Transmembrane protease serine 6 Inhibitors (IC50, Ki)

Structure ▲ ▼	Compound Name ▲ ▼	Standard Type ▲ ▼	Standard Values (in nM) ▲ ▼
	Leupeptin	Ki	2400.0 [1], 4100.0 [2]
	(2S)-2-[[(2S)-2-[[(2S)-2-Amino-3-(4-hydroxyphenyl)propanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-N-[(2S)-1-(1,3-benzothiazol-2-yl)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-3-methylbutanamide	Ki	2.56 [1], 2.6 [2]
	N-(Benzylsulfonyl)-3-Cyclohexyl-D-Alanyl-N-(4-Carbamimidoylbenzyl)-L-Prolinamide	Ki	290.0 [1], 460.0 [2]
	N-(Benzylsulfonyl)-3-Cyclohexyl-D-Alanyl-N-[2-(Aminomethyl)-5-Chlorobenzyl]-L-Prolinamide	Ki	10000.0 [1]
	(2S)-1-[(2R)-2-(Benzylsulfonylamino)-5-(diaminomethylideneamino)pentanoyl]-N-[(4-carbamimidoylphenyl)methyl]pyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid	Ki	170.0 [1], 190.0 [2]
	(2S)-N-[[2-(Aminomethyl)-5-chlorophenyl]methyl]-1-[(2R)-2-(benzylsulfonylamino)-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carboxamide;2,2,2-trifluoroacetic acid	Ki	10000.0 [1]
	4-[4-(4-Amidinophenyl)piperazinyl]benzenecarboxamidine	Ki	1160.0 [1]
	4-[4-(4-Carbamimidoylphenyl)-1,4-diazepan-1-yl]benzamidine	Ki	4390.0 [1]
	alpha,alpha'-Di(amidinophenoxy)-p-xylene	Ki	5700.0 [1]
	4-[[2-[(4-Carbamimidoylphenoxy)methyl]phenyl]methoxy]benzamidine	Ki	5200.0 [1]
	4-[7-(4-Carbamimidoylanilino)heptylamino]benzenecarboximidamide	Ki	3680.0 [1]
	4-[8-(4-Carbamimidoylanilino)octylamino]benzenecarboximidamide	Ki	1640.0 [1]
	2-[(1R,4S,7S,13S,19S,22S,25S,28S,31R,34S,40S,43S,49S)-49-(2-Amino-2-oxoethyl)-4,19-bis[(2S)-butan-2-yl]-25-[3-(diaminomethylideneamino)propyl]-28,34-bis[(1R)-1-hydroxyethyl]-22-(hydroxymethyl)-3,6,12,18,21,24,27,30,33,36,39,42,48,51-tetradecaoxo-53,54-dithia-2,5,11,17,20,23,26,29,32,35,38,41,47,50-tetradecazapentacyclo[29.20.4.07,11.013,17.043,47]pentapentacontan-40-yl]acetamide	Ki	13600.0 [1]
	CID 46899577	Ki	170.0 [1]
	Inhibitor 1 [Colombo et al., 2012]	Ki	3.3 [1]
	(2S)-1-[(2S)-5-Amino-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-5-oxopentanoyl]-N-[(2S)-1-(1,3-benzothiazol-2-yl)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]pyrrolidine-2-carboxamide	Ki	7.8 [1]
	(2S)-2-[[(2S)-2-Amino-5-(diaminomethylideneamino)pentanoyl]amino]-N-[(2S)-1-[[(2S)-1-(1,3-benzothiazol-2-yl)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]pentanediamide	Ki	0.74 [1]
	(2S)-2-[[(2S)-2-Amino-5-(diaminomethylideneamino)pentanoyl]amino]-N-[(2S)-1-[[(2S)-1-(1,3-benzothiazol-2-yl)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxo-3-phenylpropan-2-yl]pentanediamide	Ki	1.4 [1]
	(2S)-2-Amino-N-[(2S)-1-[[(2S)-1-[[(2S)-1-(1,3-benzothiazol-2-yl)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]-5-(diaminomethylideneamino)pentanamide	Ki	6.3 [1]
	(2S)-2-Amino-N-[(2S)-1-[[(2S)-1-[[(2S)-1-(1,3-benzothiazol-2-yl)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-5-(diaminomethylideneamino)pentanamide	Ki	15.4 [1]
