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Tyrosine-protein kinase CSK Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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SaracatinibIC50840.0 [1]
IbrutinibIC502.2 [1]
7-[cis-4-(4-Methylpiperazin-1-Yl)cyclohexyl]-5-(4-Phenoxyphenyl)-7h-Pyrrolo[2,3-D]pyrimidin-4-AmineIC5041.0 [1], 4270.0 [2]
2-PropenaMide, N-[cis-4-[4-aMino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyriMidin-1-yl]cyclohexyl]-IC502.4 [1]
TofacitinibIC5010000.0 [1]
BosutinibIC5063.0 [1]
PD173074IC5019800.0 [1]
DoramapimodIC5030000.0 [1]
Nvp-aew541IC5010000.0 [1]
Pyridone 6IC502100.0 [1]
Azd-1152hqpaKi10000.0 [1]
1-(Tert-Butyl)-3-(p-tolyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC50640.0 [1]
Tak-285IC504700.0 [1]
4-Amino-5-(4-Phenoxyphenyl)-7h-Pyrrolo[2,3-D]pyrimidin-7-Yl-CyclopentaneIC505180.0 [1]
1,4-DiaminoanthraquinoneIC5040000.0 [1]
1-Tert-butyl-3-(naphthalen-1-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC50510.0 [1]
LY-3009120IC50290.0 [1]
Amg-458IC50165.0 [1]
1-(Tert-Butyl)-3-(naphthalen-1-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amineIC501970.0 [1]
CID 59604787IC5010000.0 [1]
CID 44814409IC5010000.0 [1]
CID 9916282IC5021000.0 [1]
7-(2,6-Dimethylphenyl)-5-methyl-N-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1,2,4-benzotriazin-3-amineIC50659.0 [1]
(S)-2-Amino-N-hydroxy-3-phenylpropanamideIC5015500.0 [1]
N'-(5-Chloro-1,3-benzodioxol-4-yl)-N-(3-methylsulfonylphenyl)pyrimidine-2,4-diamineIC5010700.0 [1]
(2S)-2-Amino-N-hydroxy-3-(4-hydroxyphenyl)propanamideIC509500.0 [1]
5,7-Diphenyl-4-aminopyrrolo[2,3-d]pyrimidineIC505000.0 [1]
2-((4-(4-Amino-5-(3-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenethyl)(methyl)amino)ethanolIC505000.0 [1]
N-(5-Chloro-1,3-benzodioxol-4-yl)-6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-amineIC501700.0 [1]
2-[4-[4-Amino-5-(3-methoxyphenyl)pyrrolo[2,3-d]pyrimidin-7-yl]phenyl]-N-(2-hydroxyethyl)acetamideIC505000.0 [1]
2-[3-(4-Amino-5-phenyl-pyrrolo[2,3-d]pyrimidin-7-yl)-benzylamino]-ethanolIC505000.0 [1]
CID 11675054IC5010000.0 [1]
1-[5-Amino-4-(3,4-dichlorophenyl)-3-methylpyrazol-1-yl]ethanoneIC50100000.0 [1]
8-[2-(Dimethylamino)ethoxy]-2-(4-phenoxyphenyl)-6,11-dihydro-5H-pyrazolo[5,1-b][1,3]benzodiazepine-1-carboxamideIC501.7 [1]
5-(3-Methoxyphenyl)-7-phenyl-4-aminopyrrolo[2,3-d]pyrimidineIC505000.0 [1]
(13R,15S)-13-Methyl-16-oxa-8,9,12,22,24-pentazahexacyclo[15.6.2.16,9.112,15.02,7.021,25]heptacosa-1(24),2,4,6,17,19,21(25)-heptaene-23,27-dioneIC501000.0 [1]
N-[2-[3-(Dimethylamino)propyl-methylamino]-5-(trifluoromethyl)phenyl]-2-fluoro-5-[3-[4-(methylamino)-1,3,5-triazin-2-yl]pyridin-2-yl]oxybenzamideIC5025000.0 [1]
(3-(4-Amino-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)phenyl)methanolIC505000.0 [1]
2-(4-(4-Amino-5-(3-methoxyphenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)benzylamino)ethanolIC505000.0 [1]
2-(4-(4-Amino-5-phenyl-7H-pyrrolo[2,3-d]pyrimidin-7-yl)benzylamino)ethanolIC504300.0 [1]
5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-tert-butylpyridine-3-sulfonamideIC5010000.0 [1]
