![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_af6c849cab29e175678bc52964f46c9c.svg) | Tofacitinib | IC50 | 3.2 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_af6c849cab29e175678bc52964f46c9c.svg) | Tofacitinib | Ki | 0.68 [1], 0.7 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_d2d7249f5aa78b82528878cc48786202.svg) | Ruxolitinib | IC50 | 3.3 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_d2d7249f5aa78b82528878cc48786202.svg) | Ruxolitinib | Ki | 0.09 [1], 0.2 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_7c73239bc31d4875fd802deba6fd37c5.svg) | Filgotinib | IC50 | 10.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_c0ff4e3dfe8e08fa2c67203215e88178.svg) | Baricitinib | IC50 | 0.99 [1], 4.0 [2], 6.0 [3] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_1d5eba4b4bb57896dda18b1604bab021.svg) | Staurosporine | IC50 | 1.0 [1], 1.01 [2], 3.0 [3], 12.5 [4] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_4dca88aa08927c7f18d35895207aad16.svg) | Decernotinib | IC50 | 11.0 [1], 13.2 [2], 50.0 [3], 112.0 [4] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_07d2d0af7904836ad3cf5ea2273c6a53.svg) | 1-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-one | IC50 | 1640.0 [1], 10000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_a92539978431a7a08422a93880d9c42f.svg) | 3-(4-Cyanoanilino)-1-[(3R,4S)-4-cyanooxan-3-yl]pyrazole-4-carboxamide | IC50 | 0.07 [1], 0.15 [2], 13.0 [3], 220.0 [4] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_94feb385cecaa610e1d68d9fb9d55ef3.svg) | Pyridone 6 | IC50 | 4.0 [1], 15.0 [2], 600.0 [3] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_dbd3ed1b80e21bd85c700e0d0e711b46.svg) | N-{cis-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl}propane-1-sulfonamide | IC50 | 29.0 [1], 572.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_9a65d2cfdcb6c2711e673a4cb101fbc0.svg) | 3-[5-[4-(2-Hydroxy-2-methylpropanoyl)piperazin-1-yl]-2-(trifluoromethyl)phenyl]-4-(1H-indol-3-yl)pyrrole-2,5-dione | IC50 | 311.0 [1], 344.0 [2], 1017.0 [3] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_9ac0c928c31ed7fa85b590bf9dfdc697.svg) | 3-Cyclohexyl-4-methyl-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaene | IC50 | 20.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_9ac0c928c31ed7fa85b590bf9dfdc697.svg) | 3-Cyclohexyl-4-methyl-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaene | Ki | 1.3 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_91e0692d3723120edf686097f028d3e7.svg) | 3-(4-Chloro-3-methoxyanilino)-1-[(3R,4S)-4-cyanooxan-3-yl]pyrazole-4-carboxamide | IC50 | 0.1 [1], 13.0 [2], 1760.0 [3] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_d94f1f526eca023017f43522bae874b0.svg) | 4-[(4-Aminocyclohexyl)amino]-3-(1h-Benzimidazol-2-Yl)-1h-Pyridin-2-One | IC50 | 0.1 [1], 0.6 [2], 3.0 [3] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_436a3d40fc0e42d0c13869b5e16832f3.svg) | N-[5-[4-(Morpholin-4-ylmethyl)phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide | IC50 | 52.11 [1], 92.0 [2], 5590.0 [3] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_d3f644ad35318ebfe0eb4c3c2e52f92c.svg) | N-[5-[4-[(4,4-Difluoropiperidin-1-yl)methyl]phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide | IC50 | 7.69 [1], 27.0 [2], 2749.0 [3] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_5040f429615a8ddee53c066f46eebc4a.svg) | 1-Cyclopropyl-N-[3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]cyclobutyl]methanesulfonamide | IC50 | 42.0 [1], 1030.