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Tryptophan 2,3-dioxygenase Inhibitors (IC50, Ki)

Structure
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▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
6-Fluoro-3-((E)-2-pyridin-3-yl-vinyl)-1H-indoleIC50280.0 [1], 376.5 [2], 1300.0 [3]
6-Fluoro-3-((E)-2-pyridin-3-yl-vinyl)-1H-indoleKi30.0 [1], 880.0 [2]
4-Amino-N-(3-chloro-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamideIC503000.0 [1], 10000.0 [2], 70000.0 [3]
(E)-3-(2-(1H-Tetrazol-5-YL)vinyl)-6-fluoro-1H-indoleIC50620.0 [1], 28000.0 [2]
(E)-3-(2-(1H-Tetrazol-5-YL)vinyl)-6-fluoro-1H-indoleKi5600.0 [1]
7-Chloro-3-[(E)-2-pyridin-3-ylethenyl]-1H-indoleIC5032000.0 [1], 50000.0 [2]
7-Chloro-3-[(E)-2-pyridin-3-ylethenyl]-1H-indoleKi21000.0 [1]
N-(1,3-Benzodioxol-5-yl)-2-[[5-(4-methylphenyl)-[1,3]thiazolo[2,3-c][1,2,4]triazol-3-yl]sulfanyl]acetamideIC5062500.0 [1]
3-(5-Fluoro-1H-indol-3-yl)pyrrolidine-2,5-dioneIC5050000.0 [1], 140000.0 [2]
NavoximodIC50140.0 [1], 1500.0 [2]
4-(3-Chlorophenyl)-1,2-oxazol-5-amineIC50500.0 [1], 2940.0 [2]
ISOXAZOLE, 5-AMINO-4-(p-CHLOROPHENYL)-IC50830.0 [1], 4210.0 [2]
TryptophanKi11500000.0 [1]
1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanolIC501000.0 [1]
4-Phenyl-1H-1,2,3-triazoleIC50100000.0 [1]
4-Phenyl-1H-pyrazol-5-amineIC5025000.0 [1]
4-Methyl-N'-[(3E)-2-oxo-1,2-dihydro-3H-indol-3-ylidene]benzenesulfonohydrazideIC5052900.0 [1]
3-[2-(3-Chlorophenyl)hydrazinyl]indol-2-oneIC5046810.0 [1]
1-(3-Methylbenzyl)-1H-naphtho[2,3-d][1,2,3]triazole-4,9-dioneIC501745.0 [1]
beta-3-OxindolylalanineIC5060220.0 [1]
1-(2-Methylbenzyl)-1H-naphtho[2,3-d]triazole-4,9-dioneIC50561.0 [1]
4-(3-Methylphenyl)-1H-1,2,3-triazoleIC50100000.0 [1]
4-(2-Methoxyphenyl)-1h-1,2,3-triazoleIC50100000.0 [1]
3-Methyl-4-phenylisoxazol-5-amineIC5025000.0 [1]
N-[2-(Dimethylamino)ethyl]-5,12-dioxoindolizino[2,3-g]quinoline-6-carboxamideIC503350.0 [1]
4-PhenylisoxazoleIC5025000.0 [1]
4-Pyridin-2-ylisoxazol-5-amineIC501700.0 [1]
5-Chloro-3-[(E)-2-pyridin-3-ylethenyl]-1H-indoleIC5010000.0 [1]
6-Chloro-3-[(E)-2-pyridin-3-ylethenyl]-1H-indoleIC505000.0 [1]
4-(3-Bromophenyl)-1H-1,2,3-triazoleIC50100000.0 [1]
1-Cyclohexyl-2-(5H-imidazo[5,1-a]isoindol-5-yl)ethanoneIC501000.0 [1]
1H-1,2,3-Triazole, 5-(3-fluorophenyl)-IC50100000.0 [1]
5-(2-Methylphenyl)-1H-1,2,3-triazoleIC50100000.0 [1]
3-(1H-1,2,3-Triazol-4-yl)phenolIC50100000.0 [1]
4-(4-Fluorophenyl)-1H-1,2,3-triazoleIC50100000.0 [1]
5-(2-Bromophenyl)-1H-1,2,3-triazoleIC50100000.0 [1]
3-(2H-1,2,3-Triazol-4-yl)anilineIC50100000.0 [1]
1H-1,2,3-Triazole, 5-(2-chlorophenyl)-IC50100000.0 [1]
1-(4-Fluorobenzyl)-1H-naphtho[2,3-d]triazole-4,9-dioneIC507380.0 [1]
4-Cyclopentyl-1,2-oxazol-5-amineIC50640.0 [1]