	(2S)-2-[[(2S)-2-Amino-4-methylpentanoyl]amino]-N-[(2S)-1-[[(2S)-1-(1,3-benzothiazol-2-yl)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]pentanediamide	Ki	13.47 [1]
	(2S)-2-[[(2S)-2-Amino-3-hydroxypropanoyl]amino]-N-[(2S)-1-[[(2S)-1-(1,3-benzothiazol-2-yl)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]pentanediamide	Ki	34.8 [1]
	(4S)-4-[[(2S)-2-[[(2S)-2-Amino-3-(1H-indol-3-yl)propanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-[[(2S)-1-(1,3-benzothiazol-2-yl)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-5-oxopentanoic acid	Ki	46.78 [1]
	(2S)-1-[(2S)-4-Amino-2-[[(2S)-2-amino-5-(diaminomethylideneamino)pentanoyl]amino]-4-oxobutanoyl]-N-[(2S)-1-(1,3-benzothiazol-2-yl)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]pyrrolidine-2-carboxamide	Ki	47.77 [1]
	(2S)-N-[(2S)-1-[[(2S)-1-(1,3-Benzothiazol-2-yl)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]-2-[[(2S)-2,6-diaminohexanoyl]amino]butanediamide	Ki	24.84 [1]
	(2S)-2-[[(2R)-2-[[(2S)-2-Amino-3-(1H-indol-3-yl)propanoyl]amino]-3-sulfanylpropanoyl]amino]-N-[(2S)-1-(1,3-benzothiazol-2-yl)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-3-(4-hydroxyphenyl)propanamide	Ki	1.03 [1]
	(2S)-2-Amino-N-[(2S)-1-[[(2S)-1-[[(2S)-1-(1,3-benzothiazol-2-yl)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-4-methylpentanamide	Ki	1.98 [1]
	(2S)-2-[[(2S)-2-Amino-5-(diaminomethylideneamino)pentanoyl]amino]-N-[(2S)-1-[[(2S)-1-(1,3-benzothiazol-2-yl)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]-4-methylpentanamide	Ki	2.48 [1]
	(2S)-6-Amino-2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]-N-[(2S)-1-[[(2S)-1-(1,3-benzothiazol-2-yl)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxopropan-2-yl]hexanamide	Ki	20.79 [1]
	2-[(1R,4S,7S,13S,19S,22S,25S,28S,31R,34S,40S,43S,49S)-19,49-Bis(2-amino-2-oxoethyl)-4-[(2S)-butan-2-yl]-25-[3-(diaminomethylideneamino)propyl]-28,34-bis[(1R)-1-hydroxyethyl]-22-(hydroxymethyl)-3,6,12,18,21,24,27,30,33,36,39,42,48,51-tetradecaoxo-53,54-dithia-2,5,11,17,20,23,26,29,32,35,38,41,47,50-tetradecazapentacyclo[29.20.4.07,11.013,17.043,47]pentapentacontan-40-yl]acetamide	Ki	19300.0 [1]
	(2S)-2-[[(3S,9S,12S,15S,18S,21R,26R,29S,32S)-21-[[(2S)-2-[(2-Aminoacetyl)amino]-5-(diaminomethylideneamino)pentanoyl]amino]-15-(4-aminobutyl)-9-[(2S)-butan-2-yl]-29-[3-(diaminomethylideneamino)propyl]-18-[(1R)-1-hydroxyethyl]-12-(hydroxymethyl)-2,8,11,14,17,20,28,31-octaoxo-23,24-dithia-1,7,10,13,16,19,27,30-octazatricyclo[30.3.0.03,7]pentatriacontane-26-carbonyl]amino]-3-(1H-imidazol-5-yl)propanoic acid	Ki	81.9 [1]
	(2S)-2-[[(3S,9S,12S,15S,18S,21R,26R,29S,32S)-21-[[(2S)-2-[(2-Aminoacetyl)amino]-5-(diaminomethylideneamino)pentanoyl]amino]-15-(4-aminobutyl)-9-(carboxymethyl)-29-[3-(diaminomethylideneamino)propyl]-18-[(1R)-1-hydroxyethyl]-12-(hydroxymethyl)-2,8,11,14,17,20,28,31-octaoxo-23,24-dithia-1,7,10,13,16,19,27,30-octazatricyclo[30.3.0.03,7]pentatriacontane-26-carbonyl]amino]-3-(1H-imidazol-5-yl)propanoic acid	Ki	87.0 [1]
