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Tyrosinase Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
Kojic acidIC5066550.0 [1]
Kojic acidKi350000.0 [1]
ArbutinIC5030260.0 [1], 230000.0 [2], 32000000.0 [3]
2-Hydroxypyridine 1-oxideIC50150000.0 [1], 1300000.0 [2]
2-Hydroxypyridine 1-oxideKi128000.0 [1]
1-Hydroxy-5-[(Z)-(6-hydroxy-3-oxo-1-benzofuran-2-ylidene)methyl]pyridin-2-oneIC5016600.0 [1], 85300.0 [2]
1-Hydroxy-5-[(Z)-(6-hydroxy-3-oxo-1-benzofuran-2-ylidene)methyl]pyridin-2-oneKi350.0 [1]
5-[(Z)-(4,6-Dihydroxy-3-oxo-1-benzofuran-2-ylidene)methyl]-1-hydroxypyridin-2-oneIC5034000.0 [1], 119000.0 [2]
1-Hydroxy-5-[(Z)-(4-hydroxy-3-oxo-1-benzofuran-2-ylidene)methyl]pyridin-2-oneIC5030000.0 [1], 120000.0 [2]
Ascorbic acidIC5032500.0 [1]
LevodopaIC508400000.0 [1]
ResveratrolIC503680000.0 [1]
KaempferolIC501000.0 [1]
BenzaldehydeIC50820000.0 [1]
4-Hydroxybenzoic acidIC509350.0 [1]
PhenylthioureaIC501800.0 [1]
SalicylaldehydeIC503300000.0 [1]
Tert-ButylhydroquinoneIC5054200.0 [1]
UmbelliferoneIC50420000.0 [1]
4-MethoxybenzaldehydeIC50320000.0 [1]
HexylresorcinolIC50560.0 [1]
GlabridinIC5090.0 [1]
OxyresveratrolIC5012700.0 [1]
2-Hydroxy-4-methoxybenzaldehydeIC5030000.0 [1]
4-IsopropylbenzaldehydeIC5050000.0 [1]
2,3',4,5'-TetramethoxystilbeneIC50100000.0 [1]
(1E,4E)-1,5-Bis(4-hydroxy-3-methoxyphenyl)penta-1,4-dien-3-oneIC50250000.0 [1]
NorartocarpetinIC5023.0 [1]
1,5-Bis(4-hydroxyphenyl)penta-1,4-dien-3-oneIC5079050.0 [1]
HispidolIC5038400.0 [1]
Glyasperin DIC50154.0 [1]
2,6-Bis(4-hydroxybenzylidene)cyclohexanoneIC50250000.0 [1]
GlabreneIC507500.0 [1]
7-Hydroxy-3-phenyl-2H-chromen-2-oneIC5010000000.0 [1]
(1E,4E)-1,5-Bis(4-fluorophenyl)penta-1,4-dien-3-oneIC50250000.0 [1]
2,4,6-Cycloheptatrien-1-one, 2-hydroxy-3-(1-methylethyl)-IC501000000.0 [1]
4-IsopropylsalicylaldehydeIC502300.0 [1]
2,6-Bis(4-chlorobenzylidene)cyclohexanoneIC50250000.0 [1]
Glyasperin CIC50177.0 [1]
(Z)-4,6-Dihydroxy-2-(4-hydroxybenzylidene)benzofuran-3(2H)-oneIC5038000.0 [1]
(Z)-2-(4-Hydroxybenzylidene)-4-hydroxybenzofuran-3(2H)-oneIC5031700.0 [1]
4-[2-(3,5-Dihydroxyphenyl)ethyl]benzene-1,3-diolIC501600.0 [1]
4-[2-(2,4-Dihydroxyphenyl)ethyl]benzene-1,3-diolIC50370.0 [1]
3-(3,5-Dihydroxyphenyl)-7-hydroxycoumarinIC5010000000.0 [1]
1-[3-[(1R)-1-[3-Acetyl-2,6-dihydroxy-4-methoxy-5-(3-methylbut-2-enyl)phenyl]-3-methylbutyl]-2,4,6-trihydroxy-5-(3-methylbut-2-enyl)phenyl]ethanoneIC50333000.0 [1]
4-Hydroxyphenethyl 3,4,5-trihydroxybenzoateIC504930.0 [1]
Fortuneanoside EIC50140000.0 [1]
1,5-Bis(2-fluoro-4-methoxyphenyl)penta-1,4-dien-3-oneIC50250000.0 [1]
1-[2-(2,4-Dimethoxyphenyl)ethyl]-3,5-dimethoxybenzeneIC50100000.0 [1]
(2S,3R,4S,5R)-2-[2-[2-(2,4-Dihydroxyphenyl)ethyl]-5-hydroxyphenoxy]oxane-3,4,5-triolIC501600.0 [1]
