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Transmembrane domain-containing protein TMIGD3 Inhibitors (IC50, Ki)

Structure
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Compound Name
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Standard Type
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Standard Values (in nM)
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N-Benzoyl-N-(2-phenylimidazo[1,2-a]pyrazin-8-yl)benzamideIC50187.0 [1]
N-Benzoyl-N-(2-phenylimidazo[1,2-a]pyrazin-8-yl)benzamideKi64.0 [1]
N-(2,6-Diphenylimidazo[1,2-a]pyrazin-8-yl)-4-methoxybenzamideIC5073.0 [1]
N-(2,6-Diphenylimidazo[1,2-a]pyrazin-8-yl)-4-methoxybenzamideKi25.0 [1]
N-(2,6-Diphenylimidazo[1,2-a]pyrazin-8-yl)pyridine-3-carboxamideIC50172.0 [1]
N-(2,6-Diphenylimidazo[1,2-a]pyrazin-8-yl)pyridine-3-carboxamideKi54.0 [1]
N-(2,6-Diphenylimidazo[1,2-a]pyrazin-8-yl)benzamideIC50235.0 [1]
N-(2,6-Diphenylimidazo[1,2-a]pyrazin-8-yl)benzamideKi82.0 [1]
N-(2-Phenylimidazo[1,2-a]pyrazin-8-yl)benzamideIC50163.0 [1]
N-(2-Phenylimidazo[1,2-a]pyrazin-8-yl)benzamideKi52.0 [1]
TheophyllineKi86400.0 [1]
5'-N-EthylcarboxamidoadenosineKi16.0 [1]
Propyl 6-ethyl-5-ethylsulfanylcarbonyl-2-phenyl-4-propylpyridine-3-carboxylateKi19.0 [1]
Diethyl 2-methyl-6-phenyl-4-[(E)-2-phenylethenyl]-1,4-dihydropyridine-3,5-dicarboxylateKi108.0 [1]
6-Ethylthieno[2,3-d]pyrimidin-4(3H)-oneKi13489.63 [1]
6-Ethyl-2-(pyrrolidin-1-yl)-3H,4H-thieno[2,3-d]pyrimidin-4-oneKi2290.87 [1]
6-Ethyl-2-(4-pyridinyl)thieno[2,3-d]pyrimidin-4(3H)-oneKi1995.26 [1]
(2R,3R,4S,5S)-3,4-Dihydroxy-2-[6-[(3-iodophenyl)methylamino]purin-9-yl]-1-oxa-7-azaspiro[4.4]nonan-6-oneIC5042.0 [1]
9-Propyl-9h-purin-6-amineKi100000.0 [1]
(1R,2R,3S,4R,5S)-4-[2-Chloro-6-[(3-chlorophenyl)methylamino]purin-9-yl]bicyclo[3.1.0]hexane-2,3-diolKi4900.0 [1]
(1R,2R,3S,4R,5S)-4-[2-Chloro-6-(dicyclopropylmethylamino)purin-9-yl]bicyclo[3.1.0]hexane-2,3-diolKi470.0 [1]
8-Bromo-9-propyl-9H-purin-6-ylamineKi100000.0 [1]
(1S,2R,3S,4R,5S)-4-[5-[2-(5-Chlorothiophen-2-yl)ethynyl]-7-(ethylamino)imidazo[4,5-b]pyridin-3-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamideKi1.69 [1]
(1S,2R,3S,4R,5S)-4-[2-[4-(5-Chlorothiophen-2-yl)triazol-1-yl]-6-(methylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamideKi0.73 [1]
(1S,2R,3S,4R,5S)-4-[2-[4-(5-Chlorothiophen-2-yl)triazol-1-yl]-6-(ethylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamideKi1.22 [1]
2-Chloro-N-[(3-chlorophenyl)methyl]-7H-purin-6-amineKi165.0 [1]
3-O-Ethyl 5-O-phenyl 2-methyl-6-phenyl-4-(2-phenylethynyl)-1,4-dihydropyridine-3,5-dicarboxylateKi31.4 [1]
(1S,2R,3S,4R,5S)-2,3-Dihydroxy-N-methyl-4-[6-(methylamino)-2-(4-phenyltriazol-1-yl)purin-9-yl]bicyclo[3.1.0]hexane-1-carboxamideKi0.96 [1]
(1S,2R,3S,4R,5S)-4-[2-[4-(2-Chlorophenyl)triazol-1-yl]-6-(methylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamideKi0.95 [1]
(1S,2R,3S,4R,5S)-4-[2-[4-(3,4-Difluorophenyl)triazol-1-yl]-6-(methylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamideKi1.06 [1]
(1S,2R,3S,4R,5S)-2,3-Dihydroxy-N-methyl-4-[6-(methylamino)-2-(4-pyridin-2-yltriazol-1-yl)purin-9-yl]bicyclo[3.1.0]hexane-1-carboxamideKi1.84 [1]
(1S,2R,3S,4R,5S)-2,3-Dihydroxy-N-methyl-4-[6-(methylamino)-2-(4-pyrimidin-2-yltriazol-1-yl)purin-9-yl]bicyclo[3.1.0]hexane-1-carboxamideKi3.48 [1]