	(1R,4S,7S,13S,19S,22S,25S,28S,31R,34S,41S,44S,50S)-50-Benzyl-4,19-bis[(2S)-butan-2-yl]-25,34-bis[3-(diaminomethylideneamino)propyl]-28-[(1R)-1-hydroxyethyl]-22-(hydroxymethyl)-3,6,12,18,21,24,27,30,33,36,39,43,49,52-tetradecaoxo-54,55-dithia-2,5,11,17,20,23,26,29,32,35,38,42,48,51-tetradecazapentacyclo[29.21.4.07,11.013,17.044,48]hexapentacontane-41-carboxylic acid	Ki	546.0 [1]
	(1R,4S,7S,13S,19S,22S,25S,28S,31R,34S,41S,44S,50S)-50-Benzyl-4-[(2S)-butan-2-yl]-25,34-bis[3-(diaminomethylideneamino)propyl]-28-[(1R)-1-hydroxyethyl]-22-(hydroxymethyl)-19-[(4-hydroxyphenyl)methyl]-3,6,12,18,21,24,27,30,33,36,39,43,49,52-tetradecaoxo-54,55-dithia-2,5,11,17,20,23,26,29,32,35,38,42,48,51-tetradecazapentacyclo[29.21.4.07,11.013,17.044,48]hexapentacontane-41-carboxylic acid	Ki	50000.0 [1]
	N,N'-Bis(4-carbamimidoylphenyl)oxamide	Ki	6230.0 [1]
	(2S)-2-Amino-N-[(2S)-1-[[(2S)-1-[[(2S)-1-(1,3-benzothiazol-2-yl)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-naphthalen-2-yl-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]-3-(4-hydroxyphenyl)propanamide	Ki	5.3 [1]
	N-[(2S)-1-[[(2S)-1-[[(2S)-1-(1,3-Benzothiazol-2-yl)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]-4-methylpentanamide	Ki	6.0 [1]
	(2S)-2-Amino-N-[(2S)-1-[[(2S)-1-[[(2S)-1-(1,3-benzothiazol-2-yl)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]-3-(4-hydroxyphenyl)propanamide	Ki	56.0 [1]
	(2R)-N-[(2S)-1-(1,3-Benzothiazol-2-yl)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-3-methyl-2-[[(2S)-4-phenyl-2-(3-phenylpropanoylamino)butanoyl]amino]butanamide	Ki	7.0 [1]
	(2S)-2-[[(2S)-2-[[(2S)-2-Amino-3-(4-hydroxyphenyl)propanoyl]amino]-3-phenylpropanoyl]amino]-N-[(2S)-1-(1,3-benzothiazol-2-yl)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-3-methylbutanamide	Ki	9.0 [1]
	(2S)-N-[(2S)-1-(1,3-Benzothiazol-2-yl)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-3-methyl-2-[[(2S)-3-(4-phenylmethoxyphenyl)-2-(3-phenylpropanoylamino)propanoyl]amino]butanamide	Ki	3.5 [1]
	(2R,3R)-N-[(2S)-1-(1,3-Benzothiazol-2-yl)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-3-methyl-2-[[(2S)-4-phenyl-2-(3-phenylpropanoylamino)butanoyl]amino]pentanamide	Ki	5.0 [1]
	(2S,3R)-N-[(2S)-1-(1,3-Benzothiazol-2-yl)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-3-hydroxy-2-[[(2S)-4-phenyl-2-(3-phenylpropanoylamino)butanoyl]amino]butanamide	Ki	5.3 [1]
	(2S)-2-Amino-N-[(2S)-1-[[(2S)-1-[[(2S)-1-(1,3-benzothiazol-2-yl)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxo-3-thiophen-2-ylpropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]-3-(4-hydroxyphenyl)propanamide	Ki	6.0 [1]
	(2S)-2-Amino-N-[(2S)-1-[[(2S)-1-[[(2S)-1-(1,3-benzothiazol-2-yl)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-(3,4-dihydroxyphenyl)-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]-3-(4-hydroxyphenyl)propanamide	Ki	5.0 [1]
