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Tumour suppressor p53/oncoprotein Mdm2 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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Nutlin-3AIC5070.0 [1]
Nutlin-3AKi55.0 [1], 230.0 [2]
2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-[(2S,3S)-2-hydroxypentan-3-yl]-3-methyl-2-oxopiperidin-3-yl]acetic acidIC501.0 [1], 1.1 [2], 4.2 [3], 6.0 [4]
2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxo-1-pentan-3-ylpiperidin-3-yl]acetic acidIC502.8 [1], 3.0 [2], 36.3 [3], 55.0 [4]
2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxo-1-propan-2-ylpiperidin-3-yl]acetic acidIC506.0 [1], 9.0 [2], 30.0 [3], 119.0 [4]
2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-[(1S)-2-methyl-1-pyridin-2-ylpropyl]-2-oxopiperidin-3-yl]acetic acidIC502.0 [1], 9.0 [2], 25.0 [3], 30.0 [4]
2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-[(2S)-1-hydroxybutan-2-yl]-3-methyl-2-oxopiperidin-3-yl]acetic acidIC501.7 [1], 2.0 [2], 6.8 [3], 20.0 [4]
Tert-butyl (2S)-2-[(3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxo-3-(2H-tetrazol-5-ylmethyl)piperidin-1-yl]butanoateIC500.9 [1], 1.0 [2], 9.0 [3], 10.0 [4]
2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxo-1-[(1S)-1-pyridin-2-ylpropyl]piperidin-3-yl]acetic acidIC503.0 [1], 10.0 [2], 28.0 [3], 30.0 [4]
2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxo-1-[(1S)-1-pyridin-4-ylpropyl]piperidin-3-yl]acetic acidIC509.0 [1], 31.0 [2], 40.0 [3]
(2'R,3S,3'S,5'R)-6-Chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-N-(2-morpholin-4-ylethyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamideIC509.0 [1], 21.0 [2]
(2'R,3S,3'S,5'R)-6-Chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-N-(2-morpholin-4-ylethyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamideKi3.0 [1]
2-[(3S,5S,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-(cyclopropylmethyl)-2-oxopiperidin-3-yl]acetic acidIC502420.0 [1], 18900.0 [2]
2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-[(2S)-1-[(2-methylpropan-2-yl)oxy]-1-oxobutan-2-yl]-2-oxopiperidin-3-yl]acetic acidIC502.2 [1], 19.9 [2]
2-Amino-4,5-bis(4-chlorophenyl)-N-cyclopropylthiophene-3-carboxamideIC502080.0 [1]
2-Amino-4,5-bis(4-chlorophenyl)-N-cyclopropylthiophene-3-carboxamideKi540.0 [1]
Methyl 2-amino-4,5-bis(4-chlorophenyl)thiophene-3-carboxylateIC504230.0 [1]
Methyl 2-amino-4,5-bis(4-chlorophenyl)thiophene-3-carboxylateKi1520.0 [1]
2-Amino-4,5-bis(4-chlorophenyl)-N-cyclohexylthiophene-3-carboxamideIC50900.0 [1]
2-Amino-4,5-bis(4-chlorophenyl)-N-cyclohexylthiophene-3-carboxamideKi230.0 [1]
[2-Amino-4,5-bis(4-chlorophenyl)thiophen-3-yl]-pyrrolidin-1-ylmethanoneIC502840.0 [1]
[2-Amino-4,5-bis(4-chlorophenyl)thiophen-3-yl]-pyrrolidin-1-ylmethanoneKi740.0 [1]
(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-(cyclopropylmethyl)-3-(2H-tetrazol-5-ylmethyl)piperidin-2-oneIC5014.0 [1], 90.0 [2], 190.0 [3]
2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-(cyclopropylmethyl)-2-oxopiperidin-3-yl]acetamideIC50270.0 [1], 1370.0 [2], 7630.0 [3]
