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Transthyretin Inhibitors (IC50, Ki)

Structure
▲
▼
Compound Name
▲
▼
Standard Type
▲
▼
Standard Values (in nM)
▲
▼
LevothyroxineIC502187.76 [1], 10500.0 [2]
ApigeninIC50653.0 [1], 18000.0 [2]
Niflumic acidIC50289.0 [1], 130000.0 [2]
TafamidisIC501550.0 [1], 3090.3 [2]
DiclofenacIC50140000.0 [1]
TriclosanIC5053500.0 [1]
LuteolinIC507000.0 [1]
GemfibrozilIC50180000.0 [1]
Flufenamic acidIC502900.0 [1]
IsatinIC5050000.0 [1]
Meclofenamic acidIC5050000.0 [1]
DiflunisalIC5025000.0 [1]
AceclofenacIC50170000.0 [1]
Tolfenamic acidIC5040000.0 [1]
DextrothyroxineIC507170.0 [1]
3,5-DinitrocatecholIC50741.0 [1]
N-MethylisatinIC506300.0 [1]
(3,4-Dihydroxy-5-nitrophenyl)(2-fluorophenyl)methanoneIC50755.0 [1]
2,4,6-TriiodophenolIC503200.0 [1]
3,3',5,5'-Tetrachloro-4,4'-biphenyldiolIC501584.89 [1]
(3E)-3-[(4-Methoxyphenyl)imino]-1,3-dihydro-2H-indol-2-oneIC508100.0 [1]
(5Z)-5-[3-(Trifluoromethyl)benzylidene]-1,3-thiazolidine-2,4-dioneIC50815.0 [1]
3-(Phenylimino)oxindoleIC5050000.0 [1]
3-(4-Methylanilino)indol-2-oneIC5050000.0 [1]
5-{[2-(Phenylmethoxy)phenyl]methylene}-1,3-thiazolidine-2,4-dioneIC505803.0 [1]
6-Benzylsulfanyl-2-(2-hydroxyphenyl)-4-oxo-2,3-dihydro-1,3-thiazine-5-carbonitrileIC504786.0 [1]
2,3,6-Trichloro-N-(4H-1,2,4-triazol-3-yl)benzamideIC501060.0 [1]
CID 9551082IC5010957.0 [1]
6-(Benzylthio)-2,2-dimethyl-4-oxo-3,4-dihydro-2H-1,3-thiazine-5-carbonitrileIC50433.0 [1]
4-[5-(2-Ethoxyphenyl)-1,2,4-oxadiazol-3-yl]pyridineIC50329.1 [1]
5-Bromo-3-(4-methoxy-phenylimino)-1,3-dihydro-indol-2-oneIC5050000.0 [1]
2H-Indol-2-one, 1,3-dihydro-3-(4-nitrophenylimino)-IC502800.0 [1]
2-(5-Mercapto-1,3,4-oxadiazol-2-yl)phenolIC503100.0 [1]
4-[3-(2-Fluorophenoxy)propyl]-3,5-dimethyl-1H-pyrazoleIC50296.0 [1]
5-(Chloromethyl)-2-(2,4-dichlorophenoxy)phenolIC50850.0 [1]
4-(2,4-Dichlorophenoxy)-3-hydroxybenzoic acidIC502590.0 [1]
4-(2,4-Dichlorophenoxy)-3-hydroxybenzaldehydeIC50520.0 [1]
(6Z)-5-Imino-3-methylsulfanyl-6-(naphthalen-1-ylmethylidene)-[1,2,4]thiadiazolo[4,5-a]pyrimidin-7-oneIC504881.0 [1]
2-[2-(3,5-Dimethyl-1H-pyrazol-4-yl)ethyl]-[1,2,4]triazolo[1,5-c]quinazoline-5-thiolIC501306.0 [1]
(5Z)-5-(Naphthalen-1-ylmethylidene)-1,3-thiazolidine-2,4-dioneIC50842.0 [1]
1-Methyl-3-(phenylimino)indoline-2-oneIC5011000.0 [1]
5-[(E)-2-(5-Chlorofuran-2-yl)ethenyl]-4-methylfuran-3-carboxylic acidIC502041.74 [1]
2,6-Dimethyl-4-(2-quinolin-2-ylethynyl)phenolIC502180.0 [1]
4-[2-(6-Aminoquinolin-2-yl)ethynyl]-2,6-dimethylphenolIC501900.0 [1]
5-[(E)-2-(5-Chlorofuran-2-yl)ethenyl]-2-methylfuran-3-carboxylic acidIC502511.89 [1]
2,6-Dimethyl-4-[2-(6-nitroquinolin-2-yl)ethynyl]phenolIC502060.0 [1]
2-[2-(4-Hydroxy-3,5-dimethylphenyl)ethynyl]quinolin-6-olIC502590.0 [1]
2H-Indol-2-one, 1,3-dihydro-3-[(4-methoxyphenyl)imino]-5-nitro-IC5050000.0 [1]
(3Z)-3-[(4-Iodophenyl)imino]-1,3-dihydro-2H-indol-2-oneIC5050000.0 [1]
(3Z)-3-[(4-Methoxyphenyl)imino]-5-methyl-1,3-dihydro-2H-indol-2-oneIC5050000.0 [1]
3-(4-Iodo-phenylimino)-5-methyl-1,3-dihydro-indol-2-oneIC5050000.0 [1]
5-Bromo-3-(4-iodophenyl)imino-1H-indol-2-oneIC5050000.0 [1]
3-(4-Iodophenyl)imino-5-nitro-1H-indol-2-oneIC5050000.0 [1]
5-Iodo-3-phenylimino-1H-indol-2-oneIC5050000.0 [1]
5-Iodo-3-(4-methoxyphenyl)imino-1H-indol-2-oneIC5050000.0 [1]
