Type-1 angiotensin II receptor Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Losartan	IC50	0.33 [1], 8.0 [2], 28.0 [3], 88.0 [4]
	Losartan	Ki	12.0 [1], 17.0 [2]
	Telmisartan	IC50	3.0 [1], 150.0 [2]
	Saralasin	IC50	0.57 [1], 1.0 [2]
	Saralasin	Ki	0.22 [1], 0.33 [2]
	Irbesartan	IC50	0.9 [1], 20.8 [2]
	Irbesartan	Ki	0.8 [1], 1.1 [2], 2.0 [3]
	Angiotensin II	IC50	0.72 [1]
	Angiotensin II	Ki	0.16 [1], 0.5 [2], 0.9 [3]
	Candesartan	IC50	0.69 [1], 10.72 [2], 110.0 [3]
	Candesartan	Ki	10.4 [1]
	Butyl 3-(4-((1H-imidazol-1-yl)methyl)phenyl)-5-isobutylthiophen-2-ylsulfonylcarbamate	Ki	10000.0 [1]
	Bms-248360	IC50	6.0 [1]
	Bms-248360	Ki	10.0 [1]
	Valsartan	IC50	2.7 [1]
	Valsartan	Ki	3.0 [1], 4700.0 [2]
	2-Ethyl-7-methyl-5-(2-methylpropyl)-3-[(1S)-5-[2-(2H-tetrazol-5-yl)phenyl]-2,3-dihydro-1H-inden-1-yl]imidazo[4,5-b]pyridine	IC50	1.6 [1]
	2-Ethyl-7-methyl-5-(2-methylpropyl)-3-[(1S)-5-[2-(2H-tetrazol-5-yl)phenyl]-2,3-dihydro-1H-inden-1-yl]imidazo[4,5-b]pyridine	Ki	0.69 [1]
	Angiotensin IV	Ki	407.38 [1]
	Eprosartan	IC50	2.0 [1], 7.3 [2]
	Tasosartan	IC50	32.0 [1], 38.0 [2]
	2-Ethyl-5,7-dimethyl-3-((4-(2-(2H-tetrazol-5-yl)phenyl)phenyl)methyl)imidazo(4,5-b)pyridine	IC50	0.3 [1], 2.7 [2]
	(1,1'-Biphenyl)-2-sulfonamide, N-(3,4-dimethyl-5-isoxazolyl)-4'-(2-oxazolyl)-	Ki	0.0 [1], 10000.0 [2]
	Sparsentan	Ki	0.8 [1]
	Butyl N-[2-[4-[(2-ethyl-5,7-dimethylimidazo[4,5-b]pyridin-3-yl)methyl]phenyl]-4-propylphenyl]sulfonylcarbamate	IC50	1.5 [1]
	N-[4-Oxo-2-propyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]quinazolin-6-yl]-N-pentylbenzamide	IC50	1.7 [1], 7.0 [2]
	N-[2-[4-[[3-Butyl-5-oxo-1-[2-(trifluoromethyl)phenyl]-1,2,4-triazol-4-yl]methyl]phenyl]phenyl]sulfonylbenzamide	IC50	2.5 [1]
	N-[2-[4-[[3-Butyl-5-oxo-1-[2-(trifluoromethyl)phenyl]-1,2,4-triazol-4-yl]methyl]phenyl]phenyl]sulfonylbenzamide	Ki	1.7 [1]
	3-Butyl-2-[2'-(1H-tetrazole-5-yl)-4-biphenylylmethyl]-2,3-diazaspiro[4.4]nonane-1,4-dione	Ki	25.0 [1]
	7-Methyl-N-(2-phenylpropyl)-2-propyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]benzimidazole-5-carboxamide	IC50	0.9 [1], 16.7 [2]
	Tert-butyl N-[2-[4-[[1-[2-bromo-5-(pentanoylamino)phenyl]-3-ethyl-5-oxo-1,2,4-triazol-4-yl]methyl]-3-fluorophenyl]phenyl]sulfonylcarbamate	IC50	0.2 [1], 3.5 [2]
	Unii-A9T9wvah03	IC50	1.2 [1], 31.0 [2]
	2,4-Bis(hydroxymethyl)-8-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]pyrido[2,3-d]pyrimidin-7-one	IC50	44.0 [1]
	2-[4-[[4-Methyl-6-(2-phenylethylcarbamoyl)-2-propylbenzimidazol-1-yl]methyl]phenyl]benzoic acid	IC50	3.0 [1], 23.1 [2]
	4-Methyl-7-oxo-8-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-5,6-dihydropyrido[2,3-d]pyrimidine-2-carboxylic acid	IC50	11.0 [1], 23.0 [2]
	2-(1,3-Benzodioxol-5-yl)-2-[4-[(2-ethyl-5,7-dimethylimidazo[4,5-b]pyridin-3-yl)methyl]-2-propylphenoxy]-N-(4-propan-2-ylphenyl)sulfonylacetamide	IC50	13.0 [1]