	(2S,3S)-N-[(2S)-1-(1,3-Benzothiazol-2-yl)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-3-hydroxy-2-[[(2S)-4-phenyl-2-(3-phenylpropanoylamino)butanoyl]amino]butanamide	Ki	3.1 [1]
	(2S)-N-[(2S)-1-(1,3-Benzothiazol-2-yl)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-2-[[(2S)-4-phenyl-2-(3-phenylpropanoylamino)butanoyl]amino]pentanamide	Ki	2.3 [1]
	(2R,3S)-N-[(2S)-1-(1,3-Benzothiazol-2-yl)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-3-methyl-2-[[(2S)-4-phenyl-2-(3-phenylpropanoylamino)butanoyl]amino]pentanamide	Ki	690.0 [1]
	(2S)-2-Amino-N-[(2S)-1-[[(2S)-1-[[(2S)-1-(1,3-benzothiazol-2-yl)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxo-3-(1,3-thiazol-4-yl)propan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]-3-(4-hydroxyphenyl)propanamide	Ki	13.0 [1]
	(2S)-N-[(2S)-1-(1,3-Benzothiazol-2-yl)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-2-[[(2S)-3-(4-hydroxyphenyl)-2-(3-phenylpropanoylamino)propanoyl]amino]-3,3-diphenylpropanamide	Ki	340.0 [1]
	(2S)-N-[(2S)-1-(1,3-Benzothiazol-2-yl)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-4-methyl-2-[[(2S)-4-phenyl-2-(3-phenylpropanoylamino)butanoyl]amino]pentanamide	Ki	5.2 [1]
	(2S)-N-[(2S)-1-(1,3-Benzothiazol-2-yl)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-3-methyl-2-[[(2S)-2-(3-phenylpropanoylamino)-3-(1,3-thiazol-4-yl)propanoyl]amino]butanamide	Ki	0.4 [1]
	(2S)-2-Amino-N-[(2S)-1-[[(2S)-1-[[(2S)-1-(1,3-benzothiazol-2-yl)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]-3-(4-hydroxyphenyl)propanamide	Ki	1.1 [1]
	(2S)-2-[[(2S)-2-[[2-(1-Adamantyl)acetyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-N-[(2S)-1-(1,3-benzothiazol-2-yl)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-3-methylbutanamide	Ki	6.0 [1]
	(2S)-N-[(2S)-1-(1,3-Benzothiazol-2-yl)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-2-[[(2S)-3-(4-hydroxyphenyl)-2-(3-phenylpropanoylamino)propanoyl]amino]-3-methylbutanamide	Ki	1.74 [1]
	(2S)-N-[(2S)-1-(1,3-Benzothiazol-2-yl)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-3,3-dimethyl-2-[[(2S)-4-phenyl-2-(3-phenylpropanoylamino)butanoyl]amino]butanamide	Ki	560.0 [1]
	(2S)-N-[(2S)-1-(1,3-Benzothiazol-2-yl)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-2-[[(2S)-3-(4-hydroxyphenyl)-2-[3-(4-hydroxyphenyl)propanoylamino]propanoyl]amino]-3-methylbutanamide	Ki	1.2 [1]
	(2S)-2-Amino-N-[(2S)-1-[[(2S)-1-[[(2S)-1-(1,3-benzothiazol-2-yl)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(4-hydroxyphenyl)-1-oxopropan-2-yl]-3-(4-hydroxyphenyl)propanamide	Ki	3.1 [1]
	(2S,3R)-N-[(2S)-1-(1,3-Benzothiazol-2-yl)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-3-methyl-2-[[(2S)-4-phenyl-2-(3-phenylpropanoylamino)butanoyl]amino]pentanamide	Ki	2.6 [1]