Chlorobenzodioxole deriv. 27IC502000.0 [1]
1-[5-Tert-butyl-3-[4-[2-(dimethylamino)ethyl]-5-oxo-1,4-diazepane-1-carbonyl]thiophen-2-yl]-3-(2,3-dichlorophenyl)ureaIC5030000.0 [1]
7,8-Dichloro-9-methyl-1-oxospiro[2,4-dihydropyrido[3,4-b]indole-3,4'-piperidine]-4-carbonitrileIC5010000.0 [1]
6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-oneIC5010000.0 [1]
5-(3-Tert-butyl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-4-(2,4-difluorophenyl)-1,3-oxazoleIC5010000.0 [1]
N-(5-Chloro-1,3-benzodioxol-4-yl)-5-(oxan-4-yloxy)-7-(3-pyrrolidin-1-ylpropoxy)quinazolin-4-amineIC50270.0 [1]
5-(3-Propan-2-yl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-4-(2,4,5-trifluorophenyl)-1,3-oxazoleIC5010000.0 [1]
2-[3-(3-Piperidin-4-ylpropoxy)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamideKi2000.0 [1]
N-(6-Amino-5-chloropyridin-3-yl)-2-chloro-5-(3-(trifluoromethyl)benzamido)benzamideIC5030000.0 [1]
2-[3-(Methanesulfonamido)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamideKi2000.0 [1]
4-[8-Amino-3-[(3R)-1-(2-methylpropanoyl)piperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-3-fluoro-N-[4-(trifluoromethyl)pyridin-2-yl]benzamideIC501154.0 [1]
4-[8-Amino-3-[(2R)-4-(oxan-4-yl)morpholin-2-yl]imidazo[1,5-a]pyrazin-1-yl]-3-fluoro-N-[4-(trifluoromethyl)pyridin-2-yl]benzamideIC50665.0 [1]
4-[8-Amino-3-[(3R)-1-(oxan-4-yl)piperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-3-fluoro-N-[4-(trifluoromethyl)pyridin-2-yl]benzamideIC50455.0 [1]
4-[8-Amino-3-[(2R)-4-(2-methylpropanoyl)morpholin-2-yl]imidazo[1,5-a]pyrazin-1-yl]-3-fluoro-N-[4-(trifluoromethyl)pyridin-2-yl]benzamideIC502145.0 [1]
5-(1,3-Benzodioxol-5-yl)-7-[[(2R)-1-ethenylsulfonylpyrrolidin-2-yl]methyl]pyrrolo[2,3-d]pyrimidin-4-amineIC502826.0 [1]
N'-[5-[2-(3,4,5-Trimethoxyanilino)pyrimidin-4-yl]pyridin-2-yl]ethane-1,2-diamineIC5010000.0 [1]
(S)-2-Amino-3-(4-aminophenyl)-N-hydroxypropanamideIC5047000.0 [1]
(S)-2-Amino-3-(4-azidophenyl)-N-hydroxypropanamideIC5021000.0 [1]
4-((S)-2-(Hydroxycarbamoyl)-2-aminoethyl)phenylboronic acidIC5034000.0 [1]
(S)-2-Amino-N-hydroxy-3-(4-isopropylphenyl)propanamideIC503300.0 [1]
(S)-2-Amino-N-hydroxy-3-[4-(nitrophenyl)phenyl]propanamideIC504900.0 [1]
(2S)-2-Amino-3-(4-fluorophenyl)-N-hydroxypropanamideIC5011000.0 [1]
(S)-2-Amino-3-(3,4-difluorophenyl)-N-hydroxypropanamideIC5018000.0 [1]
(2S)-2-Amino-3-(4-bromophenyl)-N-hydroxypropanamideIC505600.0 [1]
(S)-2-Amino-N-hydroxy-3-(2-iodophenyl)propanamideIC503400.0 [1]
(2S)-2-Amino-N-hydroxy-2-(4-hydroxyphenyl)acetamideIC5057000.0 [1]
(S)-2-Benzylamino-N-hydroxy-3-(4-hydroxyphenyl)propanamideIC5029000.0 [1]
(S)-N-Hydroxy-3-(4-hydroxyphenyl)-2-phenylpropanamideIC50290000.0 [1]
(2S)-2-Amino-N-hydroxy-3-(4-hydroxyphenyl)propanethioamideIC502500.0 [1]
(S)-2-Amino-N-benzyl-N-hydroxy-3-(4-hydroxyphenyl)propanamideIC50291000.0 [1]
(2S)-2-Amino-3-(4-cyanophenyl)-N-hydroxypropanamideIC5028000.0 [1]
(S)-2-Amino-N-hydroxy-3-(4-nitrophenyl)propanamideIC507000.0 [1]
(S)-2-Amino-N-hydroxy-3-[4-(phenyl)phenyl]propanamideIC5012000.0 [1]