	2-Propyl-5-[(4-pyridin-2-ylpiperazin-1-yl)methyl]-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]imidazole-4-carboxylic acid	IC50	4.2 [1]
	Tert-butyl N-[2-[4-[[3-butyl-1-[2-chloro-5-[(2-ethoxyacetyl)amino]phenyl]-5-oxo-1,2,4-triazol-4-yl]methyl]-3-fluorophenyl]phenyl]sulfonylcarbamate	IC50	0.38 [1], 0.56 [2]
	Tert-butyl N-[2-[4-[[3-butyl-5-oxo-1-[5-(pentanoylamino)-2-(trifluoromethyl)phenyl]-1,2,4-triazol-4-yl]methyl]-3-fluorophenyl]phenyl]sulfonylcarbamate	IC50	0.41 [1], 0.9 [2]
	N-[2-[4-[[3-Butyl-5-oxo-1-[5-(propanoylamino)-2-(trifluoromethyl)phenyl]-1,2,4-triazol-4-yl]methyl]-3-fluorophenyl]phenyl]sulfonyl-2-chlorobenzamide	IC50	0.25 [1], 0.43 [2]
	3-[2-[4-[[2-Butyl-6-oxo-4-propan-2-yl-5-(2-pyrrolidin-1-yl-2-sulfanylideneethyl)pyrimidin-1-yl]methyl]phenyl]phenyl]-4H-1,2,4-oxadiazol-5-one	IC50	2.2 [1], 10.5 [2]
	(2S)-2-[N-(4-Hydroxypentanoyl)-4-[2-(2H-tetrazol-5-yl)phenyl]anilino]-3-methylbutanoic acid	IC50	0.47 [1]
	(2S)-2-[N-(4-Hydroxypentanoyl)-4-[2-(2H-tetrazol-5-yl)phenyl]anilino]-3-methylbutanoic acid	Ki	370.0 [1]
	[Sar1,Bpa2]AngII	Ki	0.6 [1], 18.3 [2]
	(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-3-(4-Benzoylphenyl)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[2-(methylamino)acetyl]amino]pentanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]propanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoic acid	Ki	0.7 [1], 250.0 [2]
	(2S)-2-[[(2S)-1-[(2S)-3-(4-Benzoylphenyl)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[2-(methylamino)acetyl]amino]pentanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoic acid	Ki	31.6 [1], 500.0 [2]
	(2S)-2-[[(2S)-3-(4-Benzoylphenyl)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[2-(methylamino)acetyl]amino]pentanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]propanoyl]amino]-3-phenylpropanoic acid	Ki	12.8 [1], 500.0 [2]
	[Tdf1]AngII	Ki	0.7 [1], 26.4 [2]
	[Sar1,Tdf2]AngII	Ki	0.4 [1], 24.7 [2]
	[Sar1,Tdf3]AngII	Ki	0.3 [1], 1.3 [2]
	(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-(Diaminomethylideneamino)-2-[[2-(methylamino)acetyl]amino]pentanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-[4-[3-(trifluoromethyl)diazirin-3-yl]phenyl]propanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoic acid	Ki	0.5 [1], 250.0 [2]
	(2S)-2-[[(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-(Diaminomethylideneamino)-2-[[2-(methylamino)acetyl]amino]pentanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-3-[4-[3-(trifluoromethyl)diazirin-3-yl]phenyl]propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoic acid	Ki	58.2 [1], 500.0 [2]