5-Iodo-3-(4-iodophenyl)imino-1H-indol-2-oneIC5050000.0 [1]
2-Chloro-3-[(E)-2-(4-hydroxy-3,5-dimethylphenyl)ethenyl]quinolin-7-olIC501490.0 [1]
4-(2,4-Dinitrophenoxy)-3-methoxybenzoic acidIC5020000.0 [1]
3-Methoxy-4-phenoxybenzaldehydeIC501310.0 [1]
3-Hydroxy-4-phenoxybenzoic acidIC503180.0 [1]
2,4-Dichloro-1-[4-(Chloromethyl)-2-Methoxyphenoxy]benzeneIC503160.0 [1]
2-(2,4-Dichlorophenoxy)-5-(hydroxymethyl)phenolIC501360.0 [1]
4-(2,4-Dichlorophenoxy)-3-methoxybenzoic acidIC50475.0 [1]
4-(Chloromethyl)-2-methoxy-1-phenoxybenzeneIC501940.0 [1]
3-(4-Iodophenyl)imino-1-methylindol-2-oneIC5050000.0 [1]
1-Methyl-3-(4-nitrophenyl)iminoindol-2-oneIC506300.0 [1]
1-Methyl-3-[(4-methylphenyl)imino]-1,3-dihydro-2H-indol-2-oneIC506300.0 [1]
3-[(4-Methoxyphenyl)imino]-1-methyl-1,3-dihydro-2H-indol-2-oneIC507700.0 [1]
3-Methoxy-4-phenoxybenzoic acidIC5041000.0 [1]
5-(Hydroxymethyl)-2-phenoxyphenolIC5045000.0 [1]
4-(2,4-Dinitrophenoxy)-3-hydroxybenzaldehydeIC5055000.0 [1]
(Z)-5-(3,5-Dibromo-4-methoxybenzylidene)thiazolidine-2,4-dioneIC50301.0 [1]
5-[(4-Carboxy-5-methylfuran-2-yl)methylsulfanylmethyl]-2-methylfuran-3-carboxylic acidIC507100.0 [1]
{4-[4-(Hydroxymethyl)-2-Methoxyphenoxy]benzene-1,3-Diyl}bis[hydroxy(Oxo)ammonium]IC5020000.0 [1]
N-(3,5-Dibromo-2-hydroxybenzyl)benzamideIC5010039.0 [1]
5-(3,4-Dichlorophenyl)-7-(trifluoromethyl)pyrazolo[1,5-a]pyrimidine-2-carboxylic acidIC502585.0 [1]
Benzenesulfonamide, N-(3,5-dibromo-4-oxo-2,5-cyclohexadien-1-ylidene)-IC505414.0 [1]
2-[2-(2-Chloro-6-hydroxyanilino)phenyl]acetic acidIC503742.0 [1]
(5z)-2-Amino-5-(3,5-Dibromo-4-Hydroxybenzylidene)-1-Methyl-1,5-Dihydro-4h-Imidazol-4-OneIC501152.0 [1]
2-{3-Bromo-5-ethoxy-4-[(2-methylbenzyl)oxy]phenyl}-1,3-thiazolidine-4-carboxylic acidIC504933.0 [1]
N-{4-[(3-{[(4-Methylphenyl)sulfonyl]amino}-2-quinoxalinyl)amino]phenyl}acetamideIC5010552.0 [1]
(6E)-5-Imino-6-[[3-methoxy-4-[(2-methylphenyl)methoxy]phenyl]methylidene]-2-methylsulfonyl-[1,3,4]thiadiazolo[3,2-a]pyrimidin-7-oneIC509764.0 [1]
9-Benzyl-7-(trifluoromethyl)pyrido[3',2':4,5]thieno[3,2-d]pyrimidine-2,4-diolIC505604.0 [1]
3-(2-Bromophenoxy)-7-hydroxychromen-4-oneIC503707.0 [1]
3-(2-Chlorophenoxy)-7-hydroxy-2-(trifluoromethyl)-4H-chromen-4-oneIC504217.0 [1]
3-(4-Cyano-3-methyl-1-oxo-4a,5-dihydro-4H-pyrido[1,2-a]benzimidazol-2-yl)propanoic acidIC508690.0 [1]
5-(2-Methyl-benzylidene)-thiazolidine-2,4-dioneIC503349.0 [1]
2-Chloro-5-[5-[(Z)-(2,4-dioxo-1,3-thiazolidin-5-ylidene)methyl]furan-2-yl]benzoic acidIC503927.0 [1]
2-Methoxy-5-({[3-sulfanyl-5-(trifluoromethyl)-4H-1,2,4-triazol-4-yl]imino}methyl)phenolIC50277.0 [1]
1-(2,4-Dihydroxyphenyl)-2-(2-methoxyphenyl)ethanoneIC502656.0 [1]
2-(2-Chloro-6-hydroxy-3-methylanilino)benzoic acidIC50504.0 [1]
10-Oxo-2-oxa-20-azapentacyclo[11.7.0.03,11.04,9.014,19]icosa-1(13),4,6,8,14,16,18-heptaene-12,12-dicarbonitrileIC50586.0 [1]
Items per page: 1 - 10 of 92
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References

This online tool may be cited as follows

MLA

"Quest Database™ Transthyretin Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/transthyretin-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2025, February 21). Quest Database™ Transthyretin Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/transthyretin-inhibitors-ic50-ki.
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