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Tyrosine-protein kinase BRK Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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StaurosporineIC50247.0 [1], 1250.0 [2]
IbrutinibIC503.3 [1]
Tyrphostin AG 808IC502320.0 [1], 53240.0 [2]
[3-Fluoro-4-[[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino]phenyl]-piperazin-1-ylmethanoneIC5010.0 [1], 54.0 [2]
5-{[(5-Bromo-2-methoxyphenyl)methylidene]amino}-2,3-dihydro-1H-1,3-benzodiazol-2-oneIC5017110.0 [1], 100000.0 [2]
N-[6-Methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]-3-(piperidin-1-ylmethyl)-1,2-thiazol-5-amineIC5013.0 [1], 94.0 [2]
CID 56675928IC502.0 [1], 5.0 [2]
[4-[[6-Cyclopropyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino]-3-fluorophenyl]-morpholin-4-ylmethanoneIC5030.0 [1], 52.0 [2]
TilfrinibIC503.15 [1], 3.2 [2]
5-[(5-Chloro-2-hydroxy-3-methoxyphenyl)methylideneamino]-1,3-dihydrobenzimidazol-2-oneIC501680.0 [1], 74040.0 [2]
5-[(5-Bromo-2-hydroxy-3-methoxyphenyl)methylideneamino]-1,3-dihydrobenzimidazol-2-oneIC504730.0 [1], 52440.0 [2]
5-[(2-Hydroxy-5-iodo-3-methoxyphenyl)methylideneamino]-1,3-dihydrobenzimidazol-2-oneIC504980.0 [1], 58100.0 [2]
2-(1,3-Benzothiazol-5-yliminomethyl)-3,4-dibromo-6-ethoxyphenolIC501170.0 [1], 2540.0 [2]
2-(3H-Benzimidazol-5-yliminomethyl)-3,4-dibromo-6-ethoxyphenolIC50130.0 [1], 4710.0 [2]
5-[(2,3-Dichloro-5-ethoxy-6-hydroxyphenyl)methylideneamino]-1,3-dihydrobenzimidazol-2-oneIC501290.0 [1], 3480.0 [2]
5-[(2,3,5-Tribromo-6-hydroxyphenyl)methylideneamino]-1,3-dihydrobenzimidazol-2-oneIC50410.0 [1], 11750.0 [2]
5-[(6-Bromo-2-hydroxy-3-methoxyphenyl)methylideneamino]-1,3-dihydrobenzimidazol-2-oneIC503900.0 [1], 16630.0 [2]
5-[(2-Bromo-6-hydroxyphenyl)methylideneamino]-1,3-dihydrobenzimidazol-2-oneIC501350.0 [1], 24490.0 [2]
5-[(5-Chloro-3-ethoxy-2-hydroxyphenyl)methylideneamino]-1,3-dihydrobenzimidazol-2-oneIC501990.0 [1], 51250.0 [2]
3,4-Dibromo-6-ethoxy-2-(1H-indol-5-yliminomethyl)phenolIC50360.0 [1], 7580.0 [2]
2-(1,3-Benzothiazol-5-yliminomethyl)-3,4-dibromo-6-methoxyphenolIC501300.0 [1], 4610.0 [2]
2-(3H-Benzimidazol-5-yliminomethyl)-3,4-dibromo-6-methoxyphenolIC50200.0 [1], 5520.0 [2]
3,4-Dibromo-2-(1H-indol-5-yliminomethyl)-6-methoxyphenolIC50270.0 [1], 3490.0 [2]
5-[(2-Hydroxyphenyl)methylideneamino]-1,3-dihydrobenzimidazol-2-oneIC502000.0 [1], 100000.0 [2]
5-{[(E)-(3,5-Dibromo-2-hydroxyphenyl)methylidene]amino}-1,3-dihydro-2H-benzimidazol-2-oneIC505600.0 [1], 48960.0 [2]
5-{[(5-Bromo-2-hydroxyphenyl)methylidene]amino}-2,3-dihydro-1H-1,3-benzodiazol-2-oneIC501900.0 [1], 100000.0 [2]
5-[(5-Bromo-3-ethoxy-2-hydroxyphenyl)methylideneamino]-1,3-dihydrobenzimidazol-2-oneIC505830.0 [1], 23510.0 [2]
[4-[[6-Cyclopropyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino]-3-fluorophenyl]-piperazin-1-ylmethanoneIC503.0 [1], 7.0 [2]