	(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-(Diaminomethylideneamino)-2-[[2-(methylamino)acetyl]amino]pentanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]-3-[4-[3-(trifluoromethyl)diazirin-3-yl]phenyl]propanoyl]amino]-3-phenylpropanoic acid	Ki	3.8 [1], 500.0 [2]
	[Bpa1]AngII	Ki	0.8 [1], 19.4 [2]
	[Sar1,Bpa3]AngII	Ki	0.4 [1], 0.7 [2]
	(2S)-2-[[(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-3-(4-Benzoylphenyl)-2-[[(2S)-2-[[(2S)-5-(diaminomethylideneamino)-2-[[2-(methylamino)acetyl]amino]pentanoyl]amino]-3-methylbutanoyl]amino]propanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoic acid	Ki	250.0 [1], 500.0 [2]
	(2S)-2-[[(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-5-(Diaminomethylideneamino)-2-[[2-(methylamino)acetyl]amino]pentanoyl]amino]-3-methylbutanoyl]amino]-3-[4-[3-(trifluoromethyl)diazirin-3-yl]phenyl]propanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoic acid	Ki	250.0 [1], 500.0 [2]
	[Sar1,Bpa8]AngII	Ki	0.6 [1], 0.8 [2]
	[Sar1,Tdf8]AngII	Ki	0.7 [1], 0.9 [2]
	2-Butyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-2,3-diazaspiro[4.4]nonane-6,9-dione	IC50	22.0 [1]
	2-Butyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-2,3-diazaspiro[4.4]nonane-6,9-dione	Ki	25.0 [1]
	N-[2-[4-[(2-Butyl-6,9-dioxo-2,3-diazaspiro[4.4]nonan-3-yl)methyl]phenyl]phenyl]sulfonylbenzamide	IC50	12.0 [1]
	N-[2-[4-[(2-Butyl-6,9-dioxo-2,3-diazaspiro[4.4]nonan-3-yl)methyl]phenyl]phenyl]sulfonylbenzamide	Ki	10.0 [1]
	(2-Benzoylphenyl)methyl 5-ethyl-3-[[2-fluoro-4-[2-(3-methylbutoxycarbonylsulfamoyl)phenyl]phenyl]methyl]-2-propylimidazole-4-carboxylate	IC50	0.5 [1], 570.0 [2]
	Propranolol	IC50	5011.87 [1]
	Losartan potassium	IC50	5.5 [1]
	Fimasartan	IC50	4.5 [1]
	CID 121879	IC50	3600.0 [1]
	ZD 7155 hydrochloride	Ki	0.5 [1]
	Cipargamin	IC50	30000.0 [1]
	Piboserod	Ki	10000.0 [1]
	Butyl N-[3-[4-[(2-ethyl-5,7-dimethylimidazo[4,5-b]pyridin-3-yl)methyl]phenyl]-5-(2-methylpropyl)thiophen-2-yl]sulfonylcarbamate	IC50	1.1 [1]
	Forasartan	IC50	6.9 [1]
	(Sar1,Ile8)-Angiotensin II	Ki	0.65 [1]
	Zolasartan	Ki	2.0 [1]
	Ripisartan	Ki	24.0 [1]
	Edonentan	Ki	10.0 [1]
	Potassium;2-[[5-ethyl-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]-1,3,4-thiadiazol-2-ylidene]carbamoyl]cyclopentene-1-carboxylate	IC50	0.4 [1]
	(6S)-1-[(4-Amino-3-methylphenyl)methyl]-5-(2,2-diphenylacetyl)-6,7-dihydro-4H-imidazo[4,5-c]pyridine-6-carboxylic acid	IC50	100000.0 [1]
	3-((2'-(Benzoylaminosulfonyl)biphenyl-4-yl)methyl)-2-ethyl-5,7-dimethyl-3H-imidazo(4,5-b)pyridine	IC50	0.2 [1]
	4-Ethyl-2-propyl-1-(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methylimidazole-5-carboxylic acid	IC50	6.0 [1]
	4-Oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-nitrobenzoate	IC50	79000.0 [1]
	2-[4-[[2-Butyl-6-(cyclohexylcarbamoylamino)benzimidazol-1-yl]methyl]phenyl]benzoic acid	Ki	29.0 [1]
