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Tyrosine-protein kinase BLK Inhibitors (IC50, Ki)

Structure
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▼
Compound Name
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Standard Type
▲
▼
Standard Values (in nM)
▲
▼
IbrutinibIC500.5 [1]
CanertinibIC5029.0 [1], 50.0 [2]
4-[(3-Bromophenyl)amino]-6-acrylamidoquinazolineIC505470.0 [1], 10000.0 [2]
7-[cis-4-(4-Methylpiperazin-1-Yl)cyclohexyl]-5-(4-Phenoxyphenyl)-7h-Pyrrolo[2,3-D]pyrimidin-4-AmineIC5046.0 [1], 370.0 [2]
1-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-oneIC5019000.0 [1]
1-((2S,5R)-5-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-2-methylpiperidin-1-yl)prop-2-en-1-oneKi32400.0 [1]
2-PropenaMide, N-[cis-4-[4-aMino-3-(4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyriMidin-1-yl]cyclohexyl]-IC500.2 [1]
DoramapimodIC5030000.0 [1]
SulfuretinIC502880.0 [1]
Bms-777607IC50500.0 [1]
Amg-458IC50519.0 [1]
JNK Inhibitor VIC5010000.0 [1]
JNK Inhibitor VIIIKi1500.0 [1]
9-(1-Methylpyrazol-4-yl)-1-(1-prop-2-enoyl-2,3-dihydroindol-6-yl)benzo[h][1,6]naphthyridin-2-oneIC50366.0 [1]
CID 59604787IC5010000.0 [1]
Bmx-IN-1IC50377.0 [1]
CID 118295624IC50371.0 [1]
Bms-986142IC5023.0 [1]
7-(2,6-Dimethylphenyl)-5-methyl-N-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-1,2,4-benzotriazin-3-amineIC501320.0 [1]
2-Methyl-N-[2-[3-[[2-(prop-2-enoylamino)acetyl]amino]anilino]pyrimidin-5-yl]-5-[[3-(trifluoromethyl)benzoyl]amino]benzamideIC504.2 [1]
N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)acetamideKi1500.0 [1]
JAK3 covalent inhibitor-1IC5010000.0 [1]
4-Amino-5-chloro-6-ethoxy-pyridine-2-carboxylic acid 4-methanesulfonyl-benzylamideKi1400.0 [1]
7-Chloro-3-oxo-8-(1,3-thiazol-5-ylmethylamino)-11,16-dioxa-2,4,19,21-tetrazatricyclo[15.3.1.05,10]henicosa-1(20),5,7,9,17(21),18-hexaene-18-carbonitrileKi1453.0 [1]
1-({4-[(3,4-Dichlorophenyl)methoxy]phenyl}methyl)azetidine-3-carboxylic acidIC5010000.0 [1]
2-Methyl-N-[2-[3-(prop-2-enoylamino)anilino]pyrimidin-5-yl]-5-[[3-(trifluoromethyl)benzoyl]amino]benzamideIC502.7 [1]
7-Chloro-8-(3-hydroxypropoxy)-3-oxo-11,17-dioxa-2,4,20,22-tetrazatricyclo[16.3.1.05,10]docosa-1(21),5,7,9,18(22),19-hexaene-19-carbonitrileKi10000.0 [1]
7-Chloro-8-(3-hydroxypropyl)-3-oxo-11,17-dioxa-2,4,20,22-tetrazatricyclo[16.3.1.05,10]docosa-1(21),5(10),6,8,18(22),19-hexaene-19-carbonitrileKi10000.0 [1]
