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Tryptase Inhibitors (IC50, Ki)

Structure
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▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
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▼
Bms-262084IC504.0 [1], 5.0 [2]
Unii-82AT6rbc74IC501.7 [1]
(2S,3R)-3-[[(3S)-1-Carbamimidoylpiperidin-3-yl]methyl]-4-oxo-1-[4-(6-phenylhexanoyl)piperazine-1-carbonyl]azetidine-2-carboxylic acidIC501.7 [1]
[5-[4-[(4-Carbamimidoylphenyl)methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-[(4-carbamimidoylphenyl)methylcarbamoyl]piperazine-1-carboxylateKi8.7 [1], 9.0 [2]
[5-[4-[[4-(Diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-(5-aminopentylcarbamoyl)piperazine-1-carboxylateKi0.5 [1]
(2S,3R)-4-Oxo-1-[4-(6-phenylhexanoyl)piperazine-1-carbonyl]-3-(piperidin-4-ylmethyl)azetidine-2-carboxylic acidIC501.0 [1]
(2S,3R)-3-[3-(Diaminomethylideneamino)propyl]-1-[4-(2,4-dimethylpentan-3-yloxycarbonyl)piperazine-1-carbonyl]-4-oxoazetidine-2-carboxylic acidIC504.0 [1]
[5-[4-[[4-(Diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-[(4-aminocyclohexyl)methylcarbamoyl]piperazine-1-carboxylateKi1.0 [1], 78.0 [2]
2-[(6-Carbamimidoyl-1H-benzimidazol-2-yl)methyl]-3H-benzimidazole-5-carboximidamide;zincKi50.0 [1], 2500.0 [2]
1-Hydroxy-2-naphthoyl-Arg-Pro amideKi840.0 [1]
CID 5287596Ki10.0 [1]
[5-[4-[[4-(Diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-[[4-(diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carboxylateKi0.07 [1]
(2S,3R)-4-Oxo-1-[4-(6-phenylhexanoyl)piperazine-1-carbonyl]-3-(2-piperidin-3-ylethyl)azetidine-2-carboxylic acidIC501.8 [1]
1,4-Bis[[4-(4-amidinobenzoylaminomethyl)piperidino]carbonyloxymethyl]benzeneKi0.4 [1]
[5-[4-[[4-(Diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-(benzylcarbamoyl)piperazine-1-carboxylateKi15000.0 [1]
[5-[4-(Benzylcarbamoyl)piperazine-1-carbonyl]oxycyclooctyl] 4-(benzylcarbamoyl)piperazine-1-carboxylateKi101000.0 [1]
Cyclopentanecarboxylic acid [1-(benzothiazole-2-carbonyl)-4-guanidino-butyl]-amideKi88.0 [1]
1,4-Bis[[2-oxo-2-[4-(aminomethyl)benzylamino]ethyl]carbamoyloxymethyl]benzeneKi0.6 [1]
(2S,3R)-4-Oxo-1-(phenylcarbamoyl)-3-(piperidin-4-ylmethyl)azetidine-2-carboxylic acidIC50147.0 [1]
[5-[4-[(4-Carbamimidoylphenyl)methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-(2-piperidin-4-ylethylcarbamoyl)piperazine-1-carboxylateKi0.91 [1]
N-[1-[2-[5-(Aminomethyl)-2-methylanilino]-2-oxoethyl]-2-oxoazepan-3-yl]-4-phenylbenzamideIC5074.0 [1]
