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Tyrosine-protein kinase receptor UFO Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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▼
CabozantinibIC507.0 [1]
CrizotinibIC501.0 [1], 100.0 [2], 294.0 [3], 300.0 [4]
BosutinibIC50174.0 [1], 340.0 [2], 560.0 [3]
BemcentinibIC500.7 [1], 14.0 [2], 30.0 [3]
4-[2-(Butylamino)-5-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-olIC501.65 [1], 14.0 [2], 122.0 [3]
1-[(trans-4-Aminocyclohexyl)methyl]-N-Butyl-3-(4-Fluorophenyl)-1h-Pyrazolo[3,4-D]pyrimidin-6-AmineIC5037.0 [1]
4-[5-[4-[(4-Methyl-1,4-diazepan-1-yl)methyl]phenyl]-2-[[(2S)-pentan-2-yl]amino]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-olIC5012.1 [1], 80.0 [2], 859.0 [3]
StaurosporineIC503.0 [1], 40.0 [2]
SunitinibIC509.0 [1]
ForetinibIC5011.0 [1], 100.0 [2]
Bms-777607IC501.1 [1]
MerestinibIC502.0 [1], 11.0 [2]
JNJ-28312141 free baseIC5012.0 [1], 2600.0 [2]
c-FMS inhibitorIC506.4 [1]
CID 46194178IC5010.0 [1], 500.0 [2]
ExelixisIC507.0 [1], 42.0 [2]
CID 49870909IC507.0 [1], 56.0 [2]
CID 46870258IC5058.0 [1], 1000.0 [2]
1-[(4-Aminocyclohexyl)methyl]-N-methyl-3-(4-piperazin-1-ylphenyl)pyrazolo[3,4-d]pyrimidin-6-amineIC5014.0 [1], 140.0 [2]
6-[6-Amino-5-[(1R)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]pyridin-3-yl]-1'-methylspiro[1H-indole-3,4'-piperidine]-2-oneIC5028.9 [1], 300000.0 [2]
1-[(4-Aminocyclohexyl)methyl]-N-methyl-3-phenylpyrazolo[3,4-d]pyrimidin-6-amineIC5081.0 [1], 370.0 [2]
4-[[6-(Methylamino)-3-phenylpyrazolo[3,4-d]pyrimidin-1-yl]methyl]cyclohexan-1-olIC5083.0 [1], 190.0 [2]
QuercetinIC50960.0 [1]
DoramapimodIC5030000.0 [1]
SotrastaurinIC509100.0 [1]
Nvp-aew541IC5010000.0 [1]
CID 53469448IC502705.0 [1]
GilteritinibIC501.0 [1]
AmuvatinibIC501000.0 [1]
1-(3-Chlorophenyl)-3-{5-[2-(Thieno[3,2-D]pyrimidin-4-Ylamino)ethyl]-1,3-Thiazol-2-Yl}ureaIC5084.0 [1]
NorlichexanthoneIC50100000.0 [1]
TP-0903IC5027.0 [1]
(4S,6Z,9S,10S)-9,10,18-Trihydroxy-16-methoxy-4-methyl-3-oxabicyclo[12.4.0]octadeca-1(14),6,15,17-tetraene-2,8-dioneIC5010000.0 [1]
CID 59604787IC5010000.0 [1]
CID 44155856IC503.0 [1]
Unii-T7755XP5Y6IC5085.0 [1]
4-[[2-(Butylamino)-5-[5-(morpholin-4-ylmethyl)pyridin-2-yl]pyrimidin-4-yl]amino]cyclohexan-1-olIC50270.0 [1]
R428 (BGB324; Bemcentinib)IC5014.0 [1]
CID 56847486IC5019.0 [1]
2,3,6,8-Tetrahydroxy-1-methylxanthoneIC506600.0 [1]
Epicoccolide BIC50220.0 [1]
4-(5-Phenyl-1H-pyrrolo[2,3-b]pyridin-3-yl)benzoic acidIC50182.0 [1]
3-N-[4-(4-Morpholin-4-ylcyclohexyl)phenyl]-1-pyridin-2-yl-1,2,4-triazole-3,5-diamineKi40.0 [1]
Astrogorgiadiol BIC5016900.0 [1]
2-(Butylamino)-4-[(4-hydroxycyclohexyl)amino]-N-[(4-imidazol-1-ylphenyl)methyl]pyrimidine-5-carboxamideIC50360.0 [1]
(1S,9R)-5,6,12,13,14-Pentahydroxy-4,11-dimethyl-16-oxo-8,17-dioxatetracyclo[7.7.1.02,7.010,15]heptadeca-2(7),3,5,10,12,14-hexaene-3-carbaldehydeIC50160.0 [1]
(1R,3As,4S,5R,7aR)-4-[2-(5-hydroxy-2-methylphenyl)ethyl]-7a-methyl-1-[(2R)-6-methyl-5-methylideneheptan-2-yl]-1,2,3,3a,4,5,6,7-octahydroinden-5-olIC50100000.0 [1]
Calicoferol BIC50100000.0 [1]