N-(7-Chloro-19-cyano-3-oxo-11,17-dioxa-2,4,20,22-tetrazatricyclo[16.3.1.05,10]docosa-1(21),5,7,9,18(22),19-hexaen-8-yl)methanesulfonamideKi10000.0 [1]
N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)-2-(2,5-dimethoxy-4-methylsulfonylphenyl)acetamideKi1500.0 [1]
N-(4-Amino-5-chloro-6-ethoxypyridin-2-yl)-2-(4-methanesulfonyl-2,5-dimethoxyphenyl)acetamideKi1500.0 [1]
N-(4-Amino-5-cyano-6-isopropoxypyridin-2-yl)-2-(4-methanesulfonyl-2,5-dimethoxyphenyl)acetamideKi1500.0 [1]
N-(4-Amino-5-cyano-6-phenylpyridin-2-yl)acetamideKi1500.0 [1]
Ripk1-IN-7IC50138.0 [1]
(13R,15S)-13-Methyl-16-oxa-8,9,12,22,24-pentazahexacyclo[15.6.2.16,9.112,15.02,7.021,25]heptacosa-1(24),2,4,6,17,19,21(25)-heptaene-23,27-dioneIC501000.0 [1]
5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-tert-butylpyridine-3-sulfonamideIC5010000.0 [1]
5-(2-Aminoethyl)-7-(7-(benzo[b]thiophen-2-yl)-1H-indazol-5-yl)-5H-pyrrolo[3,2-d]pyrimidin-2-amineIC508300.0 [1]
N-[3-[5-[2-(3-Morpholin-4-ylanilino)pyrimidin-4-yl]imidazo[2,1-b][1,3]thiazol-6-yl]phenyl]-2-phenylacetamideIC50320.0 [1]
1-[5-Tert-butyl-3-[4-[2-(dimethylamino)ethyl]-5-oxo-1,4-diazepane-1-carbonyl]thiophen-2-yl]-3-(2,3-dichlorophenyl)ureaIC5030000.0 [1]
6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-oneIC5010000.0 [1]
N-[2-Methyl-5-[9-(1-methylpyrazol-4-yl)-2-oxobenzo[h][1,6]naphthyridin-1-yl]phenyl]prop-2-enamideIC50339.0 [1]
N-[2-Methyl-5-[2-oxo-9-(1H-pyrazol-4-yl)-1-benzo[h][1,6]naphthyridinyl]phenyl]-2-propenamideIC5030.2 [1]
N-Tert-butyl-4-[2-oxo-1-(1-prop-2-enoyl-2,3-dihydroindol-6-yl)benzo[h][1,6]naphthyridin-9-yl]benzenesulfonamideIC5083.6 [1]
N-[5-[9-(6-Aminopyridin-3-yl)-2-oxobenzo[h][1,6]naphthyridin-1-yl]-2-methylphenyl]prop-2-enamideIC50177.0 [1]
N-[2-Methyl-5-(2-oxo-9-quinolin-3-ylbenzo[h][1,6]naphthyridin-1-yl)phenyl]prop-2-enamideIC50295.0 [1]
Chembl4166664IC5010000.0 [1]
2-[3-(Methanesulfonamido)phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamideKi10000.0 [1]
2-[3-[3-(4-Methylpiperazin-1-yl)propoxy]phenyl]-N-[4-(1H-pyrrolo[2,3-b]pyridin-3-yl)-1,3-thiazol-2-yl]acetamideKi10000.0 [1]
1-[3-[8-(Pyridin-4-ylmethylamino)imidazo[1,2-a]pyrazin-6-yl]phenyl]-3-[3-(trifluoromethyl)phenyl]ureaIC5050000.0 [1]
N-[2-Methyl-5-[2-oxo-9-[(E)-2-phenylethenyl]benzo[h][1,6]naphthyridin-1-yl]phenyl]prop-2-enamideIC50607.0 [1]
9-[4-(4-Methylpiperazin-1-yl)phenyl]-1-(1-prop-2-enoyl-2,3-dihydroindol-6-yl)benzo[h][1,6]naphthyridin-2-oneIC5010000.0 [1]