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_384a44ae7448d043c89eed5f9dc354b2.svg) | 1-[(3R,4S)-4-Cyanooxan-3-yl]-3-[(2-fluoropyridin-4-yl)amino]pyrazole-4-carboxamide | IC50 | 0.2 [1], 0.24 [2], 42.0 [3] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_60d488cdd17c872a367d67e13c697863.svg) | 1-[(3R,4S)-4-Cyanooxan-3-yl]-3-[4-[(1S)-2,2,2-trifluoro-1-hydroxyethyl]anilino]pyrazole-4-carboxamide | IC50 | 0.05 [1], 0.09 [2], 14.0 [3] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_12004a03a97cbf5a742e3657528db334.svg) | 3-(4-Chloroanilino)-1-[(3R,4S)-4-cyanooxan-3-yl]pyrazole-4-carboxamide | IC50 | 0.13 [1], 0.2 [2], 14.0 [3] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_b0f4823e09d5aed34437533059591556.svg) | 3-Anilino-1-[(3R,4S)-4-cyanooxan-3-yl]pyrazole-4-carboxamide | IC50 | 0.4 [1], 10.0 [2], 33.0 [3] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_21e1d17feb9c948fd3b3f73ed346969c.svg) | 3-(4-Chloroanilino)-1-[(1S,2S,4S)-2-cyano-4-(dimethylamino)cyclohexyl]pyrazole-4-carboxamide | IC50 | 0.55 [1], 1.5 [2], 64.0 [3] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_112d77f7d99fa9ff32b60db0198caa5e.svg) | 4-[[4-(4,5,6,8,10-Pentazatricyclo[7.3.0.02,6]dodeca-1(9),2,4,7,11-pentaen-3-yl)cyclohexyl]amino]benzonitrile | IC50 | 2.2 [1], 3.9 [2], 22.0 [3] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_2a4263b25dcfaf9e5ead7236f53dfb2e.svg) | 4-(4,5,6,8,10-Pentazatricyclo[7.3.0.02,6]dodeca-1(9),2,4,7,11-pentaen-3-yl)-N-(2-phenylethyl)cyclohexan-1-amine | IC50 | 6.1 [1], 6.3 [2], 97.0 [3] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_22a7056060ff482acf6358d79efef4d4.svg) | 4-Fluoro-N-[4-(4,5,6,8,10-pentazatricyclo[7.3.0.02,6]dodeca-1(9),2,4,7,11-pentaen-3-yl)cyclohexyl]aniline | IC50 | 5.4 [1], 6.6 [2], 69.0 [3] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_a257c791d1de1df5d4a1fa04612f9c76.svg) | Nvp-aew541 | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_147a614c1235d6ef8773ae2e78229bc4.svg) | Momelotinib | IC50 | 11.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_f480b114ef369e64dabd2826c713467d.svg) | Oclacitinib | IC50 | 9.53 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_08e4900778fa702f27e7282ff609e388.svg) | 2,6-Dichloro-N-{2-[(Cyclopropylcarbonyl)amino]pyridin-4-Yl}benzamide | Ki | 83.8 [1], 84.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_e63bb9bb954b02c8ddbeae716cd660ba.svg) | [2-[6-(2-Ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl]-3,4,6,7-tetrahydroimidazo[4,5-c]pyridin-5-yl]-(5-piperidin-1-ylpyrazin-2-yl)methanone | IC50 | 2.2 [1], 5.4 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_eb7450818c05c94eda590570345c4791.svg) | [(1S)-6-(5-Phenyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]cyanamide | IC50 | 422.0 [1], 3345.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_d5dd8eb69a7c8365eca3c63ba7cddae1.svg) | 1-(Piperidin-4-Yl)-1,6-Dihydroimidazo[4,5-D]pyrrolo[2,3-B]pyridine | Ki | 45.0 [1], 46.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_b43f9b172387f2a84cebdafc2497da4c.svg) | cis-3-[4-Amino-7-(3-azetidin-1-ylmethyl-cyclobutyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl]-phenol | IC50 | 260.