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Tyrosine-protein kinase SRC Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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▼
BosutinibIC503.8 [1]
StaurosporineIC509.7 [1]
DasatinibIC500.6 [1]
1-Tert-butyl-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC50500.0 [1]
1-Tert-butyl-3-(4-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amineKi500.0 [1]
4-[(2,4-Dichlorophenyl)amino]-6,7-dimethoxy-3-quinolinecarbonitrileIC5030.0 [1]
ImatinibIC5025000.0 [1], 100000.0 [2]
ImatinibKi31000.0 [1]
SaracatinibIC502.7 [1]
N-Benzyl-1-(2-chloro-2-phenylethyl)-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidin-4-amineKi3700.0 [1]
(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-Amino-3-(4-phosphonooxyphenyl)propanoyl]amino]-4-carboxybutanoyl]amino]-4-carboxybutanoyl]amino]-3-methylpentanoic acidIC506500.0 [1]
7-(2,6-Dichlorophenyl)-5-methyl-N-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1,2,4-benzotriazin-3-amineIC509.4 [1], 14.0 [2]
7-(2,6-Dichlorophenyl)-5-methyl-N-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1,2,4-benzotriazin-3-amineKi11.0 [1], 28.1 [2]
7-(2,6-Dimethylphenyl)-5-methyl-N-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1,2,4-benzotriazin-3-amineIC506.4 [1], 6.8 [2], 7.0 [3]
7-(2,6-Dimethylphenyl)-5-methyl-N-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1,2,4-benzotriazin-3-amineKi7.0 [1]
1-(2-Chloro-2-phenylethyl)-6-(methylthio)-N-phenethyl-1H-pyrazolo[3,4-d]pyrimidin-4-amineKi700.0 [1]
(4S)-4-[[(2S)-2-[[(2S)-2-Acetamido-3-(4-phosphonooxyphenyl)propanoyl]amino]-4-carboxybutanoyl]amino]-5-[[(2S,3S)-1-amino-3-methyl-1-oxopentan-2-yl]amino]-5-oxopentanoic acidIC501.0 [1], 150.0 [2], 6000.0 [3]
1-(2-Chloro-2-phenylethyl)-N-(3-chlorophenyl)-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidin-4-amineKi600.0 [1], 700.0 [2], 720.0 [3], 794.33 [4]
N-Acetyl-O-phosphono-Tyr-Glu-Glu-Ile-GluIC50500.0 [1], 1400.0 [2], 2000.0 [3], 2800.0 [4]
7-(2-Chlorophenyl)-5-methyl-N-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1,2,4-benzotriazin-3-amineIC5034.8 [1], 35.0 [2]
7-(2-Chlorophenyl)-5-methyl-N-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1,2,4-benzotriazin-3-amineKi35.0 [1]
6,7-Dimethoxy-4-[(3,4,5-trimethoxyphenyl)amino]quinoline-3-carbonitrileIC5034.0 [1], 35.0 [2], 108.0 [3], 190.0 [4], 650.0 [5]
Phenyl dihydrogen phosphateIC50300000.0 [1], 2500000.0 [2], 3500000.0 [3], 5000000.0 [4]
N-Benzyl-1-(2-chloro-2-phenylethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amineKi3000.0 [1], 3162.28 [2]
