Tyrosine kinase non-receptor protein 2 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	3-[8-Amino-1-(2-methoxy-4-phenoxyphenyl)imidazo[1,5-a]pyrazin-3-yl]-1-methylcyclobutan-1-ol	IC50	35.0 [1], 110.0 [2], 118.8 [3]
	3-N-(2,6-Dimethylphenyl)-6-N-[3-fluoro-4-(2-pyrrolidin-1-ylethoxy)phenyl]-1-(3-methoxy-3-methylbutyl)pyrazolo[3,4-d]pyrimidine-3,6-diamine	IC50	20.0 [1]
	3-N-(2,6-Dimethylphenyl)-6-N-[3-fluoro-4-(2-pyrrolidin-1-ylethoxy)phenyl]-1-(3-methoxy-3-methylbutyl)pyrazolo[3,4-d]pyrimidine-3,6-diamine	Ki	3.0 [1], 20.0 [2]
	6-[4-[2-(Dimethylamino)ethoxy]phenyl]-N-[[(2S)-oxolan-2-yl]methyl]-5-phenylfuro[2,3-d]pyrimidin-4-amine	IC50	11.0 [1]
	6-[4-[2-(Dimethylamino)ethoxy]phenyl]-N-[[(2S)-oxolan-2-yl]methyl]-5-phenylfuro[2,3-d]pyrimidin-4-amine	Ki	5.0 [1]
	3-N-(2,6-Dimethylphenyl)-1-(3-methoxy-3-methylbutyl)-6-N-(4-piperazin-1-ylphenyl)pyrazolo[3,4-d]pyrimidine-3,6-diamine	IC50	20.0 [1]
	3-N-(2,6-Dimethylphenyl)-1-(3-methoxy-3-methylbutyl)-6-N-(4-piperazin-1-ylphenyl)pyrazolo[3,4-d]pyrimidine-3,6-diamine	Ki	2.0 [1], 10.0 [2]
	3-N-(2,6-Dimethylphenyl)-1-(3-methoxy-3-methylbutyl)-6-N-phenylpyrazolo[3,4-d]pyrimidine-3,6-diamine	IC50	2.0 [1]
	3-N-(2,6-Dimethylphenyl)-1-(3-methoxy-3-methylbutyl)-6-N-phenylpyrazolo[3,4-d]pyrimidine-3,6-diamine	Ki	3.0 [1], 20.0 [2]
	3-[8-Amino-1-[4-(1-hydroxy-1-phenylethyl)phenyl]imidazo[1,5-a]pyrazin-3-yl]-1-methylcyclobutan-1-ol	IC50	84.0 [1], 216.1 [2], 220.0 [3]
	3-[8-Amino-1-(2,3-difluoro-4-phenoxyphenyl)imidazo[1,5-a]pyrazin-3-yl]-1-methylcyclobutan-1-ol	IC50	51.0 [1], 130.0 [2], 137.1 [3]
	3-[8-Amino-1-[4-[difluoro(phenyl)methyl]phenyl]imidazo[1,5-a]pyrazin-3-yl]-1-methylcyclobutan-1-ol	IC50	170.0 [1], 450.0 [2], 451.8 [3]
	[4-[8-Amino-3-(3-hydroxy-3-methylcyclobutyl)imidazo[1,5-a]pyrazin-1-yl]-3-fluorophenyl]-phenylmethanone	IC50	28.0 [1], 88.0 [2], 88.6 [3]
	[4-[8-Amino-3-(3-hydroxy-3-methylcyclobutyl)imidazo[1,5-a]pyrazin-1-yl]-2-methoxyphenyl]-phenylmethanone	IC50	29.0 [1], 110.0 [2], 116.8 [3]
	[4-[8-Amino-3-(3-hydroxy-3-methylcyclobutyl)imidazo[1,5-a]pyrazin-1-yl]-2-fluorophenyl]-phenylmethanone	IC50	30.0 [1], 139.6 [2], 140.0 [3]
	3-[8-Amino-1-(4-benzylphenyl)imidazo[1,5-a]pyrazin-3-yl]-1-methylcyclobutan-1-ol	IC50	58.0 [1], 230.0 [2], 233.8 [3]
	Bosutinib	IC50	2.7 [1]