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_101f274fa0d894c601461fd7747171a3.svg) | 7-[3-(Azetidin-1-ylmethyl)cyclobutyl]-5-[3-[[(2S)-oxolan-2-yl]methoxy]phenyl]pyrrolo[2,3-d]pyrimidin-4-amine | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_d38ecde7f1a2ba6ffe560323ee32d055.svg) | CID 11993785 | IC50 | 47.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_df25514b34c49b36ed660fbf7734f36b.svg) | 1-(2-Aminoethyl)-2-(4-piperidinyl)-1H-benzoimidazole-5-carboxamide | IC50 | 50.0 [1], 5700.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_771f17b91df724779a9947844c5b6f74.svg) | Unii-7N5LJ2Z26C | IC50 | 2.0 [1], 3.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_7bf3d81881048cf432d5d647aebc678b.svg) | 3-[(3r)-3-(Imidazo[4,5-D]pyrrolo[2,3-B]pyridin-1(6h)-Yl)piperidin-1-Yl]-3-Oxopropanenitrile | Ki | 0.4 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_bb1c2e58a3a6e686936e484e0ce882b8.svg) | N-[(2R)-1-(3-Cyanoazetidin-1-yl)-1-oxopropan-2-yl]-2-cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxamide | IC50 | 47.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_499d1b0d435cf587d6ff8c3cc8ded015.svg) | Jak-IN-1 | IC50 | 3.2 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_bdc8f706a1adf103eec17bc9bbe34214.svg) | 2-Methyl-1-(Piperidin-4-Yl)-1,6-Dihydroimidazo[4,5-D]pyrrolo[2,3-B]pyridine | Ki | 10.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_a2dd49dd041ed7733e8d2d1a75d2596f.svg) | 3-[4-(3,5,8,10-Tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-3-yl)piperidin-1-yl]propanenitrile | Ki | 0.6 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_9cc61cc5616fe8d8150a459f74329c57.svg) | 1-[(3Ar,7aR)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3-c]pyridin-6-yl]prop-2-en-1-one | IC50 | 984.0 [1], 10000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_6847605642a67bd3016f096251542640.svg) | 1-[(3R,4R)-4-Methyl-3-[methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]prop-2-en-1-one | IC50 | 274.0 [1], 988.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_8eea4ae29003783e3b1d131e1addec56.svg) | (E)-1-[(3R)-3-(7H-Pyrrolo[2,3-d]pyrimidin-4-ylamino)piperidin-1-yl]but-2-en-1-one | IC50 | 2290.0 [1], 10000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_82b5da8c5186922184a5871024a4771b.svg) | 1-[(3R)-3-(7H-Pyrrolo[2,3-d]pyrimidin-4-ylamino)piperidin-1-yl]prop-2-en-1-one | IC50 | 1400.0 [1], 10000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_10cb1e57c61afbed89099a5ddbc46af9.svg) | 1-[(3R)-3-[Methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino]piperidin-1-yl]prop-2-en-1-one | IC50 | 1150.0 [1], 7820.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_dd178cb02ed593d6c678362543089021.svg) | N-[5-[4-[[(2,2,2-Trifluoroacetyl)amino]methyl]phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-yl]cyclopropanecarboxamide | IC50 | 16.0 [1], 4467.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_fda32d57c206afbadf3b11f4539332be.svg) | (2R)-N-[3-[2-[(1,3-Dimethylpyrazol-4-yl)amino]-5-fluoropyrimidin-4-yl]-1H-indol-7-yl]-2-(4-methylpiperazin-1-yl)butanamide | IC50 | 4.0 [1], 75.1 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_bc0e4616dea41dec6e5bd9fd9c27f5f2.svg) | (2S)-2-[(2S)-2,4-Dimethylpiperazin-1-yl]-N-[3-[2-[(3-ethoxy-1-methylpyrazol-4-yl)amino]-5-fluoropyrimidin-4-yl]-1H-indol-7-yl]propanamide | IC50 | 3000.0 [1], 7600.