5-(3-Chlorophenyl)-2,4,7-trioxo-1,8-dihydropyrido[2,3-d]pyrimidine-6-carbonitrileIC503000.0 [1]
3-(2H-1,2,3-Triazol-4-yl)benzonitrileIC50100000.0 [1]
4-[2-(Trifluoromethyl)phenyl]-2H-triazoleIC50100000.0 [1]
3-N-(3-Chloro-4-fluorophenyl)-7-(2-morpholin-4-ylpyridin-4-yl)furo[2,3-c]pyridine-2,3-diamineIC502000.0 [1]
N-Methyl-4-phenyl-1,2-oxazol-5-amineIC50190.0 [1]
1-(3-Bromobenzyl)-1H-naphtho[2,3-d]triazole-4,9-dioneIC50768.0 [1]
1-(4-Bromobenzyl)-1H-naphtho[2,3-d]triazole-4,9-dioneIC501586.0 [1]
3-(4,9-Dioxo-1H-naphtho[2,3-d]triazole-1-ylmethyl)benzoic acidIC50167.0 [1]
4-(4,9-Dioxo-1H-naphtho[2,3-d]triazole-1-ylmethyl)benzoic acidIC50312.0 [1]
3-[(4,9-Dioxobenzo[f]benzotriazol-3-yl)methyl]-N,N-diethylbenzamideIC5090.0 [1]
4-[(4,9-Dioxobenzo[f]benzotriazol-3-yl)methyl]-N,N-diethylbenzamideIC50181.0 [1]
3-[[3-(4-Acetylpiperazine-1-carbonyl)phenyl]methyl]benzo[f]benzotriazole-4,9-dioneIC5059.0 [1]
3-[[3-(Morpholine-4-carbonyl)phenyl]methyl]benzo[f]benzotriazole-4,9-dioneIC5048.0 [1]
3-[[3-(4-Methylpiperazine-1-carbonyl)phenyl]methyl]benzo[f]benzotriazole-4,9-dioneIC5030.0 [1]
3-[[4-(4-Acetylpiperazine-1-carbonyl)phenyl]methyl]benzo[f]benzotriazole-4,9-dioneIC50176.0 [1]
3-[[4-(Morpholine-4-carbonyl)phenyl]methyl]benzo[f]benzotriazole-4,9-dioneIC50116.0 [1]
3-[[4-(4-Methylpiperazine-1-carbonyl)phenyl]methyl]benzo[f]benzotriazole-4,9-dioneIC50108.0 [1]
3-[[4-(4-Methoxypiperidine-1-carbonyl)phenyl]methyl]benzo[f]benzotriazole-4,9-dioneIC50209.0 [1]
2-[4-[(4,9-Dioxobenzo[f]benzotriazol-3-yl)methyl]phenyl]-N,N-diethylacetamideIC50145.0 [1]
2-[5-(6-Fluoro-1H-indol-3-yl)-3-methyl-1,1-dioxo-3H-1,2-benzothiazol-2-yl]ethanesulfonamideIC50309.0 [1]
3-[5-(6-Fluoro-1H-indol-3-yl)-3-methyl-1,1-dioxo-3H-1,2-benzothiazol-2-yl]-N-methylpropanamideIC5071.0 [1]
[5-(6-Fluoro-1H-indol-3-yl)-1,1-dioxo-2,3-dihydro-1,2-benzothiazol-3-yl]methanolIC5043.0 [1]
4-[[5-(6-Fluoro-1H-indol-3-yl)-3-methyl-1,1-dioxo-3H-1,2-benzothiazol-2-yl]methyl]-4-methyl-1,3-oxazolidin-2-oneIC5058.0 [1]
2-[5-(6-Fluoro-1H-indol-3-yl)-3-methyl-1,1-dioxo-3H-1,2-benzothiazol-2-yl]acetamideIC5026.0 [1]
(3R)-5-(6-Fluoro-1H-indol-3-yl)-3-methyl-2,3-dihydro-1,2-benzothiazole 1,1-dioxideIC5027.0 [1]
2-Pyridin-4-yl-[1,3]thiazolo[4,5-g]quinoline-4,9-dioneIC501200.0 [1]
1-Phenyl-1H-1,2,3-triazol-5-amineIC5025000.0 [1]
4-Phenyl-4H-1,2,4-triazol-3-amineIC5025000.0 [1]
8-(3-Chloro-4-fluorophenyl)-6-methyl-2-oxa-4,5,11,13-tetrazatricyclo[7.4.0.03,7]trideca-1(9),3,6-triene-10,12-dioneIC503000.0 [1]
8-(4-Fluorophenyl)-6,10-dimethyl-2-oxa-4,5,11,12-tetrazatricyclo[7.3.0.03,7]dodeca-1(12),3,6,9-tetraeneIC503000.0 [1]
8-(3-Chloro-4-fluorophenyl)-2-oxa-4,5,11,12-tetrazatricyclo[7.3.0.03,7]dodeca-1(12),3,6,9-tetraene-6,10-diamineIC503000.0 [1]
