![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_01384179eb1c1c1ef001bfbf31bfa500.svg) | Ibrutinib | IC50 | 0.5 [1], 1.86 [2], 7.0 [3], 77.8 [4] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_07d2d0af7904836ad3cf5ea2273c6a53.svg) | 1-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one | IC50 | 592.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_07d2d0af7904836ad3cf5ea2273c6a53.svg) | 1-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one | Ki | 679.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_7c27b0bf2a5894f5ab89b58945aa36dc.svg) | 4-Tert-butyl-N-[2-methyl-3-[6-[4-(morpholine-4-carbonyl)anilino]-7H-purin-2-yl]phenyl]benzamide | IC50 | 14.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_9dd6da7cb57ea869429d2bb32c1c121c.svg) | 2-PropenaMide, N-[cis-4-[4-aMino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyriMidin-1-yl]cyclohexyl]- | IC50 | 108.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_1d5eba4b4bb57896dda18b1604bab021.svg) | Staurosporine | IC50 | 128000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_986db0437f20070dfb14143a9f1b018d.svg) | Dasatinib | IC50 | 297.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_b5f9e60dc2b2b7e76e07307c1d8f7888.svg) | Bosutinib | IC50 | 282.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_4b5f79d180276ffc914d389afc8e08fb.svg) | Spebrutinib | IC50 | 6.2 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_168de960f77893e4878bf3b04af895fb.svg) | CID 46908026 | IC50 | 64.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_0a82b2fcefb5f2b85b04ee97b06eb370.svg) | N-[2-[[6-(2,6-Dichloro-3,5-dimethoxyphenyl)quinazolin-2-yl]amino]-3-methylphenyl]prop-2-enamide | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_9041d8083a937939ecc814af0ee443d4.svg) | Evobrutinib | IC50 | 37.9 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_35d494726d3aaaac988a7ed448c35386.svg) | Bms-509744 | IC50 | 17000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_2ad93c852946b294d6418c3b56ad8e52.svg) | Bms-986142 | IC50 | 10.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_9eb0744bcb149f9ec86c69bd7bd98df5.svg) | N-[1-(3-Amino-3-oxopropyl)-5-[benzoyl(methyl)amino]benzimidazol-2-yl]-4-cyanobenzamide | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_c33074e1aa4339917412ec783090268d.svg) | 2-Methyl-N-[2-[3-[[2-(prop-2-enoylamino)acetyl]amino]anilino]pyrimidin-5-yl]-5-[[3-(trifluoromethyl)benzoyl]amino]benzamide | IC50 | 6.3 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_07a9a7dadcb6403aa1be2fdac16a78df.svg) | JAK3 covalent inhibitor-1 | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_db1cea5586701bc53652f3f79d33c46d.svg) | 2-Methyl-N-[2-[3-(prop-2-enoylamino)anilino]pyrimidin-5-yl]-5-[[3-(trifluoromethyl)benzoyl]amino]benzamide | IC50 | 8.2 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_1b3ec3fc1a4b41d7243a93989fe970b4.svg) | (S)-Ibrutinib | IC50 | 78.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_7f0ba22193de24e94733b567461df306.svg) | N-[1-(3-Amino-3-oxopropyl)-5-[benzoyl(methyl)amino]benzimidazol-2-yl]-4-chlorobenzamide | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_a7ee75d4a7ce2e8d7ffa73cb444c324f.svg) | 5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-tert-butylpyridine-3-sulfonamide | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_51153882d3ab9f3566d96aeaf5c3eeab.svg) | 6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-one | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_9029c6353766e7a2f5eb9600298a7538.svg) | 4-[[4-Benzyl-6-[(6-ethyl-1,3-benzothiazol-2-yl)amino]pyrimidin-2-yl]amino]cyclohexan-1-ol | IC50 | 251.19 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_9c16bdd1e37ef747e5b1a806c82a0b05.svg) | 2,3-Dimethyl-4-[2-methyl-3-(prop-2-enoylamino)phenyl]-1H-indole-7-carboxamide | IC50 | 6.4 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_73a64410e42f17bda47f701b7ae2ee93.svg) | 4-[3-(Ethenylsulfonylamino)-2-methylphenyl]-2,3-dimethyl-1H-indole-7-carboxamide | IC50 | 0.9 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_43772b87c1bd7b474d957071c0da04be.svg) | 4-[3-[[4-(Dimethylamino)benzoyl]amino]-2-fluorophenyl]-7-(4-methylpiperazine-1-carbonyl)-9H-carbazole-1-carboxamide | IC50 | 41.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_ffe03ecf7e6e5217b6f4d31768d4e4fa.svg) | N-[(3R,4S)-4-[[5-[(2,6-Difluoro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-yl]amino]oxolan-3-yl]prop-2-enamide | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_fefa37c9055748854606b692d516ebaa.svg) | N-[2-[[5-[(2,6-Difluoro-3,5-dimethoxyphenyl)methoxy]pyrimidin-2-yl]amino]-3-methylphenyl]prop-2-enamide | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_2e4ac5235e28314a028e444234d1ea92.svg) | N-[3-[3-[(2-Chloro-6-fluorophenyl)methylamino]-1H-1,2,4-triazol-5-yl]phenyl]prop-2-enamide | IC50 | 306.45 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_cf61d41cb0341078e0096c6957f8977e.svg) | 7-(2-Hydroxypropan-2-yl)-4-[2-methyl-3-(prop-2-enoylamino)phenyl]-6,7,8,9-tetrahydro-5H-carbazole-1-carboxamide | IC50 | 2.3 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_6f2486997ebe727ed45fc8b2edf10dfa.svg) | 5-(Difluoromethyl)-N-[5-[[[(2S)-3,3-dimethylbutan-2-yl]amino]methyl]-1-(6-prop-2-enoyl-6-azaspiro[3.4]octan-2-yl)benzimidazol-2-yl]thiophene-2-carboxamide | IC50 | 1.78 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_0e7604735d19501035f78d1549deb551.svg) | 5-(Difluoromethyl)-N-[5-(morpholin-4-ylmethyl)-1-(6-prop-2-enoyl-6-azaspiro[3.4]octan-2-yl)benzimidazol-2-yl]thiophene-2-carboxamide | IC50 | 2.27 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_320226a0e19ff120b66802dbc40d5957.svg) | 5-(2-Oxo-1H-pyridin-4-yl)-N-[1-(6-prop-2-enoyl-6-azaspiro[3.4]octan-2-yl)benzimidazol-2-yl]thiophene-2-carboxamide | IC50 | 0.09 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_d9470ec7dd931e4effb445bf34af2675.svg) | 4-Cyano-N-[5-[[[(2S)-3,3-dimethylbutan-2-yl]amino]methyl]-1-(6-prop-2-enoyl-6-azaspiro[3.4]octan-2-yl)benzimidazol-2-yl]benzamide | IC50 | 4.32 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_ff9b827cef31f07b9e4aeee86fa516eb.svg) | N-[5-[[[(2S)-3,3-Dimethylbutan-2-yl]amino]methyl]-1-(6-prop-2-enoyl-6-azaspiro[3.4]octan-2-yl)benzimidazol-2-yl]-5-(1,3-oxazol-5-yl)thiophene-2-carboxamide | IC50 | 1.65 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_c6777c3e243b4410ecaf334a72818d7c.svg) | 5-(2-Aminopyridin-4-yl)-N-[1-(6-prop-2-enoyl-6-azaspiro[3.4]octan-2-yl)benzimidazol-2-yl]thiophene-2-carboxamide | IC50 | 0.2 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_b19444c6b09f53993e5afa81c293ab93.svg) | N-[5-(Methylamino)-1-(6-prop-2-enoyl-6-azaspiro[3.4]octan-2-yl)benzimidazol-2-yl]-5-(1,3-oxazol-5-yl)thiophene-2-carboxamide | IC50 | 0.67 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_02bd6e7fd2c08296d4582ac39a4d6369.svg) | 