N-{1-[(3-Aminomethyl-phenylcarbamoyl)-methyl]-2-oxo-azepan-3-yl}-3,3-diphenyl-propionamideIC50200.0 [1]
[5-[4-[[(4-Carbamimidoylbenzoyl)amino]methyl]piperidine-1-carbonyl]oxycyclooctyl] 4-[[(4-carbamimidoylbenzoyl)amino]methyl]piperidine-1-carboxylateKi0.85 [1]
(2S,3R)-4-Oxo-1-[4-[2-(4-phenylmethoxyphenyl)acetyl]piperazine-1-carbonyl]-3-(piperidin-4-ylmethyl)azetidine-2-carboxylic acidIC501.0 [1]
(2S,3R)-1-[4-(2,4-Dimethylpentan-3-yloxycarbonyl)piperazine-1-carbonyl]-4-oxo-3-(piperidin-4-ylmethyl)azetidine-2-carboxylic acidIC5029.0 [1]
(1,1,3-Trioxo-1,2-benzothiazol-2-yl)methyl 5-[(3,4-dichlorophenyl)methylamino]-5-oxopentanoateIC50230.0 [1]
[5-[4-[(4-Carbamimidoylphenyl)methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-(4-piperidin-4-ylbutanoyl)piperazine-1-carboxylateKi1.12 [1]
(1,1,3-Trioxo-1,2-benzothiazol-2-yl)methyl 3-(phenylmethoxycarbonylamino)propanoateIC50854.0 [1]
(1,1,3-Trioxo-1,2-benzothiazol-2-yl)methyl 4-[[(2-phenylacetyl)amino]methyl]benzoateIC50132.0 [1]
(1,1,3-Trioxo-1,2-benzothiazol-2-yl)methyl 3-(phenylmethoxycarbonylamino)benzoateIC5033000.0 [1]
(1,1,3-Trioxo-1,2-benzothiazol-2-yl)methyl 4-(phenylmethoxycarbonylaminomethyl)benzoateIC50352.0 [1]
(1,1,3-Trioxo-1,2-benzothiazol-2-yl)methyl 6-[(2-methylpropan-2-yl)oxycarbonylamino]hexanoateIC505370.0 [1]
2-[[[4-(2-Phenoxyethoxy)benzoyl]oxy]methyl]-3-oxo-2,3-dihydro-1,2-benzisothiazole 1,1-dioxideIC5033000.0 [1]
(1,1,3-Trioxo-1,2-benzothiazol-2-yl)methyl 4-(2-phenylethylcarbamoyl)benzoateIC50679.0 [1]
(1,1,3-Trioxo-1,2-benzothiazol-2-yl)methyl 4-[(phenoxycarbonylamino)methyl]benzoateIC50630.0 [1]
(1,1,3-Trioxo-1,2-benzothiazol-2-yl)methyl 4-(phenylmethoxycarbonylamino)butanoateIC50349.0 [1]
2-[[[4-(3-Benzylureido)benzoyl]oxy]methyl]-3-oxo-2,3-dihydro-1,2-benzisothiazole 1,1-dioxideIC50950.0 [1]
2-[[(4-Aminobenzoyl)oxy]methyl]-3-oxo-2,3-dihydro-1,2-benzisothiazole 1,1-dioxideIC5033000.0 [1]
(1,1,3-Trioxo-1,2-benzothiazol-2-yl)methyl 6-(phenylmethoxycarbonylamino)hexanoateIC50436.0 [1]
2-[[[4-[(3-Phenylureido)methyl]benzoyl]oxy]methyl]-3-oxo-2,3-dihydro-1,2-benzisothiazole 1,1-dioxideIC50157.0 [1]
(1,1,3-Trioxo-1,2-benzothiazol-2-yl)methyl 4-(phenylmethoxycarbonylamino)benzoateIC5064.3 [1]
(1,1,3-Trioxo-1,2-benzothiazol-2-yl)methyl 5-(phenylmethoxycarbonylamino)pentanoateIC50110.0 [1]
(1,1,3-Trioxo-1,2-benzothiazol-2-yl)methyl 4-(3-phenylpropanoylamino)benzoateIC50170.0 [1]
(1,1,3-Trioxo-1,2-benzothiazol-2-yl)methyl 2-(phenylmethoxycarbonylamino)acetateIC506940.0 [1]
(2-Methyl-1,3-dioxoisoindol-5-yl) 3-(6-aminopyridin-3-yl)propanoate;hydrochlorideIC50190.0 [1]