6,6-Dimethyl-8-[1-(oxan-4-ylmethyl)piperidin-4-yl]-11-oxo-5H-benzo[b]carbazole-3-carbonitrileIC50170.0 [1]
Calicoferol EIC5032600.0 [1]
2-Amino-N-[3-[[5-chloro-4-(2-propan-2-ylsulfonylanilino)pyrimidin-2-yl]amino]phenyl]acetamideIC501000.0 [1]
1-[5-Amino-4-(3,4-dichlorophenyl)-3-methylpyrazol-1-yl]ethanoneIC50100000.0 [1]
Ripk1-IN-7IC5035.0 [1]
(13R,15S)-13-Methyl-16-oxa-8,9,12,22,24-pentazahexacyclo[15.6.2.16,9.112,15.02,7.021,25]heptacosa-1(24),2,4,6,17,19,21(25)-heptaene-23,27-dioneIC501000.0 [1]
8-(2,3-Dihydro-1H-inden-5-yl)-2-[4-(4-methylpiperazin-1-yl)anilino]-5-oxopyrido[2,3-d]pyrimidine-6-carboxamideIC50300.0 [1]
8-(2,3-Dihydro-1H-inden-5-yl)-2-[4-[2-(4-methylpiperazin-1-yl)ethyl]anilino]-5-oxopyrido[2,3-d]pyrimidine-6-carboxamideIC50500.0 [1]
Methyl 1H-pyrrolo[2,3-b]pyridine-3-carboxylateIC5010000.0 [1]
[6-Chloro-4-methyl-3-[[3-(methylsulfamoylamino)phenyl]methyl]-2-oxochromen-7-yl] N,N-dimethylcarbamateIC5050000.0 [1]
1-(2,6-Dichlorophenyl)-3-(6-(4-(2-(diethylamino)ethoxy)phenylamino)pyrimidin-4-yl)ureaIC5010000.0 [1]
3-Hydroxy-N-(2-hydroxy-1-methyl-ethyl)-5-(4-phenylamino-phenylamino)-isothiazole-4-carboxamidineIC50389.0 [1]
3-(4-(1H-Tetrazol-5-yl)phenyl)-5-phenyl-1H-pyrrolo[2,3-b]pyridineIC50524.0 [1]
N-[4-(6,7-Dimethoxyquinolin-4-yl)oxy-3-fluorophenyl]-1-phenyl-5-(trifluoromethyl)pyrazole-4-carboxamideIC5010000.0 [1]
1-[5-Tert-butyl-3-[4-[2-(dimethylamino)ethyl]-5-oxo-1,4-diazepane-1-carbonyl]thiophen-2-yl]-3-(2,3-dichlorophenyl)ureaIC5030000.0 [1]
7,8-Dichloro-9-methyl-1-oxospiro[2,4-dihydropyrido[3,4-b]indole-3,4'-piperidine]-4-carbonitrileIC5010000.0 [1]
N-[5-[(Z)-(5-Fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrol-3-yl]-3-(4-methylpiperazin-1-yl)propanamideKi63.0 [1]
3,5-Diphenyl-1H-pyrrolo[2,3-b]pyridineIC504060.0 [1]
N-(7-Methoxyquinolin-6-yl)thieno[3,2-d]pyrimidine-7-carboxamideIC5050000.0 [1]
6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-oneIC5010000.0 [1]
4-(Cyclopentylamino)-2-[(2-methoxyphenyl)methylamino]-N-[3-(2-oxopyrrolidin-1-yl)propyl]pyrimidine-5-carboxamideIC505700.0 [1]
4-(Cyclopentylamino)-2-[(2,5-dichlorophenyl)methylamino]-N-[3-(2-oxopyrrolidin-1-yl)propyl]pyrimidine-5-carboxamideIC503200.0 [1]
4-(Cyclopentylamino)-2-[(2,5-dichlorophenyl)methylamino]-N-[3-(2-oxo-1,3-oxazolidin-3-yl)propyl]pyrimidine-5-carboxamideIC503990.0 [1]
6-(6-Fluoroindol-1-yl)-2-[2-[7-(3-morpholin-4-ylpropoxy)quinolin-4-yl]oxyethyl]pyridazin-3-oneIC501000.0 [1]
(7S)-7-Amino-N-[(4-fluorophenyl)methyl]-8-oxo-2,9,16,18,21-pentazabicyclo[15.3.1]henicosa-1(21),17,19-triene-20-carboxamideIC50120.0 [1]
5-[1-(Cyclopropylmethyl)-5-[(1R,5S)-3-(oxetan-3-yl)-3-azabicyclo[3.1.0]hexan-6-yl]pyrazol-3-yl]-3-(trifluoromethyl)pyridin-2-amineIC50448.0 [1]
(8S,16S)-3,16-Dihydroxy-9,10-seco-1,3,5(10)-cholestatrien-9-oneIC50100000.0 [1]
Calicoferol AIC5014700.0 [1]
(1R,3As,4S,7aR)-4-[2-(5-hydroxy-2-methylphenyl)ethyl]-7a-methyl-1-[(2R)-6-methyl-5-methylideneheptan-2-yl]-2,3,3a,4,6,7-hexahydro-1H-inden-5-oneIC5020200.0 [1]
5-Phenyl-1H-pyrrolo[2,3-b]pyridineIC5010000.0 [1]
Methyl 3-[[(1R,2S,4aR,8aS)-1,2,4a,5-tetramethyl-2,3,4,7,8,8a-hexahydronaphthalen-1-yl]methyl]-4,5-dihydroxybenzoateIC5013100.0 [1]