(2S,3R,4S,5R)-2-[4-[2-(2,4-Dihydroxyphenyl)ethyl]-3-hydroxyphenoxy]oxane-3,4,5-triolIC50430.0 [1]
(2S,3R,4S,5R)-2-[4-[2-(2,4-Dihydroxyphenyl)ethyl]-3-[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxyphenoxy]oxane-3,4,5-triolIC50730.0 [1]
BryoamarideIC5085010.0 [1]
3,5-Dihydroxy-N-[2-(6-hydroxy-1H-indol-3-yl)ethyl]benzamideIC509100.0 [1]
(2S,3R,4S,5R)-2-[(2S)-4-(2,4-Dihydroxyphenyl)butan-2-yl]oxyoxane-3,4,5-triolIC504560.0 [1]
(2S,3R,4S,5S,6R)-2-[(2R,3S,4R,5R,6R)-6-[(2R)-4-(2,4-Dihydroxyphenyl)butan-2-yl]oxy-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triolIC501510.0 [1]
(2S,3R,4S,5S,6R)-2-[(2R,3S,4R,5R,6R)-6-[(2S)-4-(2,4-Dihydroxyphenyl)butan-2-yl]oxy-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triolIC503830.0 [1]
(2R,3R,4S,5S,6R)-2-[(2R)-4-(2,4-Dihydroxyphenyl)butan-2-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triolIC502300.0 [1]
(2R,3R,4S,5S,6R)-2-[(2S)-4-(2,4-Dihydroxyphenyl)butan-2-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triolIC504720.0 [1]
(2S,3R,4S,5R)-2-[(2R)-4-(2,4-Dihydroxyphenyl)butan-2-yl]oxyoxane-3,4,5-triolIC501720.0 [1]
(2S)-2-[[(2S)-2-[[(2S)-2-[(5-Hydroxy-4-oxopyran-2-yl)methoxycarbonylamino]-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-3-(4-hydroxyphenyl)propanoic acidIC50330.0 [1]
(2S)-2-[[(2S)-2-[[(2S)-2-[(5-Hydroxy-4-oxopyran-2-yl)methoxycarbonylamino]-3-phenylpropanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoic acidIC50240.0 [1]
Fortuneanoside BIC502210000.0 [1]
Fortuneanoside DIC5070000.0 [1]
4-[(3S)-3-Hydroxybutyl]benzene-1,3-diolIC502170.0 [1]
4-[(3R)-3-Hydroxybutyl]benzene-1,3-diolIC501780.0 [1]
7-(2,4-Dihydroxyphenyl)-2,2-dimethylpyrano[3,2-g]chromen-8-oneIC502800.0 [1]
7-Hydroxy-3-(2-hydroxy-4-methoxyphenyl)-8-(3-methylbut-2-enyl)-2,3-dihydrochromen-4-oneIC505100.0 [1]
Cycloorbicoside GIC5054640.0 [1]
2-[4,5-Dihydroxy-2-methoxy-3-(3-methylbut-2-enyl)phenyl]-5,7-dihydroxy-3-(3-methylbut-2-enyl)chromen-4-oneIC5045300.0 [1]
CyclocarposideIC50102390.0 [1]
Askendoside DIC5048920.0 [1]
3-Hydroxyphenethyl 3,4,5-trihydroxybenzoateIC5015210.0 [1]
2-Hydroxyphenethyl 3,4,5-trihydroxybenzoateIC5014500.0 [1]
(2S)-2-[[(2S)-2-[[(2S)-2-[(5-Hydroxy-4-oxopyran-2-yl)methoxycarbonylamino]-3-phenylpropanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]butanedioic acidIC502130.0 [1]
(2S)-2-[[(2S)-2-[[(2S)-2-[(5-Hydroxy-4-oxopyran-2-yl)methoxycarbonylamino]-3-phenylpropanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-(1H-indol-3-yl)propanoic acidIC506170.0 [1]
(2S)-2-[[(2S)-2-[[(2S)-2-[(5-Hydroxy-4-oxopyran-2-yl)methoxycarbonylamino]-3-phenylpropanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-phenylpropanoic acidIC504480.0 [1]
(2S)-2-[[(2S)-2-[[(2S)-2-[(5-Hydroxy-4-oxopyran-2-yl)methoxycarbonylamino]-3-phenylpropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoic acidIC50390.0 [1]