8-(3-Chloro-4-fluorophenyl)-6,10-dimethyl-2-oxa-4,5,11,12-tetrazatricyclo[7.3.0.03,7]dodeca-1(12),3,6,9-tetraeneIC503000.0 [1]
7-Amino-5-(3-chlorophenyl)-2,4-dioxo-5,8-dihydro-1H-pyrido[2,3-d]pyrimidine-6-carbonitrileIC503000.0 [1]
8-(3,4-Difluorophenyl)-10-methyl-2-oxa-4,5,11,12-tetrazatricyclo[7.3.0.03,7]dodeca-1(12),3,6,9-tetraen-6-amineIC503000.0 [1]
8-(3,4-Difluorophenyl)-6,10-dimethyl-2-oxa-4,5,11,12-tetrazatricyclo[7.3.0.03,7]dodeca-1(12),3,6,9-tetraeneIC503000.0 [1]
5-(6-Amino-10-methyl-2-oxa-4,5,11,12-tetrazatricyclo[7.3.0.03,7]dodeca-1(12),3,6,9-tetraen-8-yl)-2-methoxyphenolIC503000.0 [1]
8-(3,4-Difluorophenyl)-2-oxa-4,5,11,12-tetrazatricyclo[7.3.0.03,7]dodeca-1(12),3,6,9-tetraene-6,10-diamineIC503000.0 [1]
8-(3,4-Difluorophenyl)-6-methyl-2-oxa-4,5,11,13-tetrazatricyclo[7.4.0.03,7]trideca-1(9),3,6-triene-10,12-dioneIC503000.0 [1]
8-(3-Chloro-4-fluorophenyl)-10-methyl-2-oxa-4,5,11,12-tetrazatricyclo[7.3.0.03,7]dodeca-1(12),3,6,9-tetraen-6-amineIC503000.0 [1]
Phenol, 2-(1H-1,2,3-triazol-5-yl)-IC50100000.0 [1]
4-Chloro-2-(1H-1,2,3-triazol-4-yl)phenolIC50100000.0 [1]
4,9-Dihydro-4,9-dioxo-2-(4-pyridyl)-naphtho[2,3-d]thiazoleIC501600.0 [1]
4-Fluoro-2-[3-[(5-fluoro-1H-indol-2-yl)methyl]imidazol-4-yl]phenolIC5084000.0 [1]
4-Chloro-2-[3-[(5-fluoro-1H-indol-2-yl)methyl]imidazol-4-yl]phenolIC5054400.0 [1]
4-Phenyl-1,2-thiazol-5-amineIC5018000.0 [1]
4-Thiophen-3-yl-1,2-oxazol-5-amineIC5028.0 [1]
4-(4-Fluoropyrazol-1-yl)-1,2-oxazol-5-amineIC50340.0 [1]
N-Methyl-4-phenyl-1,2-oxazole-5-carboxamideIC5025000.0 [1]
4-Pyrazol-1-yl-1,2-oxazol-5-amineIC50290.0 [1]
(4-Phenyl-1,2-oxazol-5-yl)methanolIC504400.0 [1]
4-Phenyl-1,2-oxazole-5-carboxamideIC5025000.0 [1]
4-(4-Methylpyrazol-1-yl)-1,2-oxazol-5-amineIC501600.0 [1]
4-(3-Methylpyrazol-1-yl)-1,2-oxazol-5-amineIC501600.0 [1]
2-Pyridin-4-yl-[1,3]thiazolo[5,4-g]quinoline-4,9-dioneIC50684.3 [1]
3-[(2-Methylphenyl)methyl]benzo[f]benzimidazole-4,9-dioneIC50100000.0 [1]
2-(1,3-Thiazol-4-yl)-[1,3]thiazolo[4,5-g]quinoline-4,9-dioneIC50321.5 [1]
Potassium;3-[(5,12-dioxoindolizino[3,2-g]quinoline-11-carbonyl)amino]benzoateIC50100000.0 [1]
N-Carbamothioylimino-5,12-dihydroxyindolizino[2,3-g]quinoline-6-carboxamideIC501200.0 [1]
5,12-Dioxo-N-phenylindolizino[3,2-g]quinoline-11-carboxamideIC50100000.0 [1]
Potassium;3-[(5,12-dioxoindolizino[2,3-g]quinoline-6-carbonyl)amino]benzoateIC5041600.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Tryptophan 2,3-dioxygenase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/tryptophan-2-3-dioxygenase-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ Tryptophan 2,3-dioxygenase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/tryptophan-2-3-dioxygenase-inhibitors-ic50-ki.
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