030.0 [1], 62.0 [2]
19-Methyl-3,13,19,20-tetrazahexacyclo[14.7.0.02,10.04,9.011,15.017,21]tricosa-1(16),2(10),4,6,8,11(15),17,20-octaen-14-oneIC501300.0 [1], 1357.0 [2]
N-[4-[3-[2-(Methylamino)pyrimidin-4-yl]pyridin-2-yl]oxynaphthalen-1-yl]-6-(trifluoromethyl)-1H-benzimidazol-2-amineIC5027.0 [1]
N-(4-(3-(2-(Methylamino)pyrimidin-4-yl)pyridin-2-yloxy)naphthalen-1-yl)benzo[d]oxazol-2-amineIC5016.0 [1]
N-(4-(3-(2-(Methylamino)pyrimidin-4-yl)pyridin-2-yloxy)naphthalen-1-yl)benzo[d]thiazol-2-amineIC5044.0 [1]
N-(4-(Benzo[d]thiazol-2-yl)-2-methylphenyl)-6,7-dimethoxyquinazolin-4-amineIC50840.0 [1]
1-(4-(3-(2-(Methylamino)pyrimidin-4-yl)pyridin-2-yloxy)naphthalen-1-yl)-3-phenylureaIC505.0 [1]
6-(3,4-Dichlorophenyl)-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-4-amineIC501778.28 [1], 1780.0 [2]
3-[4-Amino-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-6-yl]benzamideIC50537.03 [1], 540.0 [2]
3-[4-Amino-5-(4-methoxyphenyl)furo[2,3-d]pyrimidin-6-yl]-N,N-dimethylbenzamideIC501479.11 [1], 1480.0 [2]
Furo[2,3-d]pyrimidine deriv. 7dIC50300.0 [1], 302.0 [2]
Furo[2,3-d]pyrimidine deriv. 7eIC50600.0 [1], 602.56 [2]
Furo[2,3-d]pyrimidine deriv. 7fIC50190.0 [1], 190.55 [2]
Furo[2,3-d]pyrimidine deriv. 7hIC50501.0 [1], 501.19 [2]
Furo[2,3-d]pyrimidine deriv. 7iIC50851.0 [1], 851.14 [2]
Furo[2,3-d]pyrimidine deriv. 7jIC5028.0 [1], 28.18 [2]
Furo[2,3-d]pyrimidine deriv. 7lIC5021.88 [1], 22.0 [2]
Furo[2,3-d]pyrimidine deriv. 7mIC5058.88 [1], 59.0 [2]
Furo[2,3-d]pyrimidine deriv. 7nIC50275.0 [1], 275.42 [2]
Pyrazolo[3,4-d]pyrimidine 6IC50521.0 [1]
Pyrazolo[3,4-d]pyrimidine 11IC502450.0 [1]
Pyrazolo[3,4-d]pyrimidine 15IC501020.0 [1], 1130.0 [2]
Thienopyrimidine deriv. 9IC501200.0 [1], 1202.26 [2]
Thienopyrimidine deriv. 16IC501000.0 [1]
Thienopyrimidine deriv. 22IC50128.82 [1], 130.0 [2]
Thienopyrimidine deriv. 80IC50575.44 [1], 580.0 [2]
Thienopyrimidine deriv. 81IC50870.96 [1], 880.0 [2]
Thienopyrimidine deriv. 82IC50250.0 [1], 251.19 [2]
5-(4-Phenoxyphenyl)-7-tert-butyl-7H-pyrrolo[2,3-d]pyrimidine-4-amineIC502680.0 [1]
Methyl N-[6-[4-[[2-fluoro-5-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]imidazo[1,2-a]pyridin-2-yl]carbamateIC501.5 [1], 3.4 [2]
N-[6-[4-[[2-Fluoro-5-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-1H-benzimidazol-2-yl]pyridine-3-carboxamideIC5016.0 [1], 20.0 [2]
N-[6-[4-[[2-Fluoro-5-(trifluoromethyl)phenyl]carbamoylamino]phenoxy]-1H-benzimidazol-2-yl]acetamideIC502.6 [1], 3.3 [2]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Tyrosine-protein kinase TIE-2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Dec. 2024, https://www.aatbio.com/data-sets/tyrosine-protein-kinase-tie-2-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, December 21). Quest Database™ Tyrosine-protein kinase TIE-2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/tyrosine-protein-kinase-tie-2-inhibitors-ic50-ki.
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