![](https://images.aatbio.com/dataset/ic50/tumour-suppressor-protein-p53-mdm4_d82e6331764f414429c1418ba62e118b.svg) | Nutlin-3A | IC50 | 8200.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tumour-suppressor-protein-p53-mdm4_d82e6331764f414429c1418ba62e118b.svg) | Nutlin-3A | Ki | 5860.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tumour-suppressor-protein-p53-mdm4_5a5e34e37fe4d452fbc6d46798977be0.svg) | (2'R,3S,3'S,5'R)-6-Chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-N-(2-morpholin-4-ylethyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamide | Ki | 55000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tumour-suppressor-protein-p53-mdm4_54c9dd6f54d481d57717a4b39ebcf5bd.svg) | 6-Chloro-3-[1-(4-chlorobenzyl)-4-phenyl-1H-imidazol-5-yl]-1H-indole-2-carboxylic acid | Ki | 36000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tumour-suppressor-protein-p53-mdm4_77415814eddfa1b1520735c8c7e33a95.svg) | Benzamidobenzenethiol | IC50 | 7200.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tumour-suppressor-protein-p53-mdm4_63aeb98ce5d18fef5e207e3f5d7c7acc.svg) | [6-Chloro-3-[3-[(4-chlorophenyl)methyl]-5-phenylimidazol-4-yl]-1H-indol-2-yl]-[(3S)-3-[3-(dimethylamino)propyl-methylamino]pyrrolidin-1-yl]methanone | Ki | 11000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tumour-suppressor-protein-p53-mdm4_495f9a92b07b8988288cda9358dd370e.svg) | 3-Benzoyl-2-(4-bromophenyl)-1-(3-imidazol-1-ylpropyl)-4-propan-2-yloxy-2H-pyrrol-5-one | Ki | 2680.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tumour-suppressor-protein-p53-mdm4_58eac1df426a3504075a37baa35d9d9c.svg) | 6-Chloro-N-(2-sulfanylphenyl)pyridine-3-carboxamide | IC50 | 8900.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tumour-suppressor-protein-p53-mdm4_ab993e2939714e205e142f0f15ce4ed4.svg) | N-(2-Sulfanylphenyl)octanamide | IC50 | 25000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tumour-suppressor-protein-p53-mdm4_4f84d759f6b619bd49049959df2d9d15.svg) | 2-Methyl-N-(2-sulfanylphenyl)propanamide | IC50 | 6300.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tumour-suppressor-protein-p53-mdm4_98b0a7712eb8961f77078324af69a378.svg) | 4-Chloro-N-(2-sulfanylphenyl)benzamide | IC50 | 3400.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tumour-suppressor-protein-p53-mdm4_5543f657c2b19ddd05886db014c52e32.svg) | S-[2-(2-Methylpropanoylamino)phenyl] 2-methylpropanethioate | IC50 | 1500.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tumour-suppressor-protein-p53-mdm4_4505af98d5a8937d5b93f5f65bb828b5.svg) | S-(2-Benzamidophenyl) 2-methylpropanethioate | IC50 | 4600.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tumour-suppressor-protein-p53-mdm4_302d9d7164a0bbca69015d9efe5fce88.svg) | [2-(2-Methylpropanoylamino)phenyl] 2-methylpropanoate | IC50 | 25000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tumour-suppressor-protein-p53-mdm4_667436789441461311b8b7571d8c3fe7.svg) | 3-Benzoyl-2-(4-bromophenyl)-4-cyclohexyloxy-1-(3-imidazol-1-ylpropyl)-2H-pyrrol-5-one | Ki | 17930.