![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_af6c849cab29e175678bc52964f46c9c.svg) | Tofacitinib | IC50 | 2.2 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_af6c849cab29e175678bc52964f46c9c.svg) | Tofacitinib | Ki | 0.24 [1], 0.4 [2], 1.0 [3] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_d2d7249f5aa78b82528878cc48786202.svg) | Ruxolitinib | IC50 | 428.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_d2d7249f5aa78b82528878cc48786202.svg) | Ruxolitinib | Ki | 3.2 [1], 3.22 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_1d5eba4b4bb57896dda18b1604bab021.svg) | Staurosporine | IC50 | 1.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_07d2d0af7904836ad3cf5ea2273c6a53.svg) | 1-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one | IC50 | 33.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_07d2d0af7904836ad3cf5ea2273c6a53.svg) | 1-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one | Ki | 6310.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_01384179eb1c1c1ef001bfbf31bfa500.svg) | Ibrutinib | IC50 | 10.4 [1], 16.1 [2], 100.0 [3], 146.0 [4] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_c0ff4e3dfe8e08fa2c67203215e88178.svg) | Baricitinib | IC50 | 25.0 [1], 400.0 [2], 787.0 [3], 8000.0 [4] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_94feb385cecaa610e1d68d9fb9d55ef3.svg) | Pyridone 6 | IC50 | 5.0 [1], 10.0 [2], 900.0 [3] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_9a65d2cfdcb6c2711e673a4cb101fbc0.svg) | 3-[5-[4-(2-Hydroxy-2-methylpropanoyl)piperazin-1-yl]-2-(trifluoromethyl)phenyl]-4-(1H-indol-3-yl)pyrrole-2,5-dione | IC50 | 0.5 [1], 1.0 [2], 8.0 [3], 11.0 [4], 525.0 [5] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_7c73239bc31d4875fd802deba6fd37c5.svg) | Filgotinib | IC50 | 194.7 [1], 810.0 [2], 10000.0 [3] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_dbd3ed1b80e21bd85c700e0d0e711b46.svg) | N-{cis-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide | IC50 | 605.0 [1], 8000.0 [2], 10000.0 [3] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_eb7450818c05c94eda590570345c4791.svg) | [(1S)-6-(5-Phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]cyanamide | IC50 | 0.7 [1], 49.0 [2], 458.0 [3], 10000.0 [4] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_9cc61cc5616fe8d8150a459f74329c57.svg) | 1-[(3Ar,7aR)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3-c]pyridin-6-yl]prop-2-en-1-one | IC50 | 0.4 [1], 47.0 [2], 116.0 [3], 399.0 [4] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_82b5da8c5186922184a5871024a4771b.svg) | 1-[(3R)-3-(7H-Pyrrolo[2,3-d]pyrimidin-4-ylamino)piperidin-1-yl]prop-2-en-1-one | IC50 | 0.7 [1], 56.0 [2], 107.0 [3], 580.0 [4] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_eaf1188724e5cb989438b474763d0ce9.svg) | N-[3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]prop-2-enamide | IC50 | 0.3 [1], 29.0 [2], 32.0 [3], 2280.0 [4] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_701aae0e2ee5fa705dd5c8148f02f8a9.svg) | [(1S)-1-Methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydroinden-1-yl]cyanamide | IC50 | 0.7 [1], 56.0 [2], 5480.0 [3] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_c4a4374d204bc28db1123832ff1bdd33.svg) | [(1S)-6-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]cyanamide | IC50 | 3.0 [1], 256.0 [2], 598.0 [3], 10000.0 [4] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_9195481149e28f3c059402c50df16cb7.svg) | [(1S)-6-[5-[3-(Hydroxymethyl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-2,3-dihydro-1H-inden-1-yl]cyanamide | IC50 | 0.5 [1], 78.0 [2], 498.0 [3], 10000.0 [4] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_da43a042876e39d35d5303eb92a52ec0.svg) | N-[3-[5-(2-Methoxyethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]phenyl]prop-2-enamide | IC50 | 0.5 [1], 31.0 [2], 63.0 [3], 953.0 [4] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_781d4e2efc2480346cf720a202895038.svg) | 