	Aim-100	IC50	24.0 [1], 620.0 [2]
	N-[[(2S)-Oxolan-2-yl]methyl]-2,3-diphenylfuro[2,3-b]pyridin-4-amine	IC50	110.0 [1]
	N-[[(2S)-Oxolan-2-yl]methyl]-2,3-diphenylfuro[2,3-b]pyridin-4-amine	Ki	70.0 [1]
	6-[4-[2-(Dimethylamino)ethoxy]phenyl]-N-(1,3-dithiolan-2-ylmethyl)-5-phenylfuro[2,3-d]pyrimidin-4-amine	Ki	0.2 [1], 0.3 [2]
	N-(1,3-Dithiolan-2-ylmethyl)-5-phenyl-6-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine	IC50	10.0 [1]
	N-(1,3-Dithiolan-2-ylmethyl)-5-phenyl-6-[4-(2-pyrrolidin-1-ylethoxy)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine	Ki	0.3 [1]
	3-Cyclobutyl-1-(4-phenoxyphenyl)imidazo[1,5-a]pyrazin-8-amine	IC50	147.8 [1], 190.0 [2]
	1-[3-(Dimethylamino)propyl]-3-N-(2,6-dimethylphenyl)-6-N-phenylpyrazolo[3,4-d]pyrimidine-3,6-diamine	Ki	30.0 [1], 40.0 [2]
	1-[3-(Diethylamino)propyl]-3-N-(2,6-dimethylphenyl)-6-N-phenylpyrazolo[3,4-d]pyrimidine-3,6-diamine	Ki	40.0 [1], 140.0 [2]
	3-N-(2,6-Dimethylphenyl)-6-N-phenyl-1-(3-pyrrolidin-1-ylpropyl)pyrazolo[3,4-d]pyrimidine-3,6-diamine	Ki	100.0 [1], 300.0 [2]
	3-N-(2,6-Dimethylphenyl)-1-(2-morpholin-4-ylethyl)-6-N-phenylpyrazolo[3,4-d]pyrimidine-3,6-diamine	Ki	50.0 [1], 70.0 [2]
	3-N-(2,6-Dimethylphenyl)-6-N-[3-fluoro-4-(3-piperidin-1-ylpropoxy)phenyl]-1-(3-methoxy-3-methylbutyl)pyrazolo[3,4-d]pyrimidine-3,6-diamine	Ki	3.0 [1], 60.0 [2]
	1-(3-Methoxy-3-methylbutyl)-6-N-[4-(4-methylpiperazin-1-yl)phenyl]-3-N-phenylpyrazolo[3,4-d]pyrimidine-3,6-diamine	Ki	400.0 [1], 2100.0 [2]
	3-N-(4-Fluoro-2,6-dimethylphenyl)-1-(3-methoxy-3-methylbutyl)-6-N-phenylpyrazolo[3,4-d]pyrimidine-3,6-diamine	Ki	26.0 [1], 5500.0 [2]
	3-N-(4-Fluoro-2,6-dimethylphenyl)-1-(3-methoxy-3-methylbutyl)-6-N-[4-(4-methylpiperazin-1-yl)phenyl]pyrazolo[3,4-d]pyrimidine-3,6-diamine	Ki	18.0 [1], 20.0 [2]
	3-N-(2,6-Dichlorophenyl)-6-N-[3-fluoro-4-(2-pyrrolidin-1-ylethoxy)phenyl]-1-(3-methoxy-3-methylbutyl)pyrazolo[3,4-d]pyrimidine-3,6-diamine	Ki	2.0 [1], 30.0 [2]
	3-N-(2,6-Dimethylphenyl)-1-(3-methoxy-3-methylbutyl)-6-N-[4-(2-pyrrolidin-1-ylethoxy)phenyl]pyrazolo[3,4-d]pyrimidine-3,6-diamine	Ki	3.0 [1], 20.0 [2]
	(2R)-4-[6-Anilino-3-(2,6-dichloroanilino)pyrazolo[3,4-d]pyrimidin-1-yl]butane-1,2-diol	Ki	10.0 [1], 20.0 [2]
	3-Cyclobutyl-1-(4-pyridin-2-yloxyphenyl)imidazo[1,5-a]pyrazin-8-amine	IC50	1900.0 [1]
