Tumour suppressor protein p53/Mdm4 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Nutlin-3A	IC50	8200.0 [1]
	Nutlin-3A	Ki	5860.0 [1]
	(2'R,3S,3'S,5'R)-6-Chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-N-(2-morpholin-4-ylethyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide	Ki	55000.0 [1]
	6-Chloro-3-[1-(4-chlorobenzyl)-4-phenyl-1H-imidazol-5-yl]-1H-indole-2-carboxylic acid	Ki	36000.0 [1]
	Benzamidobenzenethiol	IC50	7200.0 [1]
	[6-Chloro-3-[3-[(4-chlorophenyl)methyl]-5-phenylimidazol-4-yl]-1H-indol-2-yl]-[(3S)-3-[3-(dimethylamino)propyl-methylamino]pyrrolidin-1-yl]methanone	Ki	11000.0 [1]
	3-Benzoyl-2-(4-bromophenyl)-1-(3-imidazol-1-ylpropyl)-4-propan-2-yloxy-2H-pyrrol-5-one	Ki	2680.0 [1]
	6-Chloro-N-(2-sulfanylphenyl)pyridine-3-carboxamide	IC50	8900.0 [1]
	N-(2-Sulfanylphenyl)octanamide	IC50	25000.0 [1]
	2-Methyl-N-(2-sulfanylphenyl)propanamide	IC50	6300.0 [1]
	4-Chloro-N-(2-sulfanylphenyl)benzamide	IC50	3400.0 [1]
	S-[2-(2-Methylpropanoylamino)phenyl] 2-methylpropanethioate	IC50	1500.0 [1]
	S-(2-Benzamidophenyl) 2-methylpropanethioate	IC50	4600.0 [1]
	[2-(2-Methylpropanoylamino)phenyl] 2-methylpropanoate	IC50	25000.0 [1]
	3-Benzoyl-2-(4-bromophenyl)-4-cyclohexyloxy-1-(3-imidazol-1-ylpropyl)-2H-pyrrol-5-one	Ki	17930.0 [1]
	3-Benzoyl-2-(4-bromophenyl)-1-(3-imidazol-1-ylpropyl)-4-(2-methoxyethoxy)-2H-pyrrol-5-one	Ki	2110.0 [1]
	3-Benzoyl-2-(4-bromophenyl)-4-ethoxy-1-(3-imidazol-1-ylpropyl)-2H-pyrrol-5-one	Ki	38910.0 [1]
	3-Benzoyl-2-(4-bromophenyl)-1-(3-imidazol-1-ylpropyl)-4-propoxy-2H-pyrrol-5-one	Ki	9320.0 [1]
	N-(2-Hydroxyphenyl)-2-methylpropanamide	IC50	25000.0 [1]
	3-[(2S,5S,8S,11S,14S,17S,20S,23E,33S)-33-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-Acetamido-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-phenylpropanoyl]amino]-20-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]carbamoyl]-14-(3-amino-3-oxopropyl)-17-(cyclobutylmethyl)-5-[(4-hydroxyphenyl)methyl]-8-(1H-indol-3-ylmethyl)-11,20,33-trimethyl-3,6,9,12,15,18,34-heptaoxo-1,4,7,10,13,16,19-heptazacyclotetratriacont-23-en-2-yl]propanoic acid	Ki	6.8 [1]
	3-[(6S)-6-(4-Chloro-2-methylphenyl)-5-(5-chloro-2-methylphenyl)-4-oxo-1-propan-2-yl-6H-pyrrolo[3,4-b]pyrrol-2-yl]-4-methoxy-N-methylbenzamide	IC50	264.3 [1]
	3-[5-(5-Chloro-2-methylphenyl)-6-(4-chlorophenyl)-4-oxo-1-propan-2-yl-6H-pyrrolo[3,4-b]pyrrol-2-yl]-N-(2-hydroxyethoxy)-4-methoxybenzamide	IC50	327.1 [1]
	3-[6-(4-Chlorophenyl)-5-(4-hydroxycyclohexyl)-4-oxo-1-propan-2-yl-6H-pyrrolo[3,4-b]pyrrol-2-yl]-4-methoxybenzoic acid	IC50	8788.9 [1]
	2-(2-Amino-4-methoxypyrimidin-5-yl)-6-(4-chlorophenyl)-5-(4-hydroxycyclohexyl)-1-propan-2-yl-6H-pyrrolo[3,4-b]pyrrol-4-one	IC50	7858.6 [1]
	(6S)-5-(5-Chloro-1-methyl-6-oxopyridin-3-yl)-6-(4-chlorophenyl)-2-(2,4-dimethoxypyrimidin-5-yl)-1-propan-2-yl-6H-pyrrolo[3,4-b]pyrrol-4-one	IC50	1055.1 [1]
	5-(3-Chloro-2-fluorophenyl)-6-(4-chloro-2-methylphenyl)-2-(2-methoxyphenyl)-1-propan-2-yl-6H-pyrrolo[3,4-b]pyrrol-4-one	IC50	27835.2 [1]
	3-[5-(3-Chloro-2-fluorophenyl)-6-(4-chloro-2-methylphenyl)-4-oxo-1-propan-2-yl-6H-pyrrolo[3,4-b]pyrrol-2-yl]-4-methoxy-N-methylbenzamide	IC50	2901.9 [1]
	5-(3-Chloro-2-fluorophenyl)-6-(4-chloro-2-methylphenyl)-2-(5-fluoro-2-methoxyphenyl)-1-propan-2-yl-6H-pyrrolo[3,4-b]pyrrol-4-one	IC50	54238.3 [1]