[4-[[4-[[4-(Diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carbonyl]oxymethyl]cyclohexyl]methyl 4-[[4-(diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carboxylateKi3.0 [1]
[5-[4-[2-(1-Carbamimidoylpiperidin-4-yl)acetyl]piperazine-1-carbonyl]oxycyclooctyl] 4-[2-(1-carbamimidoylpiperidin-4-yl)acetyl]piperazine-1-carboxylateKi5.0 [1]
[5-[4-[2-(1-Carbamimidoylpiperidin-4-yl)ethylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-[2-(1-carbamimidoylpiperidin-4-yl)ethylcarbamoyl]piperazine-1-carboxylateKi30.0 [1]
[5-[4-[2-(4-Carbamimidoylphenyl)ethylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-[2-(4-carbamimidoylphenyl)ethylcarbamoyl]piperazine-1-carboxylateKi440.0 [1]
[5-[4-[3-(1-Carbamimidoylpiperidin-4-yl)propanoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-[3-(1-carbamimidoylpiperidin-4-yl)propanoyl]piperazine-1-carboxylateKi2.0 [1]
[5-[4-[3-(4-Carbamimidoylphenyl)propanoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-[3-(4-carbamimidoylphenyl)propanoyl]piperazine-1-carboxylateKi0.4 [1]
[5-[4-[3-[4-(Diaminomethylideneamino)phenyl]propanoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-[3-[4-(diaminomethylideneamino)phenyl]propanoyl]piperazine-1-carboxylateKi210.0 [1]
[5-[4-[2-[4-(2-Aminoethyl)phenyl]acetyl]piperazine-1-carbonyl]oxycyclooctyl] 4-[2-[4-(2-aminoethyl)phenyl]acetyl]piperazine-1-carboxylateKi2.0 [1]
[5-[4-(4-Aminobutylcarbamoyl)piperazine-1-carbonyl]oxycyclooctyl] 4-(4-aminobutylcarbamoyl)piperazine-1-carboxylateKi510.0 [1]
[5-[4-[[4-(Aminomethyl)phenyl]methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-[[4-(aminomethyl)phenyl]methylcarbamoyl]piperazine-1-carboxylateKi0.1 [1]
[5-[4-[2-[4-(Diaminomethylideneamino)phenyl]acetyl]piperazine-1-carbonyl]oxycyclooctyl] 4-[2-[4-(diaminomethylideneamino)phenyl]acetyl]piperazine-1-carboxylateKi0.5 [1]
[5-[4-(5-Aminopentylcarbamoyl)piperazine-1-carbonyl]oxycyclooctyl] 4-(5-aminopentylcarbamoyl)piperazine-1-carboxylateKi11.0 [1]
[5-[4-(6-Aminohexylcarbamoyl)piperazine-1-carbonyl]oxycyclooctyl] 4-(6-aminohexylcarbamoyl)piperazine-1-carboxylateKi1000.0 [1]
[5-[4-[(1-Carbamimidoylpiperidin-4-yl)methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-[(1-carbamimidoylpiperidin-4-yl)methylcarbamoyl]piperazine-1-carboxylateKi610.0 [1]
[5-[4-[[4-(Diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-(4-aminobutylcarbamoyl)piperazine-1-carboxylateKi4.0 [1]
[5-[4-[[4-(Diaminomethylideneamino)phenyl]methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-(3-aminopropylcarbamoyl)piperazine-1-carboxylateKi44.0 [1]
