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Tumor necrosis factor receptor R1 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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ChalconeIC5023000.0 [1]
MegalipIC507000.0 [1]
4'-MethoxychalconeIC5014000.0 [1]
3-Phenyl-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-oneIC506000.0 [1]
6,7-Dimethyl-3-[[methyl-[2-[methyl-[[1-[3-(trifluoromethyl)phenyl]indol-3-yl]methyl]amino]ethyl]amino]methyl]chromen-4-oneIC5022000.0 [1]
3',4'-DimethoxychalconeIC508000.0 [1]
2,4,4'-TrimethoxychalconeIC5029000.0 [1]
3,4-TrimethoxychalconeIC506000.0 [1]
1,3-Diethyl-5-(5-methyl-thiophen-2-ylmethylene)-2-thioxo-dihydro-pyrimidine-4,6-dioneIC503400.0 [1]
4,4'-DifluorochalconeIC5025000.0 [1]
3-(3,4-Dimethoxyphenyl)-1-(4-methoxyphenyl)prop-2-en-1-oneIC5015000.0 [1]
(E)-1-[3,5-Dimethoxy-4-[(4-methoxyphenyl)methoxy]phenyl]-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-oneIC501000.0 [1]
(1S,2R,3R,5R)-3-(Hydroxymethyl)-5-[[2-[(2-propan-2-yloxypyridin-4-yl)amino]-5-quinolin-2-ylpyrimidin-4-yl]amino]cyclopentane-1,2-diolIC5031000.0 [1]
(1R,2S,3R,5R)-3-[[2-[(2-Cyclopropyloxypyridin-4-yl)amino]-5-quinolin-2-ylpyrimidin-4-yl]amino]-5-(hydroxymethyl)cyclopentane-1,2-diolIC5031000.0 [1]
(1S,2R,3R,5R)-3-(Hydroxymethyl)-5-[[2-[(2-methoxypyridin-4-yl)amino]-5-quinolin-2-ylpyrimidin-4-yl]amino]cyclopentane-1,2-diolIC5031000.0 [1]
(1R,2S,3R,5R)-3-[[2-[(2,6-Dimethylpyridin-4-yl)amino]-5-quinolin-2-ylpyrimidin-4-yl]amino]-5-(hydroxymethyl)cyclopentane-1,2-diolIC5031000.0 [1]
(1R,2S,3R,5R)-3-[[2-[(2,6-Dimethylpyridin-4-yl)amino]-5-(4-phenyl-1,3-thiazol-2-yl)pyrimidin-4-yl]amino]-5-(hydroxymethyl)cyclopentane-1,2-diolIC5031000.0 [1]
6-Hydroxy-5-[(Z)-indol-3-ylidenemethyl]-1-(2-methylphenyl)-2-sulfanylidenepyrimidin-4-oneIC501800.0 [1]
5-(1H-Indol-3-ylmethylene)-2-thioxo-1,3-di-o-tolyl-dihydro-pyrimidine-4,6-dioneIC50790.0 [1]
1,3-Diethyl-5-(1H-indol-3-ylmethylene)-2-thioxo-dihydro-pyrimidine-4,6-dioneIC501000.0 [1]
5-(1H-Indol-3-ylmethylene)-1,3-dimethyl-2-thioxo-dihydro-pyrimidine-4,6-dioneIC5013000.0 [1]
1,3-Diethyl-6-hydroxy-5-[(Z)-(5-phenylmethoxyindol-3-ylidene)methyl]-2-sulfanylidenepyrimidin-4-oneIC50400.0 [1]
1,3-Diethyl-6-hydroxy-5-[(Z)-(7-methylindol-3-ylidene)methyl]-2-sulfanylidenepyrimidin-4-oneIC50600.0 [1]
1,3-Diethyl-6-hydroxy-5-[(Z)-(5-nitroindol-3-ylidene)methyl]-2-sulfanylidenepyrimidin-4-oneIC505500.0 [1]
1,3-Diethyl-6-hydroxy-5-[(Z)-indol-2-ylidenemethyl]-2-sulfanylidenepyrimidin-4-oneIC5010200.0 [1]
2-(2,4-Dichlorophenyl)-N'-(pyridine-2-carbonyl)-1,3-thiazole-4-carbohydrazideIC50770.0 [1]
(E)-3-[5-(1-Benzothiophen-2-yl)-2,4-dimethoxyphenyl]-1-(2,3,4-trimethoxyphenyl)prop-2-en-1-oneIC508000.0 [1]