N-(1H-Pyrazol-5-yl)-1H-pyrrolo[2,3-b]pyridine-3-carboxamideIC5010000.0 [1]
N-Pyridin-3-yl-1H-pyrrolo[2,3-b]pyridine-3-carboxamideIC5010000.0 [1]
5-Cyano-N-[2-(cyclohexen-1-yl)-4-[1-(2-methylsulfonylethyl)piperidin-4-yl]phenyl]-1H-imidazole-2-carboxamideIC5016.0 [1]
5-Cyano-N-[2-(cyclohexen-1-yl)-4-[1-(2-morpholin-4-ylethyl)piperidin-4-yl]phenyl]-1H-imidazole-2-carboxamideIC506.0 [1]
4-[5-[4-(Morpholin-4-ylmethyl)phenyl]-2-[[(2S)-pentan-2-yl]amino]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-olIC50218.0 [1]
4-[5-[3-[(4-Methylpiperazin-1-yl)methyl]phenyl]-2-[[(2S)-pentan-2-yl]amino]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-olIC50213.0 [1]
4-[2-(Butylamino)-5-[4-(piperidin-4-ylamino)phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-olIC5042.0 [1]
4-[5-[4-[(4-Methylpiperazin-1-yl)methyl]phenyl]-2-[[(2R)-pentan-2-yl]amino]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-olIC50560.0 [1]
4-[5-[4-[(4-Methylpiperazin-1-yl)methyl]phenyl]-2-(pentan-2-ylamino)pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-olIC50125.0 [1]
4-[2-[[(2S)-Heptan-2-yl]amino]-5-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-olIC5081.0 [1]
4-[5-[4-[(4-Methylpiperazin-1-yl)methyl]phenyl]-2-[[(2S)-pentan-2-yl]amino]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-olIC50118.0 [1]
4-[5-[4-[(4-Methylpiperazin-1-yl)methyl]phenyl]-2-[[(2S)-1,1,1-trifluoropentan-2-yl]amino]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-olIC5011037.0 [1]
4-[2-(2-Methylbutylamino)-5-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-olIC50100.0 [1]
4-[2-(2-Ethylbutylamino)-5-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-olIC50206.0 [1]
4-[5-[4-[(4-Methylpiperazin-1-yl)methyl]phenyl]-2-[[(2R)-1,1,1-trifluoropentan-2-yl]amino]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-olIC502543.0 [1]
4-[2-[[(2S)-Hexan-2-yl]amino]-5-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-olIC5064.0 [1]
4-[5-[4-[[2-(Diethylamino)ethylamino]methyl]phenyl]-2-[[(2S)-pentan-2-yl]amino]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-olIC5080.0 [1]
4-[2-[[(2S)-Pentan-2-yl]amino]-5-[4-(piperidin-4-ylamino)phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-olIC50206.0 [1]
4-[5-[4-(Cyclohexylamino)phenyl]-2-[[(2S)-pentan-2-yl]amino]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-olIC507356.0 [1]
4-[5-[4-(7-Azabicyclo[2.2.1]heptan-7-ylmethyl)phenyl]-2-[[(2S)-pentan-2-yl]amino]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-olIC5084.0 [1]
4-[5-[2-Fluoro-4-(4-methylpiperazin-1-yl)sulfonylphenyl]-2-[[(2S)-pentan-2-yl]amino]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-olIC50191.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Tyrosine-protein kinase receptor UFO Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/tyrosine-protein-kinase-receptor-ufo-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ Tyrosine-protein kinase receptor UFO Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/tyrosine-protein-kinase-receptor-ufo-inhibitors-ic50-ki.
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