(2,2-Dimethylpiperazin-1-yl)-[3-fluoro-4-[[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino]phenyl]methanoneIC509.0 [1], 46.0 [2]
[4-[[6-Cyclopropyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino]-3-fluorophenyl]-(2,2-dimethylpiperazin-1-yl)methanoneIC503.0 [1], 7.0 [2]
[4-[[6-Cyclopropyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino]-3-fluorophenyl]-(3,3-dimethylpiperazin-1-yl)methanoneIC506.0 [1], 7.0 [2]
[2-Chloro-4-[[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino]phenyl]-(3,3-dimethylpiperazin-1-yl)methanoneIC5018.0 [1], 19.0 [2]
6-Methyl-N-(5-piperazin-1-ylpyridin-3-yl)-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-amineIC5075.0 [1], 244.0 [2]
[4-[[6-Methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino]phenyl]-piperazin-1-ylmethanoneIC5015.0 [1], 167.0 [2]
[2-Cyclopropyl-4-[[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino]phenyl]-piperazin-1-ylmethanoneIC5038.0 [1], 40.0 [2]
[2-Chloro-4-[[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino]phenyl]-(4-methylpiperazin-1-yl)methanoneIC508.0 [1], 600.0 [2]
[2-Chloro-4-[[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino]phenyl]-(4,7-diazaspiro[2.5]octan-4-yl)methanoneIC5016.0 [1], 42.0 [2]
[2-Chloro-4-[[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino]phenyl]-[(1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl]methanoneIC5011.0 [1], 177.0 [2]
[2-Chloro-4-[[6-cyclopropyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino]phenyl]-(4,7-diazaspiro[2.5]octan-4-yl)methanoneIC5010.0 [1], 14.0 [2]
[2-Chloro-4-[[6-cyclopropyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino]phenyl]-(4,7-diazaspiro[2.5]octan-7-yl)methanoneIC5013.0 [1], 33.0 [2]
(3,3-Dimethylpiperazin-1-yl)-[3-fluoro-4-[[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino]phenyl]methanoneIC5010.0 [1], 38.0 [2]
1-[4-[2-Chloro-4-[[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino]benzoyl]piperazin-1-yl]ethanoneIC5016.0 [1], 3000.0 [2]
[2-Chloro-4-[[6-cyclopropyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino]phenyl]-[(1R,4R)-2,5-diazabicyclo[2.2.2]octan-2-yl]methanoneIC505.0 [1], 45.0 [2]
[2-Chloro-4-[[6-cyclopropyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino]phenyl]-[(1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl]methanoneIC5010.0 [1], 17.0 [2]
[2-Fluoro-4-[[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino]phenyl]-piperazin-1-ylmethanoneIC5032.0 [1], 153.0 [2]
[2-Chloro-4-[[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino]phenyl]-(4-hydroxypiperidin-1-yl)methanoneIC5072.0 [1], 120.0 [2]
[2-Chloro-4-[[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino]phenyl]-morpholin-4-ylmethanoneIC508.0 [1], 254.0 [2]
[2-Chloro-4-[[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino]phenyl]-(2,2-dimethylpiperazin-1-yl)methanoneIC5010.0 [1], 23.0 [2]