4-Chloro-3-(5-methyl-3-(4-(2-(pyrrolidin-1-yl)ethoxy)phenylamino)benzo[e][1,2,4]triazin-7-yl)phenolIC501.6 [1], 1.8 [2]
4-Chloro-3-(5-methyl-3-(4-(2-(pyrrolidin-1-yl)ethoxy)phenylamino)benzo[e][1,2,4]triazin-7-yl)phenolKi1.3 [1]
N-Acetyl-N-[1-(1,1'-biphenyl-4-ylmethyl)-2-oxoazepan-3-YL]-O-phosphonotyrosinamideIC509.0 [1], 9000.0 [2]
3-[2-(2-Cyclopentyl-6-{[4-(dimethylphosphoryl)phenyl]amino}-9H-purin-9-YL)ethyl]phenolIC500.45 [1], 0.9 [2]
1-(2-Chloro-2-phenylethyl)-6-methylsulfanyl-N-phenylpyrazolo[3,4-d]pyrimidin-4-amineKi1200.0 [1], 1600.0 [2]
1-(2-Chloro-2-phenylethyl)-6-(2-morpholin-4-ylethylsulfanyl)-N-phenylpyrazolo[3,4-d]pyrimidin-4-amineKi210.0 [1], 240.0 [2]
2-((4-(4-Amino-5-(3-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenethyl)(methyl)amino)ethanolIC5031.62 [1], 160.0 [2], 200.0 [3]
2-Formylphenyl dihydrogen phosphateIC5080000.0 [1], 200000.0 [2], 300000.0 [3]
2-Formyl-6-methoxyphenyl dihydrogen phosphateIC5095000.0 [1], 900000.0 [2]
N-(2-Chloro-5-methoxyphenyl)-7-(3-morpholin-4-ylpropoxy)-5-(oxan-4-yloxy)quinazolin-4-amineIC5010.0 [1], 20.0 [2], 200.0 [3]
N-(2-Chloro-5-methoxyphenyl)-7-(3-morpholin-4-ylpropoxy)-5-propan-2-yloxyquinazolin-4-amineIC5040.0 [1], 150.0 [2], 180.0 [3]
N-(4-(2-(Diethylamino)ethoxy)phenyl)-7-(2,6-dimethylphenyl)-5-methylbenzo[e][1,2,4]triazin-3-amineIC509.67 [1], 10.0 [2]
N-(3-(2-(Diethylamino)ethoxy)phenyl)-7-(2,6-dimethylphenyl)-5-methylbenzo[e][1,2,4]triazin-3-amineIC5010.0 [1], 10.2 [2]
5-Methyl-7-phenyl-N-(4-(2-(pyrrolidin-1-yl)ethoxy)phenyl)benzo[e][1,2,4]triazin-3-amineIC50340.0 [1], 341.0 [2]
7-Phenylaminothieno[3,2-b]pyridine-6-carbonitrile 2IC5034.0 [1], 1200.0 [2]
7-Phenylaminothieno[3,2-b]pyridine-6-carbonitrile 3IC5013.0 [1], 720.0 [2]
7-Phenylaminothieno[3,2-b]pyridine-6-carbonitrile 4IC5050.0 [1], 4000.0 [2]
7-Phenylaminothieno[3,2-b]pyridine-6-carbonitrile 34IC507.2 [1], 430.0 [2]
7-Phenylaminothieno[3,2-b]pyridine-6-carbonitrile 42IC5025.0 [1], 2400.0 [2]
7-Thienyl-3-quinolinecarbonitrile 14IC503.8 [1], 64.0 [2], 69.0 [3]
4-(4-Chloro-5-methoxy-2-methylanilino)-7,8-dimethoxybenzo[g]quinoline-3-carbonitrileIC501.4 [1], 210.0 [2]
T338C Src-IN-1IC50150.0 [1], 207.0 [2], 424.0 [3], 5000.0 [4]
T338C Src-IN-2IC5029.0 [1], 67.0 [2], 338.0 [3], 5000.0 [4]
N-[3-(4-Amino-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-3-yl)phenyl]ethenesulfonamideIC5063.0 [1], 111.0 [2], 131.0 [3], 1004.0 [4]
GenisteinIC5010000.0 [1], 75000.0 [2], 100000.0 [3]
Su6656IC5073.0 [1], 280.0 [2], 688000.0 [3]
1-(Tert-Butyl)-3-(p-tolyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC505.0 [1], 17.0 [2], 170.0 [3]