2,2-Difluoro-6-[5-(2-methoxyethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-3H-1,4-benzoxazine-4-carbonitrile | IC50 | 3.0 [1], 162.0 [2], 456.0 [3], 7252.0 [4] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_9dd6da7cb57ea869429d2bb32c1c121c.svg) | 2-PropenaMide, N-[cis-4-[4-aMino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyriMidin-1-yl]cyclohexyl]- | IC50 | 8278.0 [1], 10000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_4dca88aa08927c7f18d35895207aad16.svg) | Decernotinib | IC50 | 1.2 [1], 2.5 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_4dca88aa08927c7f18d35895207aad16.svg) | Decernotinib | Ki | 2.5 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_969dba429fd4e580980eb0f30b530c40.svg) | 3-(2-Aminoquinazolin-6-Yl)-4-Methyl-N-[3-(Trifluoromethyl)phenyl]benzamide | IC50 | 20.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_07a9a7dadcb6403aa1be2fdac16a78df.svg) | JAK3 covalent inhibitor-1 | IC50 | 11.0 [1], 331.0 [2], 10000.0 [3] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_df25514b34c49b36ed660fbf7734f36b.svg) | 1-(2-Aminoethyl)-2-(4-piperidinyl)-1H-benzoimidazole-5-carboxamide | IC50 | 1260.0 [1], 1300.0 [2], 232500.0 [3] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_b991d5059c387da7fd3b43ec2fbab3f8.svg) | 2-Cyano-3-[5-(3-cyclohexyl-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-4-yl)furan-2-yl]-N,N-dimethylprop-2-enamide | IC50 | 0.13 [1], 2.0 [2], 9.0 [3] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_472e2766bd7aae9d640b69d9ad994353.svg) | 3-[(3R)-3-(4,5-Dimethoxy-8-oxo-9,14,16-triazatetracyclo[8.7.0.02,7.011,15]heptadeca-1(17),2,4,6,10,12,15-heptaen-9-yl)piperidin-1-yl]-3-oxopropanenitrile | IC50 | 2.55 [1], 15.3 [2], 1550.0 [3] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_f46fee874c56c559a0e4a922f87b5d64.svg) | 9-Cyclohexyl-4,5-dimethoxy-9,14,16-triazatetracyclo[8.7.0.02,7.011,15]heptadeca-1(17),2,4,6,10,12,15-heptaen-8-one | IC50 | 2.92 [1], 65.9 [2], 3720.0 [3] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_1b60ac6ea5f0778a919f423833f5ed81.svg) | N-[(1R,3S)-3-(Cyanoamino)-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]methanesulfonamide | IC50 | 0.9 [1], 38.0 [2], 2240.0 [3] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_fcdb27069d2defe5415ede7f1d899220.svg) | [(1S,3R)-3-Hydroxy-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]cyanamide | IC50 | 1.0 [1], 163.0 [2], 1728.0 [3] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_5040f429615a8ddee53c066f46eebc4a.svg) | 1-Cyclopropyl-N-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]methanesulfonamide | IC50 | 8000.0 [1], 10000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_112d77f7d99fa9ff32b60db0198caa5e.svg) | 4-[[4-(4,5,6,8,10-Pentazatricyclo[7.3.0.02,6]dodeca-1(9),2,4,7,11-pentaen-3-yl)cyclohexyl]amino]benzonitrile | IC50 | 460.0 [1], 660.0 [2], 1000.0 [3] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_2a4263b25dcfaf9e5ead7236f53dfb2e.svg) | 4-(4,5,6,8,10-Pentazatricyclo[7.3.0.02,6]dodeca-1(9),2,4,7,11-pentaen-3-yl)-N-(2-phenylethyl)cyclohexan-1-amine | IC50 | 870.0 [1], 1000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_22a7056060ff482acf6358d79efef4d4.svg) | 4-Fluoro-N-[4-(4,5,6,8,10-pentazatricyclo[7.3.0.02,6]dodeca-1(9),2,4,7,11-pentaen-3-yl)cyclohexyl]aniline | IC50 | 260.0 [1], 420.0 [2], 560.0 [3] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_291fdc26c251ab1eb139e1406ed05831.svg) | Canertinib | IC50 | 2000.0 [1], 3880.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_997fe095318226e799cbe61db5e4d8fd.svg) | 4-[(3-Bromophenyl)amino]-6-acrylamidoquinazoline | IC50 | 3140.0 [1], 10000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_fa37ae125bcd4e6df1af4be57fbea491.svg) | 1-Cyclopropyl-3-(3-(5-(morpholinomethyl)-1H-benzo[d]imidazol-2-yl)-1H-pyrazol-4-yl)urea | IC50 | 1.0 [1], 1.1 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_f480b114ef369e64dabd2826c713467d.svg) | Oclacitinib | IC50 | 95.1 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_2c95287dfd97c6644e7bee245a0525a4.svg) | CID 57336812 | IC50 | 84.7 [1], 150.