(S)-2-Amino-N-hydroxy-3-[3-(nitrophenyl)phenyl]propanamideIC506100.0 [1]
(2S)-2-Amino-3-(4-chlorophenyl)-N-hydroxypropanamideIC506300.0 [1]
(S)-2-Amino-3-(4-iodophenyl)propanehydroxamic acidIC503200.0 [1]
(S)-2-Amino-N-hydroxy-3-(4-hydroxy-3,5-diiodophenyl)propanamideIC503400.0 [1]
(2S)-2-Amino-N-hydroxy-4-(4-hydroxyphenyl)butanamideIC5018000.0 [1]
5-[2-(2-Aminopyrimidin-5-yl)ethynyl]-N-[2-[(3S)-3-(dimethylamino)piperidin-1-yl]-5-(trifluoromethyl)phenyl]-2-fluorobenzamideIC501800.0 [1]
{4-[6-((S)-3-Ethyl-piperazin-1-yl)-pyridin-3-yl]-pyrimidin-2-yl}-(3,4,5-trimethoxy-phenyl)-amineIC5010000.0 [1]
4-(2-Chloro-4-fluorophenyl)-5-(3-propan-2-yl-[1,2,4]triazolo[4,3-a]pyridin-6-yl)-1,3-oxazoleIC5010000.0 [1]
N-Ethyl-6-[4-(4-fluorophenyl)-1,3-oxazol-5-yl]-[1,2,4]triazolo[4,3-a]pyridin-3-amineIC5010000.0 [1]
6-[5-(2,5-Difluorophenyl)-1H-pyrazol-4-yl]-3-propan-2-yl-[1,2,4]triazolo[4,3-a]pyridineIC5010000.0 [1]
(3-((2-(3,5-Dimorpholinophenylamino)pyrimidin-4-yl)(methyl)amino)-4-methylphenyl)methanolIC5080.0 [1]
2-Amino-N-[2-[4-[4-(1,2-benzothiazol-4-yloxy)-3-chloroanilino]pyrrolo[3,2-d]pyrimidin-5-yl]ethyl]-2-methylpropanamideIC503900.0 [1]
(S)-2-Amino-N-hydroxy-3-p-tolylpropionamideIC509500.0 [1]
CID 46224908IC504.5 [1]
N-[5-[6-(Methylamino)pyrazin-2-yl]-2-oxo-1H-pyridin-3-yl]-4-[(2S)-2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl]benzamideKi1000.0 [1]
N-(5-Chloro-1,3-benzodioxol-4-yl)-6-methoxy-7-(3-morpholin-4-ylpropoxy)quinazolin-4-amineIC507300.0 [1]
Infigratinib phosphateIC5010000.0 [1]
4-[[(3S,4R)-1-(5-Cyanopyridin-2-yl)-3-fluoropiperidin-4-yl]amino]-1H-pyrrolo[2,3-b]pyridine-5-carboxamideIC501000.0 [1]
N~4~-[5-(Diethylamino)pentan-2-yl]-2-[(E)-2-(2,4,6-trichlorophenyl)ethenyl]quinazoline-4,6-diamineIC50100000.0 [1]
2-[3-(3-Piperazin-1-ylpropoxy)phenyl]-N-(4-pyridin-4-yl-1,3-thiazol-2-yl)acetamideIC5010000.0 [1]
1-[4-[3-[4-Amino-5-[2-fluoro-5-[[(2S)-oxolan-2-yl]methoxy]phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclobutyl]piperazin-1-yl]ethanoneIC5010000.0 [1]
3-(6-Ethoxynaphthalen-2-yl)-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-4-amine;hydrochlorideIC503100.0 [1]
3-(6-Methoxynaphthalen-2-yl)-1-propan-2-ylpyrazolo[3,4-d]pyrimidin-4-amine;hydrochlorideIC502600.0 [1]
3-(2-Ethoxyquinolin-6-yl)-1-(piperidin-4-ylmethyl)pyrazolo[3,4-d]pyrimidin-4-amine;hydrochlorideIC5010000.0 [1]
3-(6-Methoxynaphthalen-2-yl)-1-(piperidin-4-ylmethyl)pyrazolo[3,4-d]pyrimidin-4-amine;hydrochlorideIC5010000.0 [1]
3-(6-Ethoxynaphthalen-2-yl)-1-(piperidin-4-ylmethyl)pyrazolo[3,4-d]pyrimidin-4-amine;hydrochlorideIC5010000.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Tyrosine-protein kinase CSK Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Nov. 2024, https://www.aatbio.com/data-sets/tyrosine-protein-kinase-csk-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 20). Quest Database™ Tyrosine-protein kinase CSK Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/tyrosine-protein-kinase-csk-inhibitors-ic50-ki.
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