	[4-(8-Amino-3-cyclobutylimidazo[1,5-a]pyrazin-1-yl)phenyl]-phenylmethanone	IC50	86.5 [1], 87.0 [2]
	1-(4-Benzylphenyl)-3-cyclobutylimidazo[1,5-a]pyrazin-8-amine	IC50	570.0 [1], 572.9 [2]
	1-(4-Anilinophenyl)-3-cyclobutylimidazo[1,5-a]pyrazin-8-amine	IC50	380.0 [1], 380.6 [2]
	1-[4-(8-Amino-3-cyclobutylimidazo[1,5-a]pyrazin-1-yl)phenyl]-1-phenylethanol	IC50	90.0 [1]
	(2R)-4-[6-Anilino-3-(2,6-dimethylanilino)pyrazolo[3,4-d]pyrimidin-1-yl]butane-1,2-diol	Ki	30.0 [1], 60.0 [2]
	N-(2,6-Dimethylphenyl)-4-(2-ethoxyphenoxy)-2-(4-(piperazin-1-yl)phenylamino)pyrimidine-5-carboxamide	Ki	20.0 [1], 100.0 [2]
	1-(3-Methoxy-3-methylbutyl)-6-N-[4-(4-methylpiperazin-1-yl)phenyl]-3-N-(2,4,6-trimethylphenyl)pyrazolo[3,4-d]pyrimidine-3,6-diamine	Ki	12.0 [1], 50.0 [2]
	3-N-(2,6-Dichlorophenyl)-1-[2-(4-methylpiperazin-1-yl)ethyl]-6-N-phenylpyrazolo[3,4-d]pyrimidine-3,6-diamine	Ki	10.0 [1], 30.0 [2]
	3-N-(2,6-Dichlorophenyl)-1-[2-(4-hydroxypiperazin-1-yl)ethyl]-6-N-phenylpyrazolo[3,4-d]pyrimidine-3,6-diamine	Ki	30.0 [1], 50.0 [2]
	(2R)-4-[6-Anilino-3-(2,6-dimethylanilino)pyrazolo[3,4-d]pyrimidin-1-yl]-1-(dimethylamino)butan-2-ol	Ki	80.0 [1], 190.0 [2]
	3-N-(2,6-Dichlorophenyl)-1-(3-methoxy-3-methylbutyl)-6-N-phenylpyrazolo[3,4-d]pyrimidine-3,6-diamine	Ki	7.0 [1], 40.0 [2]
	3-N-(2,6-Dichlorophenyl)-1-(3-methoxy-3-methylbutyl)-6-N-(4-piperazin-1-ylphenyl)pyrazolo[3,4-d]pyrimidine-3,6-diamine	Ki	10.0 [1], 12.0 [2]
	3-N-(2,6-Dimethylphenyl)-1-(3-methoxy-3-methylbutyl)-6-N-[4-(4-methylpiperazin-1-yl)phenyl]pyrazolo[3,4-d]pyrimidine-3,6-diamine	Ki	2.0 [1], 20.0 [2]
	[(2R)-1-[2-[6-Anilino-3-(2,6-dichloroanilino)pyrazolo[3,4-d]pyrimidin-1-yl]ethyl]pyrrolidin-2-yl]methanol	Ki	30.0 [1], 50.0 [2]
	3-N-(2,6-Dichlorophenyl)-1-[2-[(3R)-3-(dimethylamino)pyrrolidin-1-yl]ethyl]-6-N-phenylpyrazolo[3,4-d]pyrimidine-3,6-diamine	Ki	10.0 [1], 20.0 [2]
	2-[6-Anilino-3-(2,6-dichloroanilino)pyrazolo[3,4-d]pyrimidin-1-yl]-N,N-dimethylacetamide	Ki	30.0 [1], 90.0 [2]
	2-[6-Anilino-3-(2,6-dichloroanilino)pyrazolo[3,4-d]pyrimidin-1-yl]-1-morpholin-4-ylethanone	Ki	70.0 [1], 140.0 [2]
	3-N-(2,6-Dichlorophenyl)-1-[2-(dimethylamino)ethyl]-6-N-phenylpyrazolo[3,4-d]pyrimidine-3,6-diamine	Ki	5.0 [1], 140.0 [2]