N-Benzyl-2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)acetamideIC5020.0 [1], 20000.0 [2], 40000.0 [3]
Unii-NA856793UTIC5050000.0 [1]
7-[cis-4-(4-Methylpiperazin-1-Yl)cyclohexyl]-5-(4-Phenoxyphenyl)-7h-Pyrrolo[2,3-D]pyrimidin-4-AmineIC5042.0 [1], 1190.0 [2]
Phenylmalonic acidIC50200000.0 [1], 2500000.0 [2], 2530000000.0 [3]
1-Cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC5014.0 [1]
CID 11973736IC5010000.0 [1]
Ac-pTyr-Glu-Glu-IleIC509.0 [1], 150.0 [2], 6500.0 [3]
2-Aminopyrido[2,3-d]pyrimidin-7(8H)-one 38IC5016.0 [1], 17.0 [2], 20.0 [3]
N-Butyl-1-(2-chloro-2-phenyl-ethyl)-6-methylsulfanyl-pyrazolo[3,4-d]pyrimidin-4-amineKi1700.0 [1], 1995.26 [2]
N-Butyl-1-(2-chloro-2-phenyl-ethyl)-6-ethylsulfanyl-pyrazolo[3,4-d]pyrimidin-4-amineKi600.0 [1], 630.96 [2]
1-[2-Amino-6-(2,6-dichlorophenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylureaIC50220.0 [1]
1-(2-Chloro-2-phenyl-ethyl)-6-methylsulfanyl-N-propyl-pyrazolo[3,4-d]pyrimidin-4-amineKi794.33 [1], 2900.0 [2]
1-(2-Chloro-2-phenylethyl)-6-(methylthio)-4-(piperidin-1-yl)-1H-pyrazolo[3,4-d]pyrimidineKi2400.0 [1], 2511.89 [2]
4-(1-(2-Chloro-2-phenylethyl)-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidin-4-yl)morpholineKi6309.57 [1], 6500.0 [2]
Bcr-abl Inhibitor IIKi354.0 [1], 550.0 [2]
1-(2-Chloro-2-phenylethyl)-N,N-diethyl-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidin-4-amineKi500.0 [1], 501.19 [2]
N-(2-Fluorobenzyl)-1-(2-chloro-2-phenylethyl)-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidin-4-amineKi21000.0 [1], 21200.0 [2]
N-(3-Chlorophenyl)-1-(2-chloro-2-phenylethyl)-6-(2-morpholin-4-ylethylsulfanyl)pyrazolo[3,4-d]pyrimidin-4-amineKi190.0 [1], 290.0 [2]
2-(4-(Phenethylamino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)-1-phenylethanolKi2400.0 [1], 2511.89 [2]
N-(4-Fluorobenzyl)-1-(2-chloro-2-phenylethyl)-6-(methylthio)-1H-pyrazolo[3,4-d]pyrimidin-4-amineKi4600.0 [1]
5,7-Diphenyl-4-aminopyrrolo[2,3-d]pyrimidineIC50100.0 [1], 3500.0 [2]
alpha-Sulfophenylacetic acidIC50192000.0 [1], 3200000.0 [2], 3230000000.0 [3]
2-[4-[(2S)-2-Acetamido-3-oxo-3-[[(3S)-2-oxo-1-[(4-phenylphenyl)methyl]azepan-3-yl]amino]propyl]-2-carboxyphenyl]propanedioic acidIC503.0 [1], 5.0 [2]
CID 447524IC50450.0 [1]
1-[2-Chloro-2-(4-fluorophenyl)ethyl]-N-(3-fluorophenyl)pyrazolo[3,4-d]pyrimidin-4-amineKi100.0 [1], 160.0 [2]
N-Acetyl-N-[1-(1,1'-biphenyl-4-ylmethyl)-2-oxoazepan-3-YL]-3-formyl-O-phosphonotyrosinamideIC500.25 [1]
4-Phenylamino-3-quinolinecarbonitrile deriv. 25IC503.8 [1], 940.0 [2]
N-(3-Bromophenyl)-6-methylsulfanyl-1-(2-phenylpropyl)pyrazolo[3,4-d]pyrimidin-4-amineKi18.0 [1], 20.0 [2]