(1S,2R,3S,4R,5S)-2,3-Dihydroxy-N-methyl-4-[6-(methylamino)-2-(4-pyrazin-2-yltriazol-1-yl)purin-9-yl]bicyclo[3.1.0]hexane-1-carboxamideKi2.21 [1]
(1S,2R,3S,4R,5S)-4-[2-[4-(5-Bromothiophen-2-yl)triazol-1-yl]-6-(methylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamideKi0.58 [1]
(1S,2R,3S,4R,5S)-4-[6-(Ethylamino)-2-iodopurin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamideKi1.22 [1]
(1S,2R,3S,4R,5S)-2,3-Dihydroxy-4-[2-iodo-6-(2-phenylethylamino)purin-9-yl]-N-methylbicyclo[3.1.0]hexane-1-carboxamideKi0.91 [1]
(1S,2R,3S,4R,5S)-4-[2-Azido-6-(2-phenylethylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamideKi0.85 [1]
(1S,2R,3S,4R,5S)-4-[6-(Cyclobutylamino)-2-iodopurin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamideKi1.53 [1]
(1S,2R,3S,4R,5S)-2,3-Dihydroxy-N-methyl-4-[6-(methylamino)-2-[4-(1-methylpyrazol-4-yl)triazol-1-yl]purin-9-yl]bicyclo[3.1.0]hexane-1-carboxamideKi2.16 [1]
(1S,2R,3S,4R,5S)-4-[2-[4-(Furan-2-yl)triazol-1-yl]-6-(methylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamideKi0.96 [1]
(1S,2R,3S,4R,5S)-4-[2-Azido-6-[(3-chlorophenyl)methylamino]purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamideKi1.08 [1]
(1S,2R,3S,4R,5S)-4-[2-Azido-6-(methylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamideKi0.54 [1]
(1S,2R,3S,4R,5S)-4-[2-Azido-6-(ethylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamideKi0.69 [1]
(1S,2R,3S,4R,5S)-4-[2-Azido-6-(cyclobutylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamideKi0.85 [1]
(1S,2R,3S,4R,5S)-4-[2-[4-(1-Benzofuran-2-yl)triazol-1-yl]-6-(methylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamideKi1.25 [1]
(1S,2R,3S,4R,5S)-4-[2-[4-(5-Chlorothiophen-2-yl)triazol-1-yl]-6-(cyclobutylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamideKi7.05 [1]
(1S,2R,3S,4R,5S)-4-[6-[(3-Chlorophenyl)methylamino]-2-[4-(5-chlorothiophen-2-yl)triazol-1-yl]purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamideKi9.02 [1]
(1S,2R,3S,4R,5S)-4-[2-[4-(5-Chlorothiophen-2-yl)triazol-1-yl]-6-(2-phenylethylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamideKi6.66 [1]
(1S,2R,3S,4R,5S)-2,3-Dihydroxy-N-methyl-4-[2-(methylamino)purin-9-yl]bicyclo[3.1.0]hexane-1-carboxamideKi604.0 [1]
(1S,2R,3S,4R,5S)-4-[2-[2-(5-Chlorothiophen-2-yl)ethynyl]-6-methylpurin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamideKi42.2 [1]
(1S,2R,3S,4R,5S)-4-[2-[2-(3,4-Difluorophenyl)ethynyl]purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamideKi124.0 [1]
(1S,2R,3S,4R,5S)-4-[2-[2-(5-Chlorothiophen-2-yl)ethynyl]purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamideKi60.0 [1]
(1S,2R,3S,4R,5S)-4-[2-[2-(5-Chlorothiophen-2-yl)ethynyl]-6-methoxypurin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamideKi684.0 [1]
(1S,2R,3S,4R,5S)-2,3-Dihydroxy-N-methyl-4-[6-methyl-2-(2-phenylethynyl)purin-9-yl]bicyclo[3.1.0]hexane-1-carboxamideKi6.01 [1]
(1S,2R,3S,4R,5S)-4-[2-[2-(3,4-Difluorophenyl)ethynyl]-6-methylpurin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamideKi98.5 [1]
(1S,2R,3S,4R,5S)-4-[2-[2-(4-Tert-butylphenyl)ethynyl]-6-methylpurin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamideKi305.0 [1]
(1S,2R,3S,4R,5S)-2,3-Dihydroxy-N-methyl-4-[6-methyl-2-(2-pyrazin-2-ylethynyl)purin-9-yl]bicyclo[3.1.0]hexane-1-carboxamideKi343.0 [1]