	3-N-(2,6-Dichlorophenyl)-1-[3-(dimethylamino)propyl]-6-N-phenylpyrazolo[3,4-d]pyrimidine-3,6-diamine	Ki	5.0 [1], 20.0 [2]
	3-Cyclobutyl-1-[4-(3-methylphenoxy)phenyl]imidazo[1,5-a]pyrazin-8-amine	IC50	238.0 [1], 240.0 [2]
	3-Cyclobutyl-1-[4-(4-fluorophenoxy)-phenyl]-imidazo[1,5-a]pyrazin-8-ylamine	IC50	5455.4 [1], 5460.0 [2]
	3-Cyclobutyl-1-(2-ethoxy-4-phenoxyphenyl)imidazo[1,5-a]pyrazin-8-amine	IC50	470.0 [1], 474.5 [2]
	3-Cyclobutyl-1-(2-fluoro-4-phenoxyphenyl)imidazo[1,5-a]pyrazin-8-amine	IC50	219.4 [1], 220.0 [2]
	3-Cyclobutyl-1-[4-(2-methylphenoxy)phenyl]imidazo[1,5-a]pyrazin-8-amine	IC50	240.0 [1], 243.0 [2]
	1-[4-(1-Benzothiophen-3-yl)phenyl]-3-cyclobutylimidazo[1,5-a]pyrazin-8-amine	IC50	4090.0 [1], 4091.0 [2]
	3-Cyclobutyl-1-(4-phenylsulfanylphenyl)-imidazo[1,5-a]pyrazin-8-ylamine	IC50	330.0 [1]
	3-Cyclobutyl-1-[4-(3-fluorophenoxy)phenyl]imidazo[1,5-a]pyrazin-8-amine	IC50	109.0 [1], 110.0 [2]
	3-Cyclobutyl-1-(3-methoxy-4-phenoxyphenyl)imidazo[1,5-a]pyrazin-8-amine	IC50	48.0 [1], 48.7 [2]
	3-[8-Amino-1-(4-phenoxyphenyl)imidazo[1,5-a]pyrazin-3-yl]-1-methylcyclobutan-1-ol	IC50	160.0 [1], 492.0 [2]
	5-(8-Amino-3-cyclobutylimidazo[1,5-a]pyrazin-1-yl)-2-phenoxybenzamide	IC50	10000.0 [1]
	1-(2-Chloro-4-phenoxyphenyl)-3-cyclobutylimidazo[1,5-a]pyrazin-8-amine	IC50	1060.0 [1], 1063.1 [2]
	1-(3-Chloro-4-phenoxyphenyl)-3-cyclobutylimidazo[1,5-a]pyrazin-8-amine	IC50	1689.1 [1], 1690.0 [2]
	1-[4-(3-Chlorophenoxy)phenyl]-3-cyclobutylimidazo[1,5-a]pyrazin-8-amine	IC50	3190.0 [1], 3195.9 [2]
	1-[4-(2-Chlorophenoxy)phenyl]-3-cyclobutylimidazo[1,5-a]pyrazin-8-amine	IC50	737.9 [1], 740.0 [2]
	3-Cyclobutyl-1-(3-fluoro-4-phenoxyphenyl)imidazo[1,5-a]pyrazin-8-amine	IC50	88.0 [1]
	3-Cyclobutyl-1-[4-(2-fluorophenoxy)phenyl]imidazo[1,5-a]pyrazin-8-amine	IC50	95.2 [1], 100.0 [2]
	3-Cyclobutyl-1-(2-methyl-4-phenoxyphenyl)imidazo[1,5-a]pyrazin-8-amine	IC50	369.4 [1], 370.0 [2]
	3-Cyclobutyl-1-(2-methoxy-4-phenoxyphenyl)imidazo[1,5-a]pyrazin-8-amine	IC50	75.0 [1]
	1-[4-(4-Chlorophenoxy)phenyl]-3-cyclobutylimidazo[1,5-a]pyrazin-8-amine	IC50	1868.5 [1], 1870.0 [2]
	N-[5-(8-Amino-3-cyclobutylimidazo[1,5-a]pyrazin-1-yl)-2-phenoxyphenyl]acetamide	IC50	10000.0 [1]
	3-Cyclobutyl-1-[4-(4-methylphenoxy)phenyl]imidazo[1,5-a]pyrazin-8-amine	IC50	898.6 [1], 900.0 [2]