[2-Chloro-4-[[6-methyl-3-(1-methylpyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino]phenyl]-piperazin-1-ylmethanoneIC50256.0 [1], 3000.0 [2]
[2-Chloro-4-[[6-cyclopropyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino]phenyl]-(3,3-dimethylpiperazin-1-yl)methanoneIC503.0 [1], 47.0 [2]
[2-Chloro-4-[[6-cyclopropyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino]phenyl]-morpholin-4-ylmethanoneIC50124.0 [1], 600.0 [2]
[2-Chloro-4-[[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino]phenyl]-piperazin-1-ylmethanoneIC507.0 [1], 157.0 [2]
[4-[[6-Methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino]-2-(trifluoromethyl)phenyl]-piperazin-1-ylmethanoneIC507.0 [1], 35.0 [2]
[2-Chloro-4-[[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino]phenyl]-[4-(2-hydroxyethyl)piperazin-1-yl]methanoneIC5068.0 [1], 132.0 [2]
[2-Chloro-4-[[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino]phenyl]-(1,4-diazepan-1-yl)methanoneIC5034.0 [1], 113.0 [2]
[2-Chloro-4-[[6-cyclopropyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino]phenyl]-piperazin-1-ylmethanoneIC506.0 [1], 22.0 [2]
[2-Methoxy-4-[[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino]phenyl]-piperazin-1-ylmethanoneIC5022.0 [1], 23.0 [2]
[2-Chloro-4-[[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino]phenyl]-piperidin-1-ylmethanoneIC5093.0 [1], 608.0 [2]
[2-Chloro-4-[[6-ethyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino]phenyl]-piperazin-1-ylmethanoneIC5010.0 [1], 38.0 [2]
[2-Chloro-4-[[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino]phenyl]-(4,7-diazaspiro[2.5]octan-7-yl)methanoneIC5019.0 [1], 62.0 [2]
[2-Chloro-4-[[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino]phenyl]-[(1R,4R)-2,5-diazabicyclo[2.2.2]octan-2-yl]methanoneIC507.0 [1], 47.0 [2]
6-Methyl-N-(2-piperazin-1-ylpyridin-4-yl)-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-amineIC5011.0 [1], 109.0 [2]
4-[2-Chloro-4-[[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino]benzoyl]piperazin-2-oneIC503.0 [1], 3000.0 [2]
[2-Chloro-4-[[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino]phenyl]-(4-methoxypiperidin-1-yl)methanoneIC5060.0 [1], 137.0 [2]
N-(3-Chlorophenyl)-9H-pyrido[2,3-b]indol-4-amineIC504.7 [1], 4.75 [2]
5-{[(E)-(5-Chloro-2-hydroxyphenyl)methylidene]amino}-1,3-dihydro-2H-benzimidazol-2-oneIC501410.0 [1], 100000.0 [2]
2-PropenaMide, N-[cis-4-[4-aMino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyriMidin-1-yl]cyclohexyl]-IC503.3 [1]
GefitinibIC50980.0 [1]
DasatinibIC509.0 [1]
DoramapimodIC5030000.0 [1]
Lfm-a13IC50267000.0 [1]
EntrectinibIC50195.0 [1]
CID 53469448IC50412.0 [1]
Nms-P937 (nms1286937)IC5010000.0 [1]
CID 59604787IC5010000.0 [1]
5-[2,4-Dihydroxy-6-(4-Nitrophenoxy)phenyl]-N-(1-Methylpiperidin-4-Yl)-1,2-Oxazole-3-CarboxamideIC5010.0 [1]