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tumour-suppressor-protein-p53-mdm4_03437f738b883b736405948e294eacd3.svg) | 3-Benzoyl-2-(4-bromophenyl)-1-(3-imidazol-1-ylpropyl)-4-(2-methoxyethoxy)-2H-pyrrol-5-one | Ki | 2110.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tumour-suppressor-protein-p53-mdm4_74ad3a031abdeaa89af3fcfd2ac1e1f7.svg) | 3-Benzoyl-2-(4-bromophenyl)-4-ethoxy-1-(3-imidazol-1-ylpropyl)-2H-pyrrol-5-one | Ki | 38910.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tumour-suppressor-protein-p53-mdm4_6cf5f0ffab24a22b1b6590a9ea0c846d.svg) | 3-Benzoyl-2-(4-bromophenyl)-1-(3-imidazol-1-ylpropyl)-4-propoxy-2H-pyrrol-5-one | Ki | 9320.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tumour-suppressor-protein-p53-mdm4_d8a07b37edafd9baf84a720045ca045c.svg) | N-(2-Hydroxyphenyl)-2-methylpropanamide | IC50 | 25000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tumour-suppressor-protein-p53-mdm4_9413a3183749355fd723e132001f56b1.svg) | 3-[(2S,5S,8S,11S,14S,17S,20S,23E,33S)-33-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-Acetamido-4-methylpentanoyl]amino]-3-hydroxybutanoyl]amino]-3-phenylpropanoyl]amino]-20-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]carbamoyl]-14-(3-amino-3-oxopropyl)-17-(cyclobutylmethyl)-5-[(4-hydroxyphenyl)methyl]-8-(1H-indol-3-ylmethyl)-11,20,33-trimethyl-3,6,9,12,15,18,34-heptaoxo-1,4,7,10,13,16,19-heptazacyclotetratriacont-23-en-2-yl]propanoic acid | Ki | 6.8 [1] |
![](https://images.aatbio.com/dataset/ic50/tumour-suppressor-protein-p53-mdm4_fa73be325e7b5662b68604864b56e3d1.svg) | 3-[(6S)-6-(4-Chloro-2-methylphenyl)-5-(5-chloro-2-methylphenyl)-4-oxo-1-propan-2-yl-6H-pyrrolo[3,4-b]pyrrol-2-yl]-4-methoxy-N-methylbenzamide | IC50 | 264.3 [1] |
![](https://images.aatbio.com/dataset/ic50/tumour-suppressor-protein-p53-mdm4_3732818887f1ce03a95788ef54c14829.svg) | 3-[5-(5-Chloro-2-methylphenyl)-6-(4-chlorophenyl)-4-oxo-1-propan-2-yl-6H-pyrrolo[3,4-b]pyrrol-2-yl]-N-(2-hydroxyethoxy)-4-methoxybenzamide | IC50 | 327.1 [1] |
![](https://images.aatbio.com/dataset/ic50/tumour-suppressor-protein-p53-mdm4_b9963313d71e5d53de20645d46db4396.svg) | 3-[6-(4-Chlorophenyl)-5-(4-hydroxycyclohexyl)-4-oxo-1-propan-2-yl-6H-pyrrolo[3,4-b]pyrrol-2-yl]-4-methoxybenzoic acid | IC50 | 8788.9 [1] |
![](https://images.aatbio.com/dataset/ic50/tumour-suppressor-protein-p53-mdm4_b72176a046d64f878865cdae2efcce47.svg) | 2-(2-Amino-4-methoxypyrimidin-5-yl)-6-(4-chlorophenyl)-5-(4-hydroxycyclohexyl)-1-propan-2-yl-6H-pyrrolo[3,4-b]pyrrol-4-one | IC50 | 7858.6 [1] |
![](https://images.aatbio.com/dataset/ic50/tumour-suppressor-protein-p53-mdm4_09951c9029b3f764545bcf0b6602ab97.svg) | (6S)-5-(5-Chloro-1-methyl-6-oxopyridin-3-yl)-6-(4-chlorophenyl)-2-(2,4-dimethoxypyrimidin-5-yl)-1-propan-2-yl-6H-pyrrolo[3,4-b]pyrrol-4-one | IC50 | 1055.1 [1] |