	3-Cyclobutyl-1-(1-phenylbenzimidazol-5-yl)imidazo[1,5-a]pyrazin-8-amine	IC50	3350.0 [1]
	3-Cyclobutyl-1-(3-methyl-4-phenoxyphenyl)imidazo[1,5-a]pyrazin-8-amine	IC50	6280.0 [1], 6281.8 [2]
	1-(4-Phenoxy-phenyl)-3-(3-pyrrolidin-1-ylmethyl-cyclobutyl)-imidazo[1,5-a]pyrazin-8-ylamine	IC50	2498.1 [1], 4205.2 [2]
	cis-3-(3-Dimethylaminomethylcyclobutyl)-1-(4-phenoxyphenyl)-imidazo[1,5-a]pyrazin-8-ylamine	IC50	1157.9 [1], 4007.3 [2]
	3-(3-Methylcyclobutyl)-1-(4-phenoxyphenyl)imidazo[1,5-a]pyrazin-8-amine	IC50	433.6 [1], 702.8 [2]
	Gefitinib	IC50	2300.0 [1]
	Lorlatinib	IC50	17.0 [1]
	Entrectinib	IC50	70.0 [1]
	Pluripotin	IC50	9.0 [1]
	JNK Inhibitor VIII	Ki	9500.0 [1]
	Nms-P937 (nms1286937)	IC50	10000.0 [1]
	CID 11478363	IC50	25.0 [1]
	CID 59604787	IC50	10000.0 [1]
	5-[2,4-Dihydroxy-6-(4-Nitrophenoxy)phenyl]-N-(1-Methylpiperidin-4-Yl)-1,2-Oxazole-3-Carboxamide	IC50	10.0 [1]
	Unii-76pnd635L1	IC50	15.0 [1]
	(1S,2S,3R,4R)-3-[[5-Chloro-2-[[(7S)-4-methoxy-7-morpholin-4-yl-6,7,8,9-tetrahydro-5H-benzo[7]annulen-3-yl]amino]pyrimidin-4-yl]amino]bicyclo[2.2.1]hept-5-ene-2-carboxamide	IC50	41.0 [1]
	N-[3-(7-Amino-1-methyl-2-oxo-4H-pyrimido[4,5-d]pyrimidin-3-yl)-4-methylphenyl]-3-(trifluoromethyl)benzamide	IC50	18.0 [1]
	5,6-Diphenylfuro[2,3-d]pyrimidin-4-amine	Ki	1000.0 [1]
	2-[1-(4,4-Difluorocyclohexyl)-piperidin-4-yl]-6-fluoro-3-oxo-2,3-dihydro-1H-isoindole-4-carboxamide	IC50	10000.0 [1]
	N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)acetamide	Ki	9500.0 [1]
	4-Amino-5-chloro-6-ethoxy-pyridine-2-carboxylic acid 4-methanesulfonyl-benzylamide	Ki	9500.0 [1]
	4-(4-Fluorophenyl)-5-pyridin-4-yl-2-(2,4,6-trichlorophenyl)pyrazol-3-amine	IC50	33.0 [1]
	N-(4-Amino-5-cyano-6-ethoxypyridin-2-yl)-2-(2,5-dimethoxy-4-methylsulfonylphenyl)acetamide	Ki	9500.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Tyrosine kinase non-receptor protein 2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 22 Dec. 2024, https://www.aatbio.com/data-sets/tyrosine-kinase-non-receptor-protein-2-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, December 22). Quest Database™ Tyrosine kinase non-receptor protein 2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/tyrosine-kinase-non-receptor-protein-2-inhibitors-ic50-ki.
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