	(2S,3S)-N-[(2S)-1-(1,3-Benzothiazol-2-yl)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-3-methyl-2-[[(2S)-4-phenyl-2-(3-phenylpropanoylamino)butanoyl]amino]pentanamide	Ki	4.0 [1]
	(2S)-2-[[(2S)-2-[[(2S)-2-Amino-3-(4-hydroxyphenyl)propanoyl]amino]-3-(3-chlorophenyl)propanoyl]amino]-N-[(2S)-1-(1,3-benzothiazol-2-yl)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-3-methylbutanamide	Ki	5.0 [1]
	(2S)-N-[(2S)-1-[[(2S)-1-(1,3-Benzothiazol-2-yl)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-1-oxobutan-2-yl]-4-phenyl-2-(3-phenylpropanoylamino)butanamide	Ki	1.5 [1]
	(2S)-N-[(2S)-1-(1,3-Benzothiazol-2-yl)-5-(diaminomethylideneamino)-1-oxopentan-2-yl]-3-methyl-2-[[(2S)-4-phenyl-2-(3-phenylpropanoylamino)butanoyl]amino]butanamide	Ki	2.1 [1]
	4-(Phenylsulfamoyl)benzenecarboximidamide;hydrochloride	Ki	88000.0 [1]
	3-(Benzylsulfamoyl)benzenecarboximidamide;hydrochloride	IC50	500000.0 [1]
	4-(Benzylsulfamoyl)benzenecarboximidamide;hydrochloride	IC50	500000.0 [1]
	(2S)-N-[(4-Carbamimidoylphenyl)methyl]-2-[(3-carbamimidoylphenyl)sulfonylamino]-3-phenylpropanamide;2,2,2-trifluoroacetic acid	Ki	16300.0 [1]
	(2R)-N-[(4-Carbamimidoylphenyl)methyl]-2-[(3-carbamimidoylphenyl)sulfonylamino]-3-phenylpropanamide;2,2,2-trifluoroacetic acid	Ki	27000.0 [1]
	(2S)-N-[(4-Carbamimidoylphenyl)methyl]-2-[(3-carbamimidoylphenyl)sulfonylamino]-3-phenylmethoxypropanamide;2,2,2-trifluoroacetic acid	Ki	24000.0 [1]
	(2R)-N-[(4-Carbamimidoylphenyl)methyl]-2-[(3-carbamimidoylphenyl)sulfonylamino]-3-phenylmethoxypropanamide;2,2,2-trifluoroacetic acid	Ki	12500.0 [1]
	2-[(3-Carbamimidoylphenyl)sulfonylamino]-N-phenylacetamide;2,2,2-trifluoroacetic acid	Ki	65000.0 [1]
	2-[(3-Carbamimidoylphenyl)sulfonylamino]-N-naphthalen-2-ylacetamide;2,2,2-trifluoroacetic acid	Ki	50000.0 [1]
	2-[(3-Carbamimidoylphenyl)sulfonylamino]-N-cyclohexylacetamide;2,2,2-trifluoroacetic acid	Ki	64000.0 [1]
	2-[(3-Carbamimidoylphenyl)sulfonylamino]-N-propan-2-ylacetamide;2,2,2-trifluoroacetic acid	Ki	148000.0 [1]
	N-(3-Carbamimidoylphenyl)-2-[(3,4-dimethoxyphenyl)sulfonylamino]acetamide;2,2,2-trifluoroacetic acid	Ki	196000.0 [1]
	N-(3-Carbamimidoylphenyl)-2-(naphthalen-2-ylsulfonylamino)acetamide;2,2,2-trifluoroacetic acid	Ki	163000.0 [1]
	N-(3-Carbamimidoylphenyl)-2-(naphthalen-1-ylsulfonylamino)acetamide;2,2,2-trifluoroacetic acid	Ki	163000.0 [1]
	Tert-butyl 4-[[2-[(4-carbamimidoylphenyl)sulfonylamino]acetyl]amino]benzoate;2,2,2-trifluoroacetic acid	Ki	42000.0 [1]
	Tert-butyl 3-[[2-[(4-carbamimidoylphenyl)sulfonylamino]acetyl]amino]benzoate;2,2,2-trifluoroacetic acid	IC50	500000.0 [1]
	Tert-butyl 4-[3-[(4-carbamimidoylphenyl)sulfonylamino]propanoylamino]benzoate;2,2,2-trifluoroacetic acid	IC50	500000.0 [1]
	Tert-butyl 3-[3-[(4-carbamimidoylphenyl)sulfonylamino]propanoylamino]benzoate;2,2,2-trifluoroacetic acid	IC50	500000.0 [1]