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_4b5f79d180276ffc914d389afc8e08fb.svg) | Spebrutinib | IC50 | 22.5 [1], 1753.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_9b1d7ab736107476be4c47e7fc861539.svg) | 9-(1-Methylpyrazol-4-yl)-1-(1-prop-2-enoyl-2,3-dihydroindol-6-yl)benzo[h][1,6]naphthyridin-2-one | IC50 | 3336.0 [1], 5180.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_08e4900778fa702f27e7282ff609e388.svg) | 2,6-Dichloro-N-{2-[(Cyclopropylcarbonyl)amino]pyridin-4-Yl}benzamide | Ki | 253.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_e63bb9bb954b02c8ddbeae716cd660ba.svg) | [2-[6-(2-Ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl]-3,4,6,7-tetrahydroimidazo[4,5-c]pyridin-5-yl]-(5-piperidin-1-ylpyrazin-2-yl)methanone | IC50 | 0.5 [1], 59.9 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_8f6edfc9fcfa78fa0564e806198cb0bd.svg) | 9-(Cyclohexylmethyl)-4,5-dimethoxy-9,14,16-triazatetracyclo[8.7.0.02,7.011,15]heptadeca-1(17),2,4,6,10,12,15-heptaen-8-one | IC50 | 1.65 [1], 76900.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_db1cea5586701bc53652f3f79d33c46d.svg) | 2-Methyl-N-[2-[3-(prop-2-enoylamino)anilino]pyrimidin-5-yl]-5-[[3-(trifluoromethyl)benzoyl]amino]benzamide | IC50 | 1705.0 [1], 2680.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_d38ecde7f1a2ba6ffe560323ee32d055.svg) | CID 11993785 | IC50 | 5.1 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_7f9f4a6a03b2d8e65131bcc49294e3e5.svg) | 4-[1-(Oxiran-2-ylmethyl)triazol-4-yl]-7H-pyrrolo[2,3-d]pyrimidine | IC50 | 35.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_771f17b91df724779a9947844c5b6f74.svg) | Unii-7N5LJ2Z26C | IC50 | 35.0 [1], 220.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_f212d574e725b6e4990a2dd9b43bcebe.svg) | 5-Fluoro-2-[[(1S)-1-(5-fluoropyridin-2-yl)ethyl]amino]-6-[(5-methyl-1H-pyrazol-3-yl)amino]pyridine-3-carbonitrile | IC50 | 7.0 [1], 15.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_bb1c2e58a3a6e686936e484e0ce882b8.svg) | N-[(2R)-1-(3-Cyanoazetidin-1-yl)-1-oxopropan-2-yl]-2-cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide | IC50 | 8.2 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_499d1b0d435cf587d6ff8c3cc8ded015.svg) | Jak-IN-1 | IC50 | 0.26 [1], 0.3 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_f6fe7a233409bb3d9a176bd8a631dc29.svg) | 6-Anilino-4-(benzylamino)pyridine-3-carboxamide | IC50 | 4.5 [1], 5.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_1195bea21f0149ddf95f17142bd9dfbe.svg) | Jak3-IN-6 | IC50 | 0.15 [1], 4.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_cd18613a443812a5f8cf423b21b92edb.svg) | 3-((1H-Pyrrol-2-yl)methylene)-5-(pyridin-3-yl)indolin-2-one | IC50 | 27.0 [1], 38.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_24e81e24053e54c3dceb32ed0bc3d39a.svg) | 4-Amino-N-methyl-2-phenylthieno[3,2-c]pyridine-7-carboxamide | IC50 | 767.0 [1], 25000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_6847605642a67bd3016f096251542640.svg) | 1-[(3R,4R)-4-Methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]prop-2-en-1-one | IC50 | 75.0 [1], 1930.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_8eea4ae29003783e3b1d131e1addec56.svg) | (E)-1-[(3R)-3-(7H-Pyrrolo[2,3-d]pyrimidin-4-ylamino)piperidin-1-yl]but-2-en-1-one | IC50 | 1610.0 [1], 10000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_10cb1e57c61afbed89099a5ddbc46af9.svg) | 1-[(3R)-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]prop-2-en-1-one | IC50 | 18.0 [1], 3840.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_419566e161be5f0ca2eb499f33b3200d.svg) | (E)-3-[5-(3-Cyclohexyl-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-4-yl)furan-2-yl]-N,N-dimethylprop-2-enamide | IC50 | 22.0 [1], 51.