![](https://images.aatbio.com/dataset/ic50/tumour-suppressor-protein-p53-mdm4_abdcfbcd170655d4b650ce9db1657c87.svg) | 5-(3-Chloro-2-fluorophenyl)-6-(4-chloro-2-methylphenyl)-2-(2-methoxyphenyl)-1-propan-2-yl-6H-pyrrolo[3,4-b]pyrrol-4-one | IC50 | 27835.2 [1] |
![](https://images.aatbio.com/dataset/ic50/tumour-suppressor-protein-p53-mdm4_7a7aadabc6da8125650d910de68da67b.svg) | 3-[5-(3-Chloro-2-fluorophenyl)-6-(4-chloro-2-methylphenyl)-4-oxo-1-propan-2-yl-6H-pyrrolo[3,4-b]pyrrol-2-yl]-4-methoxy-N-methylbenzamide | IC50 | 2901.9 [1] |
![](https://images.aatbio.com/dataset/ic50/tumour-suppressor-protein-p53-mdm4_407d0b5b0ff06d5199af3fa63d1a83d6.svg) | 5-(3-Chloro-2-fluorophenyl)-6-(4-chloro-2-methylphenyl)-2-(5-fluoro-2-methoxyphenyl)-1-propan-2-yl-6H-pyrrolo[3,4-b]pyrrol-4-one | IC50 | 54238.3 [1] |
![](https://images.aatbio.com/dataset/ic50/tumour-suppressor-protein-p53-mdm4_a01ad61bcdafdd4e6524fe44c1953e00.svg) | 3-[(6S)-5-(3-Chloro-2-fluorophenyl)-6-(4-chloro-2-methylphenyl)-4-oxo-1-propan-2-yl-6H-pyrrolo[3,4-b]pyrrol-2-yl]-4-methoxy-N-methylbenzamide | IC50 | 507.5 [1] |
![](https://images.aatbio.com/dataset/ic50/tumour-suppressor-protein-p53-mdm4_600905b3e6be67b0eda438c14cca2ef4.svg) | 5-(5-Chloro-2-methylphenyl)-6-(4-chlorophenyl)-2-(2-methoxyphenyl)-1-propan-2-yl-6H-pyrrolo[3,4-b]pyrrol-4-one | IC50 | 4025.9 [1] |
![](https://images.aatbio.com/dataset/ic50/tumour-suppressor-protein-p53-mdm4_f0dcf7099fdf3cc4e916d49125c6029f.svg) | 3-[5-(5-Chloro-2-methylphenyl)-6-(4-chlorophenyl)-4-oxo-1-propan-2-yl-6H-pyrrolo[3,4-b]pyrrol-2-yl]-4-methoxy-N-methylbenzamide | IC50 | 477.5 [1] |
![](https://images.aatbio.com/dataset/ic50/tumour-suppressor-protein-p53-mdm4_f875a7f9b7f65731be328494fe3c035c.svg) | 1-(3-Chloro-2-fluorophenyl)-6-(4-chlorophenyl)-8-(2-methoxyphenyl)-7-propan-2-yl-3,6-dihydropurin-2-one | IC50 | 1510.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tumour-suppressor-protein-p53-mdm4_e403cdfb8b00304bae9e34816f284c71.svg) | 6-(4-Chloro-2-methylphenyl)-5-(4-hydroxycyclohexyl)-2-(2-methoxyphenyl)-1-propan-2-yl-6H-pyrrolo[3,4-b]pyrrol-4-one | IC50 | 2989.9 [1] |
![](https://images.aatbio.com/dataset/ic50/tumour-suppressor-protein-p53-mdm4_f3964b03aea4647b97d1a0801634b195.svg) | 4-[6-(4-Chlorophenyl)-2-(2,4-dimethoxypyrimidin-5-yl)-4-oxo-1-propan-2-yl-6H-pyrrolo[3,4-b]pyrrol-5-yl]-N-methylpiperidine-1-carboxamide | IC50 | 3643.4 [1] |
![](https://images.aatbio.com/dataset/ic50/tumour-suppressor-protein-p53-mdm4_7fd23c6756fb9fd862a6bc83d51f7a04.svg) | 2-(2-Amino-4-methoxypyrimidin-5-yl)-6-(4-chlorophenyl)-5-(1-methyl-6-oxopiperidin-3-yl)-1-propan-2-yl-6H-pyrrolo[3,4-b]pyrrol-4-one | IC50 | 9023.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tumour-suppressor-protein-p53-mdm4_900dc3d4bcea1b3d79bddfd451dd7a22.svg) | 6-(4-Chloro-2-methylphenyl)-2-(2,4-dimethoxypyrimidin-5-yl)-5-(4-hydroxycyclohexyl)-1-propan-2-yl-6H-pyrrolo[3,4-b]pyrrol-4-one | IC50 | 4714.8 [1] |