N-[3-[9-(6-Aminopyridin-3-yl)-2-oxobenzo[h][1,6]naphthyridin-1-yl]phenyl]prop-2-enamideIC50336.0 [1]
N-[3-[2-Oxo-9-(1H-pyrazol-4-yl)benzo[h][1,6]naphthyridin-1-yl]phenyl]prop-2-enamideIC50293.0 [1]
3-[2-(4-Amino-1-ethylpyrazolo[3,4-d]pyrimidin-3-yl)ethynyl]-4-methyl-N-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]benzamideIC5019.0 [1]
1-(2,2-Diethoxyethyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)pyrazolo[3,4-d]pyrimidin-4-amineIC50100000.0 [1]
Chmfl-egfr-202IC508.1 [1]
Chmfl-abl/kit-155IC5081.0 [1]
4-[8-Amino-3-[(3R)-1-(2-methylpropanoyl)piperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-3-fluoro-N-[4-(trifluoromethyl)pyridin-2-yl]benzamideIC5053.0 [1]
4-[8-Amino-3-[(2R)-4-(oxan-4-yl)morpholin-2-yl]imidazo[1,5-a]pyrazin-1-yl]-3-fluoro-N-[4-(trifluoromethyl)pyridin-2-yl]benzamideIC5050.0 [1]
(2Z)-2-[(3,4-Dihydroxyphenyl)methylidene]-5-methoxy-1-benzofuran-3-oneIC503050.0 [1]
4-[8-Amino-3-[(3R)-1-(oxan-4-yl)piperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-3-fluoro-N-[4-(trifluoromethyl)pyridin-2-yl]benzamideIC5029.0 [1]
4-[8-Amino-3-[(2R)-4-(2-methylpropanoyl)morpholin-2-yl]imidazo[1,5-a]pyrazin-1-yl]-3-fluoro-N-[4-(trifluoromethyl)pyridin-2-yl]benzamideIC50280.0 [1]
5-(1,3-Benzodioxol-5-yl)-7-[[(2R)-1-ethenylsulfonylpyrrolidin-2-yl]methyl]pyrrolo[2,3-d]pyrimidin-4-amineIC5076.4 [1]
(2Z)-2-[(3-Ethoxy-4-hydroxyphenyl)methylidene]-5-methoxy-1-benzofuran-3-oneIC505260.0 [1]
N-[(7S)-4-Amino-6-methylidene-5-(4-phenoxyphenyl)-7,8-dihydropyrimido[5,4-b]pyrrolizin-7-yl]prop-2-enamideIC500.2 [1]
[(1S)-6-(7H-Pyrrolo[2,3-d]pyrimidin-4-yl)-2,3-dihydro-1H-inden-1-yl]cyanamideIC5010000.0 [1]
[(1S)-6-[5-[3-(Hydroxymethyl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-2,3-dihydro-1H-inden-1-yl]cyanamideIC5010000.0 [1]
4-Fluoro-N-[4-[(6-oxo-5H-benzo[c][1,8]naphthyridin-1-yl)amino]phenyl]-2-(trifluoromethyl)benzamideIC50959.0 [1]
N~4~-[5-(Diethylamino)pentan-2-yl]-2-[(E)-2-(2,4,6-trichlorophenyl)ethenyl]quinazoline-4,6-diamineIC508800.0 [1]
2-[3-(3-Piperazin-1-ylpropoxy)phenyl]-N-(4-pyridin-4-yl-1,3-thiazol-2-yl)acetamideIC5010000.0 [1]
4-[8-Amino-3-[(3R)-1-(2-methoxyacetyl)piperidin-3-yl]imidazo[1,5-a]pyrazin-1-yl]-3-fluoro-N-[4-(trifluoromethyl)pyridin-2-yl]benzamideIC509.0 [1]
4-[8-Amino-3-[(2R)-4-(2-methoxyacetyl)morpholin-2-yl]imidazo[1,5-a]pyrazin-1-yl]-3-fluoro-N-[4-(trifluoromethyl)pyridin-2-yl]benzamideIC5078.0 [1]
3-(Tert-butylamino)-4-[[2-(4-pyridin-4-ylanilino)pyrimidin-4-yl]amino]cyclobut-3-ene-1,2-dioneKi1400.0 [1]