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_eb4220c5d1848c776c91e89c438a2a98.svg) | (E)-3-[5-(3-Cyclohexyl-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-4-yl)furan-2-yl]prop-2-enenitrile | IC50 | 0.21 [1], 27.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_6e87256c47e28d2d7b4e636d10e7d32f.svg) | 3-[5-(3-Cyclohexyl-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-4-yl)furan-2-yl]propanenitrile | IC50 | 10.0 [1], 129.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_4e4f3cef2d555ec1556a0e1ef2257266.svg) | [2-[6-(2-Ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl]-3,4,6,7-tetrahydroimidazo[4,5-c]pyridin-5-yl]-(4-fluorophenyl)methanone | IC50 | 0.6 [1], 1.7 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_b32eff2382d82e8dbfa280f2478d6257.svg) | 1-[(3Ar,7aR)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3-c]pyridin-6-yl]ethanone | IC50 | 372.0 [1], 10000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_59ee2b34e1e4c6b7a5a5483dcf61018e.svg) | 9-Cycloheptyl-4,5-dimethoxy-9,14,16-triazatetracyclo[8.7.0.02,7.011,15]heptadeca-1(17),2,4,6,10,12,15-heptaen-8-one | IC50 | 1.09 [1], 18340.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_5077d4bb17831429a9e5155b4a3861ac.svg) | 9-Cyclooctyl-4,5-dimethoxy-9,14,16-triazatetracyclo[8.7.0.02,7.011,15]heptadeca-1(17),2,4,6,10,12,15-heptaen-8-one | IC50 | 1.01 [1], 28860.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_aa1f8854323e780a1211b25b86b6b435.svg) | 4,5-Dimethoxy-9-(1-methylpiperidin-4-yl)-9,14,16-triazatetracyclo[8.7.0.02,7.011,15]heptadeca-1(17),2,4,6,10,12,15-heptaen-8-one | IC50 | 124.1 [1], 61570.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_1a2b0f8c080bb5a541147f10fd01b4eb.svg) | 2-[[5-(3-Cyclohexyl-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-4-yl)furan-2-yl]methylidene]propanedinitrile | IC50 | 0.39 [1], 4.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_b253f332c2503bedb0ba9e6afa5f18e1.svg) | 3-[5-(3-Cyclohexyl-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-4-yl)furan-2-yl]-N,N-dimethylpropanamide | IC50 | 48.0 [1], 181.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_67ad73f9f4828e7dba8989c75700b268.svg) | 3-[5-(3-Cyclohexyl-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-4-yl)furan-2-yl]-2-(4-methylpiperazine-1-carbonyl)prop-2-enenitrile | IC50 | 0.74 [1], 14.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_0806eb5799c883bc009f968ec8d44840.svg) | 1-[6-[5-(2-Methoxyethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-2,3-dihydro-1,4-benzoxazin-4-yl]prop-2-en-1-one | IC50 | 0.5 [1], 49.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_408598d35085b0550d021286d969f553.svg) | [(1R,2R)-2-Methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]cyanamide | IC50 | 13.0 [1], 1530.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_549827c9bb0488fc1de6fba73e0a9d32.svg) | Methyl-[6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]cyanamide | IC50 | 230.0 [1], 10000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_129e9c7b3efef81b33b9aff7637382e4.svg) | [(1R,2S)-2-Methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]cyanamide | IC50 | 6.0 [1], 603.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_996085cd3ed899884502e651927fb78c.svg) | [(1R,2R)-2-Hydroxy-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]cyanamide | IC50 | 2.0 [1], 280.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_a462a47275271c548f26fdc10a5ce09e.svg) | [(4R)-6-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-3,4-dihydro-2H-chromen-4-yl]cyanamide | IC50 | 26.0 [1], 6110.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_67d301ca6bf740ca65df9892d21de2c5.svg) | [(1R)-6-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]cyanamide | IC50 | 66.0 [1], 5820.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_85d96b2bc682df4a5f90ad0454faac58.svg) | N-[(1R,3S)-3-(Cyanoamino)-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]-4-methoxybenzenesulfonamide | IC50 | 16.0 [1], 947.