	3-[(6S)-5-(3-Chloro-2-fluorophenyl)-6-(4-chloro-2-methylphenyl)-4-oxo-1-propan-2-yl-6H-pyrrolo[3,4-b]pyrrol-2-yl]-4-methoxy-N-methylbenzamide	IC50	507.5 [1]
	5-(5-Chloro-2-methylphenyl)-6-(4-chlorophenyl)-2-(2-methoxyphenyl)-1-propan-2-yl-6H-pyrrolo[3,4-b]pyrrol-4-one	IC50	4025.9 [1]
	3-[5-(5-Chloro-2-methylphenyl)-6-(4-chlorophenyl)-4-oxo-1-propan-2-yl-6H-pyrrolo[3,4-b]pyrrol-2-yl]-4-methoxy-N-methylbenzamide	IC50	477.5 [1]
	1-(3-Chloro-2-fluorophenyl)-6-(4-chlorophenyl)-8-(2-methoxyphenyl)-7-propan-2-yl-3,6-dihydropurin-2-one	IC50	1510.0 [1]
	6-(4-Chloro-2-methylphenyl)-5-(4-hydroxycyclohexyl)-2-(2-methoxyphenyl)-1-propan-2-yl-6H-pyrrolo[3,4-b]pyrrol-4-one	IC50	2989.9 [1]
	4-[6-(4-Chlorophenyl)-2-(2,4-dimethoxypyrimidin-5-yl)-4-oxo-1-propan-2-yl-6H-pyrrolo[3,4-b]pyrrol-5-yl]-N-methylpiperidine-1-carboxamide	IC50	3643.4 [1]
	2-(2-Amino-4-methoxypyrimidin-5-yl)-6-(4-chlorophenyl)-5-(1-methyl-6-oxopiperidin-3-yl)-1-propan-2-yl-6H-pyrrolo[3,4-b]pyrrol-4-one	IC50	9023.0 [1]
	6-(4-Chloro-2-methylphenyl)-2-(2,4-dimethoxypyrimidin-5-yl)-5-(4-hydroxycyclohexyl)-1-propan-2-yl-6H-pyrrolo[3,4-b]pyrrol-4-one	IC50	4714.8 [1]
	6-(4-Chloro-2-methylphenyl)-2-(2,4-dimethoxypyrimidin-5-yl)-5-(oxan-4-yl)-1-propan-2-yl-6H-pyrrolo[3,4-b]pyrrol-4-one	IC50	6286.2 [1]
	4-[(6S)-5-(5-Chloro-2-oxo-1H-pyridin-3-yl)-2-[2-(dimethylamino)-4-methoxypyrimidin-5-yl]-4-oxo-1-propan-2-yl-6H-pyrrolo[3,4-b]pyrrol-6-yl]benzonitrile	IC50	716.5 [1]
	6-(4-Chlorophenyl)-1-cyclopropyl-5-(1,5-dimethyl-6-oxopyridin-3-yl)-2-(1-methyl-2-oxopyridin-4-yl)-6H-pyrrolo[3,4-b]pyrrol-4-one	IC50	100000.0 [1]
	6-(4-Chlorophenyl)-1-cyclopropyl-5-(1,5-dimethyl-6-oxopyridin-3-yl)-2-(2-methoxypyrimidin-5-yl)-6H-pyrrolo[3,4-b]pyrrol-4-one	IC50	100000.0 [1]
	2-(2-Amino-4-methoxypyrimidin-5-yl)-6-(4-chlorophenyl)-5-(oxan-4-yl)-1-propan-2-yl-6H-pyrrolo[3,4-b]pyrrol-4-one	IC50	14024.7 [1]
	3-[6-(4-Chloro-2-methylphenyl)-5-(4-hydroxycyclohexyl)-4-oxo-1-propan-2-yl-6H-pyrrolo[3,4-b]pyrrol-2-yl]-4-methoxy-N-methylbenzamide	IC50	2375.7 [1]
	6-(4-Chlorophenyl)-1-cyclopropyl-2-(2,4-dimethoxypyrimidin-5-yl)-5-(1,5-dimethyl-6-oxopyridin-3-yl)-6H-pyrrolo[3,4-b]pyrrol-4-one	IC50	77606.0 [1]
	1-(3-Chloro-2-fluorophenyl)-6-(4-chloro-2-methylphenyl)-8-(2-methoxyphenyl)-7-propan-2-yl-3,6-dihydropurin-2-one	IC50	2130.0 [1]
	1-(3-Chloro-2-fluorophenyl)-6-(4-chlorophenyl)-8-(4-methoxypyridin-3-yl)-7-propan-2-yl-3,6-dihydropurin-2-one	IC50	14040.0 [1]
	6-(4-Chloro-2-methylphenyl)-1-(5-chloro-2-methylphenyl)-8-(2-methoxyphenyl)-7-propan-2-yl-3,6-dihydropurin-2-one	IC50	1450.0 [1]
	6-(4-Chloro-2-methylphenyl)-1-(5-chloro-2-methylphenyl)-8-(4-methoxypyridin-3-yl)-7-propan-2-yl-3,6-dihydropurin-2-one	IC50	16690.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 47 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Tumour suppressor protein p53/Mdm4 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/tumour-suppressor-protein-p53-mdm4-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2024, November 21). Quest Database™ Tumour suppressor protein p53/Mdm4 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/tumour-suppressor-protein-p53-mdm4-inhibitors-ic50-ki.
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