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_c01c04db39c3147730c137650660971e.svg) | (2R)-N-[3-[2-[(3-Ethoxy-1-methylpyrazol-4-yl)amino]-5-methylpyrimidin-4-yl]-1H-indol-7-yl]-2-(4-methylpiperazin-1-yl)butanamide | IC50 | 6.0 [1], 104.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_fb86903b6f3f0d3a72e618dc5208c9a9.svg) | (2R)-2-[(2S)-2,4-Dimethylpiperazin-1-yl]-N-[3-[2-[(3-methoxy-1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]-1H-indol-7-yl]propanamide | IC50 | 643.0 [1], 847.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_bb494ed0af45b13a8bc13bad819c595b.svg) | (2R)-N-[3-[5-Chloro-2-[(3-methoxy-1-methylpyrazol-4-yl)amino]pyrimidin-4-yl]-1H-indol-7-yl]-2-(4-methylpiperazin-1-yl)propanamide | IC50 | 7.0 [1], 57.9 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_5c8b332ae0eb7037ddb86cfd650b2efb.svg) | (2R)-N-[3-[2-[(1,3-Dimethylpyrazol-4-yl)amino]-5-fluoropyrimidin-4-yl]-1H-indol-7-yl]-3-methoxy-2-(4-methylpiperazin-1-yl)propanamide | IC50 | 3.0 [1], 56.6 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_9456363e83abc1cb76b9ebb80a4d53aa.svg) | 6-Chloro-2-(2,5-difluoro-4-methoxyphenyl)-N-(piperidin-4-ylmethyl)-1H-imidazo[4,5-b]pyridin-7-amine | IC50 | 71.0 [1], 173.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_d48083fcfd1af26a97eb1db4d273c63a.svg) | 6-Chloro-2-(3,4-dimethoxyphenyl)-N-(piperidin-4-ylmethyl)-1H-imidazo[4,5-b]pyridin-7-amine | IC50 | 4.9 [1], 87.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_a010b3748bc57942474a7ca55fa91b78.svg) | 6-Chloro-2-(2-fluoro-4-methoxyphenyl)-N-(piperidin-4-ylmethyl)-1H-imidazo[4,5-b]pyridin-7-amine | IC50 | 34.0 [1], 106.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_e16d2716daffa9f2930adbb24876e96c.svg) | 6-Chloro-2-(4-methoxy-2-methylphenyl)-N-(piperidin-4-ylmethyl)-1H-imidazo[4,5-b]pyridin-7-amine | IC50 | 9.0 [1], 37.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_0490e8fb5253a17e3f20c3fffd467ff1.svg) | 6-Chloro-2-(2-fluoro-5-methoxyphenyl)-N-(piperidin-4-ylmethyl)-1H-imidazo[4,5-b]pyridin-7-amine | IC50 | 49.0 [1], 76.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_dcfa71bc64a0f5ff9627b98dff874446.svg) | 6-Chloro-2-(4-methoxyphenyl)-N-(piperidin-4-ylmethyl)-1H-imidazo[4,5-b]pyridin-7-amine | IC50 | 17.0 [1], 29.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_eaf1188724e5cb989438b474763d0ce9.svg) | N-[3-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)phenyl]prop-2-enamide | IC50 | 966.0 [1], 8710.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_d3ca598bc9f23f706802f113fbd7b263.svg) | 3-(4-Cyano-3-methoxyanilino)-1-[(3R,4S)-4-cyanooxan-3-yl]pyrazole-4-carboxamide | IC50 | 0.07 [1], 19.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_abdcd30aa512beb19531bd1eb9803cdf.svg) | 1-[(3R,4S)-4-Cyanooxan-3-yl]-3-[(2-fluoro-6-methoxypyridin-4-yl)amino]pyrazole-4-carboxamide | IC50 | 0.4 [1], 39.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_4e4f3cef2d555ec1556a0e1ef2257266.svg) | [2-[6-(2-Ethyl-5-fluoro-4-hydroxyphenyl)-1H-indazol-3-yl]-3,4,6,7-tetrahydroimidazo[4,5-c]pyridin-5-yl]-(4-fluorophenyl)methanone | IC50 | 0.1 [1], 0.7 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_9b0875ef395afd4783d9fd5a84203e65.svg) | Methyl 2-[4-[(4-aminocyclohexyl)amino]-2-oxo-1H-pyridin-3-yl]-4,5,6,7-tetrahydro-3H-benzimidazole-5-carboxylate | IC50 | 0.8 [1], 44.