![](https://images.aatbio.com/dataset/ic50/tumour-suppressor-protein-p53-mdm4_56f701dfad48b0d29f88198dc4c62843.svg) | 6-(4-Chloro-2-methylphenyl)-2-(2,4-dimethoxypyrimidin-5-yl)-5-(oxan-4-yl)-1-propan-2-yl-6H-pyrrolo[3,4-b]pyrrol-4-one | IC50 | 6286.2 [1] |
![](https://images.aatbio.com/dataset/ic50/tumour-suppressor-protein-p53-mdm4_15236187c0cfb89e74e218869214e70a.svg) | 4-[(6S)-5-(5-Chloro-2-oxo-1H-pyridin-3-yl)-2-[2-(dimethylamino)-4-methoxypyrimidin-5-yl]-4-oxo-1-propan-2-yl-6H-pyrrolo[3,4-b]pyrrol-6-yl]benzonitrile | IC50 | 716.5 [1] |
![](https://images.aatbio.com/dataset/ic50/tumour-suppressor-protein-p53-mdm4_44d34eb7d842d099b39e83fac7640395.svg) | 6-(4-Chlorophenyl)-1-cyclopropyl-5-(1,5-dimethyl-6-oxopyridin-3-yl)-2-(1-methyl-2-oxopyridin-4-yl)-6H-pyrrolo[3,4-b]pyrrol-4-one | IC50 | 100000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tumour-suppressor-protein-p53-mdm4_7184b4f87e2d15583a7cf0820cb03a73.svg) | 6-(4-Chlorophenyl)-1-cyclopropyl-5-(1,5-dimethyl-6-oxopyridin-3-yl)-2-(2-methoxypyrimidin-5-yl)-6H-pyrrolo[3,4-b]pyrrol-4-one | IC50 | 100000.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tumour-suppressor-protein-p53-mdm4_65fd94aca785f947bd438e52c819945a.svg) | 2-(2-Amino-4-methoxypyrimidin-5-yl)-6-(4-chlorophenyl)-5-(oxan-4-yl)-1-propan-2-yl-6H-pyrrolo[3,4-b]pyrrol-4-one | IC50 | 14024.7 [1] |
![](https://images.aatbio.com/dataset/ic50/tumour-suppressor-protein-p53-mdm4_66dd38bdda817dd29e25c02934546e60.svg) | 3-[6-(4-Chloro-2-methylphenyl)-5-(4-hydroxycyclohexyl)-4-oxo-1-propan-2-yl-6H-pyrrolo[3,4-b]pyrrol-2-yl]-4-methoxy-N-methylbenzamide | IC50 | 2375.7 [1] |
![](https://images.aatbio.com/dataset/ic50/tumour-suppressor-protein-p53-mdm4_da4921616277702de5e5feb1e8dce082.svg) | 6-(4-Chlorophenyl)-1-cyclopropyl-2-(2,4-dimethoxypyrimidin-5-yl)-5-(1,5-dimethyl-6-oxopyridin-3-yl)-6H-pyrrolo[3,4-b]pyrrol-4-one | IC50 | 77606.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tumour-suppressor-protein-p53-mdm4_f6a6adbcca13307f0673ac42fd22dd11.svg) | 1-(3-Chloro-2-fluorophenyl)-6-(4-chloro-2-methylphenyl)-8-(2-methoxyphenyl)-7-propan-2-yl-3,6-dihydropurin-2-one | IC50 | 2130.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tumour-suppressor-protein-p53-mdm4_3defcc26ca1000c08e560714390b1871.svg) | 1-(3-Chloro-2-fluorophenyl)-6-(4-chlorophenyl)-8-(4-methoxypyridin-3-yl)-7-propan-2-yl-3,6-dihydropurin-2-one | IC50 | 14040.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tumour-suppressor-protein-p53-mdm4_98131252fea2255ab748fd848e6c6455.svg) | 6-(4-Chloro-2-methylphenyl)-1-(5-chloro-2-methylphenyl)-8-(2-methoxyphenyl)-7-propan-2-yl-3,6-dihydropurin-2-one | IC50 | 1450.0 [1] |
![](https://images.aatbio.com/dataset/ic50/tumour-suppressor-protein-p53-mdm4_eeeea2ad2eed8f168caf600e1066a491.svg) | 6-(4-Chloro-2-methylphenyl)-1-(5-chloro-2-methylphenyl)-8-(4-methoxypyridin-3-yl)-7-propan-2-yl-3,6-dihydropurin-2-one | IC50 | 16690.0 [1] |