1,4-Bis[4-(4-guanidinobenzylcarbamoyl)piperazinocarbonyloxymethyl]bicyclo[2.2.2]octaneKi0.4 [1]
N-[1-[2-[2-(Aminomethyl)anilino]-2-oxoethyl]-2-oxoazepan-3-yl]-4-phenylbenzamideIC5033000.0 [1]
N-[3-(Aminomethyl)phenyl]-2-[3-[(2-naphthalen-2-yloxyacetyl)amino]-2-oxoazepan-1-yl]acetamideIC504600.0 [1]
N-[1-[2-[3-(Aminomethyl)anilino]-2-oxoethyl]-2-oxoazepan-3-yl]-2-(4-phenylphenyl)acetamideIC505200.0 [1]
N-[1-[2-[3-(Aminomethyl)anilino]-2-oxoethyl]-2-oxoazepan-3-yl]-4-(3,4-dichlorophenyl)benzamideIC502100.0 [1]
N-[1-[2-[3-(Aminomethyl)anilino]-2-oxoethyl]-2-oxoazepan-3-yl]-4-(4-ethylphenyl)benzamideIC502900.0 [1]
N-[1-[2-[3-(Aminomethyl)anilino]-2-oxoethyl]-2-oxoazepan-3-yl]-4-cyclohexylbenzamideIC50980.0 [1]
N-[1-[2-[3-(Aminomethyl)anilino]-2-oxoethyl]-2-oxoazepan-3-yl]-4-ethylbenzamideIC504600.0 [1]
N-[1-[2-[3-(Aminomethyl)anilino]-2-oxoethyl]-2-oxoazepan-3-yl]-4-(4-methylphenyl)benzamideIC501300.0 [1]
N-[1-[2-[3-(Aminomethyl)anilino]-2-oxoethyl]-2-oxoazepan-3-yl]-5-phenylpentanamideIC502900.0 [1]
N-[1-[2-[3-(Aminomethyl)anilino]-2-oxoethyl]-2-oxoazepan-3-yl]quinoline-3-carboxamideIC5015000.0 [1]
N-[1-[2-[[3-(Aminomethyl)phenyl]methylamino]-2-oxoethyl]-2-oxoazepan-3-yl]-4-phenylbenzamideIC5013000.0 [1]
N-[1-[2-[3-(Methylaminomethyl)anilino]-2-oxoethyl]-2-oxoazepan-3-yl]-4-phenylbenzamideIC5033000.0 [1]
N-[1-[2-[4-(2-Aminoethyl)anilino]-2-oxoethyl]-2-oxoazepan-3-yl]-4-phenylbenzamideIC5011000.0 [1]
N-[1-[2-[[4-(Aminomethyl)cyclohexyl]amino]-2-oxoethyl]-2-oxoazepan-3-yl]-4-phenylbenzamideIC5012000.0 [1]
N-[1-[2-[4-(Aminomethyl)anilino]-2-oxoethyl]-2-oxoazepan-3-yl]-4-phenylbenzamideIC503600.0 [1]
N-[1-[2-[5-(Aminomethyl)-2-methoxyanilino]-2-oxoethyl]-2-oxoazepan-3-yl]-4-phenylbenzamideIC50890.0 [1]
N-[2-Oxo-1-[2-oxo-2-(1,2,3,4-tetrahydroisoquinolin-7-ylamino)ethyl]azepan-3-yl]-4-phenylbenzamideIC5033000.0 [1]
1,4-Bis[[2-oxo-2-[2-(1-amidino-4-piperidinyl)ethylamino]ethyl]carbamoyloxymethyl]benzeneKi110.0 [1]
1,4-Bis[[2-oxo-2-(1-amidino-4-piperidinylmethylamino)ethyl]carbamoyloxymethyl]benzeneKi155.0 [1]
[5-[4-[[4-[(E)-N'-Methoxycarbonylcarbamimidoyl]phenyl]methylcarbamoyl]piperazine-1-carbonyl]oxycyclooctyl] 4-(2-piperidin-4-ylethylcarbamoyl)piperazine-1-carboxylateKi40.6 [1]
1,4-Bis[[4-[4-(aminomethyl)piperidinocarbonylaminomethyl]piperidino]carbonyloxymethyl]benzeneKi24.0 [1]
1,4-Bis[[4-[4-(aminomethyl)piperidinocarbonylamino]butyl]carbamoyloxymethyl]benzeneKi112.0 [1]
[5-[4-(2-Piperidin-4-ylethylcarbamoyl)piperazine-1-carbonyl]oxycyclooctyl] 4-[2-(4-carbamimidoylphenyl)acetyl]piperazine-1-carboxylateKi6.7 [1]