5-[2-(Methylamino)pyridin-4-yl]-N-[1-(6-prop-2-enoyl-6-azaspiro[3.4]octan-2-yl)benzimidazol-2-yl]thiophene-2-carboxamide | IC50 | 0.16 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_19958f122f8609bb3d7194509dbd406b.svg) | N-[5-[[[(2S)-3,3-Dimethylbutan-2-yl]amino]methyl]-1-(6-prop-2-enoyl-6-azaspiro[3.4]octan-2-yl)benzimidazol-2-yl]-1,3-thiazole-5-carboxamide | IC50 | 4.5 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_fd2a250c5eccc1657ae0ce665fa9c3b7.svg) | N-[5-[[(4-Hydroxycyclohexyl)amino]methyl]-1-(6-prop-2-enoyl-6-azaspiro[3.4]octan-2-yl)benzimidazol-2-yl]-5-(1,3-oxazol-5-yl)thiophene-2-carboxamide | IC50 | 2.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_4e3e3961449398023936079c34c05872.svg) | 5-(Difluoromethyl)-N-[5-[[(3-hydroxy-2,2-dimethylpropyl)amino]methyl]-1-(6-prop-2-enoyl-6-azaspiro[3.4]octan-2-yl)benzimidazol-2-yl]thiophene-2-carboxamide | IC50 | 3.13 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_a94837bb405e568891bea0667cf623a5.svg) | N-[5-[[[(2S)-3,3-Dimethylbutan-2-yl]amino]methyl]-1-(6-prop-2-enoyl-6-azaspiro[3.4]octan-2-yl)benzimidazol-2-yl]-1,2-thiazole-5-carboxamide | IC50 | 3.16 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_1af8e1c8903210113a8d02fec78e5dc0.svg) | N-[5-[[(3-Hydroxy-2,2-dimethylpropyl)amino]methyl]-1-(6-prop-2-enoyl-6-azaspiro[3.4]octan-2-yl)benzimidazol-2-yl]-5-(1,3-oxazol-5-yl)thiophene-2-carboxamide | IC50 | 1.96 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_aba593a49a4f958d688d9157af4bb023.svg) | 5-(1,1-Difluoroethyl)-N-[1-(6-prop-2-enoyl-6-azaspiro[3.4]octan-2-yl)benzimidazol-2-yl]thiophene-2-carboxamide | IC50 | 0.98 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_797c5aba61a426a202c541001e83c88f.svg) | 5-(1,3-Oxazol-5-yl)-N-[1-(6-prop-2-enoyl-6-azaspiro[3.4]octan-2-yl)benzimidazol-2-yl]thiophene-2-carboxamide | IC50 | 0.62 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_bfec0ebb9c48ff72a8fa3f10a1cb698c.svg) | 5-(2-Aminopyrimidin-4-yl)-N-[1-(6-prop-2-enoyl-6-azaspiro[3.4]octan-2-yl)benzimidazol-2-yl]thiophene-2-carboxamide | IC50 | 0.1 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_359ad9c09c05fb9a518358760f0b52a7.svg) | N-[5-Fluoro-1-(6-prop-2-enoyl-6-azaspiro[3.4]octan-2-yl)benzimidazol-2-yl]-5-(1,3-oxazol-5-yl)thiophene-2-carboxamide | IC50 | 0.74 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_56ac0196983811b2932cee2250eb7cce.svg) | 5-(2-Methylpyrimidin-4-yl)-N-[1-(6-prop-2-enoyl-6-azaspiro[3.4]octan-2-yl)benzimidazol-2-yl]thiophene-2-carboxamide | IC50 | 0.11 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_15b2f8cea2dcdba2c171894aaa9d8511.svg) | 4-[8-Amino-3-[(3R)-1-(2-methylpropanoyl)piperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-3-fluoro-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide | IC50 | 378.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_748741d33d31d55972c10ed41fd023a8.svg) | 4-[8-Amino-3-[(2R)-4-(oxan-4-yl)morpholin-2-yl]imidazo[1,5-a]pyrazin-1-yl]-3-fluoro-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide | IC50 | 191.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_323e92cefd36d9d14a85ead4b64a3427.svg) | 4-[8-Amino-3-[(3R)-1-(oxan-4-yl)piperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-3-fluoro-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide | IC50 | 170.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_14d6c4d8b5472476bb7332aacbc27d0e.svg) | 4-[8-Amino-3-[(2R)-4-(2-methylpropanoyl)morpholin-2-yl]imidazo[1,5-a]pyrazin-1-yl]-3-fluoro-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide | IC50 | 428.