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_701aae0e2ee5fa705dd5c8148f02f8a9.svg) | [(1S)-1-Methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydroinden-1-yl]cyanamide | IC50 | 5.0 [1], 57.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_3e4efbfe63b749444c1b153c6a1a0a11.svg) | 1-[(3R,4S)-4-Cyanooxan-3-yl]-3-[[(3S)-3-methyl-1,1-dioxo-2,3-dihydro-1,2-benzothiazol-5-yl]amino]pyrazole-4-carboxamide | IC50 | 0.04 [1], 16.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_9477e7cf8d0294dcc3d8b9733dde1c5c.svg) | 1-[(3R,4S)-4-Cyanooxan-3-yl]-3-(3,4-dicyanoanilino)pyrazole-4-carboxamide | IC50 | 0.9 [1], 77.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_4522b2785344f2db38cc368e347cba36.svg) | 3-(3-Chloro-4-cyanoanilino)-1-[(3R,4S)-4-cyanooxan-3-yl]pyrazole-4-carboxamide | IC50 | 0.4 [1], 26.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_9a97ef53d840d56c39fd2db3e8cec701.svg) | 1-[(3R,4S)-4-Cyanooxan-3-yl]-3-[(8-fluoro-4-methoxyquinolin-6-yl)amino]pyrazole-4-carboxamide | IC50 | 0.19 [1], 24.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_7acd2334d7c9d48ae285398fd777200b.svg) | 3-[(4-Chloro-8-fluoroquinolin-6-yl)amino]-1-[(3R,4S)-4-cyanooxan-3-yl]pyrazole-4-carboxamide | IC50 | 0.24 [1], 14.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_b32eff2382d82e8dbfa280f2478d6257.svg) | 1-[(3Ar,7aR)-1-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-3,3a,4,5,7,7a-hexahydro-2H-pyrrolo[2,3-c]pyridin-6-yl]ethanone | IC50 | 863.0 [1], 10000.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_3eaf7c811b2439377fe8f9a07edaa014.svg) | 1-[(3R,4S)-4-Cyanooxan-3-yl]-3-[4-(1-methylpyrazol-4-yl)anilino]pyrazole-4-carboxamide | IC50 | 0.02 [1], 6.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_876d70d9329f8027ebdf6ab89a741ccd.svg) | 1-[(3R,4S)-4-Cyanooxan-3-yl]-3-(4-cyclopropylanilino)pyrazole-4-carboxamide | IC50 | 0.5 [1], 37.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_9fe8686977fef47c16374f561c38ae7b.svg) | 1-[(3R,4S)-4-Cyanooxan-3-yl]-3-[(4-methylquinazolin-6-yl)amino]pyrazole-4-carboxamide | IC50 | 0.16 [1], 24.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_0df6bc01eb39f288ead8cb08ea943988.svg) | 1-[(3R,4S)-4-Cyanooxan-3-yl]-3-[[2-(dimethylamino)-6-fluoropyridin-4-yl]amino]pyrazole-4-carboxamide | IC50 | 0.18 [1], 28.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_8806d62bb893e5e570241e800caee40a.svg) | 1-[(3R,4S)-4-Cyanooxan-3-yl]-3-[4-(triazol-1-yl)anilino]pyrazole-4-carboxamide | IC50 | 0.06 [1], 23.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_9bab2a49362842a6f0f634b0b694e082.svg) | 1-[(3R,4S)-4-Cyanooxan-3-yl]-3-(4-fluoroanilino)pyrazole-4-carboxamide | IC50 | 0.3 [1], 31.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_6d47bf0421e951815851300555bac5b2.svg) | 3-(4-Cyano-3-cyclopropylanilino)-1-[(3R,4S)-4-cyanooxan-3-yl]pyrazole-4-carboxamide | IC50 | 1.4 [1], 72.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_2c69ed826fb590cbce48a1f1728dfb75.svg) | 1-[(3R,4S)-4-Cyanooxan-3-yl]-3-[4-(difluoromethoxy)anilino]pyrazole-4-carboxamide | IC50 | 0.1 [1], 5.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_b991d5059c387da7fd3b43ec2fbab3f8.svg) | 2-Cyano-3-[5-(3-cyclohexyl-3,5,8,10-tetrazatricyclo[7.3.0.02,6]dodeca-1,4,6,8,11-pentaen-4-yl)furan-2-yl]-N,N-dimethylprop-2-enamide | IC50 | 52.0 [1], 668.