[5-[4-[2-(4-Carbamimidoylanilino)-2-oxoethyl]piperidine-1-carbonyl]oxycyclooctyl] 4-(2-piperidin-4-ylethylcarbamoyl)piperazine-1-carboxylateKi8.9 [1]
[5-[4-[[(4-Carbamimidoylphenyl)sulfonylamino]methyl]piperidine-1-carbonyl]oxycyclooctyl] 4-(2-piperidin-4-ylethylcarbamoyl)piperazine-1-carboxylateKi28.0 [1]
[5-[4-[[(4-Carbamimidoylbenzoyl)amino]methyl]piperidine-1-carbonyl]oxycyclooctyl] 4-(2-piperidin-4-ylethylcarbamoyl)piperazine-1-carboxylateKi16.0 [1]
[5-[4-[[(4-Carbamimidoylbenzoyl)amino]methyl]piperidine-1-carbonyl]oxycyclooctyl] 4-(4-piperidin-4-ylbutanoyl)piperazine-1-carboxylateKi16.4 [1]
(2S,3R)-1-[4-(2,4-Dimethylpentan-3-yloxycarbonyl)piperazine-1-carbonyl]-4-oxo-3-(pyrrolidin-3-ylmethyl)azetidine-2-carboxylic acidIC502605.0 [1]
(2S,3R)-3-(3-Aminopropyl)-1-[4-(2,4-dimethylpentan-3-yloxycarbonyl)piperazine-1-carbonyl]-4-oxoazetidine-2-carboxylic acidIC5033000.0 [1]
(2S,3R)-3-[(1-Carbamimidoylpiperidin-4-yl)methyl]-4-oxo-1-(phenylcarbamoyl)azetidine-2-carboxylic acidIC50515.0 [1]
(2S,3R)-3-(4-Aminobutyl)-1-[4-(2,4-dimethylpentan-3-yloxycarbonyl)piperazine-1-carbonyl]-4-oxoazetidine-2-carboxylic acidIC507.0 [1]
(2S,3R)-1-[4-[4-(4-Hexylphenyl)benzoyl]piperazine-1-carbonyl]-4-oxo-3-(piperidin-4-ylmethyl)azetidine-2-carboxylic acidIC50120.0 [1]
(2S,3R)-3-(6-Aminohexyl)-1-[4-(2,4-dimethylpentan-3-yloxycarbonyl)piperazine-1-carbonyl]-4-oxoazetidine-2-carboxylic acidIC5032.0 [1]
(2S,3R)-1-[4-[3-(3-Methylphenyl)propanoyl]piperazine-1-carbonyl]-4-oxo-3-(piperidin-4-ylmethyl)azetidine-2-carboxylic acidIC5013.0 [1]
(2S,3R)-1-[4-[3-(3-Methoxyphenyl)propanoyl]piperazine-1-carbonyl]-4-oxo-3-(piperidin-4-ylmethyl)azetidine-2-carboxylic acidIC5014.0 [1]
(2S,3R)-1-[4-[4-(3-Methyl-5-oxo-4H-pyrazol-1-yl)benzoyl]piperazine-1-carbonyl]-4-oxo-3-(piperidin-4-ylmethyl)azetidine-2-carboxylic acidIC50380.0 [1]
(2S,3R)-3-[(2-Aminopyridin-4-yl)methyl]-1-[4-(2,4-dimethylpentan-3-yloxycarbonyl)piperazine-1-carbonyl]-4-oxoazetidine-2-carboxylic acidIC5061.0 [1]
(2S,3R)-3-[(6-Aminopyridin-3-yl)methyl]-1-[4-(2,4-dimethylpentan-3-yloxycarbonyl)piperazine-1-carbonyl]-4-oxoazetidine-2-carboxylic acidIC501053.0 [1]
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References

This online tool may be cited as follows

MLA

"Quest Database™ Tryptase Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/tryptase-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ Tryptase Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/tryptase-inhibitors-ic50-ki.
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