	2-[[4-[[2-Butyl-6-[methylcarbamoyl(pentyl)amino]benzimidazol-1-yl]methyl]phenyl]carbamoyl]-3,6-dichlorobenzoic acid	Ki	20.0 [1]
	CID 5311416	Ki	10000.0 [1]
	6-(((4-Methylpyrimidin-2-yl)thio)methyl)-4-oxo-4H-pyran-3-yl furan-2-carboxylate	IC50	79000.0 [1]
	6-(((4-Methylpyrimidin-2-yl)thio)methyl)-4-oxo-4H-pyran-3-yl 2-chloro-5-nitrobenzoate	IC50	79000.0 [1]
	Butyl N-[2-[4-[(2-ethyl-5,7-dimethylimidazo[4,5-b]pyridin-3-yl)methyl]phenyl]-4-[(3-methoxyphenyl)methyl]phenyl]sulfonylcarbamate	IC50	1.4 [1]
	Butyl N-[2-[4-[(2-ethyl-5,7-dimethylimidazo[4,5-b]pyridin-3-yl)methyl]phenyl]-4-(2-methylpropyl)phenyl]sulfonylcarbamate	IC50	2.1 [1]
	6-(((4-Methylpyrimidin-2-yl)thio)methyl)-4-oxo-4H-pyran-3-yl 4-(pyrrolidin-1-ylsulfonyl)benzoate	IC50	79000.0 [1]
	[6-[(4-Methylpyrimidin-2-yl)sulfanylmethyl]-4-oxopyran-3-yl] 4-chloro-3-nitrobenzoate	IC50	79000.0 [1]
	[4-Oxo-6-(pyrimidin-2-ylsulfanylmethyl)pyran-3-yl] 4-(dimethylsulfamoyl)benzoate	IC50	79000.0 [1]
	6-(((4-Methylpyrimidin-2-yl)thio)methyl)-4-oxo-4H-pyran-3-yl benzoate	IC50	79000.0 [1]
	4-Oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 3-nitrobenzoate	IC50	79000.0 [1]
	Butyl N-[3-[3-(imidazol-1-ylmethyl)phenyl]-5-(2-methylpropyl)thiophen-2-yl]sulfonylcarbamate	Ki	10000.0 [1]
	3-[2-Butyl-4-oxo-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]quinazolin-6-yl]-1-methyl-1-propan-2-ylurea	IC50	0.1 [1]
	(E)-3-[2-Butyl-1-(2-chlorobenzyl)-1H-imidazol-5-yl]-2-(2-thienylmethyl)acrylic acid	IC50	4530.0 [1]
	(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-1-[2-[[(2S)-6-Amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-5-amino-2-[[(2S)-5-carbamimidamido-2-[[(2S)-5-carbamimidamido-2-[[(2S)-2-[[(2S)-2,6-diaminohexanoyl]amino]-3-phenylpropanoyl]amino]pentanoyl]amino]pentanoyl]amino]-5-oxopentanoyl]amino]-5-carbamimidamidopentanoyl]pyrrolidine-2-carbonyl]amino]-5-carbamimidamidopentanoyl]amino]-4-methylpentanoyl]amino]-3-hydroxypropanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]hexanoyl]amino]acetyl]pyrrolidine-2-carbonyl]amino]-4-methylsulfanylbutanoyl]pyrrolidine-2-carbonyl]amino]-3-phenylpropanoic acid	Ki	100000.0 [1]
	4-Oxo-6-((pyrimidin-2-ylthio)methyl)-4H-pyran-3-yl 4-(pyrrolidin-1-ylsulfonyl)benzoate	IC50	79000.0 [1]
	[4-Oxo-6-(pyrimidin-2-ylsulfanylmethyl)pyran-3-yl] 4-(diethylsulfamoyl)benzoate	IC50	79000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Type-1 angiotensin II receptor Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/type-1-angiotensin-ii-receptor-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 21). Quest Database™ Type-1 angiotensin II receptor Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/type-1-angiotensin-ii-receptor-inhibitors-ic50-ki.
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