(E)-1-[3-Methoxy-4-(pyridin-2-ylmethoxy)phenyl]-3-(2-methoxy-5-thiophen-2-ylphenyl)prop-2-en-1-oneIC503000.0 [1]
(E)-1-[3-Methoxy-4-(pyridin-3-ylmethoxy)phenyl]-3-(2-methoxy-5-thiophen-2-ylphenyl)prop-2-en-1-oneIC503000.0 [1]
{4-[(E)-3-(5-Benzo[b]thiophen-2-yl-2,4-dimethoxy-phenyl)-acryloyl]-phenylsulfanyl}-acetic acidIC501000.0 [1]
(E)-3-[5-(1-Benzothiophen-2-yl)-2,4-dimethoxyphenyl]-1-[4-[[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]amino]phenyl]prop-2-en-1-oneIC5017000.0 [1]
(E)-3-[5-(1-Benzothiophen-2-yl)-2,4-dimethoxyphenyl]-1-(4-hydroxy-3,5-dimethoxyphenyl)prop-2-en-1-oneIC501000.0 [1]
4-{2-Methoxy-4-[(E)-3-(2-methoxy-5-thiophen-2-yl-phenyl)-acryloyl]-phenoxymethyl}-benzoic acidIC505000.0 [1]
(E)-1-(1,3-Benzodioxol-5-yl)-3-[2-methoxy-5-(5-methylthiophen-2-yl)phenyl]prop-2-en-1-oneIC503000.0 [1]
(E)-3-(2-Methoxy-5-thiophen-2-ylphenyl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-oneIC503000.0 [1]
(E)-1-(4-Hydroxy-3-methoxyphenyl)-3-(2-methoxy-5-thiophen-2-ylphenyl)prop-2-en-1-oneIC507000.0 [1]
(E)-3-[3-(5-Acetylthiophen-2-yl)-4,5-dimethoxyphenyl]-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-oneIC503000.0 [1]
(E)-3-(2,4-Dimethoxy-5-thiophen-2-ylphenyl)-1-(2,3,4-trimethoxyphenyl)prop-2-en-1-oneIC502000.0 [1]
(E)-3-[5-(1-Benzothiophen-2-yl)-2,4-dimethoxyphenyl]-1-(3,4-dimethoxyphenyl)prop-2-en-1-oneIC5011000.0 [1]
(E)-1-(3,4-Dimethoxyphenyl)-3-[2-methoxy-5-(4-methylthiophen-2-yl)phenyl]prop-2-en-1-oneIC502000.0 [1]
(E)-3-(4-Thiophen-2-ylphenyl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-oneIC506000.0 [1]
(E)-1-(2,5-Dimethoxyphenyl)-3-(2-methoxy-5-thiophen-2-ylphenyl)prop-2-en-1-oneIC502000.0 [1]
(E)-3-[5-(1-Benzothiophen-2-yl)-2-methoxyphenyl]-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-oneIC502000.0 [1]
(E)-1-(3,4-Dimethoxyphenyl)-3-(4-thiophen-2-ylphenyl)prop-2-en-1-oneIC5012000.0 [1]
(E)-3-(3,4-Difluorophenyl)-1-(2-methoxy-4-thiophen-2-ylphenyl)prop-2-en-1-oneIC502000.0 [1]
(E)-1-(3,4-Dimethoxyphenyl)-3-(2-methoxy-5-thiophen-2-ylphenyl)prop-2-en-1-oneIC503000.0 [1]
(E)-3-[2-Methoxy-5-(5-methylthiophen-2-yl)phenyl]-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-oneIC502000.0 [1]
(E)-1-(3,4-Dimethoxyphenyl)-3-[2-methoxy-5-(5-methylthiophen-2-yl)phenyl]prop-2-en-1-oneIC502000.0 [1]
(E)-3-(4-Ethoxy-3-fluorophenyl)-1-(2-methoxy-5-thiophen-2-ylphenyl)prop-2-en-1-oneIC504000.0 [1]
(E)-1-(1,3-Benzodioxol-5-yl)-3-(2-methoxy-5-thiophen-2-ylphenyl)prop-2-en-1-oneIC504000.0 [1]
(E)-1-(2,6-Dimethoxyphenyl)-3-(2-methoxy-5-thiophen-2-ylphenyl)prop-2-en-1-oneIC503000.0 [1]
(E)-1-[4-[(4-Aminophenyl)methoxy]-3-methoxyphenyl]-3-(2-methoxy-5-thiophen-2-ylphenyl)prop-2-en-1-oneIC507000.0 [1]
(E)-1-(1,3-Benzodioxol-5-yl)-3-[2-methoxy-5-(4-methylthiophen-2-yl)phenyl]prop-2-en-1-oneIC504000.0 [1]