3-(4-Bromothiophen-2-yl)-8-hydroxychromen-2-oneKi746.0 [1]
N-[(3-Chlorophenyl)methyl]-2-[2-(3,4-difluorophenyl)ethynyl]-7H-purin-6-amineKi120.0 [1]
(1R,2R,3S,4R,5S)-4-[2-Chloro-6-(pentan-3-ylamino)purin-9-yl]-1-(hydroxymethyl)bicyclo[3.1.0]hexane-2,3-diolKi1200.0 [1]
(1R,2R,3S,4R,5S)-4-[2-Chloro-6-[[(1R)-1-cyclopropyl-2-methylpropyl]amino]purin-9-yl]-1-(hydroxymethyl)bicyclo[3.1.0]hexane-2,3-diolKi1240.0 [1]
(1R,2R,3S,4R,5S)-4-[2-Chloro-6-[[(1R)-1-cyclopropylpropyl]amino]purin-9-yl]-1-(hydroxymethyl)bicyclo[3.1.0]hexane-2,3-diolKi160.0 [1]
(1R,2R,3S,4R,5S)-4-[2-Chloro-6-[[(R)-cyclobutyl(cyclopropyl)methyl]amino]purin-9-yl]-1-(hydroxymethyl)bicyclo[3.1.0]hexane-2,3-diolKi3470.0 [1]
(1S,2R,3S,4R,5S)-4-[2-Chloro-6-(dicyclopropylmethylamino)purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hexane-1-carboxylic acidKi5980.0 [1]
(1R,2R,3S,4R,5S)-4-[2-Chloro-6-(dicyclopropylmethylamino)purin-9-yl]-1-(hydroxymethyl)bicyclo[3.1.0]hexane-2,3-diolKi1600.0 [1]
(1S,2R,3S,4R,5S)-N-(2-Acetamidoethyl)-4-[2-chloro-6-(dicyclopropylmethylamino)purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hexane-1-carboxamideKi1650.0 [1]
(1R,2R,3S,4R,5S)-4-[2-Chloro-6-[[(S)-cyclobutyl(cyclopropyl)methyl]amino]purin-9-yl]-1-(hydroxymethyl)bicyclo[3.1.0]hexane-2,3-diolKi3240.0 [1]
Ethyl (1S,2R,3S,4R,5S)-4-[2-chloro-6-(dicyclopropylmethylamino)purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hexane-1-carboxylateKi236.0 [1]
Propyl (1S,2R,3S,4R,5S)-4-[2-chloro-6-(dicyclopropylmethylamino)purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hexane-1-carboxylateKi499.0 [1]
(1S,2R,3S,4R,5S)-4-[2-Chloro-6-(dimethylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamideKi1480.0 [1]
(1S,2R,3S,4R,5S)-4-[2-Chloro-6-(dimethylamino)purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hexane-1-carboxylic acidKi1080.0 [1]
(1S,2R,3S,4R,5S)-4-[2-Chloro-6-(dicyclopropylmethylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamideKi34.0 [1]
(1R,2R,3S,4R,5S)-4-[2-Chloro-6-[[(1S)-1-cyclopropylpropyl]amino]purin-9-yl]-1-(hydroxymethyl)bicyclo[3.1.0]hexane-2,3-diolKi1810.0 [1]
Methyl (1S,2R,3S,4R,5S)-4-[2-chloro-6-(dicyclopropylmethylamino)purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hexane-1-carboxylateKi766.0 [1]
(1R,2R,3S,4R,5S)-4-[2-Chloro-6-(dimethylamino)purin-9-yl]-1-(hydroxymethyl)bicyclo[3.1.0]hexane-2,3-diolKi2470.0 [1]
(1R,2R,3S,4R,5S)-4-[2-Chloro-6-[[(1S)-1-cyclopropyl-2-methylpropyl]amino]purin-9-yl]-1-(hydroxymethyl)bicyclo[3.1.0]hexane-2,3-diolKi3450.0 [1]
(1S,2R,3S,4R,5S)-N-(3-Acetamidopropyl)-4-[2-chloro-6-(dicyclopropylmethylamino)purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hexane-1-carboxamideKi1970.0 [1]
(1S,2R,3S,4R,5S)-4-[2-[2-(5-Chlorothiophen-2-yl)ethynyl]-6-(dimethylamino)purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamideKi23.5 [1]
(1S,2R,3S,4R,5S)-4-[2-Chloro-6-[(Z)-2-hydroxy-2-phenylethenyl]purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamideKi1140.0 [1]
(1S,2R,3S,4R,5S)-2,3-Dihydroxy-4-[6-[(Z)-2-hydroxy-2-phenylethenyl]-2-(2-phenylethynyl)purin-9-yl]-N-methylbicyclo[3.1.0]hexane-1-carboxamideKi78.5 [1]
(1S,2R,3S,4R,5S)-4-[2-[2-(2-Chlorophenyl)ethynyl]-6-[(Z)-2-(2-chlorophenyl)-2-hydroxyethenyl]purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamideKi515.0 [1]