(1S,2S,3R,4R)-3-[[5-Chloro-2-[[(7S)-4-methoxy-7-morpholin-4-yl-6,7,8,9-tetrahydro-5H-benzo[7]annulen-3-yl]amino]pyrimidin-4-yl]amino]bicyclo[2.2.1]hept-5-ene-2-carboxamideIC5073.0 [1]
Unii-BL7xsd8R7BIC50310.0 [1]
5-(2-Aminopyrimidin-4-yl)-2-phenyl-1H-pyrrole-3-carboxamideIC5010000.0 [1]
2-[1-(4,4-Difluorocyclohexyl)-piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamideIC5010000.0 [1]
4-(4-Fluorophenyl)-5-pyridin-4-yl-2-(2,4,6-trichlorophenyl)pyrazol-3-amineIC5061.0 [1]
3-[(4-Morpholin-4-ylbenzoyl)amino]-N-[(1S)-1-phenyl-2-pyrrolidin-1-ylethyl]-1H-thieno[3,2-c]pyrazole-5-carboxamideIC5010000.0 [1]
Ripk1-IN-7IC50111.0 [1]
[6-Chloro-4-methyl-3-[[3-(methylsulfamoylamino)phenyl]methyl]-2-oxochromen-7-yl] N,N-dimethylcarbamateIC5050000.0 [1]
5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-tert-butylpyridine-3-sulfonamideIC5010000.0 [1]
1-[5-Tert-butyl-3-[4-[2-(dimethylamino)ethyl]-5-oxo-1,4-diazepane-1-carbonyl]thiophen-2-yl]-3-(2,3-dichlorophenyl)ureaIC5030000.0 [1]
N-(7-Methoxyquinolin-6-yl)thieno[3,2-d]pyrimidine-7-carboxamideIC5050000.0 [1]
6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-oneIC5010000.0 [1]
2-Anilino-7-[(1S)-4-hydroxy-2,3-dihydro-1H-inden-1-yl]-5,5-dimethylpyrrolo[2,3-d]pyrimidin-6-oneIC5010000.0 [1]
5-[(2,3-Dibromo-5-ethoxy-6-hydroxyphenyl)methylideneamino]-1,3-dihydrobenzimidazol-2-oneIC50520.0 [1]
3-[[5-(1,3-Benzodioxol-5-yl)-[1,2,4]triazolo[1,5-c]quinazolin-8-yl]amino]propan-1-olIC5010000.0 [1]
5-[(5-Bromo-2,3-dimethoxyphenyl)methylideneamino]-1,3-dihydrobenzimidazol-2-oneIC5010000.0 [1]
5-[(2,3-Dibromo-6-hydroxy-5-methoxyphenyl)methylamino]-1,3-dihydrobenzimidazol-2-oneIC5010000.0 [1]
5-[(2,3-Dibromo-5-ethoxy-6-hydroxyphenyl)methylamino]-1,3-dihydrobenzimidazol-2-oneIC504790.0 [1]
5-[2-[4-(Dimethylamino)phenoxy]-4,6-dihydroxyphenyl]-N-(1-methylpiperidin-4-yl)-1,2-oxazole-3-carboxamideIC5010.0 [1]
5-[(2-Hydroxy-4-methoxyphenyl)methylideneamino]-1,3-dihydrobenzimidazol-2-oneIC5010000.0 [1]
5-[2,4-Dihydroxy-6-[4-(propan-2-ylamino)phenoxy]phenyl]-N-(1-methylpiperidin-4-yl)-1,2-oxazole-3-carboxamideIC5010.0 [1]
5-[2-[4-(Dimethylamino)phenoxy]-4,6-dihydroxyphenyl]-N-[1-(1,4-dioxaspiro[4.5]decan-8-yl)piperidin-4-yl]-1,2-oxazole-3-carboxamideIC5010.0 [1]
4-[8-Amino-3-[(3R)-1-(2-methylpropanoyl)piperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-3-fluoro-N-[4-(trifluoromethyl)pyridin-2-yl]benzamideIC50350.0 [1]
4-[8-Amino-3-[(2R)-4-(oxan-4-yl)morpholin-2-yl]imidazo[1,5-a]pyrazin-1-yl]-3-fluoro-N-[4-(trifluoromethyl)pyridin-2-yl]benzamideIC50113.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Tyrosine-protein kinase BRK Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/tyrosine-protein-kinase-brk-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ Tyrosine-protein kinase BRK Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/tyrosine-protein-kinase-brk-inhibitors-ic50-ki.
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