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_c009120ca19478ba69924ce16dc2791c.svg) | 5-(1,3-Benzodioxol-5-yl)-7-[[(2R)-1-ethenylsulfonylpyrrolidin-2-yl]methyl]pyrrolo[2,3-d]pyrimidin-4-amine | IC50 | 114.8 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_f053f9f02f64e76a6508e1ef5ddb05bf.svg) | 7-(2-Hydroxypropan-2-yl)-4-[2-methyl-3-(4-oxoquinazolin-3-yl)phenyl]-6,7,8,9-tetrahydro-5H-carbazole-1-carboxamide | IC50 | 56.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_588e41573665092ceda3c99d88c95741.svg) | N-[(7S)-4-Amino-6-methylidene-5-(4-phenoxyphenyl)-7,8-dihydropyrimido[5,4-b]pyrrolizin-7-yl]prop-2-enamide | IC50 | 1.4 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_c4a4374d204bc28db1123832ff1bdd33.svg) | [(1S)-6-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]cyanamide | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_9195481149e28f3c059402c50df16cb7.svg) | [(1S)-6-[5-[3-(Hydroxymethyl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-2,3-dihydro-1H-inden-1-yl]cyanamide | IC50 | 8960.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_76e6530bf5b662857eed26d10b16f7f9.svg) | N-[1-(3-Amino-3-oxopropyl)-5-[benzoyl(ethyl)amino]benzimidazol-2-yl]-4-cyanobenzamide | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_dfc8cb27b97cd1c59333344c51046674.svg) | N-[1-(3-Aminopropyl)-5-[cyclohexanecarbonyl(methyl)amino]benzimidazol-2-yl]thiophene-2-carboxamide | IC50 | 22000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_d1a0fb35aa814f830b8fd1ce71ce1892.svg) | 4-(2-Fluorophenyl)-7-(4-methylpiperazine-1-carbonyl)-9H-carbazole-1-carboxamide | IC50 | 116.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_fba488180963c8946f3c38122b79401f.svg) | N-[6-Fluoro-2-methyl-3-[5-[(5-methyl-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazin-2-yl)amino]-6-oxo-1H-pyridazin-3-yl]phenyl]-1-benzothiophene-2-carboxamide | IC50 | 230.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_42984ff3447d9d0a9a53124388f0cbfc.svg) | 4-[[(3S,4R)-1-(5-Cyanopyridin-2-yl)-3-fluoropiperidin-4-yl]amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxamide | IC50 | 1000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_4fc7354460a303e4a2e12d22392b0f6f.svg) | 4-(3-Acetamido-2-methylphenyl)-7-(4-methylpiperazine-1-carbonyl)-9H-carbazole-1-carboxamide | IC50 | 162.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_f53592583ff8163cade38a09145190a2.svg) | 4-[8-Amino-3-[(3R)-1-(2-methoxyacetyl)piperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-3-fluoro-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide | IC50 | 63.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_61a22fc74231ad66bd487ef394e94197.svg) | 4-[8-Amino-3-[(2R)-4-(2-methoxyacetyl)morpholin-2-yl]imidazo[1,5-a]pyrazin-1-yl]-3-fluoro-N-[4-(trifluoromethyl)pyridin-2-yl]benzamide | IC50 | 232.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_5711133ca718b66fa0cee0f039b3b462.svg) | 4-Amino-8-(5-Methyl-1h-Indazol-6-Yl)cinnoline-3-Carboxamide | IC50 | 57.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_09b84360be29f45c9cbbd0c0bcab531c.svg) | 4-Amino-8-(6-methyl-1H-indazol-5-yl)cinnoline-3-carboxamide | IC50 | 57.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-tec_84415c6c1b9bdd7a85191a4b21ec4622.svg) | 6-Amino-9-[(3R)-1-but-2-ynoylpiperidin-3-yl]-7-(4-phenoxyphenyl)purin-8-one | IC50 | 5.3 [1] |