Methyl 2-[(3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-(cyclopropylmethyl)-2-oxopiperidin-3-yl]acetateIC50790.0 [1], 3630.0 [2], 30000.0 [3]
2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxo-1-[(1S)-1-pyridin-2-ylbutyl]piperidin-3-yl]acetic acidIC506.0 [1], 80.0 [2], 92.0 [3]
2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-[(1S)-1-(6-methylpyridin-2-yl)propyl]-2-oxopiperidin-3-yl]acetic acidIC502.0 [1], 10.0 [2], 32.0 [3]
2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxo-1-[(1S)-1-pyrimidin-2-ylpropyl]piperidin-3-yl]acetic acidIC507.0 [1], 50.0 [2], 60.0 [3]
2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxo-1-[(1S)-1-(1,3-thiazol-2-yl)propyl]piperidin-3-yl]acetic acidIC506.0 [1], 50.0 [2], 66.0 [3]
2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxo-1-[(1S)-1-pyridin-3-ylpropyl]piperidin-3-yl]acetic acidIC501.5 [1], 80.0 [2], 85.0 [3]
2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-[(1S)-1-(6-chloropyridin-2-yl)propyl]-3-methyl-2-oxopiperidin-3-yl]acetic acidIC500.7 [1], 1.0 [2], 23.0 [3]
IdasanutlinIC509.0 [1], 10.0 [2]
Nutlin-1IC504780.0 [1]
Nutlin-1Ki1240.0 [1]
Nvp-cgm097IC501.7 [1], 224.0 [2]
DI-Chloro-benzo-diazepineIC50420.0 [1]
DI-Chloro-benzo-diazepineKi80.0 [1]
2-Benzyl-3-(4-chlorophenyl)-3-(3-hydroxypropoxy)-2,3-dihydroisoindol-1-oneIC5015900.0 [1]
3-(4-Chlorophenyl)-3-[(4-hydroxy-3,5-dimethoxyphenyl)methoxy]-2-propylisoindol-1-oneIC505300.0 [1]
Methyl 3-(4-hydroxyphenyl)-2-(3-oxo-1-phenyl-1-propoxyisoindol-2-yl)propanoateIC5090000.0 [1]
4-Tert-butyl-N-[3-oxo-2-propyl-1-[4-(2-trimethylsilylethoxymethoxy)phenyl]isoindol-1-yl]benzamideIC5027000.0 [1]
2-Benzyl-3-[(4-hydroxy-3,5-dimethoxyphenyl)methoxy]-3-phenylisoindol-1-oneIC5017900.0 [1]
N-[2-[1-[(4-Tert-butylphenyl)methoxy]-3-oxo-1-phenylisoindol-2-yl]ethyl]acetamideIC5014000.0 [1], 14400.0 [2]
2-Benzyl-3-(3-hydroxypropoxy)-3-phenylisoindol-1-oneIC50245000.0 [1]
3-[(4-Tert-butylphenyl)methoxy]-3-phenyl-2-propylisoindol-1-oneIC50500000.0 [1]
3-(3-Hydroxypropoxy)-3-phenyl-2-propylisoindol-1-oneIC50500000.0 [1]
2-Benzyl-3-[(4-tert-butylphenyl)methoxy]-3-(4-chlorophenyl)isoindol-1-oneIC5099000.0 [1]
2-Benzyl-3-(4-chlorophenyl)-3-(2-pyridin-2-ylethoxy)isoindol-1-oneIC5026200.0 [1]
3-(4-Chlorophenyl)-2-propyl-3-(2-pyridin-2-ylethoxy)isoindol-1-oneIC5057000.0 [1]
N-[2-[1-(4-Chlorophenyl)-1-[(4-hydroxy-3,5-dimethoxyphenyl)methoxy]-3-oxoisoindol-2-yl]ethyl]acetamideIC5076000.0 [1]
3-[(4-Hydroxy-3,5-dimethoxyphenyl)methoxy]-2-propyl-3-[4-(2-trimethylsilylethoxymethoxy)phenyl]isoindol-1-oneIC50118000.0 [1]
2-Propyl-3-(2-pyridin-2-ylethoxy)-3-[4-(2-trimethylsilylethoxymethoxy)phenyl]isoindol-1-oneIC50312000.0 [1]
2-Benzyl-3-[(4-hydroxy-3,5-dimethoxyphenyl)methoxy]-3-[4-(2-trimethylsilylethoxymethoxy)phenyl]isoindol-1-oneIC50257000.0 [1]
2-Benzyl-3-[(4-tert-butylphenyl)methoxy]-3-phenylisoindol-1-oneIC5092000.0 [1]
N-[1-(4-Tert-butylphenyl)-3-oxo-2-propylisoindol-1-yl]benzamideIC5066000.0 [1]
2-Benzyl-3-phenyl-3-(2-pyridin-2-ylethoxy)isoindol-1-oneIC50206000.0 [1]
3-[(4-Hydroxy-3,5-dimethoxyphenyl)methoxy]-3-phenyl-2-propylisoindol-1-oneIC5082000.0 [1]
3-Phenyl-2-propyl-3-(2-pyridin-2-ylethoxy)isoindol-1-oneIC50100000.0 [1]