(1S,2R,3S,4R,5S)-4-[2-[2-(4-Tert-butylphenyl)ethynyl]-6-[(Z)-2-(4-tert-butylphenyl)-2-hydroxyethenyl]purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamideKi94.3 [1]
(1S,2R,3S,4R,5S)-2,3-Dihydroxy-4-[2-[(Z)-2-hydroxy-2-pyrazin-2-ylethenyl]purin-9-yl]-N-methylbicyclo[3.1.0]hexane-1-carboxamideKi1480.0 [1]
2-Phenylethyl (1S,2R,3S,4R,5S)-4-[2-[2-(5-chlorothiophen-2-yl)ethynyl]-6-(methylamino)purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hexane-1-carboxylateKi262.0 [1]
Butyl (1S,2R,3S,4R,5S)-4-[2-[2-(5-chlorothiophen-2-yl)ethynyl]-6-(methylamino)purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hexane-1-carboxylateKi17.5 [1]
Methyl (1S,2R,3S,4R,5S)-4-[2-[2-(5-chlorothiophen-2-yl)ethynyl]-6-(methylamino)purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hexane-1-carboxylateKi5.38 [1]
4-Chloro-N-(2,6-diphenylimidazo[1,2-a]pyrazin-8-yl)benzamideKi156.0 [1]
(1S,2R,3S,4R,5S)-4-[6-[2-(5-Chlorothiophen-2-yl)ethynyl]-4-(methylamino)imidazo[4,5-c]pyridin-1-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamideKi9.33 [1]
Methyl (1S,2R,3S,4R,5S)-4-[2-[2-(5-bromothiophen-2-yl)ethynyl]-6-(methylamino)purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hexane-1-carboxylateKi8.56 [1]
Propan-2-yl (1S,2R,3S,4R,5S)-4-[2-[2-(5-chlorothiophen-2-yl)ethynyl]-6-(methylamino)purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hexane-1-carboxylateKi42.9 [1]
4-Methoxy-N-(2-phenylimidazo[1,2-a]pyrazin-8-yl)benzamideKi162.0 [1]
(2S,3S,4R,5R)-5-[2-[2-(5-Chlorothiophen-2-yl)ethynyl]-6-(propylamino)purin-9-yl]-3,4-dihydroxy-N-methyloxolane-2-carboxamideKi6.25 [1]
N-(2,6-Diphenylimidazo[1,2-a]pyrazin-8-yl)-4-methylbenzamideKi223.0 [1]
(2S,3S,4R,5R)-5-[2-[2-(5-Chlorothiophen-2-yl)ethynyl]-6-(methylamino)purin-9-yl]-3,4-dihydroxy-N-methyloxolane-2-carboxamideKi1.55 [1]
Benzyl (1S,2R,3S,4R,5S)-4-[2-[2-(5-chlorothiophen-2-yl)ethynyl]-6-(methylamino)purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hexane-1-carboxylateKi7.31 [1]
N-(2,6-Diphenylimidazo[1,2-a]pyrazin-8-yl)-4-fluorobenzamideKi38.0 [1]
3-Methylbutyl (1S,2R,3S,4R,5S)-4-[2-[2-(5-chlorothiophen-2-yl)ethynyl]-6-(methylamino)purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hexane-1-carboxylateKi24.4 [1]
(1S,2R,3S,4R,5S)-N-(2-Aminoethyl)-4-[2-[2-(5-chlorothiophen-2-yl)ethynyl]-6-(methylamino)purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hexane-1-carboxamideKi156.0 [1]
N-[2-(4-Methoxyphenyl)imidazo[1,2-a]pyrazin-8-yl]benzamideKi121.0 [1]
N-(2,6-Diphenylimidazo[1,2-a]pyrazin-8-yl)thiophene-2-carboxamideKi185.0 [1]
Items per page: 1 - 10 of 100
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References

This online tool may be cited as follows

MLA

"Quest Database™ Transmembrane domain-containing protein TMIGD3 Inhibitors (IC50, Ki)." AAT Bioquest, Inc., 21 Nov. 2024, https://www.aatbio.com/data-sets/transmembrane-domain-containing-protein-tmigd3-inhibitors-ic50-ki.

APA

AAT Bioquest, Inc. (2024, November 21). Quest Database™ Transmembrane domain-containing protein TMIGD3 Inhibitors (IC50, Ki). AAT Bioquest. https://www.aatbio.com/data-sets/transmembrane-domain-containing-protein-tmigd3-inhibitors-ic50-ki.
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