(2S)-2-[[(2S)-2-[[(2S)-2-[(5-Hydroxy-4-oxopyran-2-yl)methoxycarbonylamino]-3-(1H-indol-3-yl)propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoic acidIC50780.0 [1]
(2S,3S)-2-[[(2S)-2-[[(2S)-2-[(5-Hydroxy-4-oxopyran-2-yl)methoxycarbonylamino]-3-phenylpropanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]-3-methylpentanoic acidIC502180.0 [1]
Askendoside BIC5013950.0 [1]
CyclosieversiosideIC5092250.0 [1]
Gnetucleistol DIC50100000.0 [1]
4-[(E)-2-(3-Hydroxy-5-methoxyphenyl)ethenyl]-3-methoxyphenolIC50100000.0 [1]
2-[(E)-2-(3-Hydroxy-5-methoxyphenyl)ethenyl]-5-methoxyphenolIC50100000.0 [1]
Fortuneanoside CIC50450000.0 [1]
(2S,3R,4S,5S,6R)-2-[4-[2-(2,4-Dihydroxyphenyl)ethyl]-3-hydroxyphenoxy]-6-(hydroxymethyl)oxane-3,4,5-triolIC50770.0 [1]
(2S,3R,4S,5S,6R)-2-[(2R,3S,4R,5R,6S)-6-[4-[2-(2,4-Dihydroxyphenyl)ethyl]-3-hydroxyphenoxy]-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triolIC50680.0 [1]
(2R,3R,4S,5S,6R)-2-[(2R,3S,4R,5R,6S)-6-[4-[2-(2,4-Dihydroxyphenyl)ethyl]-3-hydroxyphenoxy]-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triolIC50830.0 [1]
cis-2,4,3',5'-TetramethoxystilbeneIC50100000.0 [1]
(2R,3R,4S,5S,6R)-2-[(2R,3S,4R,5R,6R)-6-[(2R)-4-(2,4-Dihydroxyphenyl)butan-2-yl]oxy-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triolIC501980.0 [1]
(2R,3R,4S,5S,6R)-2-[(2R,3S,4R,5R,6R)-6-[(2S)-4-(2,4-Dihydroxyphenyl)butan-2-yl]oxy-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triolIC504130.0 [1]
(S)-2-(5-Hydroxy-4-oxo-4H-pyran-2-ylmethoxycarbonylamino)-propionic acidIC5023210.0 [1]
(5-Hydroxy-4-oxopyran-2-yl)methyl (2S)-2-[(5-hydroxy-4-oxopyran-2-yl)methoxycarbonylamino]propanoateIC503030.0 [1]
(2S)-2-[(5-Hydroxy-4-oxopyran-2-yl)methoxycarbonylamino]-4-methylpentanoic acidIC5014510.0 [1]
(5-Hydroxy-4-oxopyran-2-yl)methyl (2S)-2-[(5-hydroxy-4-oxopyran-2-yl)methoxycarbonylamino]-4-methylpentanoateIC502000.0 [1]
(5-Hydroxy-4-oxopyran-2-yl)methyl (2S)-2-[(5-hydroxy-4-oxopyran-2-yl)methoxycarbonylamino]-3-phenylpropanoateIC5060.0 [1]
(5-Hydroxy-4-oxopyran-2-yl)methyl (2S)-2-[(5-hydroxy-4-oxopyran-2-yl)methoxycarbonylamino]-3-methylbutanoateIC502390.0 [1]
(2S)-2-[(5-Hydroxy-4-oxopyran-2-yl)methoxycarbonylamino]-3-phenylpropanoic acidIC508000.0 [1]
(2S)-2-[(5-Hydroxy-4-oxopyran-2-yl)methoxycarbonylamino]-3-methylbutanoic acidIC5016660.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Tyrosinase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 31 Mar. 2025, https://www.aatbio.com/data-sets/tyrosinase-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, March 31). Quest Database™ Tyrosinase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/tyrosinase-inhibitors-ic50-ki.
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