2-Benzyl-3-(4-chlorophenyl)-3-[(4-hydroxy-3,5-dimethoxyphenyl)methoxy]isoindol-1-oneIC5042000.0 [1]
3-[(4-Tert-butylphenyl)methoxy]-3-(4-chlorophenyl)-2-propylisoindol-1-oneIC50187000.0 [1]
3-(4-Chlorophenyl)-3-(3-hydroxypropoxy)-2-propylisoindol-1-oneIC5016400.0 [1]
N-[2-[1-[(4-Tert-butylphenyl)methoxy]-1-(4-chlorophenyl)-3-oxoisoindol-2-yl]ethyl]acetamideIC5091400.0 [1]
3-[(4-Tert-butylphenyl)methoxy]-2-propyl-3-[4-(2-trimethylsilylethoxymethoxy)phenyl]isoindol-1-oneIC50464000.0 [1]
N-[4-[(3-Hydroxy-5-oxo-1,2-diphenylpyrazol-4-yl)diazenyl]phenyl]sulfonyl-4-propan-2-yloxybenzamideIC5030000.0 [1], 31800.0 [2]
2-Benzyl-3-[[2-hydroxy-2-(4-methoxyphenyl)ethyl]amino]-3-phenylisoindol-1-oneIC5070000.0 [1]
2-Propyl-3-propoxy-3-phenyl-2H-isoindole-1(3H)-oneIC50200000.0 [1]
2-Benzyl-3-(propylamino)-3-phenyl-2H-isoindole-1(3H)-oneIC50200000.0 [1]
2-Benzyl-3-propoxy-3-phenyl-2H-isoindole-1(3H)-oneIC50200000.0 [1]
(2S)-1-[(5R,6S)-5,6-Bis(4-chlorophenyl)-6-methyl-3-propan-2-yl-5H-imidazo[2,1-b][1,3]thiazole-2-carbonyl]-N,N-dimethylpyrrolidine-2-carboxamideIC508.3 [1], 9.2 [2]
2-[(3S,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-(cyclopropylmethyl)-2-oxopiperidin-3-yl]acetic acidIC5076.0 [1], 1110.0 [2]
2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-(cyclopropylmethyl)-2-oxopiperidin-3-yl]acetic acidIC5034.0 [1], 370.0 [2]
(1R)-7-[(2R)-Butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-[4-[methyl(pyridin-4-ylmethyl)amino]phenyl]-1,4-dihydroisoquinolin-3-oneIC501171.0 [1], 1200.0 [2]
(1S)-7-[(2R)-Butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-[4-[methyl(pyridin-4-ylmethyl)amino]phenyl]-1,4-dihydroisoquinolin-3-oneIC502.3 [1]
7-[(2R)-Butan-2-yl]oxy-1-(4-chlorophenyl)-6-methoxy-2-[4-[methyl(pyridin-4-ylmethyl)amino]phenyl]-1,4-dihydroisoquinolin-3-oneIC508.0 [1]
2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-[(1S)-1-cyclopropyl-2-[cyclopropylsulfonyl(methyl)amino]ethyl]-3-methyl-2-oxopiperidin-3-yl]acetic acidIC501.0 [1], 10.0 [2]
2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-[(2S)-1-(methanesulfonamido)butan-2-yl]-3-methyl-2-oxopiperidin-3-yl]acetic acidIC501.0 [1], 10.0 [2]
(2'R,3R,3'S,5'S)-N-[2-(4-Carbamoyl-2-methoxyphenyl)phenyl]-6-chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamideIC505.0 [1]
2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxo-1-[(1S)-1-[(2S)-oxolan-2-yl]propyl]piperidin-3-yl]acetic acidIC501.0 [1], 20.0 [2]
2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-[(1S)-1-(1,3-oxazol-5-yl)propyl]-2-oxopiperidin-3-yl]acetic acidIC508.0 [1], 36.0 [2]
2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxo-1-[(1S)-1-pyridin-2-ylethyl]piperidin-3-yl]acetic acidIC5010.0 [1], 62.0 [2]
2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-[(1S)-1-(5-methylpyridin-2-yl)propyl]-2-oxopiperidin-3-yl]acetic acidIC507.0 [1], 123.0 [2]
2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-[(1S)-1-(4-methylpyridin-2-yl)propyl]-2-oxopiperidin-3-yl]acetic acidIC503.0 [1], 60.0 [2]
2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-3-methyl-1-[(1S)-1-(3-methylpyridin-2-yl)propyl]-2-oxopiperidin-3-yl]acetic acidIC505.0 [1], 183.0 [2]