4-Methyl-N-[4-methyl-3-(4-pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamideIC50100000.0 [1]
2-[4-[4-Amino-5-(3-methoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]phenyl]-N-(2-hydroxyethyl)acetamideIC5019.95 [1], 3900.0 [2]
2-[3-(4-Amino-5-phenyl-pyrrolo[2,3-d]pyrimidin-7-yl)-benzylamino]-ethanolIC5010.0 [1], 4000.0 [2]
N-[3-(4-Pyridin-3-yl-pyrimidin-2-ylamino)-phenyl]-benzamideIC5015700.0 [1]
4-Chloro-3-(5-methyl-3-(4-(piperidin-4-ylsulfonyl)phenylamino)benzo[e][1,2,4]triazin-7-yl)phenolIC505.2 [1]
4-[[7-(2-Chloro-5-hydroxyphenyl)-5-methyl-1,2,4-benzotriazin-3-yl]amino]-N-(2-pyrrolidin-1-ylethyl)benzenesulfonamideIC503.6 [1]
4-[[7-(2-Chloro-6-hydroxyphenyl)-5-methyl-1,2,4-benzotriazin-3-yl]amino]-N-(2-pyrrolidin-1-ylethyl)benzenesulfonamideIC5012.6 [1], 13.0 [2]
5-(3-Methoxyphenyl)-7-phenyl-4-aminopyrrolo[2,3-d]pyrimidineIC5050.12 [1], 3300.0 [2]
2-(4-(4-Amino-5-(3-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)ethanolIC50100.0 [1], 1150.0 [2]
(3-(4-Amino-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)methanolIC5063.1 [1], 5000.0 [2]
2-(4-(4-Amino-5-(3-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)benzylamino)ethanolIC5031.62 [1], 500.0 [2]
2-(4-(4-Amino-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)benzylamino)ethanolIC5031.62 [1], 700.0 [2]
4-[[7-(5-Amino-2-chlorophenyl)-5-methyl-1,2,4-benzotriazin-3-yl]amino]-N-(2-pyrrolidin-1-ylethyl)benzenesulfonamideIC5051.0 [1]
4-Chloro-3-(5-methyl-3-{[4-(piperazin-1-ylcarbonyl)phenyl]amino}-1,2,4-benzotriazin-7-yl)phenolIC503.6 [1]
Phosphoric acid 3-formylphenyl esterIC50600000.0 [1], 2100000.0 [2], 2400000.0 [3]
N-[2-Phenyl-4-(1h-Pyrazol-3-Ylamino)quinazolin-7-Yl]prop-2-EnamideIC5043.0 [1], 65.0 [2], 211.0 [3]
2,6-Diformyl-4-methylphenyl dihydrogen phosphateIC5039000.0 [1], 500000.0 [2]
4-Phenylamino-3-quinolinecarbonitrile deriv. 26IC508.7 [1], 1000.0 [2]
4-Phenylamino-3-quinolinecarbonitrile deriv. 1iIC504.0 [1], 2400.0 [2]
1-(2-Amino-6-phenylpyrido[2,3-d]pyrimidin-7-yl)-3-tert-butylureaIC5019330.0 [1], 50000.0 [2]
Chlorobenzodioxole deriv. 27IC505.0 [1], 120.0 [2]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Tyrosine-protein kinase SRC Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Dec. 2024, https://www.aatbio.com/data-sets/tyrosine-protein-kinase-src-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, December 21). Quest Database™ Tyrosine-protein kinase SRC Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/tyrosine-protein-kinase-src-inhibitors-ic50-ki.
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