(E)-1-(3,5-Dimethoxyphenyl)-3-(2-methoxy-5-thiophen-2-ylphenyl)prop-2-en-1-oneIC502000.0 [1]
(E)-3-(3-Bromo-4,5-dimethoxyphenyl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-oneIC504000.0 [1]
(E)-3-[5-(1-Benzothiophen-2-yl)-2-methoxyphenyl]-1-(3,4-dimethoxyphenyl)prop-2-en-1-oneIC502000.0 [1]
(E)-3-[2-Methoxy-5-(4-methylthiophen-2-yl)phenyl]-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-oneIC502000.0 [1]
(E)-1-[3-Methoxy-4-(pyridin-4-ylmethoxy)phenyl]-3-(2-methoxy-5-thiophen-2-ylphenyl)prop-2-en-1-oneIC504000.0 [1]
(E)-3-[5-(1-Benzothiophen-2-yl)-2-methoxyphenyl]-1-(4-methoxyphenyl)prop-2-en-1-oneIC503000.0 [1]
(E)-1-(4-Methoxyphenyl)-3-(2-methoxy-5-thiophen-2-ylphenyl)prop-2-en-1-oneIC503000.0 [1]
(E)-3-(2-Methoxy-5-thiophen-2-ylphenyl)-1-(2,4,6-trimethoxyphenyl)prop-2-en-1-oneIC503000.0 [1]
1,3-Diethyl-5-(1-methyl-1H-indol-3-ylmethylene)-2-thioxo-dihydro-pyrimidine-4,6-dioneIC50130.0 [1]
5-(5-Bromo-thiophen-2-ylmethylene)-1,3-diethyl-2-thioxo-dihydro-pyrimidine-4,6-dioneIC504500.0 [1]
(E)-1-(4-Fluorophenyl)-3-(4-fluoro-3-thiophen-2-ylphenyl)prop-2-en-1-oneIC504000.0 [1]
(E)-1-[3,5-Dimethoxy-4-(2-methoxyethoxy)phenyl]-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-oneIC505000.0 [1]
(E)-3-[5-(1-Benzothiophen-2-yl)-2,4-dimethoxyphenyl]-1-[4-(cyclopropylmethoxy)-3,5-dimethoxyphenyl]prop-2-en-1-oneIC5050000.0 [1]
(E)-3-(3-Bromo-4,5-dimethoxyphenyl)-1-(2,4,5-triethoxyphenyl)prop-2-en-1-oneIC5015000.0 [1]
(E)-1-[4-[(3,4-Dimethoxyphenyl)methoxy]-3,5-dimethoxyphenyl]-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-oneIC502000.0 [1]
(E)-3-(3-Bromo-4,5-dimethoxyphenyl)-1-(2,4,5-trimethoxyphenyl)prop-2-en-1-oneIC502000.0 [1]
(E)-3-(3-Bromo-4,5-dimethoxyphenyl)-1-(3,5-dimethoxy-4-phenylmethoxyphenyl)prop-2-en-1-oneIC5050000.0 [1]
(E)-1-(3,5-Ditert-butyl-4-methoxyphenyl)-3-(4-methoxyphenyl)prop-2-en-1-oneIC5017000.0 [1]
(E)-1-(3,5-Ditert-butyl-4-methoxyphenyl)-3-phenylprop-2-en-1-oneIC509000.0 [1]
(E)-1-[3-Methoxy-4-(3-methoxy-1,4-benzodioxin-2-yl)phenyl]-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-oneIC504000.0 [1]
(E)-1-[3,5-Dimethoxy-4-[(3,4,5-trimethoxyphenyl)methoxy]phenyl]-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-oneIC503000.0 [1]
(E)-3-(2-Methoxy-5-thiophen-2-ylphenyl)-1-phenylprop-2-en-1-oneIC505000.0 [1]
(E)-1-[4-(Furan-2-ylmethoxy)-3,5-dimethoxyphenyl]-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-oneIC503000.0 [1]
(E)-1-[4-(3-Acetylphenyl)-2-methoxyphenyl]-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-oneIC504000.0 [1]
(E)-1-[3,5-Dimethoxy-4-(3-methoxy-1,4-benzodioxin-2-yl)phenyl]-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-oneIC502000.0 [1]
(E)-1-[3,5-Dimethoxy-4-(thiophen-2-ylmethoxy)phenyl]-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-oneIC503000.0 [1]