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_d9c80d6ffa830006e13e88926845c06c.svg) | [1-Methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydroinden-1-yl]cyanamide | IC50 | 1.0 [1], 92.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_7a2fdf74d7e0a29dfab1f053bfe15177.svg) | N-[(1R,3S)-3-(Cyanoamino)-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]-2-methoxyethanesulfonamide | IC50 | 1.0 [1], 111.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_5fb4049c9ff02e709add8d1c1479a148.svg) | [6-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]cyanamide | IC50 | 6.0 [1], 711.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_f6805fd43bae3445f236d87a9f3d1f4a.svg) | 6-[5-(2-Methoxyethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-2,3-dihydro-1,4-benzoxazine-4-carbonitrile | IC50 | 17.0 [1], 1226.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_ea7dd767bd6f0ded599e843d4c103539.svg) | [6-[5-(2-Methoxyethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-3,4-dihydro-2H-chromen-4-yl]cyanamide | IC50 | 49.0 [1], 5828.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_7e96b7b4891f9cc6cb45580f804adbdb.svg) | [(4S)-6-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-3,4-dihydro-2H-chromen-4-yl]cyanamide | IC50 | 7.0 [1], 781.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_22de94a8b082b489c200a66a5a8911f9.svg) | [6-[5-(2-Methoxyethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-2,3-dihydro-1H-inden-1-yl]cyanamide | IC50 | 12.0 [1], 1592.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_4af1cc2dbf497d9ac1ed053062e03ff4.svg) | 3-Cyano-N-[(1R,3S)-3-(cyanoamino)-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]benzenesulfonamide | IC50 | 14.0 [1], 468.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_37361fea2d2de9e312f90500cd49f6e8.svg) | [6-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-3,4-dihydro-2H-chromen-4-yl]cyanamide | IC50 | 7.0 [1], 1211.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_7341b94d2e572a8128f5fc048086b6aa.svg) | [(1S,3S)-3-Hydroxy-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]cyanamide | IC50 | 13.0 [1], 1338.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_3fc673a176e48cd789da2ad3346d3976.svg) | 4-Amino-2-(4-morpholin-4-ylphenyl)thieno[3,2-c]pyridine-7-carboxamide | IC50 | 18.0 [1], 25000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_ff4ae15ce71868867b122c1ca4cf6397.svg) | (R)-3-(6-(1-(4-Chlorophenyl)ethylamino)pyrimidin-4-yl)pyrazolo[1,5-a]pyrimidin-2-amine | IC50 | 81.0 [1], 11000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_a118b9d7ef84f38f1f731b8758fa491b.svg) | 3-(6-(2-(4-Fluorophenyl)pyrrolidin-1-yl)pyrimidin-4-yl)pyrazolo[1,5-a]pyrimidin-2-amine | IC50 | 86.0 [1], 3100.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_fc7a5163b01b80fd2a9bb0b3f1c6e38e.svg) | (R)-3-(6-(2,3-Dihydro-1H-inden-1-ylamino)pyrimidin-4-yl)pyrazolo[1,5-a]pyrimidin-2-amine | IC50 | 200.0 [1], 20000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_c90874e53d7225db84772f8beda4504c.svg) | (R)-3-(6-(1-(4-Fluorophenyl)butylamino)pyrimidin-4-yl)pyrazolo[1,5-a]pyrimidin-2-amine | IC50 | 10.0 [1], 2400.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_917de8bd618e6cdb4ef989e775cf1417.svg) | (R)-3-(6-(1-(4-Fluorophenyl)-2-methylpropylamino)pyrimidin-4-yl)pyrazolo[1,5-a]pyrimidin-2-amine | IC50 | 12.0 [1], 4100.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_fbac37c5d81e603c807702b6667a0713.svg) | (R)-3-(6-(1-(4-Fluorophenyl)ethylamino)pyrimidin-4-yl)pyrazolo[1,5-a]pyrimidin-2-amine | IC50 | 7.0 [1], 3200.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_94e89e9705ce8e01fe931a014495c355.svg) | Atropisomer 1 | IC50 | 1530.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_94e89e9705ce8e01fe931a014495c355.svg) | Atropisomer 1 | Ki | 0.01 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak3_1d666d1ec3bcff5beaef931e2b97af6c.svg) | 3-[6-[[(1R)-1-(4-Fluorophenyl)propyl]amino]pyrimidin-4-yl]pyrazolo[1,5-a]pyrimidin-2-amine | IC50 | 12.0 [1], 1900.0 [2] |