2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxo-1-pyridin-2-ylpiperidin-3-yl]acetic acidIC5013.0 [1], 122.0 [2]
2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-3-methyl-2-oxo-1-phenylpiperidin-3-yl]acetic acidIC504.0 [1], 55.0 [2]
(2'R,3R,3'S,5'S)-N-(4-Carbamoylphenyl)-6-chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamideIC505.0 [1]
4-[[(2'R,3R,3'S,5'S)-6-Chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carbonyl]amino]-2-methoxybenzoic acidIC504.0 [1]
(2'R,3R,3'S,5'S)-6-Chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-N-[4-(2-hydroxyethoxy)phenyl]-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamideIC507.0 [1], 8.0 [2]
(2'R,3R,3'S,5'S)-6-Chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-N-[4-(2-hydroxyethoxy)-2-methoxyphenyl]-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamideIC505.0 [1]
(2'R,3R,3'S,5'S)-N-(4-Carbamoyl-3-methoxyphenyl)-6-chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamideIC505.0 [1]
(2'R,3R,3'S,5'S)-N-(4-Carbamoylphenyl)-6-chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-5-fluoro-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamideIC506.0 [1]
(2'R,3R,3'S,5'S)-6-Chloro-3'-(3-chloro-2-fluorophenyl)-N-(4-cyano-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamideIC507.0 [1]
(2'R,3R,3'S,5'S)-N-(4-Carbamoyl-2-methoxyphenyl)-6-chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-4-fluoro-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamideIC505.0 [1], 6.0 [2]
4-[[(2'R,3R,3'S,5'S)-6-Chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carbonyl]amino]-3-methoxybenzoic acidIC505.0 [1]
2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-[(2S)-1-ethoxy-1-oxobutan-2-yl]-2-oxopiperidin-3-yl]acetic acidIC507.6 [1], 86.0 [2]
2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-[(2S)-1-[(2-methylpropan-2-yl)oxy]-1-oxobutan-2-yl]-2-oxopiperidin-3-yl]acetic acidIC504.2 [1], 43.3 [2]
(2'R,3R,3'S,5'S)-N-(4-Carbamoyl-2-methoxyphenyl)-6-chloro-3'-(3-chloro-2-fluorophenyl)-5'-(2,2-dimethylpropyl)-7-fluoro-2-oxospiro[1H-indole-3,4'-pyrrolidine]-2'-carboxamideIC5015.0 [1], 18.0 [2]
2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-[(3S)-2-hydroxy-2-methylpentan-3-yl]-3-methyl-2-oxopiperidin-3-yl]acetic acidIC502.0 [1], 10.0 [2]
2-[(3R,5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)-1-[(S)-cyclopropyl(pyridin-2-yl)methyl]-3-methyl-2-oxopiperidin-3-yl]acetic acidIC502.0 [1], 19.0 [2]
(5R,6S)-5-(3-Chlorophenyl)-6-(4-chlorophenyl)piperidin-2-oneIC5010000.0 [1], 30000.0 [2]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Tumour suppressor p53/oncoprotein Mdm2 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 20 Nov. 2024, https://www.aatbio.com/data-sets/tumour-suppressor-p53-oncoprotein-mdm2-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 20). Quest Database™ Tumour suppressor p53/oncoprotein Mdm2 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/tumour-suppressor-p53-oncoprotein-mdm2-inhibitors-ic50-ki.
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