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_0806eb5799c883bc009f968ec8d44840.svg) | 1-[6-[5-(2-Methoxyethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-2,3-dihydro-1,4-benzoxazin-4-yl]prop-2-en-1-one | IC50 | 10000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_408598d35085b0550d021286d969f553.svg) | [(1R,2R)-2-Methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]cyanamide | IC50 | 94.0 [1], 973.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_c4a4374d204bc28db1123832ff1bdd33.svg) | [(1S)-6-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]cyanamide | IC50 | 82.0 [1], 644.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_549827c9bb0488fc1de6fba73e0a9d32.svg) | Methyl-[6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]cyanamide | IC50 | 814.0 [1], 7624.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_129e9c7b3efef81b33b9aff7637382e4.svg) | [(1R,2S)-2-Methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]cyanamide | IC50 | 100.0 [1], 705.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_996085cd3ed899884502e651927fb78c.svg) | [(1R,2R)-2-Hydroxy-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]cyanamide | IC50 | 105.0 [1], 1266.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_a462a47275271c548f26fdc10a5ce09e.svg) | [(4R)-6-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-3,4-dihydro-2H-chromen-4-yl]cyanamide | IC50 | 81.0 [1], 665.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_67d301ca6bf740ca65df9892d21de2c5.svg) | [(1R)-6-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]cyanamide | IC50 | 96.0 [1], 844.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_1b60ac6ea5f0778a919f423833f5ed81.svg) | N-[(1R,3S)-3-(Cyanoamino)-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]methanesulfonamide | IC50 | 97.0 [1], 1918.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_d9c80d6ffa830006e13e88926845c06c.svg) | [1-Methyl-6-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydroinden-1-yl]cyanamide | IC50 | 8.0 [1], 94.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_9195481149e28f3c059402c50df16cb7.svg) | [(1S)-6-[5-[3-(Hydroxymethyl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-2,3-dihydro-1H-inden-1-yl]cyanamide | IC50 | 733.0 [1], 9604.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_7a2fdf74d7e0a29dfab1f053bfe15177.svg) | N-[(1R,3S)-3-(Cyanoamino)-5-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]-2-methoxyethanesulfonamide | IC50 | 775.0 [1], 8652.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_5fb4049c9ff02e709add8d1c1479a148.svg) | [6-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]cyanamide | IC50 | 113.0 [1], 909.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_f6805fd43bae3445f236d87a9f3d1f4a.svg) | 6-[5-(2-Methoxyethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-2,3-dihydro-1,4-benzoxazine-4-carbonitrile | IC50 | 991.0 [1], 6501.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_ea7dd767bd6f0ded599e843d4c103539.svg) | [6-[5-(2-Methoxyethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-3,4-dihydro-2H-chromen-4-yl]cyanamide | IC50 | 369.0 [1], 3776.0 [2] |
![](https://images.aatbio.com/dataset/ic50/tyrosine-protein-kinase-jak1_da43a042876e39d35d5303eb92a52ec0.svg) | N-[3-[5-(2-Methoxyethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]phenyl]prop-2-enamide | IC50 | 4163.0 [1], 10000.0 [2] |