Tyrosine-protein kinase ABL2 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	CID 71605047	IC50	1.0 [1], 2.0 [2]
	N-[3-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methylphenyl]-4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)benzamide	IC50	8.0 [1], 39.0 [2]
	1-[5-(2-Imidazo[1,2-a]pyrazin-5-ylethynyl)-1-methylpyrazol-3-yl]-3-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]urea	IC50	11.0 [1], 15.0 [2]
	1-[5-(2-Imidazo[1,2-a]pyrazin-3-ylethynyl)-1-methylpyrazol-3-yl]-3-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]urea	IC50	3.0 [1], 10.0 [2]
	1-[5-(2-Imidazo[1,2-b]pyridazin-3-ylethynyl)-1-methylpyrazol-3-yl]-3-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]urea	IC50	6.0 [1], 47.0 [2]
	N-[3-[2-(5-Anilinopyrimidin-2-yl)ethynyl]-4-methylphenyl]-4-(imidazol-1-ylmethyl)-3-(trifluoromethyl)benzamide	IC50	298.0 [1], 10000.0 [2]
	1-[5-(2-Imidazo[1,2-a]pyridin-3-ylethynyl)-1-methylpyrazol-3-yl]-3-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]urea	IC50	12.0 [1], 10000.0 [2]
	1-[4-[(4-Methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]-3-[1-methyl-5-(2-pyridin-3-ylethynyl)pyrazol-3-yl]urea	IC50	14.0 [1], 66.0 [2]
	1-[5-[2-(6-Aminopyridin-3-yl)ethynyl]-1-methylpyrazol-3-yl]-3-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl]urea	IC50	36.0 [1], 67.0 [2]
	4-[[4-(2-Hydroxyethyl)piperazin-1-yl]methyl]-N-[3-(2-imidazo[1,2-a]pyridin-3-ylethynyl)-4-methylphenyl]-3-(trifluoromethyl)benzamide	IC50	18.0 [1], 41.0 [2]
	4-(Imidazol-1-ylmethyl)-N-[4-methyl-3-(2-pyrimidin-5-ylethynyl)phenyl]-3-(trifluoromethyl)benzamide	IC50	40.0 [1], 163.0 [2]
	Imatinib	IC50	272.0 [1]
	Staurosporine	IC50	75.9 [1]
	Bosutinib	IC50	0.5 [1]
	Doramapimod	IC50	30000.0 [1]
	CID 59604787	IC50	10000.0 [1]
	Ripk1-IN-7	IC50	306.0 [1]
	(13R,15S)-13-Methyl-16-oxa-8,9,12,22,24-pentazahexacyclo[15.6.2.16,9.112,15.02,7.021,25]heptacosa-1(24),2,4,6,17,19,21(25)-heptaene-23,27-dione	IC50	1000.0 [1]
	5-(2-Amino-[1,2,4]triazolo[1,5-a]pyridin-7-yl)-N-tert-butylpyridine-3-sulfonamide	IC50	10000.0 [1]
	1-[5-Tert-butyl-3-[4-[2-(dimethylamino)ethyl]-5-oxo-1,4-diazepane-1-carbonyl]thiophen-2-yl]-3-(2,3-dichlorophenyl)urea	IC50	30000.0 [1]
	N-[5-[(Z)-(5-Fluoro-2-oxo-1H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrol-3-yl]-3-(4-methylpiperazin-1-yl)propanamide	Ki	180.0 [1]
	6-(2,4-Difluorophenyl)sulfonyl-2-(1H-indol-5-ylamino)-8-methylpyrido[2,3-d]pyrimidin-7-one	IC50	10000.0 [1]
	6-[4-[(5-Tert-butyl-1,2-oxazol-3-yl)carbamoylamino]phenyl]-N-[3-(dimethylamino)propyl]imidazo[2,1-b][1,3]thiazole-3-carboxamide	IC50	10000.0 [1]
	N-[(4-Methoxyphenyl)methyl]-[1]benzofuro[2,3-b]pyridin-4-amine	Ki	1000000.0 [1]
	4-Fluoro-N-[4-[(6-oxo-5H-benzo[c][1,8]naphthyridin-1-yl)amino]phenyl]-2-(trifluoromethyl)benzamide	IC50	863.0 [1]
	9-[[8-Fluoro-6-(1-methylpyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl]sulfanyl]-4-methyl-[1,4]oxazino[3,2-c]quinolin-3-one	IC50	30000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 26 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Tyrosine-protein kinase ABL2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/tyrosine-protein-kinase-abl2-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, November 21). Quest Database™ Tyrosine-protein kinase ABL2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/tyrosine-protein-kinase-abl2-inhibitors-ic50-ki.
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