	Tert-butyl 4-[4-[(4-carbamimidoylphenyl)sulfonylamino]butanoylamino]benzoate;2,2,2-trifluoroacetic acid	Ki	27000.0 [1]
	Tert-butyl 3-[4-[(4-carbamimidoylphenyl)sulfonylamino]butanoylamino]benzoate;2,2,2-trifluoroacetic acid	IC50	500000.0 [1]
	Tert-butyl 4-[[2-[(3-carbamimidoylphenyl)sulfonylamino]acetyl]amino]benzoate;2,2,2-trifluoroacetic acid	Ki	137000.0 [1]
	Tert-butyl 3-[[2-[(3-carbamimidoylphenyl)sulfonylamino]acetyl]amino]benzoate;2,2,2-trifluoroacetic acid	Ki	48000.0 [1]
	Tert-butyl 4-[3-[(3-carbamimidoylphenyl)sulfonylamino]propanoylamino]benzoate;2,2,2-trifluoroacetic acid	Ki	7600.0 [1]
	Tert-butyl 3-[3-[(3-carbamimidoylphenyl)sulfonylamino]propanoylamino]benzoate;2,2,2-trifluoroacetic acid	Ki	65000.0 [1]
	Tert-butyl 4-[4-[(3-carbamimidoylphenyl)sulfonylamino]butanoylamino]benzoate;2,2,2-trifluoroacetic acid	Ki	70000.0 [1]
	Tert-butyl 3-[4-[(3-carbamimidoylphenyl)sulfonylamino]butanoylamino]benzoate;2,2,2-trifluoroacetic acid	IC50	500000.0 [1]
	4-[[2-[(4-Carbamimidoylphenyl)sulfonylamino]acetyl]amino]benzoic acid;2,2,2-trifluoroacetic acid	IC50	500000.0 [1]
	3-[[2-[(4-Carbamimidoylphenyl)sulfonylamino]acetyl]amino]benzoic acid;2,2,2-trifluoroacetic acid	IC50	500000.0 [1]
	4-[3-[(4-Carbamimidoylphenyl)sulfonylamino]propanoylamino]benzoic acid;2,2,2-trifluoroacetic acid	IC50	500000.0 [1]
	3-[3-[(4-Carbamimidoylphenyl)sulfonylamino]propanoylamino]benzoic acid;2,2,2-trifluoroacetic acid	IC50	500000.0 [1]
	4-[4-[(4-Carbamimidoylphenyl)sulfonylamino]butanoylamino]benzoic acid;2,2,2-trifluoroacetic acid	IC50	500000.0 [1]
	3-[4-[(4-Carbamimidoylphenyl)sulfonylamino]butanoylamino]benzoic acid;2,2,2-trifluoroacetic acid	IC50	500000.0 [1]
	4-[[2-[(3-Carbamimidoylphenyl)sulfonylamino]acetyl]amino]benzoic acid;2,2,2-trifluoroacetic acid	Ki	139000.0 [1]
	3-[[2-[(3-Carbamimidoylphenyl)sulfonylamino]acetyl]amino]benzoic acid;2,2,2-trifluoroacetic acid	Ki	207000.0 [1]
	4-[3-[(3-Carbamimidoylphenyl)sulfonylamino]propanoylamino]benzoic acid;2,2,2-trifluoroacetic acid	Ki	52000.0 [1]
	3-[3-[(3-Carbamimidoylphenyl)sulfonylamino]propanoylamino]benzoic acid;2,2,2-trifluoroacetic acid	Ki	208000.0 [1]
	4-[4-[(3-Carbamimidoylphenyl)sulfonylamino]butanoylamino]benzoic acid;2,2,2-trifluoroacetic acid	Ki	217000.0 [1]

Entire TableStructureCompound NameStandard TypeStandard Values (in nM)

Items per page: 510All1 - 10 of 100 ⟨⟩

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References

This online tool may be cited as follows

MLA	"Quest Database™ Transmembrane protease serine 6 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Feb. 2025, https://www.aatbio.com/data-sets/transmembrane-protease-serine-6-inhibitors-ic50-ki.
APA	AAT Bioquest, Inc. (2025, February 21). Quest Database™ Transmembrane protease serine 6 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/transmembrane-protease-serine-6-inhibitors-ic50-ki.
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