(E)-1-[5-(2,4-Dimethoxyphenyl)-2,4-dimethoxyphenyl]-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-oneIC503000.0 [1]
(E)-1-[4-[(3,4-Dimethoxyphenyl)methoxy]-3-methoxyphenyl]-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-oneIC502000.0 [1]
(E)-1-[4-(1,3-Benzodioxol-5-ylmethoxy)-3,5-dimethoxyphenyl]-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-oneIC503000.0 [1]
3-(5-Bromo-2,4-dimethoxyphenyl)-1-(3,4,5-trimethoxyphenyl)propan-1-oneIC5050000.0 [1]
3-(5-Bromo-2-methoxyphenyl)-1-(3,4,5-trimethoxyphenyl)propan-1-oneIC5050000.0 [1]
(E)-3-(5-Bromo-2,4-dimethoxyphenyl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-oneIC502000.0 [1]
2-[5-Methoxy-2-[(E)-3-oxo-3-[4-(trifluoromethyl)phenyl]prop-1-enyl]-4-thiophen-2-ylphenoxy]-2-methylpropanoic acidIC504000.0 [1]
[4-Benzo[b]thiophen-2-yl-5-methoxy-2-((E)-3-oxo-3-phenyl-propenyl)-phenoxy]-acetic acidIC501000.0 [1]
Ethyl 4-[[2-methoxy-4-[(E)-3-(2-methoxy-5-thiophen-2-ylphenyl)prop-2-enoyl]phenoxy]methyl]benzoateIC504000.0 [1]
2-[4-[(E)-3-[5-(1-Benzothiophen-2-yl)-2,4-dimethoxyphenyl]prop-2-enoyl]phenoxy]-2-methylpropanoic acidIC506000.0 [1]
Tert-butyl N-[4-[[2-methoxy-4-[(E)-3-(2-methoxy-5-thiophen-2-ylphenyl)prop-2-enoyl]phenoxy]methyl]phenyl]carbamateIC5050000.0 [1]
2-[4-[(E)-3-(3,4-Dimethoxy-5-thiophen-2-ylphenyl)prop-2-enoyl]-2,6-dimethoxyphenoxy]acetic acidIC501000.0 [1]
2-[2,6-Dimethoxy-4-[(E)-3-(2-methoxy-5-thiophen-2-ylphenyl)prop-2-enoyl]phenoxy]acetic acidIC501000.0 [1]
(E)-1-(2,2-Dihydroxy-1,3-benzodioxol-5-yl)-3-(3,4-dimethoxy-5-thiophen-2-ylphenyl)prop-2-en-1-oneIC501000.0 [1]
2-Allyl-6,7,8-trimethoxy-3-thioxo-2,3-dihydro-imidazo[1,5-a]indol-1-oneIC50780.0 [1]
Tert-butyl 2-(2-ethyl-5-methoxy-3-oxo-1-sulfanylideneimidazo[1,5-a]indol-7-yl)oxyacetateIC50390.0 [1]
5,7-Dimethoxy-2-(3-morpholin-4-ylpropyl)-1-sulfanylideneimidazo[1,5-a]indol-3-oneIC50670.0 [1]
2-Ethyl-5-methoxy-7-(methoxymethoxy)-1-sulfanylideneimidazo[1,5-a]indol-3-oneIC50280.0 [1]
2-Ethyl-8-methoxy-6-(pyridin-2-ylmethoxy)-3-thioxo-2,3-dihydro-imidazo[1,5-a]indol-1-oneIC50310.0 [1]
6,8-Dimethoxy-2-phenethyl-3-thioxo-2,3-dihydro-imidazo[1,5-a]indol-1-oneIC501900.0 [1]
2-Ethyl-6,8-dimethoxy-3-thioxo-2,3-dihydro-imidazo[1,5-a]indol-1-oneIC501000.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Tumor necrosis factor receptor R1 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 22 Feb. 2025, https://www.aatbio.com/data-sets/tumor-necrosis-factor-receptor-r1-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 22). Quest Database™ Tumor necrosis factor receptor R1 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/tumor-necrosis-factor-receptor-r1-inhibitors-ic50-ki.
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