5-[[(3S,4S)-4-Amino-1,1-dioxothian-3-yl]amino]-3-[(4-methoxy-6-methylpyridin-2-yl)amino]pyridine-2-carboxamideIC5032.0 [1]
4-Amino-8-(5-Methyl-1h-Indazol-6-Yl)cinnoline-3-CarboxamideIC5036.0 [1]
1-(1-Prop-2-enoyl-2,3-dihydroindol-6-yl)-9-quinolin-3-ylbenzo[h][1,6]naphthyridin-2-oneIC50191.0 [1]
N-[2-Methyl-5-(2-oxo-9-phenylbenzo[h][1,6]naphthyridin-1-yl)phenyl]prop-2-enamideIC50250.0 [1]
N-[2-Methyl-5-[9-[4-(methylcarbamoylamino)phenyl]-2-oxobenzo[h][1,6]naphthyridin-1-yl]phenyl]prop-2-enamideIC501130.0 [1]
N-[2-Methyl-5-[2-oxo-9-[4-[[3-(trifluoromethyl)phenoxy]methyl]phenyl]benzo[h][1,6]naphthyridin-1-yl]phenyl]prop-2-enamideIC502060.0 [1]
N-[5-[9-(2,3-Dihydro-1,4-benzodioxin-6-yl)-2-oxobenzo[h][1,6]naphthyridin-1-yl]-2-methylphenyl]prop-2-enamideIC50160.0 [1]
N-[2-Methyl-5-(2-oxo-9-thiophen-3-ylbenzo[h][1,6]naphthyridin-1-yl)phenyl]prop-2-enamideIC50342.0 [1]
N-[5-[9-(Furan-3-yl)-2-oxobenzo[h][1,6]naphthyridin-1-yl]-2-methylphenyl]prop-2-enamideIC502090.0 [1]
N-[2-Methyl-5-(2-oxo-9-pyridin-3-ylbenzo[h][1,6]naphthyridin-1-yl)phenyl]prop-2-enamideIC501950.0 [1]
9-(6-Aminopyridin-3-yl)-1-(1-prop-2-enoyl-2,3-dihydroindol-6-yl)benzo[h][1,6]naphthyridin-2-oneIC50300.0 [1]
1-(1-Prop-2-enoyl-2,3-dihydroindol-6-yl)-9-(1H-pyrazol-4-yl)benzo[h][1,6]naphthyridin-2-oneIC50246.0 [1]
3-(3-(1H-Indazol-4-yl)phenyl)-2-cyanoacrylamideIC5022.0 [1]
Jak3-IN-1IC50157.0 [1]
5-[4-Amino-1-(2,2-diethoxyethyl)pyrazolo[3,4-d]pyrimidin-3-yl]-1,3-benzoxazol-2-amineIC50100000.0 [1]
5-[4-Amino-1-(2,2-dimethoxyethyl)pyrazolo[3,4-d]pyrimidin-3-yl]-1,3-benzoxazol-2-amineIC50100000.0 [1]
5-[4-Amino-1-(1,3-dioxolan-2-ylmethyl)pyrazolo[3,4-d]pyrimidin-3-yl]-1,3-benzoxazol-2-amineIC50100000.0 [1]
(3S,4S)-3-Methoxy-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8,10,12,14,19,21,23,25,27-nonaen-16-oneIC507.4 [1]
6-(4-Fluorophenyl)sulfanyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-oneIC5010000.0 [1]
Items per page: 1 - 10 of 92
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References

This online tool may be cited as follows

MLA

"Quest Database™ Tyrosine-protein kinase BLK Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/tyrosine-protein-kinase-blk-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ Tyrosine-protein kinase BLK Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/tyrosine-protein-kinase-blk-inhibitors-ic50-ki.
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